Clinical trials: Degenerative Disorder of Bone
Degenerative Disc Disease
Utilization of Autologous Mesenchymal Cells in Posterolateral Spinal Fusion in Degenerative Spine Disease
Subjects in whom a posterolateral fusion surgery has been planned and who meet the inclusion and exclusion criteria were proposed to receive a single-dose AMSC treatment, in order to assess its safety and efficacy on…
- Trial name
- AMSC-DSD-001 (NCT03827096)
- Testing
- Suspension of human autologous MSC 3P in 1.5 ml
- Volunteers
- 10 people
- Sponsor
- Bioinova, s.r.o.
Bone Degenerative Changes, Osteoarthritis
Parallel Study Between BMP-2 and Autologous Bone Graft After Ilizarow Treatment
Results of growth factors indicate that Bone Morphogenetic Proteins (BMP) have an exceptional ability to stimulate different characteristics of mesenchymale cells to osseous cells.
- Conditions
- Bone Degenerative Changes, Osteoarthritis, Degenerative Disorder of Bone
- Trial name
- NCT01690260
- Testing
- Bone Morphogenetic Protein 2, Autologous bone graft
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Degenerative Disc Disease, Degenerative Spondylolisthesis
TLIF Osteo3 ZP Putty Study (Also Known as the TOP Fusion Study)
In recent years there has been an increase in interest from surgeons in the use of synthetic bone graft substitutes to avoid the need of sourcing allograft or iliac crest autograft for use in spinal fusion procedures.
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- NCT05114135
- Testing
- Osteo3 ZP Putty
- Where
- Hungary
- Volunteers
- 17 people
- Sponsor
- OssDsign
Degenerative Disc Disease, Spondylolisthesis, Lumbar Region
Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions
Spinal operations including lumbar fusions for degenerative disorders are becoming more prevalent as the population ages. Inadequate or excessive postoperative analgesia can result in medical comorbidities and prolonged hospital…
- Trial name
- NCT04112550
- Testing
- Methadone Hydrochloride, Oxycodone-Acetaminophen
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Cervical Disc Herniation, Cervical Disc Degeneration
Anterior Cervical Disectomy And Fusion Using The Tritanium® C Anterior Cervical Cage For One Or Two-Levels
This is a prospective, single arm clinical study to evaluate fusion status and patient reported outcomes utilizing the Stryker Tritanium® C Anterior Cervical interbody device at one or two contiguous levels.
- Conditions
- Cervical Disc Herniation, Cervical Disc Degeneration, Degenerative Disc Disease
- Trial name
- Stryker Spine (NCT04214535)
- Testing
- Tritanium C Anterior Cervical Cage
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Corewell Health East
Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
Degenerative Spondylolisthesis Accompanying LSS: Do We Need Fusion?
This study aimed to compare clinical results of decompression alone using minimal invasive unilateral laminotomy for bilateral decompression versus classical decompression and instrumentation and fusion.
- Conditions
- Degenerative Spondylolisthesis, Lumbar Spinal Stenosis, Fusion
- Trial name
- NCT07410871
- Testing
- Unilateral laminotomy decompression, Decompression and fusion
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Kafrelsheikh University
Cervical Myelopathy, Ossification of Posterior Longitudinal Ligament in Cervical Region
The Establishment of the Integration of Surgery and Postoperative Intensive Recovery of Patients With CSM
This study aims to establish the specialist consensus of the integration of posterior approach surgical treatment and postoperative intensive recovery management for CSM or OPLL patients, and verify its safety, practicability and…
- Trial name
- NCT04947891
- Testing
- Intensive recovery management
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University Third Hospital
Degenerative Disc Disease(DDD)
Evaluation of the Safety and Effectiveness of the CORUS™ Posterior Cervical Stabilization System 3D (PCSS 3D) for the Treatment of 2-level Cervical Degenerative Disease
The objective of this clinical trial is to evaluate the treatment of patients with two-level cervical degenerative disease using a combination of Anterior Cervical Discectomy and Fusion (ACDF) and Posterior Cervical Fusion (PCF)…
- Trial name
- SECOND (NCT07721493)
- Testing
- Circumferential Cervical Fusion (CCF), Anterior Cervical Discectomy and Fusion
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Providence Medical Technology, Inc.
Cervical Spondylosis
Prognostic Factors for ACDF With BAK/C in Cervical Disc Disease
This retrospective study aimed to identify predictive prognostic factors for treatment outcomes in patients with cervical degenerative disc disease (CDDD).
- Trial name
- NCT07069114
- Testing
- Anterior Cervical Discectomy and Fusion with BAK/C Interbody Fusion
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Liang Hao
Cervical Disc Disease, Degenerative Disc Disease
Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc
A prospective, multicenter post-market clinical follow-up study to evaluate the 10-year long-term safety and effectiveness of the Simplify Disc in subjects who were enrolled in the post approval study (NCT04630626).
- Trial name
- NCT05258435
- Testing
- NuVasive Simplify Cervical Artificial Disc
- Where
- 10 sites in United States
- Volunteers
- 131 people
- Sponsor
- NuVasive
Retinitis Pigmentosa
Intravitreal Injection of MSCs in Retinitis Pigmentosa
The purpose of this study is to determine the feasibility and safety of adult human bone marrow-derived mesenchymal stem cells by intravitreal injection in patients with retinitis pigmentosa.
- Trial name
- NCT01531348
- Testing
- BM-MSC
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Mahidol University
Prolapsed Lumbar Disc, Prolapsed Cervical Disc
Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device
The registry has been designed as a prospective, observational program for patients undergoing lumbar or cervical fusion using VariLift device with the ultimate goal to aid in the development of strategic treatment pathways and…
- Conditions
- Prolapsed Lumbar Disc, Prolapsed Cervical Disc, Intervertebral Disc Degeneration, Spondylolisthesis, Grade 1
- Trial name
- NCT01944345
- Where
- 3 sites in United States
- Volunteers
- 69 people
- Sponsor
- Wenzel Spine
Degenerative Disc Disease
Study of the ReGelTec HYDRAFIL System
A study designed to treat patients with back pain associated with degenerative lumbar disc disease.
- Trial name
- NCT04984629
- Testing
- HYDRAFIL
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- ReGelTec, Inc.
Degenerative Lumbar Diseases
Efficacy and Safety of Novosis Putty for Degenerative Lumbar Disease
This clinical study aims to evaluate the efficacy and safety of NOVOSIS PUTTY for bone fusion in patients requiring posterior instrumentation and transforaminal lumbar interbody fusion (TLIF) due to degenerative lumbar disease.
- Trial name
- NCT06715345
- Testing
- Bone graft materials and rhBMP-2
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- CGBio Inc.
Degenerative Lumbar Spinal Stenosis
the Evaluation of Four Non-operative Treatments for Degenerative Lumbar Spinal Stenosis
Arthritis of the spine causes narrowing of the spinal canals and compression of the spinal nerves traveling into the legs, limiting walking ability.
- Trial name
- NCT02592642
- Testing
- Self-management Program, Workbook, Video, Pedometer, Instructional Workbook, Video, and Pedometer, Para-spinal TENS
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Mount Sinai Hospital, Canada
Cervical Myelopathy, Cervical Radiculopathy
Long-term Follow-up Motion Analysis of ACD Versus ACDA
Rationale: Cervical degenerative disc disease (CDDD) is a common cause of cervical radiculopathy, myelopathy or myeloradiculopathy.
- Conditions
- Cervical Myelopathy, Cervical Radiculopathy, Spinal Stenosis, Spinal Disease
- Trial name
- NCT04545983
- Testing
- Motion Analysis
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Zuyderland Medisch Centrum
Lumbar Degenerative Disease
Evaluation of Radiculitis Following Use of Bone Morphogenetic Protein-2 for Interbody Arthrodesis in Spinal Surgery
Clinician directed use of bone morphogenetic proteins (BMPs) in ways other than FDA approved, has increased recently due to the morbidity associated with harvest of iliac crest bone graft in spinal arthrodesis procedures.
- Trial name
- NCT00984672
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Mayo Clinic
Spinal Diseases, Surgery
Patient Reported Outcome After Surgical Treatment of DDD in Scandinavia
Purpose: The incidence of surgery for Degenerative lumbar Disc Disease (DDD). According to the national spine registries in Sweden, Norway and Denmark, there is a difference in surgical incidence between these countries.
- Conditions
- Spinal Diseases, Surgery, Degeneration Disc
- Trial name
- NCT02980822
- Volunteers
- 3,500 people
- Sponsor
- Spine Centre of Southern Denmark
Wilson's Disease
Efficacy of Invitro Expanded Bone Marrow Derived Allogeneic Mesenchymal Stem Cell Transplantation Via Portal Vein or Hepatic Artery or Peripheral Vein in Patients With Wilson Cirrhosis
Wilson's disease is an autosomal recessive genetically inherited disorder of copper metabolism, causing neurological, psychiatric and liver disease. The ATP7B gene on the 13th chromosome is responsible for the disease.
- Trial name
- NCT01378182
- Testing
- allogeneic mesenchymal stem cell transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Murat Kantarcioglu
Arthritis, Arthritis, Degenerative
Clinical Evaluation of the TITAN™ Total Shoulder System
A post market, non-randomized, multi-center, open-label,clinical study using survivorship to study the safety and efficacy of the Integra® TITAN™ Total Shoulder System 1.0 (TAS) when used for total shoulder arthroplasty.
- Conditions
- Arthritis, Arthritis, Degenerative, Rheumatoid Arthritis, Post-traumatic Arthrosis of Other Joints, Shoulder Region
- Trial name
- NCT03245320
- Testing
- Integra TITAN™ Total Shoulder Generation 1.0
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Smith & Nephew, Inc.