Clinical trials: Degenerative Joint Disease
Knee Osteoarthritis
Chatbot-based Pain Management for People With Knee Osteoarthritis
Knee osteoarthritis (OA) is a prevalent degenerative joint disease that causes chronic pain, stiffness, impaired physical function, and associated psychosocial issues such as depression, insomnia, and loneliness.
- Trial name
- C-MPPM (NCT07843784)
- Testing
- The C-MPPM intervention, Online education
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- The Hong Kong Polytechnic University
Knee Osteoarthritis, Knee Arthropathy
Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty
Knee replacement surgery can be performed in one of two ways. Traditionally the goal was for the new joint to be in a neutral position with respect to the femur (thigh bone). This is called Mechanical Alignment (MA).
- Trial name
- NCT06617871
- Testing
- Mechanical Alignment (MA), Kinematic Alignment (KA) Interventions:
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Northwestern University
Osteoarthritis, Knee
An Efficacy and Safety 6-months Study of SYNOLIS VA 80/160 and SYNOLIS VA 40/80 in the Treatment of Symptomatic Knee Osteoarthritis
Multicentre, independent assessment study on SYNOLIS VA 80/160 and SYNOLIS VA 40/80 over a period of 24 weeks
- Trial name
- NCT05829798
- Testing
- SYNOLIS VA 80/160, SYNOLIS VA 40/80
- Where
- 3 sites in Poland
- Volunteers
- 82 people
- Sponsor
- Aptissen SA
Meniscus Injury, Meniscectomy
Biomechanical Osteoarthritis Outcomes in Meniscectomy Patients
The key aim of this study is to examine biomechanical measures associated with osteoarthritis (OA) progression in patients who have lateral and medial menisci injuries during various tasks.
- Conditions
- Meniscus Injury, Meniscectomy, Osteoarthritis, Knee
- Trial name
- BOOM (NCT03350204)
- Testing
- Meniscectomy, Helathy control comparison
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Salford
Osteoarthritis
A Study to Examine the Efficacy of the Arthritis Self Management Program
This study will examine the efficacy of the Arthritis Self Managemnet Program (ASMP)and determine changes in health resource utilization after completeing the ASMP program.
- Trial name
- NCT00297726
- Testing
- Self-Management Program
- Volunteers
- 64 people
- Sponsor
- Alberta Bone and Joint Health Institute
Knee Osteoarthritis
Veteran Affairs Osteoarthritis Knee Study
A clinical study at the Dallas Veterans Affairs, is being proposed to test the efficacy of a novel electrical stimulation platform named the Pro-Sport Ultra® device by AVAZZIA to reduce pain and increase activity level in…
- Trial name
- NCT04698733
- Testing
- BEST™ HVPC microcurrent electrical stimulation Pro-Sport Ultra® device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Avazzia, Inc
Osteoarthritis
Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty
The purpose of this study is to determine whether local infiltration analgesia is more effective than intrathecal morphine in reducing postoperative pain in total knee arthroplasty.
- Trial name
- NCT00992082
- Testing
- ropivacaine, ketorolac and epinephrine, morphine
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Örebro County
Osteoarthritis (OA) of the Knee, ACL Reconstruction
Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction
Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, often due to injuries like torn ligaments. Even after surgery, these injuries can lead to long-term joint problems.
- Trial name
- PROTO-WP4 (NCT06596824)
- Testing
- Training intervention
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Osteoarthritis
Effect of Diacerein on Hand Osteoarthritis
Ostearthritis is one of the most common arthritis, affecting more than 30% of aged people world-widely. The disease is characterized by pain and stiffness of the affected joints and is the most common cause of disability in aged…
- Trial name
- NCT00685542
- Testing
- diacerein
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Hospital
Knee Osteoarthristis, Self Efficacy
Turkish Version of the Arthritis Self-Efficacy Scale-8
Self-efficacy is a psychosocial construct that reflects an individual's confidence in their ability to perform specific tasks, focusing more on one's belief in their abilities than on actual performance.
- Trial name
- T-ASES-8 (NCT06929741)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bezmialem Vakif University
Osteoarthritis
Safety, Efficacy and Acceptability of Flavocoxid (Limbrel)A Pilot Study
safety, efficacy and acceptability of Flavocoxid
- Trial name
- NCT00303017
- Testing
- flavocoxid, Naproxen
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Primus Pharmaceuticals
Early Knee Osseous Arthrophlogosis
Effect of PRP Joint Cavity Combined with Acupoint Injection on Osteoarthritis of Knee Joint
This study collected general data from 90 patients with KOA in the outpatients and ward of Henan Provincial People's Hospital from January 2023 to December 2023 to compare the long-term effects of intra-articular PRP combined…
- Trial name
- NCT06688682
- Testing
- PRP joint injection combined with acupoint injection
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhengzhou Revo-Gene Technology Co., LTD
Osteoarthritis, Knee
Residual Pain After Successful Implant of Metaphyseal Sleeves in Total Knee Arthroplasty
: Total knee revision arthroplasty is increasing in daily practice and will become more relevant in the years to come. Bone loss is a significant challenge in total knee arthroplasty (TKA) especially in revision procedures.
- Trial name
- NCT04995679
- Testing
- Implant of metaphyseal sleeves in Total knee arthroplasty
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- University of Milan
Osteoarthritis, Care Model
The Effect of Continuous Care Counseling Based on the Roy Adaptation Model on Comfort and Quality of Life in Patients Undergoing Total Knee Arthroplasty
Osteoarthritis is a common joint disease that leads to problems such as pain, restricted mobility, and decreased quality of life in the knee joint, especially among elderly individuals.
- Conditions
- Osteoarthritis, Care Model, Quality of Life, Nursing Interventions
- Trial name
- RAM-TKA (NCT07015879)
- Testing
- Continuous Care Counseling Based on the Roy Adaptation Model
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cyprus International University
Rotator Cuff Syndrome of Shoulder and Allied Disorders, Osteoarthritis Shoulder
FX Shoulder Solutions Retrospective / Prospective Clinical Study
Subjects implanted with the shoulder replacement medical devices manufactured by FX Shoulder Solutions and distributed by FX Shoulder Solutions.
- Conditions
- Rotator Cuff Syndrome of Shoulder and Allied Disorders, Osteoarthritis Shoulder, Fracture, Shoulder
- Trial name
- NCT06077942
- Testing
- FX Artificial Shoulder Prosthesis
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- FX Shoulder Solutions
Knee Osteoarthritis, Degenerative Joint Disease of the Knee
Patient Outcomes Following Kinematic and Functional Alignment in Robotic-Assisted Total Knee Arthroplasty With Randomized Insert Types
This study aims to evaluate patient outcomes following robotic-assisted total knee arthroplasty using the VELYS system. Patients undergoing surgery will receive either kinematic alignment or functional alignment as determined by…
- Trial name
- VELYS RCT (NCT07533188)
- Testing
- Medial Stabilized Insert, Cruciate Retaining Insert
- Where
- Singapore
- Volunteers
- 240 people
- Sponsor
- Singapore General Hospital
Osteoarthritis, Knee
A Study to Evaluate Safety and Tolerability of MIV-711 in Osteoarthritis Patients
This is a multicentre, open-label, one-arm Phase II extension study to evaluate the safety and tolerability of MIV-711 in patients with knee joint osteoarthritis (OA).
- Trial name
- NCT03037489
- Testing
- MIV-711
- Where
- 4 sites in Bulgaria, Georgia and 2 more
- Volunteers
- 50 people
- Sponsor
- Medivir
Osteoarthritis, Knee
Triamcinolone Ketorolac (TriKe) Knee Trial
Cortisone injections are commonly used in the treatment of osteoarthrosis of the knee, but there are known detriments to cortisone including localized tissue atrophy near the injection site and acceleration of joint degeneration…
- Trial name
- TriKe (NCT05336968)
- Testing
- Triamcinolone acetonide-Ketorolac-Ropivacaine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- United Health Services Hospitals, Inc.
Arthrosis
Pilot Experimental Study: Efficacy of Paraffin Therapy and Occupational Therapy Associated with Robotics in Patients with Erosive Osteoarthritis
This is a randomized, evaluator-blinded, non-profit, single-center, exploratory, medical device clinical trial aimed at evaluating the efficacy in terms of reduction of functional limitation of the combination of occupational…
- Trial name
- AMADEO (NCT06633796)
- Testing
- AMADEO, Standard of care
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Osteoarthritis, Knee
An Exploratory Study of PRX167700 in Patients With Knee Osteoarthritis
This is an exploratory study to evaluate a new anti-inflammatory drug, PRX167700, in subjects with painful osteoarthritis of the knee.
- Trial name
- NCT01945346
- Testing
- PRX167700
- Where
- 5 sites in United Kingdom
- Volunteers
- 74 people
- Sponsor
- Proximagen Limited
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