Clinical trials: Degenerative Joint Disease
Knee Osteoarthritis
Risk Assessment and Management Program (RAMP) on Knee Osteoarthritis in Primary Care
The goal of this clinical trial is to determine the clinical effectiveness of a Chronic Care Model (CCM) named Risk Assessment and Management Program on Knee OA (RAMP-Knee OA) in adults with knee Osteoarthritis (Knee OA) at 52…
- Trial name
- NCT06283147
- Testing
- Risk assessment and Management Programme - Knee Osteoarthritis
- Where
- Hong Kong
- Volunteers
- 228 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis, Knee
Comparison of Efficacy of Intra-articular Morphine vs Methylprednisolone in Patients With Knee Osteoarthritis.
Prospective randomized double-blind controlled study. Participating patients with knee pain secondary to knee osteoarthritis will be randomized to either the DepoMedrol 40mg + 0.25% Bupivacaine (total Volume 5 ml) vs Morphine 3mg…
- Trial name
- NCT06163755
- Testing
- Methylprednisolone 40 MG Injection
- Sponsor
- Henry Ford Health System
Osteoarthritis
Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty
This is a prospective, randomized, controlled, open label, parallel four-arm design, multi-center study to compare different intraoperative interventions in the prevention of acute PJI development.
- Trial name
- NCT04075526
- Testing
- Povidone iodine, Vancomycin powder, Conventional
- Where
- 14 sites in United States
- Volunteers
- 2,129 people
- Sponsor
- NYU Langone Health
Cartilage Diseases
Molecular Biomarkers Associated With Degenerative Joint Disease in the Knee
This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy.
- Trial name
- NCT01006278
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scuderi, Gaetano J., M.D.
Osteoarthritis, Chronic Pain
Imaging Pain Relief in Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease and is the most common form of arthritis. Pain reduction and functional recovery are the key elements of the clinical management of OA.
- Trial name
- IPRO (NCT02208778)
- Testing
- Duloxetine, Remifentanil
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- University of Nottingham
Knee Arthropathy
Persona Cohort Nordic Multicenter Study
In this project the investigators wish to: Evaluate intra-operative and postop complications, longer term survivorship and patient reported outcome measures (PROMs) following primary total knee replacement using Persona Total…
- Trial name
- NCT03495232
- Testing
- Zimmer Biomet Persona total knee system
- Where
- 4 sites in Denmark, France and 2 more
- Volunteers
- 700 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Comparing One Intraarticular Injection of a Novel HYAJOINT Plus With Synvisc-One for the Treatment of Knee OA
Viscosupplementation has been widely used for the treatment of knee osteoarthritis (OA). There is no well controlled trial comparing one injection regimen of HA for the treatment of knee OA.
- Trial name
- NCT02686047
- Testing
- HYAJOINT Plus, Synvisc-One
- Where
- Taiwan
- Volunteers
- 132 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Knee Osteoarthritis
Characteristics of Patients Declining INKA Trial Participation
The objective of this study is to compare baseline characteristics of overweight knee OA patients accepting vs. declining enrolment in the INKA trial (NCT05172843) to explore if enrolled patients differ systematically from the…
- Trial name
- n-INKA (NCT05215678)
- Testing
- Acceptance of invitation to trial participation, Declining invitation to trial participation
- Where
- Denmark
- Volunteers
- 129 people
- Sponsor
- Marius Henriksen
Osteoarthritis, Knee
Intraosseous With Intra-articular Injection of Platelet Rich Plasma in Treatment of Knee Osteoarthritis
The aim of this study was to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given a combination of intraosseous with intra-articular injection of platelet rich plasma (PRP)…
- Trial name
- NCT03329235
- Testing
- PRP, HA
- Volunteers
- 86 people
- Sponsor
- Cangzhou Central Hospital
Osteoarthritis, Knee
Evaluation of Platelet Rich Plasma (PRP) for Knee Osteoarthritis
Study was designed to evaluate efficacy of autologous platelet rich plasma (PRP) injections guided by ultrasound for treatment of knee osteoarthritis.
- Trial name
- NCT03138317
- Testing
- PRP, Plasma
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Osteoarthritis, Knee
Geniculate Nerve Ablation vs Geniculate Artery Embolization vs Sham for Knee Osteoarthritic Pain
This is a three-arm prospective double-blinded randomized comparative trial aimed at comparing results regarding knee pain improvement in patients with osteoarthritis (OA) of the knee awaiting total knee arthroplasty (TKA) by…
- Trial name
- NCT04662840
- Testing
- Geniculate artery embolization, Geniculate nerve ablation, Skin infiltration of local anesthetic at groin and knee
- Where
- 2 sites in Canada
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Post-traumatic Osteoarthritis
A Biologic Joint Replacement Strategy to Treat Patients With Severe Knee Trauma and Post-Traumatic Knee Osteoarthritis
With IRB approval and informed consent, patients (n=10) (18-50 years old) with post-traumatic knee OA and requiring a tibial plateau and meniscus arthroplasty plus a femoral condyle arthroplasty will be enrolled in the study.
- Trial name
- NCT03257371
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- James Stannard
Trapeziometacarpal Osteoarthritis
Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of Trapeziometacarpal Osteoarthritis
The objective of this clinical trial is to evaluate whether a human umbilical cord amniotic membrane allograft can serve as an interposition implant in the surgical treatment of trapeziometacarpal osteoarthritis.
- Trial name
- NCT07435571
- Testing
- with SclerFIX
- Where
- 4 sites in France
- Volunteers
- 22 people
- Sponsor
- TBF Genie Tissulaire
Chronic Pain, Perineural Analgesia
Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.
The aim of this study is to test whether the addition of dextrose to perineural injections is superior to local anesthetic alone, as some initial data have indicated.
- Conditions
- Chronic Pain, Perineural Analgesia, Prolotherapy, Knee Osteoarthritis
- Trial name
- NCT07245121
- Testing
- Dextrose 5% and Lidocaine, Lidocaine
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Knee Osteoarthritis, Physical Activity
Evaluation of the Effectiveness of Self Management Program on Changes in Physical Activity Level of Knee Osteoarthritis Patients in Spa Therapy
The primary purpose is to evaluate the benefit of an education action of exercise on the level of physical activity in patients with knee osteoarthritis with the waning of a spa treatment for three weeks, three months after the…
- Conditions
- Knee Osteoarthritis, Physical Activity, Education, Self-management
- Trial name
- GEET One (NCT02598804)
- Testing
- 5 educational workshop, written information booklet
- Where
- France
- Volunteers
- 172 people
- Sponsor
- University Hospital, Clermont-Ferrand
Knee Osteoarthritis
High Intensity Interval Training in Osteoarthritis, Effects on Metabolomics
Purpose: The purpose of this study will be to examine the feasibility and acceptability of a 6-week high intensity interval training (HIIT) program in patients with knee OA symptoms ranging from mild to severe.
- Trial name
- NCT03039452
- Testing
- High intensity interval training
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of North Carolina, Chapel Hill
Pain, Joint Stiffness
Persistent Postoperative Pain and Joint Stiffness After Total Knee Arthroplasty Performed for Osteoarthritis
Persistent pain and joint stiffness after surgery may interfere with recovery and adversely affect quality of life in up to 40% of patients who have undergone total knee arthroplasty.
- Trial name
- NCT02626533
- Testing
- Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Replacement
Innovative Gait Training for People With Knee Osteoarthritis Using Dual Belt Treadmill
Knee osteoarthritis (OA) is the most common form of arthritis and is the leading cause of chronic musculoskeletal pain and functional disability. Gait assessment is essential for the rehabilitation of people with knee OA.
- Trial name
- NCT05958212
- Testing
- Gait training program, Conventional training only
- Where
- Hong Kong
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Osteoarthritis
The Effectiveness of Strength Training and Self-management in Reducing Symptoms for Individuals With Knee Osteoarthritis
This study aims to investigate the effectiveness of an intervention combining strength training and self-management education in improving symptoms, sleep quality, emotional well-being, and quality of life in patients with knee…
- Trial name
- NCT07804212
- Testing
- Strength Training
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Pingtung Veterans General Hospital
Knee Osteoarthritis
Zurich Multiple Endpoint Vitamin D Trial in Knee OA Patients
This is a 2-year double-blind randomized controlled trial in 287 community-dwelling individuals age 60 years or older undergoing uni-lateral total knee replacement due to severe OA of the knee.We compare an oral dose of 2000 IU…
- Trial name
- NCT00599807
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Switzerland
- Volunteers
- 273 people
- Sponsor
- University of Zurich
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