Clinical trials: Degenerative Joint Disease
Osteoarthritis Ankle
MONOVISC for Ankle Joint Pain Relief Due to Osteoarthritis
The goal of this study is to demonstrate the clinical improvement and safety in patients treated with MONOVISC for ankle osteoarthritis.
- Trial name
- NCT04204278
- Testing
- Monovisc
- Where
- 4 sites in Czechia, Poland
- Volunteers
- 25 people
- Sponsor
- Anika Therapeutics, Inc.
KNEE OSTEOARTHRITIS
Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis
This study is a randomized, double-blind clinical trial in a Chinese population
- Trial name
- NCT05324163
- Testing
- X0002 Spray, Celecoxib capsules
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Jiangsu XinChen-Techfields Pharma Co., LTD.
Osteoarthritis
Effects of Comprehensive Care for Knee OA
We will study 300 people with knee osteoarthritis (OA) who receive their medical care from a large health maintenance organization (HMO) in Indianapolis.
- Trial name
- NCT00000404
- Testing
- Patient education in self-care of knee OA
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Arthritis
Staying Positive With Arthritis Study
Arthritis is a painful, disabling condition that disproportionately affects African Americans. Existing arthritis treatments yield only small to moderate improvements in pain and are not effective at reducing racial disparities…
- Trial name
- SPA (NCT02223858)
- Testing
- Positive Activities (PA) Program, Attention Control (AC) Program
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis, Pain, Postoperative
NOCTURNAL PAIN After Knee Arthroplasty : Incidence and Risk Factor: an Observational Study
In prosthetic knee surgery, there is a certain number of patients with post-operative nocturnal pain. The purpose of our study is to determine the impact of this problem and to better understand its risk factors.
- Conditions
- Knee Osteoarthritis, Pain, Postoperative, Prosthesis (Internal) Complications, Nocturnal Frequency
- Trial name
- NOCTURN-PAIN (NCT03998943)
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Osteo Arthritis Knee
Reliability and Validity of Turkish Version of Knee Injury and Osteoarthritis Outcome Score-12
Approximately 120 patients who have been diagnosed with knee osteoarthritis but have not previously operated due to this disease and who are in Kellgren Lawrence stage 2 and 3 will be compared with the KOOS scale and Short…
- Trial name
- KOOS-12 (NCT04277676)
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Bahçeşehir University
Obesity, Knee Osteoarthritis
Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)
This is a trial of tirzepatide in people with obesity and knee osteoarthritis. The main purpose of this study is to see if tirzepatide can reduce number of these participants who require a knee replacement.
- Conditions
- Obesity, Knee Osteoarthritis, Osteoarthritis, Knee
- Trial name
- STOP KNEE-OA (NCT06191848)
- Testing
- Tirzepatide
- Where
- 4 sites in Australia
- Volunteers
- 352 people
- Sponsor
- University of Melbourne
Osteoarthritis of the Shoulder
Clinical Results and RSA Migration Analysis of the GLOBAL ICON - Stemless Anatomic Shoulder
The primary goal of the clinical trial is to determine that the GLOBAL ICON implant system from DePuy does not exhibit worse shoulder function after 2 years than the SIMPLICITY from Wright Medical.
- Trial name
- NCT04468178
- Testing
- Total joint arthroplasty of the glenohumeral joint
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Hannover Medical School
Knee Osteoarthritis, Knee Pain Chronic
Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients
The present prospective trial is designed to evaluate the efficacy of CyMedica Orthopedics e-vive™ system, a multifunctional electrotherapy device providing neuromuscular electrical stimulation (NMES) for reducing pain and…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NMES (NCT03980964)
- Testing
- Active NMES
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CyMedica Orthopedics, Inc
Osteoarthritis
ARVIS TKA vs Conventional TKA
This study is a pilot analysis of a novel augmented reality guidance platform, the augmented reality visualization and information system (ARVIS, Insight Medical), with aims to demonstrate accuracy of bone resection and implant…
- Trial name
- ARVIS (NCT06663384)
- Testing
- Evaluation of Augmented Reality technology in TKA compared to standard TKA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Foundation for Orthopaedic Research and Education
Obesity, Osteoarthritis
Walking Aids in the Management of Knee Osteoarthritis
The purpose of this study is to assess whether the single point cane will relieve pain and disability in overweight or obese people with knee OA through altered joint biomechanics and what factors influence acceptance of cane use.
- Trial name
- NCT00223795
- Testing
- Single point cane
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis
Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee
That Hylan G-F 20 may act to protect cartilage from the expected degree of degradation over a 12 month period in subjects with moderate to marked osteoarthritis of the knee
- Trial name
- NCT00393393
- Testing
- intra-articular injection of Hylan G-F 20
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- Cabrini Medical Centre
Osteoarthritis, Knee
Study of SI000413 in Knee Osteoarthritis Patients
The purpose of this study is to evaluate efficacy and safety of SI000413 in patients with knee osteoarthritis by orally administration and to determine optimal dose.
- Trial name
- NCT01525758
- Testing
- SI000413, microcrystalline cellulose
- Where
- 3 sites in South Korea
- Volunteers
- 152 people
- Sponsor
- Dong-A Pharmaceutical Co., Ltd.
Osteoarthritis of the Knee
Prospective Randomized Trial of Navigated and Conventional TKA
Evaluation of the component position and kinematics after navigated and conventional Total Knee Arthroplasty.
- Trial name
- NCT01022099
- Testing
- Implantation of a Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technische Universität Dresden
Osteoarthritis Shoulder, Rotator Cuff Tears
DenCT Shoulder Bone Quality Evaluation
The objective of the study is to evaluate the preoperative bone quality assessment based on CT to later establish a scale for the decision of stemless shoulder arthroplasty.
- Trial name
- NCT06032416
- Testing
- Preoperative CT Scan
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Intraarticular Dextrose Prolotherapy for Symptomatic Knee Osteoarthritis
The purpose of this research is to learn more about treating Symptomatic Knee Osteoarthritis (OA) with an ultrasound-guided hypertonic dextrose injection.
- Trial name
- NCT05160532
- Testing
- Dextrose prolotherapy (DPT)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients
Total knee arthroplasty (TDA) is an effective surgical method applied to reduce pain, improve joint function, and enhance quality of life in patients with advanced osteoarthritis or joint degeneration.
- Trial name
- AI-KNEE (NCT07545447)
- Testing
- Standard Clinical Education, Video-Supported Education, AI-Assisted Anatomical Visualization Training
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Munzur University
Osteoarthritis, Knee
Autologous Culture Expanded Mesenchymal Stromal Cells for Knee Osteoarthritis
The study seeks to determine the safety and feasibility of using adipose-derived mesenchymal stromal cells to treat symptoms of mild to severe knee osteoarthritis.
- Trial name
- NCT02805855
- Testing
- Autologous Adipose-Derived Mesenchymal Stromal Cells
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Jacob L. Sellon, M.D.
Knee Osteoarthritis
Prolotherapy Intervention Effect in Patient With Knee Osteoarthritis
Introduction : Prolotherapy is regenerative tissue therapy which is considered to be efficacious in reducing symptoms and morbidity of Knee Osteoarthritis (KOA), but only a few studies demonstrate the effect of prolotherapy at…
- Trial name
- NCT04557943
- Testing
- Prolotherapy, Sodium Hyaluronate
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Hasanuddin University
Osteoarthritis, Knee
Efficacy Study of Intra-articular Hyaluronic Acid in the Knee Osteoarthritis
The purpose of this study is to prove the non-inferiority of the intra-articular injection of hyaluronic acid (Sinovial®) in the symptomatic treatment of knee OA in comparison to Synvisc®.
- Trial name
- NCT00556608
- Testing
- Sinovial® (syringe containing sodium hyaluronate solution), Synvisc® ( syringe containing Hylan G-F 20 solution)
- Where
- 20 sites in Czechia, France and 4 more
- Volunteers
- 381 people
- Sponsor
- IBSA Institut Biochimique SA
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