Clinical trials: Degenerative Joint Disease
Knee Osteoarthritis, Older Women
Adding Group-Based Pain Neuroscience Education to a Community Exercise Program for Older Women With Knee Osteoarthritis
This pilot trial aimed to estimate preliminary clinical effects and to assess the feasibility of adding group-based pain neuroscience education (PNE) to exercise in women aged ≥60 years with medically diagnosed knee…
- Conditions
- Knee Osteoarthritis, Older Women, Pain, Disability
- Trial name
- NCT07565298
- Testing
- Pain neuroscience education (PNE), Exercise program
- Where
- Chile
- Volunteers
- 19 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Knee Osteoarthristis
Evaluating the Impact of a Meta Quest 3 Gamified VR Rehabilitation Program in Knee Osteoarthritis
The goal of this clinical trial is to learn if a gamified virtual reality (VR) rehabilitation program can effectively reduce pain, improve functionality, and enhance balance in adults aged 40-64 years diagnosed with knee…
- Trial name
- NCT06735963
- Testing
- Meta Quest 3 Virtual Reality, Exercise, Electrotherapy
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Umm Al-Qura University
Hallux Valgus, Hallux Rigidus
Effect of Topical CBD Cream for Degenerative Hallux Disorders
Hallux rigidus and hallux valgus are chronic forefoot conditions associated with pain, inflammation and functional impairment. Topical cannabidiol (CBD) cream has been shown to decrease inflammation, swelling, and pain response…
- Trial name
- NCT04103814
- Testing
- magnesium-cannabidiolic acid cream
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
Intrawound Administration of Vancomycin in TKA
The purpose of this study is to determine the intra-articular and serum levels of vancomycin over the first 24 hours postoperatively after intra-articular administration of a standard dose of vancomycin in primary total knee…
- Trial name
- NCT05338021
- Testing
- Intrawound administration of vancomycin after closure of the arthrotomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Knee Osteoarthristis, Radiofrequency Ablation
Comparative Effectiveness of Genicular Nerve Radiofrequency Thermocoagulation and Intra-Articular Pulsed Radiofrequency in the Management of Knee Osteoarthritis Pain
Osteoarthritis (OA) is a degenerative disease characterized by progressive cartilage deterioration, osteophyte formation, subchondral sclerosis, and a number of biochemical and morphological changes in weight-bearing joints that…
- Trial name
- GNRFT & IAPRF (NCT07098455)
- Testing
- GNRFT- genicular nerve radiofrequency ablation, IAPRF- Intraarticular pulsed radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Ankara City Hospital Bilkent
Hand Osteoarthritis, Osteoarthritis
Effect of Semiconductor Embedded Therapeutic Gloves for Hand Osteoarthritis
The goal of this study is to evaluate change in symptoms using semiconductor embedded gloves for hand osteoarthritis.
- Trial name
- NCT06744855
- Testing
- Non-invasive circulation gloves, Fabric gloves
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Altoona Center for Clinical Research
Knee Osteoarthristis
Effect of Knee and Heel Off-Loader Brace With Non Weight Bearing Strength in Knee Osteoarthritis
The current study is a single-blinded, parallel-group pilot randomized controlled trial involving 20 participants diagnosed with knee osteoarthritis (KOA).
- Trial name
- NCT07562685
- Testing
- Knee and Heel Off-Loader Brace with NWB Strength Training, Conventional Knee Off-Loader Brace with NWB Strength Training
- Volunteers
- 20 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Thumb Osteoarthritis
The Role of the Proprioceptive Training in Functional Recovery of Patient With Thumb Base Osteoarthritis
Diseases that have implications for the thumb impact its function, and consequently, people occupational performance. Carpometacarpal joint (CMC) thumb degeneration translates into osteoarthritis (OA).
- Trial name
- NCT04892589
- Testing
- Proprioceptive thumb exercises.
- Where
- 2 sites in Argentina, Spain
- Volunteers
- 50 people
- Sponsor
- Clinica Universitaria Reina Fabiola, Universidad Catolica de Cordoba
Hip Osteoarthritis
Relationship of Radiographic Findings With Pain, Function, Physical Performance and Balance
The objective of this investigation was to examine the correlation between radiographic findings and clinical outcomes, including pain, functional ability, physical performance, and balance parameters, in patients diagnosed with…
- Trial name
- NCT07186374
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Artvin Coruh University
Digital Arthrosis
Study of Association Between Digital Osteoarthritis and Lower Limb Osteoarthritis
Among the risk factors for lower limb osteoarthritis, if obesity is probably the most studied, digital osteoarthritis received increasing interest in recent years.
- Trial name
- Khoala (NCT01805349)
- Testing
- Hand X-rays
- Where
- France
- Volunteers
- 479 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteoarthritis
Roadmap for Succeeding in Bundled Payment for Orthopedic Joint Replacements
The objective of the study is to provide a road map that can help organizational leaders understand how to sequence their financial and human capital investments related to bundled payment arrangements.
- Trial name
- NCT02734043
- Sponsor
- University of Pennsylvania
Knee Osteoarthritis
Psychological and Pain Factors in Knee Osteoarthritis
This study aims to determine if baseline measures of psychology and pain sensitivity can predict changes in physical function at 1 year in patients with knee osteoarthritis.
- Trial name
- NCT05949489
- Testing
- WOMAC pain subscale
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ahram Canadian University
Osteoarthritis
Long-Term Comparison of Fixed- and Mobile-Bearing Total Knee Arthroplasties (TKAs) in Patients With OA ≤50 Years Old
The purpose of the prospective study was to evaluate the minimum fifteen year follow-up of prospective total knee arthroplasties performed in patients younger than fifty years of age with osteoarthritis, using fixed- and…
- Trial name
- NCT01361152
- Testing
- anatomic modular fixed-bearing, low contact stress rotating platform mobile-bearing
- Where
- South Korea
- Volunteers
- 216 people
- Sponsor
- Ewha Womans University
Anterior Cruciate Ligament Tear, Osteoarthritis, Knee
Long Term Clinical and Radiographical Outcomes of Different Anterior Cruciate Ligament Reconstruction Techniques
The purpose of this study is to evaluate the long-term results of various anterior cruciate ligament reconstruction techniques. This assessment is necessary for the current context of anterior cruciate ligament research as…
- Trial name
- NCT05088278
- Testing
- Anatomical single bundle ACL reconstruction with hamstrings, Anatomical single bundle ACL reconstruction with patellar tendon, ACL reconstruction with over the top plus lateral plasty technique
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis, Hip
Outcomes Following Anterior Approach to Total Hip Arthroplasty
Osteoarthritis disables approximately 10% of people who are 60 years or older and compromises the quality of life of more than 20 million Americans every year.
- Trial name
- AAP (NCT01353885)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Clinical Investigation to Compare the Safety and Efficacy of Cellular Matrix to Those of Ostenil® Plus and to Those of PRP Only
Platelet-rich plasma (PRP) is an autologous product prepared from the patient's own blood, representing a powerful source of platelet-derived growth factors, particularly useful in the field of regenerative medicine.
- Trial name
- NCT02964143
- Testing
- Cellular Matrix / A-CP HA, Ostenil® Plus, RegenKit-BCT-1
- Volunteers
- 306 people
- Sponsor
- Regen Lab SA
Knee Osteoarthritis
sAfety PerfoRmance chitOsan osteOarthritis ViscosupplEmentation
KIO014 is an innovative chitosan-based biomaterial intended for synovial fluid viscosupplementation indicated for the symptomatic treatment of knee osteoarthritis (OA).
- Trial name
- APROOVE (NCT03679208)
- Testing
- Investigational device coded KIO014, Durolane(r) as control device
- Volunteers
- 100 people
- Sponsor
- Kiomed Pharma
Hip Osteoarthritis
Effect of Local Infiltration Anesthesia in a Hip Arthroplasty Fast Track Program.
Fast-track programs in Orthopaedic Surgery require early motion that can only be achieved by optimal pain management protocols. Multimodal analgesia protocols including local infiltration anesthesia (LIA) have obtained excellent…
- Trial name
- NCT03513276
- Testing
- 100cc of 2% ropivacaine, Saline Solution, Adrenaline 10mcg/ml
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Hospital Mutua de Terrassa
Knee Osteoarthritis
Custom Guides for Total Knee Arthroplasty (TKA)
The goal of the study is to know if the reconstruction of the lower limb mechanical axis and the patient knee function is improved after Total Knee Arthroplasty (TKA) using patient specific instruments.
- Trial name
- NCT01573208
- Testing
- Custom guides
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Lausanne Hospitals
Osteoarthritis, Knee, Pain
Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain
Chronic painful knee OA is a major cause of disability in older adults. In patients whose symptoms are refractory to conservative management but who do not wish to undergo TKA or, alternatively, are not operative candidates…
- Conditions
- Osteoarthritis, Knee, Pain, Nerve; Lesion
- Trial name
- NCT02578108
- Testing
- genicular nerve diagnostic block with lidocaine (local anesthetic), genicular nerve radiofrequency ablation
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Northwestern University
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