Clinical trials: Degenerative Lumbar Spondylolisthesis
Lumbar Degenerative Disc Disease, Spinal Stenosis
Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease
The purpose of this study is to compare the effect and safety of NuCel to DBX on patients undergoing posteriolateral lumbar spinal fusions for degenerative disc disease.
- Conditions
- Lumbar Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis, Spondylosis
- Trial name
- NCT02070484
- Testing
- NuCel, Demineralized Bone Matrix
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- OhioHealth
Intervertebral Disc Disease, Intervertebral Disc Degeneration
Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine
The purpose of this study is to determine whether NuCel is effective in promoting spinal fusion in degenerative disease of the lumbar spine.
- Conditions
- Intervertebral Disc Disease, Intervertebral Disc Degeneration, Spondylosis, Spondylolisthesis
- Trial name
- NCT02023372
- Testing
- NuCel with Autograft
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- NuTech Medical, Inc
Degenerative Lumbar Spinal Stenosis, Degenerative Spondylolisthesis
Clinical Evaluation of Orion Lamina Cover in Patients Undergoing Lumbar Laminectomy With Instrumented Fusion
Laminectomy with internal fixation and osseofusion is a common surgery for treating degenerative spinal diseases. It removes excessive bone spurs and removes the lamina for decompression to relieve nerve compression, and then…
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Spondylolisthesis, Spinal Stenosis, Scoliosis
- Trial name
- NCT06532968
- Testing
- ORION spinal lamina cover
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Orion Biotech Inc.
Spine Degeneration, Spine Disorder
Rate of Bone Union After Surgery With Stand-alone Fibergraft
Some people have back problems caused by degenerative conditions or instability of the spine (eg. Spondylolisthesis). These problems can lead to pain, nerve issues, or difficulties in walking.
- Conditions
- Spine Degeneration, Spine Disorder, Spine Pain, Spine Fusion
- Trial name
- Fibergraft (NCT07199075)
- Testing
- Questionnaires, Computer Tomography
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- AO Innovation Translation Center
Distal Radius Fractures, Degenerative Lumbar Spondylolisthesis
Long-term Safety Trial with NVDX3
An study evaluating the long-term safety of all patients previously treated with NVDX3.
- Trial name
- X3LTFU (NCT06532253)
- Testing
- NVDX3
- Where
- Luxembourg
- Volunteers
- 15 people
- Sponsor
- Novadip Biosciences
Degenerative Lumbar Spinal Stenosis, Facet Joint Arthrosis
Mid- or High-flex Rods Versus Low-flex Rods of SpineShape System IV for Treatment of Degenerative Lumbar Spine Diseases
The purpose of this multi-center, randomized, clinical study is to show that the treatment of degenerative lumbar spine with high- or mid-flex rods is not inferior to the treatment with low-flex rods in terms of clinical and…
- Conditions
- Degenerative Lumbar Spinal Stenosis, Facet Joint Arthrosis, Spondylarthritis, Discopathy
- Trial name
- NCT06320899
- Testing
- SpineShape System IV straight rod elastic, SpineShape System IV straight rod medium, SpineShape System IV straight rod stiff
- Where
- 2 sites in Switzerland
- Volunteers
- 126 people
- Sponsor
- SpineSave AG
Lumbar Spondylolisthesis, Degenerative Lumbar Scoliosis
A Study on the Clinical Use of a New Expandable OLIF Cage With Posterior Bone Grafting in Lumbar Spine Surgery
This clinical trial aims to evaluate the safety and effectiveness of a novel expandable OLIF (Oblique Lateral Interbody Fusion) cage with posterior bone grafting in patients with lumbar degenerative diseases.
- Conditions
- Lumbar Spondylolisthesis, Degenerative Lumbar Scoliosis, Lumbar Disc Herniation, Lumbar Spinal Stenosis
- Trial name
- NCT07028099
- Testing
- Expandable OLIF cage with posterior bone grafting, Conventional OLIF cage
- Volunteers
- 340 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Lumbar Spinal Stenosis, Spondylolisthesis
Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis
Lumbar spinal stenosis (LSS), is a common disorder of narrowing of the spinal canal in the lower part of the back. This causes discomfort in the legs when standing or walking because of pressure on the spinal nerves.There are…
- Conditions
- Lumbar Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease
- Trial name
- NCT01455805
- Testing
- Minuteman Fusion Implant, surgical decompression
- Where
- 4 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- Spinal Simplicity LLC
Spondylolisthesis, Scoliosis
A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP®
OsteoAMP is a novel allograft bone graft substitute (BGS) that has been processed to retain multiple endogenous growth factors for use in spinal fusion.
- Conditions
- Spondylolisthesis, Scoliosis, Intervertebral Disc Disease
- Trial name
- NCT02225444
- Testing
- OsteoAMP
- Where
- 9 sites in United States
- Volunteers
- 42 people
- Sponsor
- Bioventus LLC
Spondylolisthesis
Posterior Lateral Fusion (PLF) With Dynesys
The primary purpose of this study is to track and document the clinical outcomes of patients with radicular pathology following posterior lateral fusion with the Dynesys Spinal System.
- Trial name
- NCT00791180
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Zimmer Biomet
Disk Herniated Lumbar, Disc Disease Degenerative
Clinical Outcome and Fusion Rate of 3D Printed Interbody Fusion Cages and Titanium Coated PEEK Cages
Prospective, Randomized, Single-Blind Study for the Evaluation of the Clinical Outcome and the Fusion Rate of 3D Printed Interbody Fusion Cages and Titanium Coated PEEK Cages in Transforaminal Lumbar Interbody Fusion
- Conditions
- Disk Herniated Lumbar, Disc Disease Degenerative, Spondylolisthesis
- Trial name
- PRINTLIF (NCT05237908)
- Testing
- Transforaminal Lumbar Interbody Fusion
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Aesculap AG
Degenerative Disc Disease, Degenerative Spondylolisthesis
Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion
The aim of this study is to evaluate the effectiveness and safety of Natural Matrix Protein™ (NMP™) fibers when used in cervical or lumbar interbody fusion in patients with degenerative disc disease (DDD), spinal stenosis…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT06000319
- Testing
- Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Induce Biologics USA Inc.
Spinal Stenosis Lumbar, Spondylolisthesis
Randomized Control Trial of Quadratus Lumborum Block for Lumbar Spine Decompression and Fusion Surgery
Lumbar spinal decompression and fusion is a commonly performed procedure fro neural impingement and back pain from a variety of pathologies.
- Conditions
- Spinal Stenosis Lumbar, Spondylolisthesis, Fusion of Spine, Lumbar Region, Degeneration Spine
- Trial name
- NCT04447950
- Testing
- Type 2/posterior Quadratus Lumborum block
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assuta Medical Center
Degenerative Spondylolisthesis, Lumbar Spondylosis
Re-operation Rates of Concorde Bullet Device Versus Conduit Titanium Interbody Graft for Lumbar Fusion
The purpose of this early study is to compare the clinical results of the new Conduit Interbody device to the traditional Concorde Bullet Device.
- Conditions
- Degenerative Spondylolisthesis, Lumbar Spondylosis, Lumbar Spondylolisthesis
- Trial name
- NCT05993195
- Testing
- Conduit Titanium Interbody Graft, Concorde Bullet Device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Lahey Clinic
Spinal Stenosis, Spondylolisthesis
RAMP Study: A Study Comparing Two Lumbar Fusion Procedures
This is a post-marketing, on-label Efficacy, Effectiveness and Safety Study designed in a Multicenter, Randomized, Prospective format.
- Conditions
- Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease
- Trial name
- RAMP (NCT01716182)
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- Baxano Surgical, Inc.
Lumbar Spondylolisthesis, Grade 1 Spondylolisthesis
SLIP II Registry: Spinal Laminectomy Versus Instrumented Pedicle Screw Fusion
The purpose of the project is to perform an RCT comparing patient satisfaction and outcome with or without the use of an expert panel.
- Conditions
- Lumbar Spondylolisthesis, Grade 1 Spondylolisthesis, Lumbar Spinal Stenosis, Degenerative Spondylolisthesis
- Trial name
- SLIPII (NCT03570801)
- Testing
- Expert Panel Review
- Where
- 17 sites in United States, Canada
- Volunteers
- 662 people
- Sponsor
- Lahey Clinic
Degenerative Lumbar Spinal Stenosis, Degenerative Spondylolisthesis
Instability in the Lumbar Spine of Patients With Age Related Changes and Narrowing of the Spinal Canal (Spinal Stenosis)
Age related changes in the lumbar spine can lead to narrowing of the spinal canal (spinal stenosis) causing leg and back pain. Spinal stenosis can be associated with a misalignment of the spine caused by forward slippage of a…
- Trial name
- NCT04406987
- Testing
- decompression, fusion
- Where
- Denmark
- Volunteers
- 235 people
- Sponsor
- Spine Centre of Southern Denmark
Degenerative Lumbar Spondylolisthesis
Degenerative Spondylolisthesis; Micro-decompression vs Decompression + Instrumented Fusion; Long Term Follow up
In many countries a majority of patients with degenerative spondylolisthesis are operated on with decompression plus instrumented fusion, but the scientific evidence for adding fusion is controversial.
- Trial name
- DS-registry (NCT03469791)
- Testing
- Surgical treatment of Degenerative Spondylolisthesis
- Where
- Norway
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
Degenerative Spondylolisthesis Accompanying LSS: Do We Need Fusion?
This study aimed to compare clinical results of decompression alone using minimal invasive unilateral laminotomy for bilateral decompression versus classical decompression and instrumentation and fusion.
- Conditions
- Degenerative Spondylolisthesis, Lumbar Spinal Stenosis, Fusion
- Trial name
- NCT07410871
- Testing
- Unilateral laminotomy decompression, Decompression and fusion
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Kafrelsheikh University
Disc Degeneration of Pfirrmann Grade III or Greater, Degenerative Spondylolisthesis
Valeo OL Interbody Fusion Devices for Posterior Lumbar Interbody Fusion SNAP Trial
This study randomizes degenerative spondylolisthesis and/or degenerative disc patients into two groups: one to receive a new ceramic implant and a control group with a more traditional PEEK plastic implant.
- Conditions
- Disc Degeneration of Pfirrmann Grade III or Greater, Degenerative Spondylolisthesis, Isthmic Spondylolisthesis of Grade I or II
- Trial name
- SNAP (NCT01557829)
- Testing
- Posterior lumbar interbody fusion with a PEEK cage, Posterior lumbar interbody fusion with a Valeo OL cage
- Where
- 2 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Amedica Corporation