Clinical trials: Degenerative Joint Disease
Osteoarthrosis
Effect of Methylprednisolone on Complement Activation in Patients Undergoing Total Knee-arthroplasty
This study evaluates the pathophysiological effects of a single dose of methylprednisolone administered prior to total knee-arthroplasty surgery. The investigators examine the effect on complement activation.
- Trial name
- NCT02332616
- Testing
- Methylprednisolone, Isotonic Sodium Chloride
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Osteoarthritis, Knee
Delivra-Celecoxib 8% Cream and Osteoarthritis
This is an observation of the current use of a transdermal preparation of Celecoxib 8% which is being used in the treatment of patients with primary OA of the knees. Subjects will be followed for 12 weeks.
- Trial name
- NCT03698916
- Testing
- Celecoxib cream 8%
- Where
- 3 sites in Canada
- Volunteers
- 6 people
- Sponsor
- Credit Valley Rheumatology
Osteoarthritis
A Study to Access the Efficacy and Safety of Meloxicam in Patients With Osteoarthritis of the Knee
To Access the Efficacy and Safety of Meloxicam 7.5mg once daily over a treatment period of 56 days
- Trial name
- NCT02183116
- Testing
- Meloxicam
- Volunteers
- 30 people
- Sponsor
- Boehringer Ingelheim
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Degenerative Joint Disease
Post Market Clinical Follow Up of LEGION™ Primary TKS With VERILAST™
LEGION™ Primary Total Knee System is CE-marked and marketed in all study regions. This study serves as post-market surveillance for LEGION™ Primary Total Knee System with the VERILAST™ bearing surface (OXINIUM™ femoral component…
- Trial name
- NCT02380092
- Testing
- LEGION™ Primary TKS with VERILAST™ Bearing Surface
- Where
- 7 sites in Austria, Germany and 1 more
- Volunteers
- 163 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis
Durolane Versus Methylprednisolone in Knee Osteoarthritis
The primary objective is to determine whether Durolane is non-inferior to methylprednisolone, as assessed by level of pain, when each are given as single intra-articular injections for the relief of pain, in the treatment of…
- Trial name
- NCT01209364
- Testing
- Durolane is a device, methylprednisolone in a drug
- Where
- 23 sites in Canada, Sweden and 1 more
- Volunteers
- 442 people
- Sponsor
- Galderma R&D
Osteoarthritis, Knee
A Mechanism Based Proof of Concept Study of the Effects of Duloxetine in the Treatment of Patients With Osteoarthritic Knee Pain
Background: Duloxetine provides an analgesic effect of patients with OA. The mode of action of duloxetine is partly believed to act through modulating the descending inhibitory pain pathways from the brainstem towards the spinal…
- Trial name
- NCT04224584
- Testing
- Duloxetine
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Kristian Kjær Petersen
Knee Osteoarthritis
Assessment of Efficacy of Low Intensity Resistance Training in Men at Risk for Symptomatic Knee Osteoarthritis
The purpose of this research study is to determine whether low intensity resistance training with concurrent application of a peripheral blood flow restriction device to the exercising limb will elicit increased quadriceps…
- Trial name
- PBFR3 (NCT01487525)
- Testing
- Double leg press with partial blood flow restriction, Double leg press without partial blood flow restriction
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteoarthritis, Hip
Use of Cooled Radiofrequency for the Treatment of Hip Pain Associated With Hip OA Compared to Intra-articular Steroid Injections
This will be a multi-center, prospective, single-blinded randomized clinical trial to investigate the effectiveness of using cooled radiofrequency ablation (CRFA) for the treatment of osteoarthritis (OA) hip pain and function in…
- Trial name
- NCT04329884
- Testing
- Cooled RFA treatment with COOLIEF* device, intra-articular corticosteroid injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis, Rheumatoid Arthritis
Anterior Advantage With KINCISE
This is a post-market prospective, 1:1 randomized, multicenter non-inferiority study to compare the femoral broaching time for THA with the Anterior Advantage approach with KINCISE vs. without KINCISE.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
- Trial name
- NCT04191733
- Testing
- KINCISE(TM) Surgical Automated System
- Where
- 11 sites in United States
- Volunteers
- 250 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
Range of Motion of Standard and High-Flexion Posterior Cruciate Retaining Total Knee Prostheses
The purpose of this prospective, randomized study was to compare pain, functional outcome and ranges of motion of the knees in patients receiving either a standard posterior cruciate-retaining or a high-flexion posterior…
- Trial name
- NCT00837447
- Testing
- Total knee replacement with NexGen CR knee prosthesis, Total knee replacement(TKR) with Nexgen CR-flex
- Volunteers
- 54 people
- Sponsor
- Ewha Womans University
Osteoarthritis Knees
Impact of Blood Flow Restriction and Electrical Stimulation on Postoperative Muscle Atrophy and Pain After Total Knee Arthroplasty
This study investigate the impact of Blood Flow Restriction Training and Electrostimulation Training on postoperative muscle atrophy and pain after elective total knee arthroplasty.
- Trial name
- NCT06944808
- Testing
- BFR + EMS
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bonn
Osteoarthritis
The Effects of Disease Management Training and Telephone Counseling Service for Elderly Patients With Osteoarthritis
The study will be conducted to determine the difference on functional status, self-efficacy, and quality of life between groups with and without telephone counseling and training on disease management for participants.
- Trial name
- NCT04816474
- Testing
- Online education and Phone Counseling Service
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- KTO Karatay University
Osteo Arthritis Knee, Osteoarthritis
Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis
This study will be a randomised control trial of the use of intra-articular Arthrosamid® a novel intraarticular hydrogel vs. standard of care (steroid and local anaesthetic) for the non-operative management of knee osteoarthritis.
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Intraarticular Injection
- Trial name
- NCT07489521
- Testing
- Arthrosamid® 2.5% iPAAG injectable implant, Steroid Drug
- Where
- Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cappagh National Orthopaedic Hospital
Knee Osteoarthritis
Comparison of the Efficacy of Duloxetine and Pregabalin in Patients With Knee Osteoarthritis With Mix Type Pain
Osteoarthritis (OA) is a common degenerative joint disorder associated with chronic pain at older age.It is known that patients with osteoarthritis experience nociceptive and neuropathic pain to varying degrees.
- Trial name
- NCT04532684
- Testing
- Duloxetine, Pregabalin
- Volunteers
- 66 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Degenerative Joint Disease
Post-Market Study of the ICONACY Hip System
The purpose of this study is to evaluate the use and efficacy of the Iconacy Hip System for total hip replacement surgery.
- Trial name
- NCT02027974
- Testing
- Iconacy Hip System, Stryker Accolade Hip System
- Sponsor
- Iconacy Orthopedic Implants, LLC.
Knee Osteoarthristis
Gender Based Comparison of the Effects of Sensory Modulated Graded Weight Bearing Physiotherapy In Adults With Knee Osteoarthritis
This comparative experimental study aims to evaluate the effectiveness of Sensory-Modulated Graded Weight-Bearing Physiotherapy (SMGWBP) in patients with knee osteoarthritis and compare treatment outcomes between male and female…
- Trial name
- GSMGWBP (NCT07784998)
- Testing
- Sensory-Modulated Graded Weight-Bearing Physiotherapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Shifa Tameer-e-Millat University
Knee Osteoarthritis
Long-term Evaluation of Outcomes of Patients Undergoing Autologous Bone Marrow Concentrate Infiltration vs. Hyaluronic Acid
This is a prospective observational study for long-term clinical evaluation (minimum 4-year follow-up) in patients treated within the research protocol "OA-bi-blind" (Double-blind randomized trial on the treatment of bilateral…
- Trial name
- NCT06164899
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Ortopedico Rizzoli
Hip Joint, Osteoarthritis
RCT Comparing Ion Levels and Clinical Outcomes of A-Class BFH to Metal on Polyethylene Total Hip Replacement
The main purpose of this prospective randomized controlled trial is to compare the concentrations of metal ions in the blood and urine of patients receiving implants that are identical except for the acetabular component: one is…
- Conditions
- Hip Joint, Osteoarthritis, Arthroplasty
- Trial name
- RCT (NCT00911599)
- Testing
- Blood metal ion levels
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis of the Knee
MINIMALLY INVASIVE SURGERY in Total Knee Arthroplasty
Overall study design: A prospective, randomized, multi-center clinical studies comparing the minimal invasive and the standard surgical total knee replacement technique (control) using the Genesis II total knee system.
- Trial name
- MIS GEN II (NCT00853398)
- Testing
- surgical technique
- Where
- Germany
- Sponsor
- Smith & Nephew Orthopaedics AG
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