Clinical trials: Degenerative Lumbar Disease
Degenerative Disc Disease, Degenerative Spondylolisthesis
Fibergraft Interbody Fusion Retrospective
A single center study of clinical and radiological outcomes in a retrospective cohort of patients treated with Lumbar Interbody Fusion augmented with Prosidyan Fibergraft for 1 or 2 level degenerative spinal disease by a single…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Degeneration, Spinal Stenosis
- Trial name
- FIFR (NCT03898232)
- Testing
- Computed Tomography (CT) Scan of the Lumbar Spine
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Bone and Joint Clinic of Baton Rouge
Degenerative Lumbar Disease
Comparing Lumbar Fusion With and Without Stress Endplate Augmentation in Patients With Low Bone Mass
Degenerative lumbar disease can cause back pain, leg pain, and difficulty with daily activities. Some patients require lumbar fusion surgery.
- Trial name
- NCT07891663
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Lumbar Spinal Stenosis
Effect of the Posterior Ligamentous Complex on the Adjacent Segments Degeneration After Lumbar Surgery
To investigate whether destroying the adjacent posterior ligamentous complex (PLC) has an effect on adjacent segment degeneration (ASD) after L5/S1 posterior lumbar interbody fusion (PLIF)
- Trial name
- NCT04946487
- Testing
- total laminectomy
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Lumbar Degenerative Disease
The Study of INTRA Spine Non Fusion Technique in the Treatment of Lumbar Degenerative Disease
Lumbar degenerative diseases such as lumbar disc herniation (LDH) and lumbar spinal stenosis (LSSS) are common and frequently encountered in orthopaedics.
- Trial name
- NCT06075966
- Testing
- Non-fusion group, Fusion group
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Qianfoshan Hospital
Degenerative Disc Disease (DDD)
HYDRAFIL-D: HYDRogel Augmentation For Intervertebral Lumbar Discs
A multi-center, prospective, dual arm, randomized, controlled pivotal study to evaluate the safety and effectiveness of the ReGelTec HYDRAFIL™ System.
- Trial name
- HYDRAFIL-D (NCT06011551)
- Testing
- The ReGelTec HYDRAFIL™ System, Conservative Care Management
- Where
- 16 sites in United States, Canada
- Volunteers
- 225 people
- Sponsor
- ReGelTec, Inc.
Lumbar Disc Herniation, Lumbar Spinal Stenosis
Effect of Irrigation Pressure on Postoperative Complications and Surgical Field Clarity in Unilateral Biportal Endoscopic Surgery
This study is being done to find out if the height of the fluid bag and the direction of the surgical cut affect the pressure of the fluid used during unilateral biportal endoscopic (UBE) spine surgery.
- Conditions
- Lumbar Disc Herniation, Lumbar Spinal Stenosis, Lumbar Degenerative Disease
- Trial name
- NCT07837427
- Testing
- Unilateral Biportal Endoscopic Surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fan Zhang
Degenerative Disc Disease
INDEPENDENCE Spacer for Lumbar Fusion
The primary objective of this study is to evaluate radiographic outcomes, intra-operative parameters, clinical outcomes, and patient satisfaction following circumferential fusion using the INDEPENDENCE® integrated plate and…
- Trial name
- NCT02299323
- Testing
- INDEPENDENCE
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Globus Medical Inc
Spondylolisthesis, Spinal Stenosis
Prospective Follow-up of Elderly Patients Undergoing Instrumented Lumbar Arthrodesis Supplemented by the Implanet Jazz System(TM)
Establish a data repository of patients who have undergone single, two-, or three-level lumbar instrumented arthrodesis procedures supplemented by the Implanet Jazz System.
- Conditions
- Spondylolisthesis, Spinal Stenosis, Degenerative Disease
- Trial name
- NCT03434223
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Ohio State University
Degenerative Disc Disease
A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease
The objectives of the study are to evaluate the safety and preliminary efficacy of a single administration of AGA111 for lumbar interbody fusion in patients with degenerative disc disease.
- Trial name
- NCT05574543
- Testing
- AGA111
- Where
- 6 sites in China
- Volunteers
- 60 people
- Sponsor
- Angitia Biopharmaceuticals
Lumbar Spinal Stenosis
Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant
Neurogenic intermittent claudication is a specific symptom complex occurring in patients with lumbar spinal stenosis. Characteristic of this disease is the occurrence of increasing leg, buttock or groin pain with or without lower…
- Trial name
- NCT01057641
- Testing
- Spacer, physiotherapy
- Where
- 2 sites in Germany
- Volunteers
- 22 people
- Sponsor
- University of Cologne
Degenerative Disc Disease, Back Pain, Low
The SPINUS I Study: Spinal Fusion for a Single Level SPECT/CT Positive Lumbar Degenerative Disc Disease
The aim of the present study is to find out whether fusion of a sinlge level SPECT/CT positive degenerative disc disease leads to a significant improvement of pain and disability.
- Trial name
- NCT04876586
- Testing
- Lumbar fusion
- Where
- 2 sites in Czechia
- Volunteers
- 38 people
- Sponsor
- Military University Hospital, Prague
Chronic Back Pain, Degenerative Disc Disease Lumbar
CELZ-201-DDT for the Treatment of Chronic Lower Back Pain
CELZ-201-DDT is an investigational (experimental) cell therapy currently being studied for people with degenerative disc disease who have chronic lower back pain.
- Trial name
- ADAPT (NCT07137559)
- Testing
- CELZ-201-DDT
- Sponsor
- Creative Medical Technology Holdings Inc
Lumbar Disc Degeneration, Low Back Pain
Interleukin-1β (rs 1143627 T/C) Gene Polymorphism May Increase the Risk of Developing LDD in Turkish Population
This study aims to show the association between the Interleukin-1β (rs 1143627 T/C) gene polymorphism and the patient's pain level, radiological features, functional disability, and spinal flexibility.
- Conditions
- Lumbar Disc Degeneration, Low Back Pain, Inflammation
- Trial name
- NCT05601739
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Degenerative Disc Disease
Evaluate Effectiveness of the Biomet Lumbar Spinal Fusion System
The purpose of this study is to evaluate the effectiveness of the Biomet Lumbar Spinal Fusion System in patients undergoing lumbar fusion surgery.
- Trial name
- NCT00758719
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- Zimmer Biomet
Stenosis, Spondylosis
Efficacy and Safety of Accell Evo3 Demineralized Bone Matrix (DBM) in Instrumented Posterolateral Lumbar Spine Fusion
The objective of this study is to prospectively evaluate the performance of Integra Accell Evo3 Demineralized Bone Matrix as an adjunct for posterolateral spine fusion with a retrospective comparison to a historical patient…
- Conditions
- Stenosis, Spondylosis, Degenerative Changes
- Trial name
- NCT01430299
- Testing
- Demineralized Bone Matrix, rh-BMP2
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- SeaSpine, Inc.
Spinal Diseases
A-MAV™ Anterior Motion Segment Replacement
The purpose of this clinical trial is to collect safety and effectiveness data concerning the A-MAV™ Anterior Motion Segment Replacement device as a method of treating patients with lumbar degenerative disc disease at one level…
- Trial name
- NCT00635934
- Testing
- A-MAV™ disc
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Medtronic Spinal and Biologics
Spondylolisthesis
Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis
A prospective multi-centre, randomised, controlled study to evaluate the safety and preliminary effectiveness of NVD-001 for the treatment of low grade degenerative lumbar spondylolisthesis by interbody fusion (L1 - S1).
- Trial name
- Spine1 (NCT03100032)
- Testing
- NVD-001, Standard of Care
- Where
- 12 sites in Belgium, Czechia and 1 more
- Volunteers
- 48 people
- Sponsor
- Novadip Biosciences
Degenerative Disc Disease
Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion
Among existing surgical techniques, spinal fusion is considered as the gold standard to treat a broad spectrum of degenerative spine disorders, including spondylolisthesis and scoliosis, with regard to pain reduction and…
- Trial name
- NCT02205138
- Testing
- ALLOB® cells with ceramic scaffold
- Where
- 8 sites in Belgium
- Volunteers
- 38 people
- Sponsor
- Bone Therapeutics S.A
Lumbar Spine Degeneration
Development of a Patient-reported Outcome Instrument for Patients With Lumbar Degenerative Disease After Lumbar Fusion
The commonly used scales (ODI+JOA-29+VAS) lack the assessment of lumbar stiffness, and there is no scale for evaluating lumbar stiffness in China.Based on the Delphi method and the analytic hierarchy process, this study will…
- Trial name
- DPROIPLDDALF (NCT04781517)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Lumbar Degenerative Disease, Lumbar Spondylolisthesis
Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar Surgery
Patients undergoing open posterior lumbar fusion surgery often experience postoperative gastrointestinal problems, such as bloating, constipation, and delayed passage of gas and stool, and may be at nutritional risk.
- Conditions
- Lumbar Degenerative Disease, Lumbar Spondylolisthesis, Lumbar Disc Herniation
- Trial name
- NCT07893938
- Testing
- Oral nutritional supplements (ONS), Carbohydrate loading (OCL), 'Probiotics (Bifidobacterium and Lactobacillus triple live capsules)'
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University