Clinical trials: Degenerative Joint Disease
Knee Osteoarthritis
Non-Surgical Management of Knee Osteoarthritis in the Military Health System (MHS)
This study will compare two different treatment approaches for the management of knee osteoarthritis (OA). All subjects will receive a standardized approach consistent with the core set of recommendation from the Department of…
- Trial name
- NCT03747393
- Testing
- DoD/VA CPG Core Set + PT, DoD/VA CPG Core Set
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Brooke Army Medical Center
Knee Osteoarthritis
The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Plasma and Hyaluronic Acid
The aim of this study is to compare therapeutic and clinical effects of intra-articular injection of Bone Marrow Aspirate Concentrate (BMAC), inta-articular injection of Leukocyte Rich Platelet Rich plasma (LR-PRP) and 3 weekly…
- Trial name
- NCT03825133
- Testing
- Bone Marrow Aspirate Concentrate, Leukocyte Rich Platelet Rich Plasma, Hyaluronic Acid
- Where
- Serbia
- Volunteers
- 180 people
- Sponsor
- Clinical Center of Vojvodina
Pain Dysfunction, Sleep Disturbance
Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older Adults
This study compares the efficacy of three group interventions for people with co-morbid osteoarthritis (OA) and insomnia to help them manage their OA symptoms.
- Conditions
- Pain Dysfunction, Sleep Disturbance, Osteoarthritis
- Trial name
- Lifestyles (NCT01142349)
- Testing
- Lifestyles A, Lifestyles B, Lifestyles C
- Where
- 2 sites in United States
- Volunteers
- 367 people
- Sponsor
- University of Washington
Osteoarthritis (OA) of the Knee, Osteoarthritis Knee Pain
First in Human Study of SakuraBead for Genicular Artery Embolization to Treat Pain Secondary to Knee Osteoarthritis
A prospective, single-centre, single-arm, unmasked, First in Human study that aims to evaluate the safety and efficacy of SakuraBead resorbable microspheres in adult patients suffering from pain secondary to knee osteoarthritis.
- Conditions
- Osteoarthritis (OA) of the Knee, Osteoarthritis Knee Pain, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT06718478
- Testing
- SakuraBead Resorbable Microspheres
- Where
- Uzbekistan
- Volunteers
- 15 people
- Sponsor
- CrannMed
Knee Osteoarthritis
Calisthenic and Neuromuscular Training in Patients With Knee OA.
The aim of the study is to compare effects of calisthenics and neuromuscular training in patients with knee osteoarthritis.
- Trial name
- NCT05173649
- Testing
- Calisthenic Training, Neuromuscular Training
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Osteoarthritis of the Knee
A Multiple Injection Study Evaluating Safety and Efficacy of Ampion in Osteoarthritis
This study will evaluate the efficacy of three intra-articular injections, given 2 weeks apart, of Ampion™ in Adults with pain due to osteoarthritis of the knee.
- Trial name
- NCT02242435
- Testing
- 4 mL injection of Ampion
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Osteoarthritis of the Knee
Teriparatide for Improved Knee Prosthesis Fixation
The investigators will study how well knee joint prostheses become fixed to the bone when patients get teriparatide, compared to placebo. Measurements will use high resolution 3D radiography (radiostereometry, RSA).
- Trial name
- NCT01063504
- Testing
- teriparatide
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- University Hospital, Linkoeping
Knee Osteoarthritis
Total Knee Arthroplasty With Vitamin E Polyethylene
The aim of this observational study is to investigate if there is any difference in survival rate, clinical and radiological results after total knee replacement with vitamin E-blended polyethylene in comparison to conventional…
- Trial name
- NCT05810285
- Testing
- GKS Prime Flex Mobile knee
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- Permedica spa
Osteoarthritis
A Randomized Clinical Study Comparing a Fully-Coated Cementless Stem Versus a Cemented Stem for Total Hip Replacements
The purpose of this study is to answer the question as to whether or not a fully coated cementless stem is equal to or better than a cemented stem in patients over 72 years with good bone quality.
- Trial name
- NCT00689689
- Testing
- Fully coated Prodigy stem, Cemented Endurance Stem
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Nova Scotia Health Authority
Pain, Chronic Postsurgical, Knee Osteoarthritis
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain.
- Conditions
- Pain, Chronic Postsurgical, Knee Osteoarthritis, Sensitization, Central
- Trial name
- NCT05575310
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Barcelona
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Extended Post-operative Oral TXA in Primary THA
The goal of this clinical trial is to learn if extended post-operative oral tranexamic acid (TXA) - a medication that reduces bleeding by slowing the breakdown of blood clots - can improve functional recovery following surgery in…
- Trial name
- NCT07685743
- Testing
- Extended oral tranexamic acid regimen
- Volunteers
- 170 people
- Sponsor
- Oregon Health and Science University
Osteoarthritis
A Multi-Center Study on the Clinical Advantages of Personalized Total Knee Arthroplasty System
The purpose of this study is to evaluate the clinical benefits of personalized total knee arthroplasty (TKA) in comparison with conventional TKA.
- Trial name
- NCT07003035
- Where
- China
- Volunteers
- 80 people
- Sponsor
- YujiakuoTHU
Arthropathy of Knee, Arthritis and/or Post-traumatic Degenerative Problems
Optetrak Posterior Stabilized Versus Optetrak Hi-Flex
The purpose of this study is to evaluate the differences in clinical outcomes between the Optetrak® Posterior Stabilized ("Optetrak® PS", Exactech, Gainesville, FL) and the Optetrak® Hi-Flex™ ("Optetrak® HF", Exactech…
- Trial name
- NCT00808613
- Testing
- Optetrak PS, Optetrak Hi-Flex
- Where
- United States
- Sponsor
- Exactech
Osteoarthritis, Knee
Effects of Denosumab on Bone Microarchitecture After Total Knee Arthroplasty
This study evaluates single dose of Denosumab in decreasing systemic and periprosthetic bone resorption after Total Knee Arthroplasty compared to placebo in 60 patients (30 placebo and 30 Denosumab) within 2 months after surgery.
- Trial name
- NCT05559268
- Testing
- Denosumab 60 MG/ML Injectable Solution [Prolia]
- Volunteers
- 60 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Osteoarthritis, Muscle Pain
An Bioequivalence Study of Loxoprofen Sodium Patches in Healthy Volunteers
This study was a single-center, randomized, open-label, two-agent, two-cycle, double-cross bioequivalence trial.
- Conditions
- Osteoarthritis, Muscle Pain, Swelling Muscle
- Trial name
- NCT06510413
- Testing
- Loxoprofen Sodium Patches(reference product), Loxoprofen Sodium Patches(test product )
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Frontier Biotechnologies Inc.
Knee Osteoarthritis, Hip Osteoarthritis
An Analysis of the Outcomes From Protocolized Perioperative Care for Patients Receiving Total Hip or Knee Arthroplasty
The care for patients receiving total hip and knee arthroplasty at the University of Arkansas for Medical Sciences has followed a structured care pathway since July 2015.
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Knee Arthritis, Hip Arthritis
- Trial name
- NCT03071250
- Testing
- Total knee or Hip Arthroplasty
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Arkansas
Total Knee Arthroplasty for Gonarthrosis
Analysis of the Functional Impact of Total Knee Arthroplasty Using Quantified Gait Analysis and Proprioceptive Evaluation
Total knee arthroplasty remains the gold standard in the management of disabling gonarthrosis. Improved functional results, increased availability of care and an ageing population have all contributed to the rise in total knee…
- Trial name
- ARTHROPROMA (NCT06907368)
- Testing
- Quantitative Gait Analysis
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Osteoarthritis, Hip
Analysis of a Tapered Porous Coated Stem and a Cementless Hemispherical Acetabular Component
This prospective study will evaluate the hip function and quality of life of patients operated for total hip arthroplasty with Masterloc femoral stem and MPACT acetabular cup.
- Trial name
- NCT03168750
- Testing
- Femoral Component:Medacta Masterloc Stem and Medacta MPACT cup.
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Knee Osteoarthritis, Osteoarthritis
"Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
This randomized, double-blind clinical trial aims to evaluate the effect of high-intensity pulsed electromagnetic field therapy (HI-PEMF) applied either exclusively on the knee joint or bimodally on the knee and quadriceps, in…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteo Arthritis of the Knee, Gonarthrosis
- Trial name
- HIPEMF-OAK (NCT07198750)
- Testing
- HI-PEMF - Knee (Chronic Pain Protocol), HI-PEMF - Quadriceps (Muscle Strengthening Protocol), Home-Based Exercise Program
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Hospital Civil de Guadalajara
Osteoarthritis
A Study Comparing Ceramic-on-metal Articulation to Metal-on-metal Articulation in Cementless Primary Hip Arthroplasty
The aim of this study is to demonstrate the non-inferiority of the ceramic on metal articulation using M2a-38™ mm cup compared to the metal on metal articulation using the same cup.
- Trial name
- NCT00754520
- Testing
- Ceramic On Metal, Metal on Metal
- Where
- 3 sites in Finland, United Kingdom
- Volunteers
- 213 people
- Sponsor
- Zimmer Biomet
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