Clinical trials: Degenerative Joint Disease
Hip Osteoarthritis
Comparison of the Effect of Intra Articular Steroid Injection and Pericapsular Nerve Group Block for Hip Osteoarthritis
The most common cause of hip joint dysfunction in the elderly is degenerative osteoarthritis of the hip. Innervation of the hip joint capsule is provided by the obturator nerve, the accessory obturator nerve, and the femoral…
- Trial name
- NCT05136248
- Testing
- intraarticular injection, peng block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Knee Osteoarthritis
The McKenzie System With Arthritic Knees: Do Some Knees Respond to Specific Exercise More Than General or no Exercise
The purpose of the study is to explore if a subgroup of people with osteoarthritic knees can be identified using the McKenzie System of Mechanical Diagnosis and Therapy.
- Trial name
- NCT01641874
- Testing
- Exercise, Evidence based exercise
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis
The Effect of Reflexology and Knee Massage With Black Cumin Oil on Pain and Fatigue
In this study, black cumin extract oil was used in elderly individuals with Knee Osteoarthritis (OA). The effects of foot reflexology and knee massage on pain and fatigue symptoms.
- Trial name
- NCT06298760
- Testing
- Knee Massage With Black Cumin Oil Group:, Foot Reflexology Group With Black Cumin Oil
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Erzurum Technical University
Calcaneocuboid Osteoarthritis Secondary to Trauma
Calcaneocuboid Arthrodesis in Triple Arthrodesis by Plate Versus Screw: Randomized Controlled Trial
Investigators aim to compare clinical and radiological outcome of use of plate versus screw fixation for calcaneocuboid arthrodesis in adult population.
- Trial name
- NCT06003296
- Testing
- Calcaneocuboid arthrodesis
- Where
- Egypt
- Volunteers
- 3 people
- Sponsor
- Assiut University
Osteoarthritis, Knee
Mechanics of Knee Bracing
The overall objective of this project is to determine whether the provision of a pneumatic knee brace in patients with medial knee osteoarthritis (OA) improves knee mechanics.
- Trial name
- NCT00823888
- Testing
- pneumatic brace
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The New England Baptist Hospital
Knee Osteoarthritis
Effectiveness and Safety of Embosphere Microspheres for Embolization of the Geniculate Artery for the Treatment of Pain With Known Moderate to Severe Knee Osteoarthritis
The purpose of this research study is to evaluate the effectiveness and safety of a permanent embolic (Embosphere Microspheres) for embolization of the geniculate artery for the treatment of moderate to severe knee osteoarthritis.
- Trial name
- NCT05112926
- Testing
- Embosphere Microspheres
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Miami
Osteoarthritis of the Knee, Avascular Necrosis of the Femoral Condyle
Multicentre GMK UNI Anatomical Cementless Study - FR
Unicompartmental Knee Arthroplasty (UKA) is the principal surgical alternative to Total Knee Arthroplasty (TKA) in patients with end-stage unicompartmental tibiofemoral osteoarthritis (OA) of the knee.
- Conditions
- Osteoarthritis of the Knee, Avascular Necrosis of the Femoral Condyle, Revision Surgery
- Trial name
- NCT06715917
- Where
- 5 sites in France, Switzerland
- Volunteers
- 249 people
- Sponsor
- Medacta International SA
Thumb Carpometacarpal Osteoarthritis, Thumb Basal Joint Osteoarthritis
Mechanisms of a Dynamic Stability Approach
Background. Arthritis is the leading cause of disability in the United States and osteoarthritis (OA) of the hand affects an estimated 25.6 US residents.
- Trial name
- NCT05247398
- Testing
- Dynamic Stability Exercise Program
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Minnesota
Arthrosis
Evaluation of the Efficacy of an Intra-articular Injection of Autologous Microfat Combined With Autologous Platelet-enriched Plasma in the Treatment of Radiocarpal Osteoarthritis: a Randomized Controlled Non-inferiority Trial Versus Total Wrist Denervation (Established Standard Treatment).
This is a phase II, prospective, comparative, randomized, single-center, open-label, parallel-group therapeutic trial. It is a non-inferiority trial to establish the efficacy of intra-articular injection of autologous microfat…
- Trial name
- AMIPREP-2 (NCT05501743)
- Testing
- Intra-articular injection of microfat and PRP, Total denervation of the wrist
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Osteoarthritis
Complex Āyurvedic Treatment in Osteoarthritis of the Knee Compared to Standard Care.
The aim of this study is to evaluate the effectiveness of a complex āyurvedic diagnosis and treatment compared to conventional standard care in patients with OA of the knee.
- Trial name
- CARAKA (NCT01225133)
- Testing
- Complex Ayurvedic Treatment, Conventional Care
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate to severe pain due to OA.
- Trial name
- NCT00348452
- Testing
- tramadol HCl ER; celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Bausch Health Americas, Inc.
Osteoarthritis, Knee
Bioavailability and Pharmacokinetic Measures of H. Procumbens Extract
Study will define the bioavailability and short term pharmacokinetics of the principal secondary metabolites of a aqueous-ethanolic extract of H. procumbens in non-enteric and enteric capsules.
- Trial name
- NCT03641248
- Testing
- Enteric coated Devil's Claw, Non-enteric coated Devil's Claw
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Osteoarthritis, Knee
Effects of Duloxetine on Postoperative Wound Complication of Total Knee Arthroplasty (TKA) in Central Sensitization Patients
Postoperative wound complications such as wound dehiscence, skin necrosis, persistent wound drainage, delayed healing, and superficial skin infection could have devastating consequences, leading to arthroplasty failure and…
- Trial name
- NCT03880916
- Testing
- Duloxetine
- Volunteers
- 80 people
- Sponsor
- The Catholic University of Korea
Knee Osteoarthritis, Pain
Cabbage Leaf Application in Knee Osteoarthritis
Among non-pharmacological treatment methods, herbal therapies are widely used, and cabbage leaves are recognized for their analgesic and anti-edematous effects.
- Trial name
- NCT07318116
- Testing
- Cabbage leaf compress for knee pain
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Inonu University
Arthritis, Degenerative
Pilot Study Evaluating the Safety and Efficacy of a New Hard-on-Hard Total Hip Replacement System
The purpose of this study is to assess the early and long term safety and efficacy of the hard-on-hard total hip replacement system (R3 ODH-ODH utilization) in patients with non-inflammatory arthritis.
- Trial name
- NCT02154516
- Testing
- ODH Hip System
- Where
- 2 sites in South Africa
- Volunteers
- 26 people
- Sponsor
- Smith & Nephew, Inc.
Avascular Necrosis of Hip, Osteoarthritis, Hip
Allofit® IT Ceramic Bearing System in Total Hip Arthroplasty
This is a multi-center, prospective, non-controlled post market surveillance study. The objectives of this study are to obtain survival and outcome data on the Allofit IT Shell in combination with the BIOLOX® delta Taper Liner…
- Conditions
- Avascular Necrosis of Hip, Osteoarthritis, Hip, Inflammatory Arthritis, Post-Traumatic Osteoarthritis of Hip
- Trial name
- NCT03672916
- Where
- 4 sites in Germany, Sweden
- Volunteers
- 185 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Audio Recording for Improved Surgical Outcome (ARISO)
Use of audio recordings (with suggestions and imagery for a better surgical outcome) studied in orthopedic patients.
- Trial name
- NCT00569933
- Testing
- Audio recording
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hip Osteoarthritis
Study of the Clinical and Radiographic Results of a Fixed Polyethylene Posteriorly Stabilized Cemented Total Knee Prosthesis With a Minimum Follow-up of 1 Year.
The knee replacement market is experiencing constant growth. Alongside this growth, there is also an increasing interest in customizing implantation based on specific phenotypes to restore the morphology of the native knee.
- Trial name
- PTG-Anatomic (NCT07313449)
- Where
- France
- Volunteers
- 960 people
- Sponsor
- University Hospital, Strasbourg, France
Osteoarthritis, Knee
RCT Mesenchymal Stem Cells Versus Hyaluronic Acid in OA Knee):
The purpose of this study is to evaluate the therapeutic effect of adult autologous mesenchymal stem cells (abbreviated as MSCs) in patients with osteoarthritic knee and compare to intra articular injection of Synvisc-One.
- Trial name
- MSC (NCT04326985)
- Testing
- Autologous Mesenchymal Stem Cells Treatment (MSCs), Hyaluronic acid (HA)
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis, Total Knee Replacement
Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement
This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and…
- Trial name
- MDOA&TKR (NCT06829433)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
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