Clinical trials: Degenerative Joint Disease
Osteoarthritis, Hip, Arthropathy of Hip
Evaluation of Cemented and Cementless Fixation of Dual-mobility Hip Prosthesis in Elderly Patients With Osteoarthritis
The aim of this project is to investigate prosthesis fixation in the bone, respectively cemented and uncemented operation method of Avantage® dual-mobility acetabular cup in elderly patients, wear of the plastic in dual-mobility…
- Trial name
- NCT02404727
- Testing
- cup fixation, Avantage® Cup
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Thumb Osteoarthritis
Variable Immobilization Protocol for Arthroplasty of the Carpometacarpal Joint of the Thumb
Thumb carpometacarpal (CMC) osteoarthritis (OA) is common, seen frequently in middle-aged and elderly women. While a variety of surgical treatments have been described with none superior to any other, there is no consensus on the…
- Trial name
- NCT04828954
- Testing
- Immobilization for 2-weeks postoperative, Immobilization for 6-weeks postoperative
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Chicago
Knee Osteoarthritis (OA)
Clinical Study on the Combination of Xiaoyu Zhitong Formula and Lymphatic Drainage Technique to Improve the Symptoms of Knee Pain and Swelling in Cold Dampness Obstruction Type
This research project applies a combination of blood stasis relieving and pain relieving formula and lymphatic drainage technique to treat patients with cold dampness obstruction type knee joint pain.
- Trial name
- NCT06911437
- Testing
- treatment group, control group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- tang jie
Knee Osteoarthritis, Knee Injuries
The Relationship Between Disease Severity and Various Lower Extremity Parameters in Individuals With Knee Osteoarthritis
This study perform to investigate the relationship between quadriceps femoris (QF) strength, QF thickness, femoral cartilage thickness, knee function, balance, kinesiophobia and gait of the patients with knee osteoarthritis.
- Trial name
- NCT05294224
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dilara Özen Oruk
Osteoarthritis (OA) of the Knee
Photographic Evidence on Total Knee Arthroplasty Outcomes
Historically, total knee arthroplasty (TKA) has been performed to restore knee range of motion and relieve pain, with postoperative rehabilitation focused on helping patients regain mobility and function.
- Trial name
- NCT07223359
- Testing
- Photographic Evidence of Postoperative Knee Range of Motion, Standard Postoperative Care
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Loyola University
Osteoarthritis, Low Back Pain
An Exploratory Study of Tramadol Hydrochloride in Patients With Osteoarthritis of the Knee or Low Back Pain
The purpose of this study is to find the clinical dose range of an active ingredient of JNS013 - Tramadol hydrochloride in chronic-pain patients who cannot attain a sufficient analgesic effect from non-steroidal anti-inflammatory…
- Trial name
- NCT00752661
- Testing
- Tramadol Hydrochloride; JNS013
- Volunteers
- 119 people
- Sponsor
- Janssen Pharmaceutical K.K.
Osteoarthritis of Hip
Pedometer Based Intervention After Total Hip Replacement-A Pilot Study
Total hip replacement is designed to alleviate pain, reduce disability and improve function and physical activity levels. Whilst pain, disability and function are often measured following surgery, actual physical activity is not.
- Trial name
- NCT01972594
- Testing
- Targetted protocol with pedometer, Accelerometer(ActivPAL)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Ben Stansfield
Post-traumatic; Arthrosis, Osteoarthritis Thumb
The Angle of the Metacarpophalangeal Joint of the Thumb During Maximal Pinch Strength
The aim of the study is to measure the position of the metacarpophalangeal joint of the thumb during key-pinch, tripod-pinch and opposition-pinch in normal volunteers, to determine the optimal position of metacarpophalangeal…
- Trial name
- NCT04875156
- Testing
- measurement of range of motion and strength
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Rheumatoid Arthritis, Osteoarthritis
A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the Pinnacle™ Cup with a ceramic-on-ceramic bearing combination in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872222
- Testing
- Pinnacle™ Acetabular System
- Where
- Czechia
- Volunteers
- 98 people
- Sponsor
- DePuy International
Chondromalacia Patellae
Temporal Activation of Core Muscles and Vasti in Isolated Patellofemoral Osteoarthritis
Objective: To compare the temporal muscle activation between females with PF OA and normal controls during stair ascent. Methods: An observational comparative study was conducted with thirty-one females with PF OA and 11 healthy…
- Trial name
- NCT04589702
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Knee Osteoarthritis, Arthroplasty, Replacement, Knee
Implementation of Indication Criteria for Total Knee Replacement in Osteoarthritis (Value-based TKR)
The aim of this trial is to investigate the effect of a medical decision aid (EKIT-Tool) on decision quality for knee arthroplasty.
- Trial name
- NCT04837053
- Testing
- Digital decision aid for physicians and patients, Routine care
- Where
- Germany
- Volunteers
- 1,092 people
- Sponsor
- Technische Universität Dresden
Osteoarthritis
Safety and Effectiveness of Cartiva Implant in the Treatment of First CMC Joint Osteoarthritis Compared to LRTI (GRIP 2)
This study will evaluate whether Cartiva is an effective treatment for individuals with osteoarthritis of the first CMC joint in the hand compared to LRTI.
- Trial name
- GRIP 2 (NCT03247439)
- Testing
- Cartiva
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 74 people
- Sponsor
- Cartiva, Inc.
Osteoarthritis, Knee, Knee Degenerative Disease
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells
In this prospective study we aim to evaluate the feasibility and safety of the implantation of 40 millions MSV in knees with osteoarthritis of grade II-IV (Kellgren and Lawrence).
- Conditions
- Osteoarthritis, Knee, Knee Degenerative Disease, Knee Osteoarthritis
- Trial name
- KDD&MSV (NCT01183728)
- Testing
- Autologous bone marrow mesenchymal stem cells (MSV)
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- Red de Terapia Celular
Osteoarthritis, Rheumatoid Arthritis
Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System
Prospective, multi-center clinical study to evaluate the clinical outcomes of the posterior stabilized design of the LCS® Complete Mobile-bearing Total Knee System
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Juvenile Arthritis
- Trial name
- NCT00487565
- Testing
- Total knee arthroplasty
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis, Knee
Robotic-Assisted Versus Conventional Total Knee Arthroplasty With Virtual Home-Based Rehabilitation
The goal of this clinical trial is to learn whether robotic-assisted total knee replacement improves recovery compared with conventional total knee replacement in adults with knee osteoarthritis when both groups follow the same…
- Trial name
- R-TKR VCare (NCT07716267)
- Testing
- Robotic-assisted Total Knee Arthroplasty, Conventional Total Knee Arthroplasty, Hybrid Virtually-Assisted Peri-operative Rehabilitation Program
- Volunteers
- 60 people
- Sponsor
- Mark Hurworth
Osteoarthritis
Microfluidic Organotypic Model for Monocyte Transendothelial Migration to the Joint in Obese Osteoarthritic Patients
Osteoarthritis (OA) is the fastest growing cause of disability worldwide due to population ageing and increasing obesity incidence.
- Trial name
- MOTEM (NCT03347500)
- Testing
- use of patient-derived biological samples
- Volunteers
- 88 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Platelet Rich Plasma Injection, Ultrasonography
The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee Osteoarthritis
The primary objective of this study is to evaluate and compare the effectiveness of ultrasound-guided combined intra-articular and peri-articular platelet-rich plasma (PRP) injections with intra-articular PRP injections alone in…
- Conditions
- Platelet Rich Plasma Injection, Ultrasonography, Gonarthrosis
- Trial name
- NCT07339137
- Testing
- Conservative Therapy, Intra-Articular PRP, Peri-Articular PRP
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma
Osteoarthritis of Hip, Traumatic Arthritis of Hip
Evaluation of the Wear of Vitamin E Treated Polyethylene Components in Primary THA Using RSA
The specific aim of this proposed study is to conduct a prospective RSA clinical study at Massachusetts General Hospital involving 50 patients receiving primary total hip replacements.
- Trial name
- NCT00551967
- Testing
- Hip replacement
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Hip Osteoarthritis, Complications; Arthroplasty
Correlation of Spinopelvic Parameters and Acetabular Cup Orientation
In total hip arthroplasty, cup anteversion is an important factor in stability. Lewinnek's safe zone and functional anteversion are often used to assess appropriate orientation.
- Trial name
- NCT02598700
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Duke University
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