Clinical trials: Degenerative Joint Disease
Hip Dysplasia, Femoroacetabular Impingement
Cam Type FAI is a Cause of Hip Pain in the Young Adult and a Precursor to OA
An abnormally formed hip joint (cam deformity) is a major cause of osteoarthritis (OA). Individuals may not experience any symptoms until OA is severe due to extensive cartilage loss and changes in underlying bone.
- Conditions
- Hip Dysplasia, Femoroacetabular Impingement, Osteoarthritis
- Trial name
- NCT04080466
- Testing
- Low-dose CT Scan, Blood/Urine Collection, Patient Reported Questionnaires
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis
COVID-19 in Osteoarthritis Patients
While the coronavirus pandemic has spread rapidly around the world, it has generated a considerable degree of fear, concern and anxiety among the population in general and among certain groups in particular, such as older…
- Trial name
- NCT04791462
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Knee Osteoarthritis
Unicondylar- or Total Knee Replacement? Patient Satisfaction, Function and Muscle Mass
Patients with medial gonarthritis are randomised to a unicompartmental or a total knee replacement. Primary outcome: Thigh muscle cross sectional area and radiological attenuation measured by CT Secondary aims: functional tests…
- Trial name
- UKA or TKA? (NCT02563756)
- Testing
- Unicompartmental knee replacement, Total knee replacement
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Osteoarthritis of Acromioclavicular Joint
Ultrasound Examination and Guided Injection Into the Acromio-clavicular Joint
Is it possible to improve the accuracy of injection into the acromio-clavicular joint with the use of ultrasound?
- Trial name
- NCT01628796
- Testing
- contrast material injection
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Osteoarthritis, Hip, Rheumatoid Arthritis
Exception Cementless Hip Stem
This study is a multicenter, retrospective and prospective, non-controlled, non-randomized post market clinical follow-up study.
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Inflammatory Arthritis, Congenital Hip Dysplasia
- Trial name
- Exception (NCT04349046)
- Testing
- Total hip arthoplasty (THA)
- Where
- 6 sites in Belgium, France
- Volunteers
- 332 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
Randomized Control Trial on Postoperative Weight Bearing After High Tibial Osteotomy (HTO)
The study analyzes the consequences of weight bearing after an HTO in a population of young patient with medial osteoarthritis (immediate weight bearing versus two month weight bearing).
- Trial name
- NCT00799370
- Testing
- Early weight bearing, Delayed weight bearing
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Knee Osteoarthritis, Metabolic Disease
Bracing for Patellofemoral Osteoarthritis
BACKGROUND: Despite the prevalence of patellofemoral ostearthritis (OA), this joint has received relatively little attention in the OA literature and there are few treatment options for individuals with patellofemoral OA.
- Trial name
- NCT02984254
- Testing
- Womac, Lequesne, Timed-up-and-go (TUG)
- Volunteers
- 52 people
- Sponsor
- University of Sao Paulo General Hospital
Osteoarthritis
Effect of Glucosamine on Joint Structure and Quality of Life (JOG)
The goal of this study is 1) to develop a biomarker of of cartilage synthesis by determining if there is a relationship between changes in the status of knee cartilage and the amount of a biomarker called CTX-II in urine.
- Trial name
- NCT00377286
- Testing
- Glucosamine (a dietary supplement), 16 oz lite lemonade
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- University of Pittsburgh
Trapeziometacarpal Osteoarthritis, Rhizarthrosis
Evaluation of the Performance and Safety of a Type I Collagen-Based Medical Device (MD-Small Joints Collagen Medical Device) i the Treatment of RHIZOARTROSIS
Collagen is a structural protein biopolymer consisting of three polypeptide chains wrapped around to form a right-handed triple helix.
- Conditions
- Trapeziometacarpal Osteoarthritis, Rhizarthrosis, MEDICAL DEVICE, Infiltrate
- Trial name
- SMAGENART (NCT06781554)
- Testing
- MD-Small Joints Collagen Medical Device
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Guna S.p.a
Osteoarthritis
The Subvastus Approach in Total Knee Arthroplasty
The purpose of this study is to determine if the observed benefits of minimally invasive total knee arthroplasty, namely decreased hospital stay and increased range of motion, can be achieved with standard knee arthroplasty using…
- Trial name
- NCT00346788
- Testing
- Surgical approach for total knee arthroplasty
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis, Knee, Hypertension
Staying Active With Arthritis: RCT of Physical Activity for Older Adults With Osteoarthritis and Hypertension
The purpose of the Staying Active with Arthritis (STAR) research study is to determine if a 6-month program will improve leg exercise, fitness walking, and clinical outcomes (function, blood pressure, leg strength, pain, fatigue…
- Trial name
- STAR (NCT01280903)
- Testing
- STAR Intervention, Attention-Control
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Pittsburgh
Low Back Pain, Radicular Syndrome
Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal Disorders
This pilot randomized controlled trial aims to compare the clinical effectiveness of advanced high-intensity physical therapy modalities with conventional physical therapy in patients suffering from musculoskeletal disorders.
- Conditions
- Low Back Pain, Radicular Syndrome, Sacroiliac Joint Dysfunction, Shoulder Impingement Syndrome
- Trial name
- NCT07903142
- Testing
- Repetitive Peripheral Magnetic Stimulation (rPMS), High-Intensity Laser Therapy (HIL), Extracorporeal Shockwave Therapy (ESWT)
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- BTL Industries Ltd.
Osteoarthritis, Knee
fMRI Study of Expectancy on Acupuncture Treatment Outcomes in Knee OA
The results of the proposed experiments will directly inform clinicians who treat patients with osteoarthritis of the knee about how to maximize the benefits of acupuncture treatments.
- Trial name
- KOA (NCT01040754)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Massachusetts General Hospital
Osteoarthritis, Knee, Menopause
Efficacy Study of Shortwave Diathermy for the Treatment of Patients With Knee Osteoarthritis
The purpose of this study is to determine whether shortwave diathermy is effective in reducing knee pain and increasing function of the patients with knee osteoarthritis.
- Trial name
- NCT00199914
- Testing
- Shortwave diathermy
- Where
- Thailand
- Volunteers
- 113 people
- Sponsor
- Mahidol University
Osteoarthritis, Knee
Steroids, Hyaluronic Acid or Platelet Rich Plasma Versus Placebo for the Knee Osteoarthritis
This study investigates clinical outcome and imaging outcome parameters after intraarticular injection of steroids, platelet-rich-plasma (prp), hyaluronic acid or placebo in patients with early osteoarthritis of the knee joint.
- Trial name
- KIT (NCT02776514)
- Testing
- Triamcort, Platelet-rich-plasma, Suplasyn1
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Balgrist University Hospital
Platelet-Rich Plasma (PRP), Knee Osteoarthritis (OA)
Validation of a Low-cost Platelet-Rich Plasma (PRP)
Knee osteoarthritis is an extremely common and debilitating condition, more common in women, with an estimated global prevalence of 16%, and as high as 50% by the age of 80.
- Trial name
- PRP (NCT06184048)
- Testing
- Intra-Articular knee injection of LC-PRP
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Osteoarthritis, Knee
Efficacy and Safety of NAVIO
The goal of the study is to compare the efficacy, safety and costs of the NAVIO™ system with the conventional intramedullary alignment guide for total knee replacement in a clinical setting.
- Trial name
- NCT04230616
- Testing
- total knee arthroplasty, CT scan
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Sint-Trudo Hospital
Osteoarthritis, Knee, Musculoskeletal Diseases
A Study of the Safety and Efficacy of Hylan G-F 20 (Synvisc) in Patients With Symptomatic Osteoarthritis of the Knee
This clinical study is to evaluate the safety and efficacy of hylan G-F 20 (Synvisc) in patients with symptomatic knee osteoarthritis (OA).
- Trial name
- NCT00131352
- Testing
- hylan G-F 20, Phosphate Buffered Saline
- Where
- 21 sites in Belgium, Czechia and 4 more
- Volunteers
- 253 people
- Sponsor
- Genzyme, a Sanofi Company
Patella-Dislocation, Patellofemoral Osteoarthritis
A Prospective Randomized Study of Medial Patellofemoral Ligament (MPFL) Reconstruction
The operative management of chronic patellar instability has been controversial. Medial patellofemoral ligament reconstruction has gained success recently and might be superior to other soft-tissue procedures.
- Conditions
- Patella-Dislocation, Patellofemoral Osteoarthritis, Patellar Instability
- Trial name
- NCT00816647
- Testing
- Patellofemoral stabilizing surgery
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Finnish Defense Forces
Osteoarthritis
Comparison of Ways to Prepare Patients for Decisions About Joint Replacement Surgery
Ministries of Health consider wait lists for total joint replacement a top priority. Research priorities to manage wait lists indicate the need to establish benchmarks that consider patient preferences.
- Trial name
- NCT00911638
- Testing
- Patient decision aid, Usual care
- Where
- 2 sites in Canada
- Volunteers
- 343 people
- Sponsor
- Ottawa Hospital Research Institute
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