Clinical trials: Degenerative Joint Disease
Osteoarthritis of the Knee
Computer Aided Gap Balancing Improves Sagittal Stability and Outcomes for Cruciate-Retaining Total Knee Arthroplasty
Computer Aided Surgery in total knee arthroplasty improves knee stability and functional outcomes more than conventional total knee arthroplasty.
- Trial name
- NCT00865865
- Testing
- Computer aided total knee arthroplasty, Conventional total knee arthroplasty
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Osteoarthritis Finger, Osteoarthritis Thumb
Prospective Study of Arthrodesis of Finger Distal Interphalangeal Joints Using the Kerifuse Device
Arthrodesis of a distal interphalangeal joint of the finger (DIP) is mainly performed for a degenerated and painful joint. Various stabilization methods have been used to provide compression at the arthrodesis site such as pins…
- Trial name
- KF23 (NCT06151834)
- Testing
- KeriFuse implant implantation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Clinique Saint François, Nice, France
Knee Osteoarthritis, Sleep Disturbance
Neuropathic Pain and it's Relation to Sleep Quality in Knee Osteoarthritis
The primary aim is to investigate the frequency and severity of neuropathic pain and its association with night pain in patients with knee osteoarthritis. For this purpose a progressive longitudinal study design was planned.
- Conditions
- Knee Osteoarthritis, Sleep Disturbance, Neuropathic Pain
- Trial name
- NCT06430918
- Testing
- physical examination, questionnaires and inventories
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bozyaka Training and Research Hospital
Osteoarthritis, Osteoarthritis, Hip
Incorporating Wearable Technology for Enhanced Rehabilitation Monitoring After Hip and Knee Replacement
This study focuses on the impact of osteoarthritis (OA), a leading cause of disability among older adults, with the hip and knee joints being particularly affected.
- Trial name
- MOVEUP-WT (NCT06157190)
- Testing
- Unsupervised monitoring
- Where
- Belgium
- Volunteers
- 1,144 people
- Sponsor
- PXL University College
Osteoarthritis
Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.
The Purpose of this trial is to evaluate the use of a cross-over trial design in an osteoarthritis population. We will determine the inter- and intra-subject variability in osteoarthritis (OA) endpoints and evaluate if efficacy…
- Trial name
- NCT00484718
- Testing
- celecoxib, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
Osteoarthritis of the Knee, Inflammation, and the Effect of Adalimumab (OKINADA)
This is a Canadian randomized, double-blind, placebo-controlled, multicenter study designed to evaluate the clinical efficacy and safety of adalimumab versus placebo when used to treat subjects with a diagnosis of osteoarthritis…
- Trial name
- OKINADA (NCT02471118)
- Testing
- Adalimumab 40 mg
- Where
- 7 sites in Canada
- Volunteers
- 62 people
- Sponsor
- CARE ARTHRITIS LTD.
Osteoarthritis, Knee / Osteoarthritis, Hip
Efficacy and Safety of MT-5547 in Patients With Osteoarthritis Accompanied by Moderate to Severe Pain
The objective of this study is to verify the superiority of 16 weeks of MT-5547 treatment to placebo, as evidenced by the WOMAC pain score (the efficacy outcome measure), in patients with osteoarthritis of the knee or hip.
- Trial name
- NCT03245008
- Testing
- MT-5547
- Where
- 27 sites in Japan
- Volunteers
- 626 people
- Sponsor
- Tanabe Pharma Corporation
Rheumatoid Arthritis
Transplantation of Bone Marrow Derived Mesenchymal Stem Cells in Affected Knee Osteoarthritis by Rheumatoid Arthritis
Osteoarthritis of the knee is one of the most common causes of disability among elderly. Arthritis rheumatoid is an autoimmune disease which causes multi articular arthritis, such as knee osteoarthritis.
- Trial name
- NCT01873625
- Testing
- mesenchymal cell transplantation
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Royan Institute
Knee Osteoarthritis
Shock Wave Versus Iontophoresis in Treatment of Subjects With Knee Osteoarthritis
Both extra corporeal shock wave and dexamethasone iontophoresisare effective in treatment of knee osteoarthritis but which one is more effective is not clear yet .
- Trial name
- Shockwave (NCT04731350)
- Testing
- radial extracorporeal shock wave, iontophoresis, Exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Knee Osteoarthritis
Exercise Therapy in Patients With Knee Osteoarthritis
Osteoarthritis (OA) is one of the most common form of chronic diseases in the adult population, and approximately 800 000 people in Sweden (population of 9 million people) suffer from this disease, which causes joint pain…
- Trial name
- NCT02024126
- Testing
- Exercise therapy
- Where
- Sweden
- Volunteers
- 189 people
- Sponsor
- Karolinska Institutet
Osteoarthritis
A Study to Investigate the Efficacy and Safety of GSK3196165 in Inflammatory Hand Osteoarthritis
This is a randomized, Phase IIa, multicentre, double-blind, placebo-controlled parallel group study with the primary objective to assess the efficacy potential of GSK3196165 on pain, in subjects with active inflammatory hand…
- Trial name
- NCT02683785
- Testing
- GSK3196165
- Where
- 16 sites in United States, Germany and 3 more
- Volunteers
- 44 people
- Sponsor
- GlaxoSmithKline
Knee Osteoarthritis
Prospective Multi-centre Outcomes Study of Persona Knee System in Total Knee Arthroplasty
This is a prospective, multi-centre, non comparative, post market clinical follow-up study involving orthopaedic surgeons skilled in TKA and experienced implanting the devices included in this study.
- Trial name
- NCT04461626
- Testing
- Persona fixed bearing knee system (All patients will receive Persona fixed bearing knee system)
- Where
- 18 sites in Australia, India and 4 more
- Volunteers
- 1,017 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
Cemented Versus Cementless Unicompartmental Knee Arthroplasty
Unicompartmental knee replacement for selected cases of osteoarthritis is less invasive than total knee replacement. It gives better range of movement; patients stay for shorter time in the hospital and have a more natural feel…
- Trial name
- NCT05935878
- Testing
- Cementless Oxford Unicompartmental Knee Arthroplasty, Cemented Oxford Unicompartmental Knee Arthroplasty
- Volunteers
- 47 people
- Sponsor
- Oxford University Hospitals NHS Trust
Hip Osteoarthritis
Platelet-Rich Plasma and Hip Osteoarthritis
To evaluate the effect of platelet-rich plasma (PRP) injection on pain, function and quality of life in patients with hip osteoarthritis.
- Trial name
- NCT04820231
- Testing
- intra-articular PRP injection
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Osteo Arthritis Knee
Geniculate Artery Embolization for Knee Pain Secondary to Osteoarthritis (OA)
Purpose: To evaluate embolization as a treatment for OA related knee pain versus placebo to demonstrate the actual effect of embolization on pain and disability.
- Trial name
- NCT03362957
- Testing
- Geniculate Artery Embolization
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis, Knee
The Effects of End-of-range Grade A+ Mobilization Following Acute Primary TKA
The purpose of the study is to find the best way to mobilize a knee after total knee arthroplasty (TKA). In particular, the aim of this study will be to investigate the advantages of adding a gentle knee mobilization to the…
- Trial name
- NCT02105857
- Testing
- grade A+ knee mobilization
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Lausanne Hospitals
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Efficacy of Platelet-Rich Plasma Combined With Hyaluronic Acid in Knee Osteoarthritis
This prospective, randomized, open-label, single-centre post-market clinical follow-up (PMCF) study evaluates the clinical performance and safety of a single intra-articular injection of hyaluronic acid (HA) combined with…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
- Trial name
- NCT07784907
- Testing
- Hyaluronic Acid (HA) and Platelet rich plasma (PRP), Hyaluronic Acid (HA)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Implai Sp z o.o
Osteoarthritis, Knee
The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee
A clinical study to measure the effects of injection-site cooling on pain experienced after knee injections of capsaicin in healthy subjects and in patients with knee osteoarthritis.
- Trial name
- NCT03472677
- Testing
- Ice Pack and Cooling Device, CNTX-4975-05 (trans-capsaicin), Capsaicin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Osteoarthritis, Knee
Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis
The goal of this randomized clinical trial is to learn whether taking ibuprofen, a nonsteroidal anti-inflammatory drug, after a platelet-rich plasma (PRP) injection changes pain relief and knee function in adults with knee…
- Trial name
- NCT07766330
- Testing
- Leukocyte-Rich Platelet-Rich Plasma, ibuprofen, Acetaminophen
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Federal University of São Paulo
Osteoarthritis
Anterior Referencing Versus Posterior Referencing in Minimally Invasive Total Knee Arthroplasty
The purpose of this study is to look at two different referencing systems for total knee replacement surgery. In anterior referencing system, referencing cuts are made from the front surface of the femur.
- Trial name
- AR vs PR (NCT01135030)
- Testing
- Total knee
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Heekin Orthopedic Research Institute
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