Clinical trials: Degenerative Cervical Myelopathy, active
Cervical Stenosis, Myelopathy
Assessing Microbiome in Primary Anterior Cervical Fusion Patients
Patients who are about to undergo cervical fusion surgery at Hospital for Special Surgery (HSS) are being asked to take part in this research study.
- Conditions
- Cervical Stenosis, Myelopathy, Cervical Spondylosis With Myelopathy, Degenerative Disc Disease
- Trial name
- NCT07877766
- Testing
- Primary Anterior Cervical Discectomy Procedures
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Hospital for Special Surgery, New York
Cervical Spondylosis With Myelopathy, Cervical Radiculopathy
Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty
This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and/or radiculopathy today: Biomet Zimmer Mobi-C and…
- Conditions
- Cervical Spondylosis With Myelopathy, Cervical Radiculopathy, Cervical Disc Herniation, Degenerative Disc Disease
- Trial name
- NCT05701059
- Testing
- Cervical arthroplasty, Semi-Constrained Nuvasive Simplify, Unconstrained Biomet Zimmer Mobi-C
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Degenerative Cervical Myelopathy
Stimulation-based Therapy to Improve Balance in DCM
The goal of this clinical trial is to determine if a treatment called transcutaneous spinal cord stimulation (tSCS), when combined with balance training, can help improve balance in adults who have had surgery for degenerative…
- Trial name
- STIM-DCM (NCT07298460)
- Testing
- Transcutaneous spinal cord stimulation, Balance and Gait Training
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Medical College of Wisconsin
Degenerative Cervical Myelopathy, Non-myelopathic Degenerative Cervical Cord Compression
A Multicenter Registry-Based Study Across the Spectrum of Degenerative Cervical Myelopathy
This is a multicenter, prospective, longitudinal, observational registry-based study of degenerative cervical myelopathy (DCM) across the full disease spectrum, linked to a disease-specific biobank.
- Conditions
- Degenerative Cervical Myelopathy, Non-myelopathic Degenerative Cervical Cord Compression, Asymptomatic Degenerative Cervical Cord Compression, Cervical Spinal Cord Compression
- Trial name
- DCM-RB (NCT07641699)
- Testing
- Registry-based observation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wangjing Hospital, China Academy of Chinese Medical Sciences
Cervical Myelopathy
Activity Monitors as a Measure of Physical Function in Degenerative Cervical Myelopathy
The investigators objective of this research is to compare activity monitor results with standard of care (SOC) question-based outcome measures for degenerative cervical myelopathy patients before and after treatment with…
- Trial name
- NCT04498806
- Testing
- Fitbit
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Radiculopathy, Cervical, Myelopathy Cervical
Pilot Study of ZetaFuse™ Bone Graft for the Treatment of Cervical Degenerative Disc Disease
The goal of this pilot clinical trial is to test the safety and preliminary performance of the ZetaFuse Bone Graft in patient requiring fusion of the C3-C7 vertebral bones due to pain or loss of neurological function.
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Neurological Abnormality, Disc Disease
- Trial name
- NCT05971329
- Testing
- Cervical Fusion (ZetaFuse™ Bone Graft)
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Zetagen Therapeutics, Inc
Cervical Spondylosis With Myelopathy
Cervical Spondylotic Myelopathy Surgical Trial
The purpose of the study is to determine the optimal surgical approach (ventral vs dorsal) for patients with multi-level cervical spondylotic myelopathy (CSM).
- Trial name
- NCT02076113
- Testing
- Ventral (Front) decompression with Fusion, Dorsal (Back) Decompression with Fusion, Dorsal (back) Laminoplasty
- Where
- 16 sites in United States, Canada
- Volunteers
- 269 people
- Sponsor
- Lahey Clinic
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Cervical Degenerative Disc Disease
Real World Data Collection on the Synergy Disc
This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts.
- Trial name
- NCT06383949
- Testing
- Synergy Cervical Disc system
- Where
- Ireland
- Volunteers
- 50 people
- Sponsor
- Synergy Spine Solutions
Cervical Spinal Stenosis, Cervical Myelopathy
CSS-Assessing the Course of Degenerative Cervical Spinal Stenosis Using Functional Outcomes
The study will consist of two parts: In Study A, objectively assessed physical activity, gait, balance, range of movement of specific joints during walking and neurophysiological findings between patients with cervical spine…
- Trial name
- NCT04381663
- Testing
- conservative treatment, surgical treatment
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Degenerative Cervical Spinal Stenosis
A Novel Surgical Criteria for Degenerative Cervical Myelopathy in Chinese Ethnicity
Degenerative Cervical Myelopathy (DCM) is an age-related irreversible degenerative disease predominantly affecting the elderly aged 50 and over.
- Trial name
- NCT06528730
- Testing
- DCM
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Degenerative Cervical Myelopathy
Conservative Care Versus Decompression Trial for Degenerative Cervical Myelopathy Pilot
This study is a pilot randomized clinical trial designed to test whether it is feasible to conduct a larger study comparing two standard treatments for mild degenerative cervical myelopathy (DCM).
- Trial name
- CADET-DCM (NCT07358273)
- Testing
- Decompression Surgery, Conservative Care
- Volunteers
- 56 people
- Sponsor
- McMaster University
Degenerative Cervical Myelopathy
Vagus Nerve Stimulation for Myelopathy
The objective of this study is to generate preliminary data to establish the feasibility and effectiveness of transauricular vagus nerve stimulation (taVNS) to improve post-operative outcomes of moderate to severe degenerative…
- Trial name
- NCT07660250
- Testing
- Vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cervical Myelopathy
Degenerative Cervical Myelopathy Repository
To create a research repository of patients with known degenerative cervical myelopathy (DCM) and a control cohort of subjects who have non-myelopathic spinal disease.
- Trial name
- DCM (NCT05446259)
- Testing
- Standard clinical care procedures and outcome measurements.
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Francis Farhadi
Cervical Myelopathy
Timing of Rehabilitation Following Cervical Spinal Surgery in Degenerative Myelopathy
The goal of this clinical trial is to learn whether starting rehabilitation earlier after surgery can improve recovery and is feasible and acceptable for adults with degenerative cervical myelopathy (DCM) undergoing cervical…
- Trial name
- NCT07636135
- Testing
- Physical Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Spinal Cord Injuries, Neurogenic Bladder Dysfunction
Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury
Building on recent improvements, state-of-the-art functional MRI will be applied as an advanced diagnostic tool for the lumbosacral cord in spinal cord injury (SCI) patients to characterize the remaining neuronal activity of the…
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder Dysfunction, Degenerative Cervical Spinal Stenosis
- Trial name
- NCT05681936
- Where
- Switzerland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spondylosis, Cervical, Spinal Cord Compression
Validity of the Turkish Translation of the Modified JOA
Degenerative cervical myelopathy (DCM) is the most common cause of non-traumatic spinal cord dysfunction in adults and may lead to progressive motor, sensory, and autonomic impairment.
- Trial name
- NCT07448883
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Izmir Democracy University
Degenerative Disc Disease, Craniocervical Injuries
Posterior Cervical Fixation Study
The objective of this study is to evaluate the safety and performance of occipito-cervico-thoracic spine surgery using posterior fixation as measured by reported complications, radiographic outcomes, and patients reported…
- Conditions
- Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
- Trial name
- NCT04770571
- Testing
- observational study
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- NuVasive
Degenerative Disc Disease (DDD), Spinal Stenosis
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials
This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems…
- Conditions
- Degenerative Disc Disease (DDD), Spinal Stenosis, Spondylolisthesis, Spinal Deformities
- Trial name
- INFO SPINE (NCT07615491)
- Testing
- Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 561 people
- Sponsor
- Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.
ALS, Amyotrophic Lateral Sclerosis
NYSCF Scientific Discovery Biobank
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells…
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Alzheimer Disease, Alzheimer Disease, Early Onset
- Trial name
- NCT06203106
- Testing
- Biological Sample Collection
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- New York Stem Cell Foundation Research Institute