Clinical trials: Degenerative Neurologic Disease
Amyotrophic Lateral Sclerosis (ALS)
PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS
The purpose of this study is to test the effects of PHENOGENE-1A, which is the treatment under investigation in this study. This research will investigate if PHENOGENE-1A can help people with ALS by measuring their function using…
- Trial name
- NCT07142291
- Testing
- Cromolyn Sodium (34.2 mg BID), Cromolyn Sodium (17.1 mg BID), Riluzole (100 mg)
- Where
- 22 sites in United States, Czechia and 4 more
- Volunteers
- 105 people
- Sponsor
- PhenoNet, Inc.
Optic, Atrophy, Hereditary, Leber
Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE)
The goal of this clinical trial is to assess the effectiveness of GS010, a gene therapy, in improving the visual outcome in participants with Leber Hereditary Optic Neuropathy (LHON) due to the G11778A ND4 mitochondrial mutation…
- Trial name
- REVERSE (NCT02652780)
- Testing
- GS010
- Where
- 7 sites in United States, France and 3 more
- Volunteers
- 37 people
- Sponsor
- GenSight Biologics
Amyotrophic Lateral Sclerosis
Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis
The objective of this study is to compare two combinations of drugs, minocycline and creatine or celecoxib and creatine, in a phase II trial designed to determine which combination is more effective for ALS.
- Trial name
- NCT00355576
- Testing
- Celecoxib, Creatine, Minocycline
- Where
- 19 sites in United States
- Volunteers
- 86 people
- Sponsor
- Columbia University
Magnetic Resonance Imaging, Alzheimer's Disease
fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease
The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory…
- Conditions
- Magnetic Resonance Imaging, Alzheimer's Disease, Dementia, Adult Children
- Trial name
- ALZ (NCT00478491)
- Where
- United States
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Parkinson Disease
fNIRS Studies of Music Intervention of Parkinson's Disease
Functional near-infrared spectroscopy (fNIRS) will be used to monitor neuronal activities and connectivity to elucidate the correlation between physiological changes within the brain and the benefits of music therapy for patients…
- Trial name
- NCT04212897
- Testing
- Music Therapy
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Huntington Disease
Extracellular Vesicles for HD
The primary objective of this study is to discover blood-based biomarker of brain Huntingtin (HTT) protein using extracellular vesicles to be used in evaluating target engagement in HTT lowering clinical trials.
- Trial name
- NCT06082713
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Myotonic Dystrophy 1
Effects of a 12-week Strength Training Program in Men With Myotonic Dystrophy Type 1
Eleven men with myotonic dystrophy type 1 (DM1) underwent a 12-week lower-limb strength training program. The training program consisted of 3 series of 6 to 8 maximal repetitions of 5 different exercises: Leg extension, leg…
- Trial name
- NCT04018820
- Testing
- Training program
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Élise Duchesne
Parkinson's Disease
Imaging Non-motor Symptoms of Parkinson's Disease by Novel 18F-DTBZ and Florbetapir F-18 PET
The primary objective of this protocol is to investigate the monoaminergic (dopamine、serotonin、and norepinephrine ) nervous system and amyloid deposition in Parkinson's disease patients with non-motor symptoms (focus on impulse…
- Trial name
- NCT02039024
- Testing
- 18F- DTBZ
- Where
- Taiwan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Parkinson Disease
Studying Automatic Movements in Patients With Parkinson's Disease
Parkinson's disease patients usually have difficulty making automatic movements. Automatic movements are movements people often make without conscious thought.
- Trial name
- NCT00063661
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Progressive Supranuclear Palsy
A Study to Test the Safety and Tolerability of UCB0107 in Study Participants With Progressive Supranuclear Palsy (PSP)
The purpose of the study is to assess the safety and tolerability of UCB0107 in study participants with Progressive Supranuclear Palsy (PSP).
- Trial name
- NCT04185415
- Testing
- bepranemab
- Where
- 13 sites in Belgium, Germany and 2 more
- Volunteers
- 25 people
- Sponsor
- UCB Biopharma SRL
Parkinson Disease, Freezing of Gait
Understand FoG in PD: Behavioral Physiology and Clinical Application
The overall goals of this proposed study are to investigate the behavioral and neurophysiological mechanisms of patients with Parkinson's disease (PD) experiencing freezing of gait (FoG).
- Trial name
- NCT02987140
- Testing
- Clinical evaluations
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Insomnia, Alzheimer Disease
Transdermal Trigeminal Electrical Neuromodulation on Mild Cognitive Impairment With Insomnia
This study aims to validate the safety and impact of transdermal trigeminal electrical neuromodulation(Cefaly) on mild cognitive impairment patients with insomnia on brain functional and structural connectivity as well as sleep…
- Conditions
- Insomnia, Alzheimer Disease, Mild Cognitive Impairment, Amyloid
- Trial name
- NCT05200897
- Testing
- Transdermal trigeminal electrical neuromodulation(Cefaly)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Saint Vincent's Hospital, Korea
Detection Autoantibody of Myasthenia Gravis
The Specificity, Sensitivity and Clinical Correlation of CBA, RIPA and ELISA in Detecting AChR and MuSK IgG of Myasthenia Gravis
Myasthenia gravis (MG) is a neuromuscular junction (NMJ) disorder mediated by autoantibodies against AChR, MuSK or other autoantigens located at the post synaptic membrane of the neuromuscular junction.
- Trial name
- NCT05219097
- Testing
- CBA Assay
- Where
- 2 sites in China
- Volunteers
- 2,663 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Myotonic Dystrophy 1, Muscular Dystrophies
Myotonic Dystrophy Type 1 Aerobic Exercise Study
Myotonic dystrophy type 1 (DM1) is a genetic disease that primarily targets skeletal muscle resulting in severe weakness and muscle loss.
- Trial name
- DM1ex (NCT04187482)
- Testing
- Exercise training
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- McMaster University
Multiple System Atrophy
Long-term Follow-up of Phase 1 Clinical Trial of CS10BR05(CS10BR05-MSA101)
The study purpose is conducting follow-up surveillance for the incidence of adverse events and efficacy of subjects participated in phase 1 trial to evaluate the safety and tolerability of autologous bone marrow-derived…
- Trial name
- NCT04495582
- Where
- South Korea
- Volunteers
- 8 people
- Sponsor
- Corestemchemon, Inc.
Parkinson Disease(PD)
Adaptive DBS for PD
The goal of this clinical trial is to evaluate the efficacy and safety of an adaptive deep brain stimulation (aDBS) system for managing Parkinson's disease symptoms.
- Trial name
- SMART-DBS (NCT07635823)
- Testing
- adaptive deep brain stimulation, conventional deep brain stimulation
- Where
- 9 sites in China
- Volunteers
- 60 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Post-Operative Confusion, Neuroinflammatory Response
Neuroinflammation and Alzheimer's Pathology in POCD
The purpose of this project is to investigate the role of both neural inflammation and pre-existing neurodegenerative pathology in the risk and pathogenesis of post-operative cognitive dysfunction (POCD).
- Conditions
- Post-Operative Confusion, Neuroinflammatory Response, Alzheimer Disease
- Trial name
- POCD (NCT05378659)
- Testing
- Montreal Cognitive Assessment, Stroop Test, 4AT Delirium
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Parkinson Disease
Age Dependents Benefits of Virtual Reality Rehabilitation
ntroduction: Parkinson\'s disease (PD) is characterized as a neurodegenerative disorder associated with progressive loss of dopamine in the basal ganglia region, resulting in classic motor symptoms such as bradykinesia…
- Trial name
- NCT05922046
- Testing
- Leap Motion Controller on flat display
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Parkinson Disease (PD)
Effects of Dual-Task Training on Upper Extremity Function in Parkinson's Disease
The goal of this clinical trial is to investigate the effects of dual-task training on upper extremity function and muscle thickness in individuals with Parkinson's disease.
- Trial name
- NCT07536542
- Testing
- Dual-Task Training
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Ankara University
Advanced Cancer
A Study of WXFL10030390 in Patients With Advanced Solid Tumors or Lymphoma
WXFL10030390 (WX390) is a novel oral small molecular that inhibits phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) and has demonstrated potent inhibitory effects on multiple human tumor xenografts.
- Trial name
- NCT03730142
- Testing
- WXFL10030390
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Shanghai Jiatan Pharmatech Co., Ltd
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