Clinical trials: Degenerative Joint Disease
Hand Osteoarthritis
Cross-sectorial Management Program for People Living with Hand Osteoarthritis: a Randomised Controlled Pilot and Feasibility Study
To investigate the research design (pilot-RCT) and feasibility of the HANDY program for people with hand osteoarthritis (version 2.0).
- Trial name
- HANDY (NCT06794632)
- Testing
- HANDY occupational therapy intervention
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Parker Research Institute
Bilateral Knee Osteoarthritis
Gait, Stair Climbing and Postural Stability in Knee Osteoarthritis Patients After Hyaluronic Acid Injection
Treatment: five intro-articular Hyaluronic Acid injection Assessment has two parts, that are as follow: 1. Postural stability and risk of fall assessment using Biodex stability index and "Timed up and Go" test 2.
- Trial name
- NCT02063373
- Testing
- Hyaluronic acid
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Patellofemoral Osteoarthritis
Treatment of Patellofemoral Osteoarthritis With Engineered Cartilage.
The purpose of this investigator-initiated study is to assess the efficacy of treating patellofemoral osteoarthritis with an Advanced Therapy Medicinal Product (ATMP), autologous nasal chondrocyte tissue engineered cartilage…
- Trial name
- NCT06163573
- Testing
- N-TEC, Platelet rich plasma
- Where
- 9 sites in Croatia, Germany and 1 more
- Volunteers
- 75 people
- Sponsor
- University Hospital, Basel, Switzerland
Leg Length Inequality, Osteoarthritis, Knee
Shoe Lifts for Leg Length Inequality in Adults With Knee or Hip Symptoms
Limb length inequality is when a person has one leg that is longer than the other. This research will look at correcting limb length inequality in adults with knee or hip symptoms.
- Conditions
- Leg Length Inequality, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT01894100
- Testing
- Shoe lift correction for leg length inequality
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of North Carolina, Chapel Hill
Knee Osteoarthritis, Total Knee Arthroplasty
In Vivo Kinematics for Subjects With Smith & Nephew Journey II BCS TKA, Journey II CR TKA, Or Journey II XR TKA
The objective of this study is to determine and compare the in vivo kinematics and vibroarthrography (VAG) signals for subjects implanted with Journey II Bi-Cruciate Stabilized (BCS), CR (Cruciate Retaining), and Bi-Cruciate…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Knee
- Trial name
- NCT04612036
- Testing
- Journey II Bi-Cruciate Stabilized TKA, Journey II Cruciate Retaining TKA, Journey II Bi-Cruciate Retaining TKA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Tennessee, Knoxville
Osteoarthritis
A Population-based Cohort of Osteoarthritis: the Tsinghua University Tiantongyuan Community Osteoarthritis Study
The purpose of this study is to examine the natural history and risk factors of osteoarthritis (OA) and to explore the relationship between metabolic factors and OA progression.
- Trial name
- NCT07006701
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Osteo Arthritis of Hip
Effects of Modified Clamshell Exercises in Patients With Hip Osteoarthritis Grade Ⅱ.
This study focuses on patients diagnosed with Grade II hip osteoarthritis, a degenerative joint condition characterized by pain, reduced range of motion, muscle weakness, and functional limitations.
- Trial name
- NCT07401719
- Testing
- Modified clamshell exercise, Clamshell Exercises, Conventional exercises
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Osteoarthritis: Joint Replacement Surgery
Comparing Pain Relief Between Exparel® Injection vs. On-Q Catheter as the Postsurgical Analgesia Following Total Knee Arthroplasty (TKA)
The goal of this research project is to evaluate the effectiveness of a novel treatment to control pain after Total Knee Arthroplasty (TKA).
- Trial name
- NCT02739230
- Testing
- Exparel, On-Q pain intra-articular catheter
- Sponsor
- Rothman Institute Orthopaedics
Knee Arthropathy, Osteoarthritis, Knee
Investigating the Effectiveness of Vibration Therapy on Sarcopenia in Osteoarthritis Knee Patients
Osteoarthritis (OA) is one of the commonest chronic degenerative conditions affecting our aging population. It limits joint movement and causing disability in elderlies due to discordant symptoms such as pain and stiffness.
- Conditions
- Knee Arthropathy, Osteoarthritis, Knee, Knee Osteoarthritis
- Trial name
- NCT03880344
- Testing
- Vibration Therapy, Physiotherapy
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Knee Arthrosis
Regenerative Injection Therapy and Osteoarthritis
The objective is to assess the effectiveness of regenerative injection therapy (RIT) to relieve pain and restore function in patients with knee osteoarthritis. The study design is a randomized controlled trial with cross-over.
- Trial name
- NCT01206634
- Testing
- Regenerative injection therapy, Exercise
- Volunteers
- 45 people
- Sponsor
- Réseau de Santé Vitalité Health Network
Knee Osteoarthritis
The Efficacy of Exercise and Alternative Applications of NMES on Pain and Function in Patients With Knee OA
The aim of the study was to investigate the efficacy of exercise and different size electrodes of neuromuscular electrical stimulation (NMES) applications on pain, range of motion (ROM), muscle strength, function status and…
- Trial name
- NCT03571698
- Testing
- Neuromuscular Electrical Stimulator
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Hip Osteoarthritis, Knee Osteoarthritis
Patient-reported Outcome Measures in Patient Underwent Total Hip and Knee Arthroplasty
Registry of Galeazzi Orthopedic Institute: provides for the regular and systematic collection of all data (clinical and some PROMs) obtained from patients undergoing hip and knee arthroplasty to which questionnaires are proposed…
- Conditions
- Hip Osteoarthritis, Knee Osteoarthritis, Prosthesis Survival
- Trial name
- NCT04960098
- Testing
- arthroplasty
- Where
- Italy
- Volunteers
- 5,816 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteoarthritis of the Knee
A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee
This is a Phase 2 study, involving a 4-week treatment period, designed to test the ability of investigational study drug ARRY-371797 to reduce pain in patients with moderate to severe pain due to osteoarthritis (OA) of the knee…
- Trial name
- NCT01366014
- Testing
- ARRY-371797, p38 inhibitor; oral, Oxycodone hydrochloride (HCl) extended release (ER), opioid agonist; oral
- Where
- 13 sites in United States
- Volunteers
- 157 people
- Sponsor
- Pfizer
Osteoarthritis
The Effectiveness of Behavioral Graded Activity in Patients With Osteoarthritis of the Hip and/or Knee
We performed a randomized controlled trial to study the effectiveness of Behavioral graded activity (BGA) in patients with OA of the hip or knee.
- Trial name
- GRADIT (NCT00522106)
- Testing
- Behavioral graded activity, Exercise therapy
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Netherlands Instititute for Health Services Research
Osteoarthritis
Prospective Single Center Open Label Study of Shoulder OA Pain
Open label, prospective, single cohort study of Durolane 3ml intra-articular injection into the shoulder for pain in mild to moderate patients
- Trial name
- NCT02610504
- Testing
- Durolane
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Bioventus LLC
Knee Osteoarthritis
Effectiveness and Safety of Sphaeralcea Angustifolia Standardized Extract as a Topical Treatment of Knee Osteoarthritis
Knee Osteoarthritis is one of the most frequent rheumatic disorders in the population and, in many cases, it causes disability due to pain, stiffness and deformation.
- Trial name
- NCT04511195
- Testing
- Standardized extract of Sphaeralcea angustifolia, Diclofenac Sodium Gel
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Meniscal Degeneration, Osteoarthritis of Knee
Evaluation of Clinical and Radiographic Outcomes of Meniscal Lesion Treatment Using Collagen Scaffolds (CMI)
Meniscal lesions represent the most frequently encountered joint pathology in the adult population and can cause pain symptoms, mechanical blockages, and recurrent effusions.
- Conditions
- Meniscal Degeneration, Osteoarthritis of Knee, Meniscus Injury
- Trial name
- SUPER CMI (NCT06597357)
- Testing
- Arthroscopy & saline irrigation alone
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis
The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty
The purpose of this study is to use a new combination of anesthesia techniques in an attempt to minimize early pain after surgery and improve the patient's ability to participate more fully with physical therapy.
- Trial name
- NCT00620828
- Testing
- Ropivicaine 0.5%
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Duke University
Osteoarthritis of Shoulder
Evaluation of Structural and Functional Integrity of the Rotator Cuff After Total Shoulder Arthroplasty
The purpose of this study is to examine the rotator cuff muscles in your shoulder at one and two year post total shoulder replacement surgery.
- Trial name
- NCT03921944
- Testing
- CT scan of the shoulders
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
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