Clinical trials: Degenerative Joint Disease
Bone Degenerative Changes, Osteoarthritis
Parallel Study Between BMP-2 and Autologous Bone Graft After Ilizarow Treatment
Results of growth factors indicate that Bone Morphogenetic Proteins (BMP) have an exceptional ability to stimulate different characteristics of mesenchymale cells to osseous cells.
- Conditions
- Bone Degenerative Changes, Osteoarthritis, Degenerative Disorder of Bone
- Trial name
- NCT01690260
- Testing
- Bone Morphogenetic Protein 2, Autologous bone graft
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteoarthritis, Knee
Effects of Different Collagen Formulations on Knee Osteoarthritis
The purpose of this study is to evaluate and compare the effects of two different collagen supplement formulations on pain, physical function, and overall quality of life in adults with knee osteoarthritis.
- Trial name
- NCT07800780
- Testing
- 10g Hydrolyzed Collagen, 5g Bioactive Collagen Peptide
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Cihangir Türemiş
Osteoarthritis, Knee
Descriptive Study of Strength Training Exercises to Activate the Muscles of the Operated Leg After Total Knee Replacement
Background: In the early phase after a total knee replacement (TKA), patients experience multi-level weakness in the operated leg, which is caused primarily by reduced central (CNS) activation failure of the muscles - especially…
- Trial name
- NCT01708980
- Testing
- Six different strength training exercises
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Osteoarthritis, Knee, Total Knee Arthroplasty
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent…
- Conditions
- Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
- Trial name
- NCT06083480
- Testing
- GlyNAC (combination of glycine and n-acetylcysteine)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Vanderbilt University Medical Center
Osteoarthritis Patient
Study of Evaluating the Duration of Efficacy of One Intra Articular Injection of Sodium Hyaluronate 2.0% in Patients With Painful Osteoarthritis of the Knee
A pilot, open, randomised, controlled, add-on study evaluating the duration of efficacy of one intra articular injection of sodium hyaluronate 2.0% in patients with painful osteoarthritis of the knee
- Trial name
- NCT01288001
- Testing
- Ostenil plus
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- TRB Chemedica
Hip Osteoarthritis, Knee Osteoarthristis
The Outcome of Three Weeks Rehabilitation in Patients With a Total Hip or Knee Replacement Experiencing Persistent Physical Impairments
Patients with total hip or knee replacement experiencing persistant problems are offered 3 weeks of intensive rehabilitation.
- Trial name
- Rehab-hip-knee (NCT07105657)
- Testing
- Rehabilitation
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Horsens Hospital
Osteoarthritis, Knee, Knee Injuries
Motor-Sparing Femoral Nerve Block Dose
Femoral nerve blocks are commonly used to provide pain control for total knee replacement, anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT02909257
- Testing
- Same Bupivacaine Concentration, Lower Bupivacaine Concentration
- Where
- Chile
- Volunteers
- 31 people
- Sponsor
- University of Chile
Knee Osteoarthritis, Knee Pain Chronic
The Effect of PEMF for Patients With Knee OA
Health care costs are increasing alarmingly, which will impose an overwhelming economic burden to an aging society like that of Hong Kong.
- Trial name
- NCT05548712
- Testing
- Pulse Electromagnetic Field
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis
26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle
26 week open label study of treatment with Durolane for OA pain of the ankle
- Trial name
- NCT02627859
- Testing
- Durolane SJ
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Bioventus LLC
Osteoarthritis, Hip, Osteoarthritis, Knee
Evaluation of Teleconsulting on Rehabilitation After Hip and Knee Surgical Procedures
The objective of this study is to assess the medical and economic relevance of teleconsulting for Rehabilitation After Hip and Knee Surgical Procedures.
- Trial name
- SSRHAD (NCT02229279)
- Testing
- Teleconsulting
- Where
- France
- Volunteers
- 430 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis, Osteosarcoma
Clinical Orthopaedic Data Bank (Acute and Chronic)
Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF)…
- Conditions
- Osteoarthritis, Osteosarcoma, Scoliosis, Cerebral Palsy
- Trial name
- NCT00411060
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Florida
Painful Unilateral Femorotibial Knee Osteoarthritis of Any Etiology
Trial Comparing Botulin Toxin Versus Hyaluronic Acid by Intra-articular Injection for the Treatment of Painful Knee Osteoarthritis
In France, osteoarthritis affects about 10 million people and knee osteoarthritis represents 35% of cases. It is thought that more than 2.5 million people older than 65 years have knee osteoarthritis.
- Trial name
- GOTOX (NCT02832713)
- Testing
- Botulinum toxin A ( BoNT-A), Hyaluronic acid (HA)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Osteoarthritis
Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn®
LT-NS001 is a prodrug of Naproxen, which is inactive as a cox inhibitor while intact and is rapidly metabolized to Naproxen once absorbed.
- Trial name
- NCT01063920
- Testing
- LT-NS001, Naprosyn®
- Where
- 65 sites in United States
- Volunteers
- 534 people
- Sponsor
- Logical Therapeutics
Osteoarthritis, Knee
A Dose-Ranging Study Of Valdecoxib 5 Mg, 10 Mg, And 20 Mg Once Daily Versus Placebo In Patients With Osteoarthritis Of The Knee (Japan)
To determine the therapeutic dose range of valdecoxib by comparing the efficacy of three dosing regimens (5 mg, 10 mg and 20 mg once daily) with placebo for relief of the signs and symptoms of osteoarthritis of the knee.
- Trial name
- NCT00650624
- Testing
- valdecoxib
- Where
- 22 sites in Japan
- Volunteers
- 416 people
- Sponsor
- Pfizer
Osteoarthritis, Arthritis
Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up
In this study the investigators will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction…
- Conditions
- Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT02717559
- Volunteers
- 225 people
- Sponsor
- Vanderbilt University Medical Center
Osteoarthritis, Knee
FiH Safety and Feasibility Study Assessing Intra-articular Administration of aeGF in Patients With Knee Osteoarthritis
The company funding this study has developed an advanced therapy medicinal product (a cell therapy) from human donor cells which it wants to assess as a possible treatment for knee osteoarthritis (OA).
- Trial name
- NCT06690710
- Testing
- allogeneic engineered Gingival Fibroblasts (aeGF)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Scarcell Therapeutics S.A.S.
Trapeziometacarpal Osteoarthritis
Thumb Proprioception in Trapeziometacarpal Osteoarthritis
This study looks at people who have osteoarthritis at the base of the thumb. It examines how well the thumb can sense its position and movement. The study has three goals: 1.
- Trial name
- NCT07447323
- Testing
- Thumb Proprioception Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Nonalcoholic Steatohepatitis, Osteoarthritis
FTIH Study of ECC0509 in Healthy Volunteers
A Phase 1, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Single And Multiple Ascending Dose, First-Time-In-Human Study to Assess The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ECC0509 in…
- Trial name
- NCT05012423
- Testing
- ECC0509
- Where
- Australia
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Eccogene
Osteoarthritis, Total Knee Replacement
Adductor Canal Block
The investigators aim to investigate whether the addition of a surgeon-administered adductor canal blockade to a multimodal periarticular injection cocktail provides additional pain relief for patients undergoing total knee…
- Trial name
- NCT04513145
- Testing
- Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- OrthoCarolina Research Institute, Inc.
Osteoarthritis, Knee
MAKO Total Knee Artroplasty
The purpose of this study is to determine the early clinical and radiographic outcomes of robotically assisted total knee arthroplasty with the MAKO surgical robot using the Triathlon knee system.
- Trial name
- NCT05744895
- Testing
- Device: Robotic MAKO total knee, FocusMotion knee brace, Fitbit tracking device
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Washington University School of Medicine
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