Clinical trials: Degenerative Neurologic Disease
Amyotrophic Lateral Sclerosis (ALS), Neuromuscular Diseases
Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
This project seeks to investigate the effects of a single acute intermittent hypoxia (AIH) session on respiratory and non-respiratory motor function and EMG (electromyography) activity on patients with ALS (amyotrophic lateral…
- Trial name
- AIH-ALS (NCT03645031)
- Testing
- Acute Intermittent Hypoxia
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Florida
Myasthenia Gravis, Generalized
Study of Aritinercept in Patients With Generalized Myasthenia Gravis
This clinical study will enroll patients with generalized myasthenia gravis (gMG). The goal of this clinical study is to assess the safety, tolerability, effectiveness, pharmacokinetics (how the body processes the drug) and…
- Trial name
- NCT07596901
- Testing
- Aritinercept
- Where
- 11 sites in United States
- Volunteers
- 81 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Parkinson's Disease
Effect of an Apomorphine Pump on the Quality of Sleep in Parkinson's Disease Patients (POMPRENELLE).
Parkinson's disease is not only a pathology of movements. There are many non-motor symptoms that complicate and impair patients' quality of life. Among those disorders are sleep disorders. Insomnia is the most frequent symptom.
- Trial name
- POMPRENELLE (NCT02688465)
- Testing
- Apomorphine
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Parkinson Disease
Managing Fatigue in People With Parkinson's Disease
This pilot study aims to evaluate the feasibility of Managing Fatigue: The Individual Program (MFIP) in people living with Parkinson's disease.
- Trial name
- MFIP (NCT04267107)
- Testing
- Individual Managing Fatigue Program
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Dalhousie University
Incomplete Spinal Cord Injury, Spasticity, Muscle
Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity
For many people with spinal cord injury (SCI), the goal of walking is a high priority. There are many approaches available to restore walking function after SCI; however, these approaches often involve extensive rehabilitation…
- Trial name
- NCT05429736
- Testing
- Motor Skill Training (MST), Transcutaneous Spinal Stimulation (TSS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Shepherd Center, Atlanta GA
Tourette Syndrome, Tic Disorders
Study of Tics in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder
This study will investigate which areas of the brain are primarily involved in and responsible for tics in patients with Tourette's syndrome and chronic motor disorder.
- Trial name
- NCT00033995
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Huntington Disease
Move to Improve: Telehealth Exercise to Music for HD
The purpose of this study is to determine if a movement to music exercise program delivered via telehealth is feasible and safe for individuals with neurodegenerative disease and their caregivers (Aim 1).
- Trial name
- MtI (NCT05270681)
- Testing
- Movement to Music
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Parkinson Disease, Mild Cognitive Impairment
Adaptango Performance PRocess for Older Adults Community reHabilitation
This study is being done to answer the question: How do people with Parkinson's disease, people with Mild Cognitive Impairment, and younger people process difficult topics in conversation? It will also explore themes related to…
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Old Age; Dementia
- Trial name
- APPROACH (NCT07824128)
- Testing
- Adaptango Performance Process (APP) program
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Parkinson's Disease, Essential Tremor
Evaluation of Directional Recording and Stimulation Using spiderSTN
The purpose of this study is to provide proof-of-concept that directional stimulation and directional recording, in an intraoperative setting, is perceivable in a subject.
- Trial name
- NCT02894567
- Testing
- Intraoperative test during a deep brain stimulation surgery
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- Aleva Neurotherapeutics SA
Parkinson's Disease
Efficacy of Ethnodyne Visio in Parkinson's Disease
ETHNODYNE VISIO is a food supplement composed of an innovative plant-based active ingredient acting alongside vitamin B2. It is proposed in patients with visual problems.
- Trial name
- ETHNOPARK (NCT02815800)
- Testing
- ETHNODYNE VISIO
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Strasbourg, France
Deep Brain Stimulation, PARKINSON DISEASE (Disorder)
Cortical Network Modulation by Subthalamic Nucleus DBS
Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) can provide substantial motor benefit yet can also produce unwanted mood and cognitive side effects.
- Trial name
- NCT04922411
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Bladder Outlet Obstruction, Multiple Sclerosis
GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology
Male self catherterisng observational study.
- Conditions
- Bladder Outlet Obstruction, Multiple Sclerosis, Cauda Equina Syndrome, Enlarged Prostate With Lower Urinary Tract Symptoms
- Trial name
- NCT05470751
- Testing
- Intermittent self-catheterisation
- Where
- 16 sites in United States, France and 1 more
- Volunteers
- 72 people
- Sponsor
- ConvaTec Inc.
Metastatic Cancer
A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change
This study will test whether reduced-dose radiotherapy is an effective treatment for metastatic tumors with an ATM mutation. The researchers want to find the lowest dose of radiation that would still be effective to treat these…
- Trial name
- NCT05010031
- Testing
- Palliative radiotherapy
- Where
- 7 sites in United States
- Volunteers
- 45 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Infantile Spinal Muscular Atrophy
Test of Aquatic Mobility of SMA Infants
Spinal muscular atrophy (SMA) is a genetic neurodegenerative disease impacting spinal cord motor neurons, leading to motor and respiratory issues and, ultimately, death.
- Trial name
- BAINSMA (NCT06152302)
- Testing
- Mobility study in dry conditions, Mobility study in water conditions
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mindfulness Based Stress Reduction, Caregiver Burnout
Mindfulness-Based Stress Reduction in Dementia Caregivers
Aims: The study will contribute to our understanding of how the cultivation of caregiver mindfulness might improve their overall relational well-being (Primary Outcome), their psychological well-being (Secondary Outcome), and…
- Conditions
- Mindfulness Based Stress Reduction, Caregiver Burnout, Caregiver Stress Syndrome, Dementia
- Trial name
- MBSR (NCT04977245)
- Testing
- Mindfulness-Based Stress Reduction, Self-Guided Mindfulness eCourse
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alzheimer's Disease
A Study of SHR-1707 With Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease
This study aims to evaluate the safety, tolerability and pharmacodynamics of intravenous administration of SHR-1707 In patients with mild cognitive impairment due to Alzheimer's Disease or mild Alzheimer's Disease.
- Trial name
- NCT05681819
- Testing
- SHR-1707
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Shanghai Hengrui Pharmaceutical Co., Ltd.
Alzheimer Disease
Lecanemab for Early Onset Familial Alzheimer's Disease
The goal of this observational study is to learn about the efficacy of Lecanemab treatment for early-onset familial Alzheimer's disease (AD) in patients under 65 years of age with a family history of AD.
- Trial name
- NCT06883019
- Where
- 15 sites in China
- Volunteers
- 114 people
- Sponsor
- RenJi Hospital
Parkinson's, Parkinson Disease
Longitudinal Investigation of I2BS in PD
In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI).
- Conditions
- Parkinson's, Parkinson Disease, Parkinson's Disease, Neurodegenerative Diseases
- Trial name
- FOX_2 (NCT05516719)
- Testing
- Positron Emission Tomography (PET) scan using BU99008 tracer, FP-CIT Single-photon Emission Computed Tomography (SPECT) scan, Magnetic Resonance Imaging (MRI) Scan
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Androgenetic Alopecia, Hair Loss
Efficacy of Platelet-Rich Plasma Versus Mesotherapy in Androgenetic Alopecia: A Retrospective Study
This is a comparative retrospective study of the efficacy of platelet-rich plasma injections and injections with commercial products advertised to promote hair regrowth for patients with androgenetic alopecia.
- Conditions
- Androgenetic Alopecia, Hair Loss, Alopecia
- Trial name
- NCT05129800
- Testing
- Platelet-rich plasma, Mesotherapy
- Volunteers
- 72 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Old Age; Dementia
Tango for Older People With Dementia
Cognitive impairment (CI) is the leading cause of loss of autonomy and has a huge impact on physical performance and quality of life (QOL) in older people.
- Trial name
- NCT05744011
- Testing
- Tango intervention, Adapted Physical Activity
- Where
- 2 sites in France
- Volunteers
- 124 people
- Sponsor
- University of Burgundy
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