Clinical trials: Degenerative Joint Disease
Osteoarthritis, Knee
Muscle Fatigability and Trip-specific Fall Risk in Adults With Knee Osteoarthritis
The goal of this clinical trial is to learn about how fatigue affects the risk of falling in adults aged 55-70 years with and without knee osteoarthritis.
- Trial name
- NCT06229691
- Testing
- 30 minute treadmill walk
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Osteoarthritis of the Knee
EMBARK Follow-up Project
The purpose of the EMBARK Follow-up Project (EFP) is to determine if there is a significant correlation between post-study massage-seeking and changes in pain reported by participants during the Exploring Massage Benefits for…
- Trial name
- EFP (NCT02195674)
- Volunteers
- 240 people
- Sponsor
- Duke University
Knee Osteoarthritis
Multi-center Clinical Research of Acupuncture Treatment of Knee Osteoarthritis
Knee osteoarthritis (KOA) is a major public health problem among the elderly and is associated with considerable disability. A recent analysis of data indicated that about 35% of women and men aged 60 years and above had…
- Trial name
- NCT02948218
- Testing
- Acupuncture treatment
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Osteoarthritis, Knee
Standard Versus Novel RFA for Chronic Knee Pain in Osteoarthritis
Brief Summary The goal of this pilot study is to evaluate the feasibility and safety of conducting a randomized comparison of two standard-of-care knee radiofrequency ablation (RFA) techniques in adults with chronic knee pain…
- Trial name
- NCT07674082
- Testing
- Radiofrequency ablation - 3-target technique, Radiofrequency ablation - 6-target technique
- Volunteers
- 24 people
- Sponsor
- Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee
Oral Steroid Taper After Total Knee Arthroplasty
This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).
- Trial name
- NCT07070882
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Columbia University
Osteoarthritis, Intraoperative Bleeding
Use of a Novel Fibrin Sealant in Total Knee Arthroplasty
Applying a fibrin spray, after knee device implantation, will help in reducing patient blood loss and decrease the drop in both hemoglobin and hematocrit levels.
- Trial name
- NCT01656759
- Testing
- Evicel Fibrin Spray
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis, Hip Osteoarthritis
A Disease-based Treatment Study for Diagnosed Osteoarthritis Utilizing Adipose-derived Regenerative Cells
This is a prospective, multi-location safety and effectiveness study, and data registry of autologous adult ADRCs generated by the Transpose® RT System in subjects with OA in the shoulder, wrist, knee, hip, or ankle.
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Ankle Osteoarthritis, Shoulder Osteoarthritis
- Trial name
- NCT04405297
- Testing
- Adipose-derived regenerative cells
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Sanford Health
Trapeziometacarpal Osteoarthritis
Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA)
Thumb osteoarthritis or trapeziometacarpal osteoarthritis (TMO) is a common and painful form of hand arthritis that limits thumb mobility and hand function, affecting patients' quality of life.
- Trial name
- CASITOA (NCT06401317)
- Testing
- Saline Solution (NaCl 0,9%), Triamcinolone Acetonide
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Université du Québec à Trois-Rivières
Osteoarthritis, Knee
Treatment of Osteoarthritis With Autologous, Microfragmented Adipose Tissue.
The study is a blinded, multicenter, randomized, controlled trial with participants individually randomized to one of two parallel groups: 1.
- Trial name
- NCT03771989
- Testing
- autologous, micro-fragmented adipose tissue, Saline
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Hvidovre University Hospital
Osteoarthritis
Safety and Biologic Activity Study of Gevokizumab to Treat Erosive Osteoarthritis of the Hand
The purpose of this proof-of-concept study is to determine whether gevokizumab is effective in the treatment of inflammatory erosive osteoarthritis of the hand.
- Trial name
- NCT01882491
- Testing
- gevokizumab
- Where
- 23 sites in United States
- Volunteers
- 91 people
- Sponsor
- XOMA (US) LLC
Hand Osteoarthritis
Splinting to Treat Hand Osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis and the hand is the most frequently affected site.Interphalangeal (IP) joints (the small joints of the fingers) are often involved causing pain, progressive loss of hand…
- Trial name
- SPLINTOA (NCT01249391)
- Testing
- Splinting
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Imperial College London
Osteoarthritis
Safety of Diclofenac Sodium Gel in Knee Osteoarthritis
This study will test the efficacy and safety of topical Voltaren in the treatment of knee osteoarthritis.
- Trial name
- NCT00171691
- Testing
- Diclofenac Topical Sodium Gel 1%
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Novartis
Knee Osteoarthritis
Colchicine for Symptom and Inflammation in Knee Osteoarthritis
Uric acid may be involved in the activation of the innate immune response in osteoarthritis (OA) pathology and progression. This suggests that traditional gout therapy may be beneficial for OA.
- Trial name
- NCT02176460
- Testing
- Colchicine
- Where
- Singapore
- Volunteers
- 109 people
- Sponsor
- Singapore General Hospital
Low Back Pain
Effectiveness of Facet Joint Infiltration in Low Back Pain
The purpose of this study is to evaluate the effectiveness of facet joint infiltration with corticosteroids in the treatment of low back pain due to facet joint osteoarthritis.
- Trial name
- NCT01447160
- Testing
- Cortisone
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Hip Arthroplasty, Osteoarthritis
Minimally Invasive Surgery of the Hip Versus Standard Approach
The purpose of this study is to determine if there is a difference in terms of length of hospital stay and post-operative outcomes between patients whose total hip replacement surgery is performed with a minimally invasive versus…
- Trial name
- NCT00261040
- Testing
- Minimally Invasive Surgery, Standard Surgery
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis of the Knee or Hip
Comparison Between Blocks or Not in Joint Arthroplasty
The purpose of this study is to evaluate the effect on postoperative pain, opioid consumption and function by adding a combination of regional blocks with local anaesthetic before total hip- and knee arthroplasty compared to…
- Trial name
- BLAST (NCT06230081)
- Testing
- Ropivacain 5 mg/ml + Clonidine
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Region Skane
Knee Osteoarthritis
Comparing Efficacy of PRP Combined With Different Hyaluronan for the Treatment of Knee Osteoarthritis
Either PRP or HA is each effective for treating knee OA. However, the efficacy of combined PRP and HA injections remains unknown clinically.
- Trial name
- NCT04931719
- Testing
- PRP+Artz group, PRP+ HYAJOINT Plus group
- Where
- Taiwan
- Volunteers
- 95 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Coxarthrosis
Measurement of Early Bone Loss Around a Total Hip Arthroplasty
Research with DXA has shown the pattern of bone remodelling around an implant. The baseline and reference value for such calculations is the first measurement after the operation.
- Trial name
- DXACorail (NCT01046019)
- Volunteers
- 23 people
- Sponsor
- Ullevaal University Hospital
Knee Osteoarthritis
Tourniquet vs. no Tourniquet During High Tibial Osteotomy
The purpose of this study is to correlate functional outcomes and perioperative complications with tourniquet use during high tibial osteotomy.
- Trial name
- NCT04992533
- Testing
- Long-duration tourniquet, Short-duration tourniquet
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qilu Hospital of Shandong University
Effusion Joint
Effect of Therapeutic Joint Arthrocentesis on Pain and Quadriceps Function in Patients With Knee Osteoarthritis
This will be prospective study of patients with knee effusion associated with degenerative osteoarthritis or symptomatic primary total knee arthroplasty that undergo therapeutic joint arthrocentesis.
- Trial name
- NCT04146649
- Testing
- Arthrocentesis
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Colorado Joint Replacement
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