Clinical trials: Degenerative Joint Disease
Pain, Acute, Knee Osteoarthritis
Comparison of the Analgesic Effect of Subsartorial Saphenous Block and Popliteal Sciatic vs Subsartorial Saphenous Block and IPACK in Total Knee Replacement Surgery.
Total knee replacement surgery is associated with significant pain in the immediate postoperative period, especially in movement. In turn, this is associated with more subsequent chronic pain.
- Conditions
- Pain, Acute, Knee Osteoarthritis, Anesthesia
- Trial name
- NCT06514365
- Testing
- IPACK block with Bupivacaine 0.25% with adrenaline
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Germans Trias i Pujol Hospital
Osteoarthritis of the Knee
VISIONAIRE™ Value Study
This is a single center randomized observational study that evaluates the cost benefit ratio between the use of two types of instrumentation in TKA: standard instrumentation vs. VISIONAIRE™ Patient Matched Technology.
- Trial name
- NCT01107769
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Knee
Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement
Osteoarthritis (OA), the most common type of arthritis, affects more than 32.5 million adults in the United States. It is also among the most expensive condition to treat when joint replacement surgery is required.
- Trial name
- NCT04732962
- Testing
- AposHealth, Total Knee Replacement (TKR)
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Geisinger Clinic
Osteoarthritis of the Knee
A Phase III Study of CLS2901C in Patients With Osteoarthritis of the Knee
To evaluate the efficacy and safety of CLS2901C human allogenic chondrocyte sheets used in the osteotomy + RMSC group compared to in the osteotomy alone group of patients with osteoarthritis of the knee (OAK).
- Trial name
- NCT06549686
- Testing
- CLS2901C (human [allogeneic] chondrocyte sheets)
- Where
- 6 sites in Japan
- Volunteers
- 96 people
- Sponsor
- CellSeed Inc.
Osteoarthritis, Knee
BION Treatment of Knee Osteoarthritis
Osteoarthritic changes in the knee are a common cause of pain that restricts the subject's ability to move and may lead to surgical intervention with total knee replacement.
- Trial name
- NCT00689286
- Testing
- BION
- Where
- United States
- Sponsor
- University of Southern California
Osteoarthritis
Glucosamine Sulphate and Increased Level of Blood Cholesterol
Glucosamine sulphate causes no changes in blood levels of cholesterol
- Trial name
- NCT00251069
- Testing
- Glucosamine sulphate
- Where
- Denmark
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Slidgigtinstituttet
Knee Osteoarthritis
Unicompartmental Knee Arthroplasty vs. High Tibial Osteotomy for Medial Knee Osteoarthritis (UNIKORN): a Study Protocol of a Randomized Controlled Trial
Unicompartmental knee arthroplasty (UKA) and High Tibial Osteotomy are both valid treatment options for isolated medial knee osteoarthritis.
- Trial name
- UNIKORN (NCT05442242)
- Testing
- Unicompartmental knee arthroplasty, High tibial osteotomy
- Volunteers
- 100 people
- Sponsor
- Töölö Hospital
Knee Osteoarthritis
NANOVAE to Treat Knee Osteoarthritis (KOA)
The below summarizes relevant information for investigator(s) to consider the use of Allogenic Human Amniotic Fluid product in a clinical protocol detailing study design and conduct for a phase I/II randomized, double-blinded…
- Trial name
- NCT06606561
- Testing
- NANOVAE - Acellular Allogenic Human Amniotic Fluid (hAF), 0.9% Sodium Chloride Injection, USP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Nova Vita Laboratory
Osteoarthritis, Knee, Cartilage Degeneration
Analysis of the Pathophysiological and Functional State of the Knee Joint
Osteoarthritis is the most common degenerative condition affecting the knee joint globally, with an incidence of about 7% of the population.
- Trial name
- Gait-MRI-Knee (NCT06490770)
- Testing
- Gait analysis, Magnetic Resonance Imaging
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Ortopedico Rizzoli
Ankle Sprains
Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation
The purpose of this project is to compare a novel sensorimotor ankle rehabilitation training (SMART) protocol for Lateral ankle sprains (LASs) against a standard of care (SOC) protocol to determine if it is more successful at…
- Trial name
- NCT03663361
- Testing
- SMART Intervention, Standard of Care Intervention
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Phillip Gribble
Knee Osteoarthritis, Total Knee Arthroplasty
Improvement of Total Knee Arthroplasty Effectiveness Using Preoperative Prehabilitation
Total knee arthroplasty (TKA) is the most effective treatment for stage III-IV knee osteoarthritis (OA). However, up to 30% of patients remain dissatisfied due to periarticular functional insufficiency, pain, and movement…
- Trial name
- TKA-PREHAB (NCT07790146)
- Testing
- Multimodal phenotype-based prehabilitation
- Where
- Russia
- Volunteers
- 64 people
- Sponsor
- Samara State Medical University
Osteoarthritis
An RSA and DEXA Study on Migration of Proximal Interphalangeal (PIP) Joint Prostheses of the Hand
The purpose of this study is to compare the early migration and the periprosthetic bone changes of cemented versus non-cemented interphalangeal implants using Roentgen stereophotogrammetric analysis and dual energy x-ray…
- Trial name
- NCT00175188
- Testing
- Avanta (PIP joint implant with a titanium porous coating)
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Knee Osteoarthritis
Hydrolyzed Collagen Formulation vs Placebo in Knee Osteoarthritis
The aim of the study is to compare the 6 months clinical outcome of the treatment with a single intra-articular collagen injection versus a single placebo (saline solution) infiltration in the infiltrative treatment of knee…
- Trial name
- NCT04998188
- Testing
- Collagen
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis of the Shoulder, Osteoarthritis of the Hip
Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip
This is an open-label study to compare systemic exposure to triamcinolone acetonide following a dose of extended-release FX006 or immediate-release TAcs (triamcinolone acetonide suspension) in patients with osteoarthritis of the…
- Trial name
- NCT03382262
- Testing
- FX006 32 mg, TAcs 40 mg
- Where
- 6 sites in United States
- Volunteers
- 55 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis
The Impact of Dietary Restriction of Animal Protein and Fat on Osteoarthritis
Patients will be randomized into the control or intervention group. Based on patient preference, the intervention group will be trained for one hour in either individual or group format on vegan diet.
- Trial name
- NCT01939262
- Testing
- Limitation of Animal Fat and Protein in the Diet, Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Essentia Health
Knee Osteoarthritis
Efficacy of Radial Shockwave Therapy for Treatment of Pain in Knee Osteoarthritis
The objective of this study is to compare the results of 2000 impulses of radius shockwaves per week with 2000 placebo shockwaves on the treatment of pain and functional incapacity of patients with severe primary knee…
- Trial name
- NCT02197962
- Testing
- Extracorporeal Radial shockwaves
- Where
- 2 sites in Brazil
- Volunteers
- 105 people
- Sponsor
- Marta Imamura
Osteoarthritis, Knee
Radiofrequency Ablation on Pain Relief of Knee Osteoarthritis
Introduction Osteoarthritis (OA) is a chronic, progressive disease with high disability and teratogenicity in the joints. Deterioration of the articular cartilage is the main problem associated with osteoarthritis, which…
- Trial name
- NCT05050396
- Testing
- Cooled versus thermocoagulant Radiofrequency Ablation in pain relief of knee osteoarthritis
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Assiut University
Knee Osteoarthritis, Knee Arthritis
Comparison of Two Robotic-Assisted Total Knee Arthroplasty Systems
The goal of this prospective study is to compare two different knee replacement robots. This study will look at patient reported outcome measures and data collected during the operation.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Disease
- Trial name
- NCT06284824
- Testing
- Stryker Triathlon with MAKO Robotic-Arm, DePuy Attune with VELYS Robotic-Assistance
- Volunteers
- 120 people
- Sponsor
- Southeast Orthopedic Specialists
Osteoarthritis
Intra-articular Hyaluronic Acid in Mild to Moderate Knee Osteoarthritis
Objective: To assess the impact of intraarticular hyaluronic acid (HA) on clinical outcome and on volumetric and T2 relaxation based changes of articular cartilage in mild to moderate osteoarthritis (OA) of the knee joint.
- Trial name
- Ostenil (NCT01239810)
- Testing
- Hyaluronic Acid
- Volunteers
- 34 people
- Sponsor
- Technical University of Munich
Osteo Arthritis Knee
pAF for the Treatment of Osteoarthritis
This is a Phase I/II Randomized Double-Blinded Standard of Care (Corticosteroid) vs. Sterile Amniotic Fluid for Osteoarthritis
- Trial name
- NCT04886960
- Testing
- Amniotic Fluid Injection, Standard of Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
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