Clinical trials: Degenerative Joint Disease
Osteoarthritis
Etoricoxib in the Treatment of Osteoarthritis (MK-0663-007)
The purpose of this study is to evaluate the safety and efficacy of etoricoxib in the treatment of osteoarthritis of the knee.
- Trial name
- NCT00242489
- Testing
- MK0663, etoricoxib / Duration of Treatment: Part I (6 weeks), Part II (8 weeks)
- Volunteers
- 1,167 people
- Sponsor
- Organon and Co
KNEE OSTEOARTHRITIS
Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis
This study is a randomized, double-blind clinical trial in a Chinese population.
- Trial name
- NCT03691818
- Testing
- X0002 Spray, Ibuprofen Tablet
- Where
- China
- Volunteers
- 353 people
- Sponsor
- Tianjin XinChen-Techfields Pharma Co., LTD.
Osteoarthritis, Knee
The Effect of Weight Loss and Exercise on Knee Osteoarthritis
This study will evaluate whether a program of weight loss and exercise can help individuals with knee osteoarthritis (OA).
- Trial name
- NCT00061490
- Testing
- Behavioral weight control and lifestyle exercise
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Degenerative Osteoarthritis, Rheumatic Arthritis
CoreHip - Post Market Clinical Follow-Up Study
The study is designed as a prospective, non-interventional multicentre cohort study. The product under Investigation will be used in Routine clinical practice and according to the authorized Instructions for Use (IfU).
- Conditions
- Degenerative Osteoarthritis, Rheumatic Arthritis, Fractures, Hip, Necrosis, Femur Head
- Trial name
- NCT03685110
- Testing
- CoreHip Total Hip Arthroplasty
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 248 people
- Sponsor
- Aesculap AG
Osteoarthritis, Arthroplasty Complications
Varus Stem Positioning of a Cementless Anatomical THA. (VARABG)
Varus positioning is the most common femoral malposition in total hip arthroplasty (THA). The aim of this study was to compare the long-term results of an anatomical cementless femoral stem positioned in varus with those in…
- Trial name
- VARABG (NCT04653090)
- Testing
- Xray
- Where
- France
- Volunteers
- 283 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Hip Osteoarthritis
Prospective Clinical Follow-up of the Echo Bi-Metric Microplasty Stem for Total Hip Arthroplasty
The primary objective of this study is to characterize survivorship of the Echo Bi-Metric Microplasty stem in unilateral or bilateral primary total hip arthroplasty at 5 years postoperative.
- Trial name
- NCT04326010
- Testing
- Surgery
- Where
- 6 sites in United States
- Volunteers
- 206 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Comparison of Hip Strengthening Exercises and Core Stability Exercises in Patients With Knee Osteoarthritis
Knee Osteoarthritis is a chronic degenerative joint disease with complex etiology that results in loss of normal joint function due to damage to the articular cartilage.
- Trial name
- NCT06120920
- Testing
- Assigned Interventions, Conventional Physical Therapy and Routine Knee Exercises with Hip Strengthening Exercises.
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Knee Osteoarthritis
Effect of Alexithymia on Response to Physical Therapy in Patients With Knee Osteoarthritis
Knee osteoarthritis is one of the most common degenerative joint diseases and is associated with chronic pain, functional impairment, and reduced quality of life.
- Trial name
- ALEX-KOA (NCT07651410)
- Testing
- Standard Physical Therapy Program
- Volunteers
- 60 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Hip Osteoarthritis, Surgery
Physical Therapy Following Total Hip Arthroplasty
130 patients undergoing primary unilateral total hip arthroplasty through anterior approach were enrolled and randomized into one of two groups.
- Trial name
- NCT04199390
- Testing
- total hip arthroplasty
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Orthopedic One
Hip Arthropathy, Hip Arthrosis
Superiority Randomized Controlled Trial of Ultrasound-guided PENG Block Compared to Surgical Infiltration in the Analgesia of Posterior Total Hip Arthroplasty Surgery
Pain after total hip replacement (THR) surgery is severe. The target population is elderly and comorbid. Level III analgesics are responsible for significant side effects in this population.
- Trial name
- PENGORINF (NCT06257160)
- Testing
- Surgical infiltration, PENG Block ultrasound-guided
- Where
- France
- Volunteers
- 224 people
- Sponsor
- CHU de Reims
Knee Osteoarthritis
Total Knee Arthroplasty Using an Active Robotic System
For the first time in Russia, it is planned to introduce and study primary knee arthroplasty using an active robotic system. The aim is to increase the efficiency of primary total knee arthroplasty using an active robotic…
- Trial name
- NCT04667390
- Testing
- total knee arthroplasty
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Osteoarthritis
Effect of Tourniquet Application on Postoperative Functional Outcome Following Total Knee Arthroplasty
A pneumatic tourniquet is often used during total knee arthroplasty. However, its effect on postoperative outcomes as soft tissue damage resulting in delayed recovery remains unclear.
- Trial name
- NCT02308410
- Testing
- Tourniquet application during surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 99 people
- Sponsor
- Medicort Sports & Orthopedic Care
Anemia
Safety Study of ECO Conversion System For Red Blood Cells.
The purpose of this study is to demonstrate that small amounts of a person's own red cells, when treated with an enzyme to make A-ECO Red Blood Cells, can be safely re-infused, repeatedly.
- Trial name
- NCT00261274
- Testing
- A-ECO, Saline
- Where
- 6 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Velico Medical
Osteoarthritis, Knee, Knee Pain Chronic
Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain
As the aging and obese populations continue to increase, there is a rapidly growing number of people at risk for knee osteoarthritis. Treatment typically starts conservatively with analgesics, physical therapy, and bracing.
- Trial name
- NCT04989660
- Testing
- 6% aqueous phenol, Isotonic saline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Osteoarthritis, Knee
An Acupuncture Functional Magnetic Resonance Imaging (fMRI) Study on Chronic Pain: Response Reliability and Dose Effect
In this proposal, we plan to dynamically investigate brain response to verum acupuncture (of two different "doses") and placebo acupuncture, using a paradigm that approximates clinical acupuncture practice across multiple…
- Trial name
- NCT01079390
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Massachusetts General Hospital
Osteoarthritis
Clinical Trial to Examine the Pain Relief of PH-797804 Alone Or With Naproxen in Subjects With Osteoarthritis of the Knee
PH-797804 is a potent inhibitor of inflammatory mediators that have a potential role in pain signalling following nerve injury and inflammation. Blocking such mediators may potentially have a therapeutic benefit by reducing pain.
- Trial name
- NCT01102660
- Testing
- PH-797804, Naproxen, Naproxen + PH-797804
- Where
- 26 sites in United States
- Volunteers
- 172 people
- Sponsor
- Pfizer
Diabetes Mellitus Type 2, Breast Neoplasms
AI-Based Phenome Data Analysis for Predicting the Onset of Major Diseases
This study aims to develop and validate an artificial intelligence (AI)-based predictive model to estimate the risk of incident onset of five major diseases or conditions: cardiovascular disease, type 2 diabetes mellitus, breast…
- Conditions
- Diabetes Mellitus Type 2, Breast Neoplasms, Low Back Pain, Osteoarthritis
- Trial name
- NCT07595718
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Jae Yong Jeon, MD
Osteoarthritis
Simplex High Viscosity Bone Cement in Primary Total Knee Arthroplasty
In this study the investigators propose to monitor subjects who have received Triathlon total knee components inserted with HV cement.
- Trial name
- NCT02572310
- Testing
- Simplex High Viscosity Bone Cement
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Michael Dunbar
Osteoarthritis of the Knee
A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee
Knee osteoarthritis (KOA) is one of the most common and disabling conditions among Veterans. Management of KOA is challenging as there are few effective treatments other than joint replacement.
- Trial name
- MOVE-OK (NCT05035810)
- Testing
- Social Incentives and Gamification to Promote Exercise, Corticosteroid Injection given in A-B order, No Social Incentive applied
- Where
- 4 sites in United States
- Volunteers
- 221 people
- Sponsor
- VA Office of Research and Development
Temporomandibular Degenerative Joint Disease
Topical Diclofenac Efficacy in Symptomatic Relief of Temporomandibular Degenerative Joint Disease
The use of a topical medication was compared to placebo to be applied over the symptomatic temporomandibular joint in women with the diagnosis of osteoarthritis of the temporomandibular joint(s).
- Trial name
- NCT00471393
- Testing
- 1.5% diclofenac in 45.5% DMSO (topical treatment)
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alberta
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