Clinical trials: Degenerative Neurologic Disease
Parkinson Disease
Evaluation of the Efficacy and Safety of Fecal Microbiota Transplantation for Constipation in Parkinson's Disease
Participants will be allocated to FMT group or placebo group at a 1:1 ratio. For interventional group, patients will be given six FMT capsules twice a week for 24 weeks.
- Trial name
- NCT06388863
- Testing
- Healthy donor-derived FMT capsule
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Parkinson Disease
Effect of Multimodal Exercise Training on Walking Economy in Individuals With Parkinson's Disease
Sustained ambulation is a challenge for individuals with Parkinson's disease (PD) as walking economy is frequently compromised. There are also various disease-related skeletal muscle alterations that may contribute to performance…
- Trial name
- NCT03864393
- Testing
- Multimodal overground locomotor training
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- George Mason University
Idiopathic Parkinson's Disease
Dopamine Effect on Inhibitory Control
The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications.
- Trial name
- DEI (NCT03665493)
- Testing
- PD patients H&Y=1.5-2 Medications ON, PD patients H&Y=1.5-2 Medications OFF, Healthy age-matched controls
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Giovanni Mirabella
Bladder, Overactive, Parkinson Disease
Effect of Medical Cannabis for Non-motor Symptoms of Parkinson's Disease
Medical cannabis (MC) is a standard treatment in Israel to Parkinson's disease (PD) patients suffering from pain. Nevertheless, it is not known about MC effectiveness for other non-motor symptoms of the disease.
- Trial name
- NCT05106504
- Testing
- Medical Cannabis
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Alzheimer Disease
Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of SAM-531
To assess the safety and tolerability of ascending multiple oral doses of SAM-531, an investigational drug, in healthy Japanese young male and elderly subjects.To provide the pharmacokinetics (PK) and pharmacodynamics (PD)…
- Trial name
- NCT00479349
- Testing
- SAM-531
- Where
- Japan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of Web-based Training to Educate Physicians in the Methods of Interpreting Florbetapir-PET Scans
This study will investigate the performance of physician readers trained to read florbetapir-PET scans using electronic media training.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Neurodegenerative Diseases
- Trial name
- NCT01550549
- Testing
- florbetapir F 18
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease
This project aims to longitudinally profile plasma-derived GDEVs and plasma biomarkers of neuroinflammation across three stages of the AD continuum (Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease Dementia, Alzheimer's Disease (AD)
- Trial name
- GLEVAD (NCT07803055)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Myasthenia Gravis, Thymoma
The Role of the Thymus in Myasthenia Gravis
Although the association between thymic hyperplasia / thymoma and autoimmune myasthenia gravis has been known for some time, the question of causality remains uncertain.
- Trial name
- NCT01102192
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Amblyopia
Prospective Evaluation of a Smartphone Application, GoCheckKids™, to Detect Amblyopia Risk Factors in Young Children
The objective is evaluation of GoCheck Kids, a smartphone application ('App'), for use as a photo screening device in a pediatric population to detect amblyopia risk factors (ARFs).
- Trial name
- NCT03447171
- Testing
- App Vision Screening
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- Gobiquity Mobile Health
Multiple Sclerosis, Stroke
Clinical and Instrumental Treatment's Predictors in Subjects With Neurological Diseases Using G-EO Robotic System
The aim of this work is to elaborate a statistical model to predict the effectiveness of robotic treatment in subjects with neurological diseases.
- Conditions
- Multiple Sclerosis, Stroke, Parkinson Disease, Acquired Brain Injury
- Trial name
- NCT05493514
- Testing
- Robotic Assisted Gait Training with G-EO system
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Age-related Macular Degeneration
Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON)
This was a 64-week randomized, double-masked, multi-center, active-controlled, two-arm study in patients with neovascular age related macular degeneration (nAMD) who have not previously received anti- vascular endothelial growth…
- Trial name
- TALON (NCT04005352)
- Testing
- Brolucizumab 6 mg, Aflibercept 2 mg
- Where
- 118 sites in United States, Argentina and 18 more
- Volunteers
- 734 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson Disease, Deep Brain Stimulation
Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting
The primary objective of the proposed pilot study is to assess the safety and tolerability of active patterned Deep Brain Stimulation (pDBS) when administered in a home setting for patients with Parkinson's disease (PD) who have…
- Trial name
- NCT07410598
- Testing
- Biphasic deep brain stimulation, Conventional deep brain stimulation, Theta burst deep brain stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Parkinson's Disease (PD)
Coordinated Reset Deep Brain Stimulation
The study will explore the viability of an alternative/novel programming strategy in Deep Brain Stimulation (DBS) for patients with Parkinson's Disease (PD).
- Trial name
- RESET-DBS (NCT03732898)
- Testing
- Novel Programming (nDBS), Conventional Programming (cDBS)
- Where
- 2 sites in Germany
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Spinal Muscular Atrophy
Spinal Muscular Atrophy Neonatal Screening Program
Spinal muscular atrophy (SMA) is a group of disorders caused by the degeneration of the motor neuron cells of the anterior horn of the spinal cord and, in some subtypes, of the bulbar motor neurons.
- Trial name
- NCT06310421
- Testing
- Screening SMA test
- Where
- 2 sites in Italy
- Volunteers
- 11,500 people
- Sponsor
- IRCCS Burlo Garofolo
Alzheimer's Disease, Hippocampus
Using Neuroimaging to Early Diagnose Alzheimer's Disease Through Hippocampal Atrophy Assessment
This study aims to better understand Alzheimer's disease by looking at brain scans, specifically MRI images, to detect early signs of brain changes linked to the disease.
- Conditions
- Alzheimer's Disease, Hippocampus, Brain Atrophy, Magnetic Resonance Imaging
- Trial name
- NCT06965816
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Denis
Myasthenia Gravis
Biomarkers for Fatigue in Patients with Myasthenia Gravis
Rationale: Myasthenia Gravis (MG) is a chronic autoimmune disease affecting the neuromuscular junction. Although a hallmark of MG is muscle fatigability due to dysfunction of the neuromuscular junction (peripheral fatigue), a…
- Trial name
- NCT06860347
- Where
- Netherlands
- Volunteers
- 115 people
- Sponsor
- Leiden University Medical Center
Parkinson Disease
Comparison of Effects of TT With and Without Visual and Auditory Cues for Freezing & Gait Patients With PD
To determine the comparison of effects of treadmill training with and without visual and auditory cues for freezing and gait in patients with Parkinson's disease
- Trial name
- NCT05854147
- Testing
- Treadmill Training With Visual and Auditory Cues, Treadmill Training Without Visual and Auditory Cues
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Superior University
Parkinson's Disease
Gait Characteristics and Cognitive Evolution in Parkinson Disease
Parkinson's disease (PD) is a chronic progressive nervous system disease with gradual motor impairment. Cognitive dysfunction is common in PD, even in the early stages, and it is characterized by impairments in executive…
- Trial name
- GECO-PD (NCT04297800)
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Parkinson Disease, Dystonia
Physiological Brain Atlas Development
Enrollment of candidates undergoing a deep brain stimulator (DBS) implant.
- Conditions
- Parkinson Disease, Dystonia, Tremors, Obsessive Compulsive Disorder
- Trial name
- NCT01210534
- Testing
- No intervention
- Where
- United States
- Volunteers
- 456 people
- Sponsor
- Ohio State University
Parkinson's Disease and Parkinsonism, Tai Chi
Seated Tai Chi Improves Dynamic Finger Pointing Task and Sitting Balance Control in Subjects With Parkinson's Disease
The goal of this prospective study is to investigate the effects of 3 months seated Tai Chi (TC) practice on the eye-hand coordination and sitting balance control of subjects with Parkinson's disease.
- Trial name
- NCT06928532
- Testing
- Seated TC
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The Hong Kong Polytechnic University