Clinical trials: Degenerative Joint Disease
Osteoarthritis, Cancer Pain
Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies
A4091065 is a multicenter, prospective, cohort study with enhance physical an neurodevelopmental surveillance to characterize the outcomes related to the development of infants up to the age of 15 months who were potentially…
- Conditions
- Osteoarthritis, Cancer Pain, Recurrent Low Back Pain
- Trial name
- NCT03031938
- Testing
- Investigational medical product (IMP) administered in parent study
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- Pfizer
Osteoarthritis, Total Knee Replacement
Time-dependent Improvement of Functional Outcome Following LCS Rotating Platform TKR
The objective of this prospective study is to determine (1) the time course of patient-relevant functional outcome evaluated by the Knee injury and Osteoarthritis Outcome Score (KOOS) and (2) the time course of range of motion…
- Trial name
- NCT01030848
- Testing
- Total Knee Replacement (LCS rotating platform)
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Vestre Viken Hospital Trust
Knee Osteoarthritis, Central Pain Syndrome
Effects of Vagus Nerve Stimulation on Central Pain Sensitivity & Parasympathetic Function in Knee Osteoarthritis
The goal of this clinical trial is to test the feasibility and effectiveness of transcutaneous vagus nerve stimulation (tVNS) to the ear on pain and autonomic function in people with knee osteoarthritis (OA).
- Trial name
- NCT05625178
- Testing
- Transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas, El Paso
Sports Physical Therapy
Effects of Strength and Balance Training to Reduce the Fall Risk in Knee Osteoarthritis Patients
This study will address the scarcity of research and the variations in recommendations regarding the effects of strength and balance training to reduce the fall risk in knee osteoarthritis patients.
- Trial name
- NCT04993911
- Testing
- Experimental Group, Control Group
- Where
- Pakistan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Knee Osteoarthritis
Intra-articular Pulsed Radiofrequency Neuromodulation Versus Intra-articular Steroids for Painful Knee Osteoarthritis
To compare the efficacy of intra-articular pulsed radiofrequency to intra-articular steroids in patients with moderate-severe painful osteoarthritis of the knee.
- Trial name
- NCT04238598
- Testing
- Pulse Radiofrequency, Standard of Care Intra- Articular Injection
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Center For Interventional Pain and Spine
Knee Osteoarthritis
The Effect of Remote Ischemic Preconditioning on Postoperative Cognitive Dysfunction in Total Knee Replacement
The patients were allocated randomly to receive remote preconditioning group (RIPC group, R) or not (Control group, C) using sealed envelopes with the options inside the sealed envelope of R and C before anaesthesia induction.
- Trial name
- NCT02478216
- Testing
- Remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Konkuk University Medical Center
Osteoarthritis
Exploring Massage Benefits for Arthritis of the Knee
The purpose of this study is to verify the efficacy of an 8-week course of manualized Swedish massage for reducing pain and increasing function compared to light-touch bodywork, and usual care, in 222 adults with OA of the knee.
- Trial name
- EMBARK (NCT01537484)
- Testing
- Massage Therapy
- Where
- 3 sites in United States
- Volunteers
- 222 people
- Sponsor
- Duke University
Knee Osteoarthritis
Etodolac Nanogel as an Adjunct to Physiotherapy for Knee Osteoarthritis
Brief Summary: Knee osteoarthritis (OA) is a common, disabling condition affecting the weight-bearing knee joint, leading to pain, reduced function, and muscle weakness, particularly of the quadriceps.
- Trial name
- NCT07308470
- Testing
- Etodolac-Loaded Solid Lipid Nanoparticle Gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Osteoarthritis of Hip
Management of Postoperative Pain After Total Hip Arthroplasty
Orthopedic surgery is reportedly among the most painful surgical procedures. Surgical damage following major orthopedic surgery often involves a large, deep incision with considerable tissue dissection and muscle, bone, and…
- Trial name
- NCT01040273
- Testing
- Bupivacaine
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis, Knee
nCap Pain Relief Patch vs. Placebo
The purpose of this study is to determine whether use of the nCap Medical Nano-Capacitive pain relief patch reduces subject pain as measured by subject pain scores, WOMAC scores (pain, stiffness and physical function), global…
- Trial name
- NCT04753567
- Testing
- nCap pain relief patch
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- nCap Medical
Obesity, Overweight
A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee
The main purpose of this study is to evaluate the safety and efficacy of retatrutide once-weekly in participants who have obesity or are overweight and have osteoarthritis (OA) of the knee. The study will lasts about 77 weeks.
- Conditions
- Obesity, Overweight, Osteo Arthritis Knee
- Trial name
- TRIUMPH-4 (NCT05931367)
- Testing
- Retatrutide
- Where
- 49 sites in United States, Australia and 4 more
- Volunteers
- 445 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis
Leukocyte-rich PRP vs Leukocyte-poor PRP for the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial
Platelet-rich Plasma (PRP) is the most exploited biologic agents currently used for the treatment of osteoarthritis (OA) of different joints, in particular knee OA.
- Trial name
- PRP014 (NCT02923700)
- Testing
- Leukocyte-rich PRP intra-articular injections, Leukocyte-poor PRP intra-articular injections
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Istituto Ortopedico Rizzoli
Hip Osteoarthritis, Indication for Total Hip Replacement
Evaluation of Locomotor Activity Before and After Total Hip Replacement in Patients With Hip Osteoarthritis.
The investigators believe that the application of non-linear methods of analysis using the ganglion and neural network technique will make it possible to analyse all of the complex data obtained in patients with hip…
- Trial name
- NCT02042586
- Testing
- Analysis of movement before total hip replacement, Analysis of movement after total hip replacement
- Where
- France
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Osteoarthritis of Knee, Proprioception
Proprioceptive Fatigue Adaptation in Osteoarthritis
This study aims to investigate the effects of fatigue induced by isokinetic exercise on passive and active joint position sense in postmenopausal women diagnosed with knee osteoarthritis (gonarthrosis).
- Conditions
- Osteoarthritis of Knee, Proprioception, Isokinetic Test, Gonarthritis
- Trial name
- PROFA-OA (NCT06972186)
- Testing
- Fatigue Protocol + Joint Position Sense Testing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kocaeli Sağlık ve Teknoloji Üniversitesi
Osteoarthritis (OA) of the Knee
Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist
Studies have shown that obese patients undergoing total knee replacement (TKR) surgery face a higher risk of perioperative issues such as increased use of pain medication, surgical site infections, and the need for revision…
- Trial name
- NPO-OOPS-TKR (NCT06807970)
- Testing
- Glucagon-like peptide-1 receptor agonists (GLP 1 RA), Control (Standard treatment)
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Hip Osteoarthritis
Comparison of Two Hydroxy-apatite Coated Hip Stems
In this study, the investigators propose to randomize 80 subjects to receive either the Avenir cementless hip stem or a competing, HA-coated hip stem (Corail, DePuy-Synthes) and follow these patients for a period of 2 years…
- Trial name
- NCT03577522
- Testing
- Avenir cementless hip stem, Corail HA-coated hip stem
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
Osteoarthritis
Osteoarthritis Bedside Testing Kit
Develop and test a bedside testing kit for evaluating pain and symptoms of osteoarthritis
- Trial name
- NCT00794651
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Analgesic Solutions
Obesity, Osteoarthritis
Arthritis Pilot for Preserving Muscle While Losing Weight
The purpose of this research study is to see whether wearing a weighted vest during a period of active weight loss can decrease the loss of muscle and bone that occurs during weight loss.
- Trial name
- APPLE (NCT02239939)
- Testing
- Vest, Diet
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Thumb Osteoarthritis, Proprioceptive Disorders
Position Sense, Force Control and Pain Intensity in Basal Thumb Osteoarthritis
In practice, a single test is used to quantify thumb proprioception. Previous studies have found a decrease in joint position sense (JPS) and force sense (FS) in patients diagnosis of thumb carpometacarpal osteoarthritis, but no…
- Conditions
- Thumb Osteoarthritis, Proprioceptive Disorders, Pain, Chronic
- Trial name
- NCT04819139
- Testing
- Active Excersises, Reeducation ADL, Joint protection
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Malaga
Osteoarthritis, Stem Cells
Intra-articular Injection of MSCs in Treatment of Knee OA
In this study, researchers want to determine the safety of MSCs that a patient can tolerate without causing side effects. Moreover researchers will also be looking at the function of the knee over time, which may give them some…
- Conditions
- Osteoarthritis, Stem Cells, MSC
- Trial name
- NCT03028428
- Testing
- Placenta Derived Mesenchymal Stem Cell, Sodium Hyaluronate
- Volunteers
- 1 people
- Sponsor
- Affiliated Hospital of Jiangsu University
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