Clinical trials: Degenerative Neurologic Disease
Advanced Parkinson Disease
Long Term Effectiveness of Levodopa-Entacapone-Carbidopa Intestinal Gel in Participants With Advanced Parkinson's Disease
The primary objective of the study is to assess the effectiveness of LECIGON® treatment on the reduction in OFF time (h/day) from baseline at 12 months as measured by Movement Disorder Society-Unified Parkinson's Disease Rating…
- Trial name
- SWITCH-ON (NCT07313176)
- Testing
- No Intervention
- Where
- 4 sites in Germany, Spain and 1 more
- Volunteers
- 1 people
- Sponsor
- Britannia Pharmaceuticals Ltd.
Amyotrophic Lateral Sclerosis
Efficacy and Safety of Nitrazine in the Treatment of ALS
To evaluate the trend of safety and effectiveness of Nitroketazine tablets for ALS patients, and to explore the best effective dose.
- Trial name
- NCT04950647
- Testing
- Nitrofurazone Group 1, Nitroketazine Group 2
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Myotonic Dystrophy 1
DM-IMT - Controlled, Randomized, Three-arm Intervention Study on the Safety and Efficacy of Regular Respiratory Muscle Training in Patients With Myotonic Dystrophy Type 1
For some diseases, regular respiratory muscle training could delay the start of ventilation. For DM1, however, there are no clinically high-quality studies.
- Trial name
- DM-IMT (NCT04052958)
- Testing
- IMT - inspiratory muscle training
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- LMU Klinikum
Idiopathic Parkinson's Disease
Evaluating the Effectiveness of Neupro® (Rotigotine) and L-dopa Combination Therapy in Patients With Parkinson's Disease
This study aims to evaluate the effectiveness of Rotigotine and Levodopa combination therapy for younger and older patients with Parkinson's Disease under real life conditions.
- Trial name
- NEUPART (NCT02227355)
- Where
- 42 sites in France, Germany and 3 more
- Volunteers
- 195 people
- Sponsor
- UCB Biopharma S.P.R.L.
Alzheimer's Disease
Effect of Exercises Training in Patients With Mild Cognitive Impairment and Early Alzheimer's Disease
Recent studies have shown that aerobic exercises and dual-task training are effective in improving overall cognitive function in patients with cognitive impairment or dementia.
- Trial name
- NCT02074215
- Testing
- Aerobic exercises, Stretch exercise
- Where
- Taiwan
- Volunteers
- 19 people
- Sponsor
- National Taiwan University Hospital
Alzheimer Disease, Dementia
Enhancing Sleep Quality for Nursing Home Residents With Dementia
This was a pilot study (R61) to prepare for a full clinical trial (R33) aiming to improve clinical outcomes for an important, growing, and vulnerable population-nursing home (NH) residents with Alzheimer's disease or related…
- Conditions
- Alzheimer Disease, Dementia, Sleep Disorder, Sleep Disturbance
- Trial name
- 40Winks (NCT04533815)
- Testing
- LOCK sleep intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Alabama, Tuscaloosa
Huntington's Disease
Efficacy and Safety of Tetrabenazine in Chorea
The primary objective of this study was to establish the absolute reduction of chorea in participants with Huntington's disease(HD) treated with tetrabenazine or placebo
- Trial name
- NCT00219804
- Sponsor
- Prestwick Pharmaceuticals
Amyotrophic Lateral Sclerosis
Systematic Laryngoscopic Evaluation of Upper Airways in Ventilated ALS Patients in Portugal and in Norway
The study examines if titration of Non-Invasive mechanical ventilation (NIV) settings during ongoing laryngoscopic visualization can improve the compliance of NIV in subjects with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT03887338
- Testing
- Transnasal Fiberoptic Laryngoscopy
- Where
- 2 sites in Norway, Portugal
- Volunteers
- 60 people
- Sponsor
- Tiina Maarit Andersen
Degenerative Disc Disease, Spondylolisthesis
The European Robotic Spinal Instrumentation (EUROSPIN) Study
In a multinational prospective study, preoperative, intraoperative, perioperative and follow-up data on patients receiving thoracolumbar pedicle screw placement for degenerative disease or infections or tumors will be collected.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis, Recurrent Disc Herniation
- Trial name
- EUROSPIN (NCT03398915)
- Testing
- Transpedicular Instrumentation
- Where
- 12 sites in Austria, France and 5 more
- Volunteers
- 932 people
- Sponsor
- Marc Schröder
Progressive Supranuclear Palsy
Rehabilitation in Patients With Progressive Supranuclear Palsy
The investigators evaluate whether an aerobic, intensive, goal based and multidisciplinary rehabilitation treatment, previously conceived for Parkinson's disease, is effective for patients with progressive supranuclear palsy and…
- Trial name
- PSP-MIRTLoko (NCT02109393)
- Testing
- MIRT, MIRT+Lokomat
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Alzheimer Disease
Cognitive and Neurophysiological Effects of Raloxifene in Alzheimer's Disease
The aim of this study is to determine the effectiveness of treatment with raloxifene, an estrogen-like medication approved by the Food and Drug Administration for the treatment of osteoporosis, in improving memory and the ability…
- Trial name
- NCT00065767
- Testing
- Raloxifene
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease
Exploratory Study of Low-Dose Whole-Brain Radiation Therapy With HeLaXON 1X in Patients With Mild Alzheimer's Disease Dementia
This randomized, sham-controlled, exploratory clinical trial will evaluate the efficacy and safety of HeLaXON, an investigational low-dose radiation therapy device, in patients with mild Alzheimer's disease dementia.
- Trial name
- LDRT-AD-03 (NCT07863011)
- Testing
- HeLaXON 1X Low-Dose Radiation Therapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- ReadyCure Inc.
Parkinson Disease
Acceptability of Palliative Care in Parkinson Disease Care
This study will assess the feasibility of using specific criteria to standardize the referral of individuals with Parkinson disease to a group of medical providers known as palliative care specialists.
- Trial name
- Palliate-PD (NCT03697434)
- Testing
- Palliative Care referral
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Parkinson Disease, Idiopathic
The Impact of Deep Brain Stimulation on Speech and Swallow Function in Parkinson Disease
Nearly one-million people in North America are now living with Parkinson's disease (PD), and that number is projected to rise to nearly 1.2 million by 2030.
- Trial name
- NCT07026734
- Testing
- Deep brain stimulation surgery - GPi, Deep Brain Stimulation Surgery - STN
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Parkinson's Disease
Optimization of fMRI for the Study of Basal Ganglia Activation in Parkinson's Disease
Functional magnetic resonance imaging (fMRI) is a non-invasive imaging technique assessing neuronal activations during motor or cognitive tasks.
- Trial name
- 2010-A01115-34 (NCT01429909)
- Testing
- MAGNETOM Avanto (MRI device)
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Alexander Disease
Evaluation of Outcome Metrics in Alexander Disease
The purpose of this study is to define the natural history of Alexander Disease, a leukodystrophy that causes neurological dysfunction.
- Trial name
- AxD Outcomes (NCT02714764)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Philadelphia
Parkinson's Disease
18F-DTBZ for l Diagnosis of Parkinson's Disease and Monitoring the Severity of Disease by VMAT2 PET Imaging
The primary objective of this protocol is to analyze the sensitivity and specificity of 18F-DTBZ PET to the differential diagnosis of Parkinson's Disease (PD) and normality.
- Trial name
- 8F-DTBZ (NCT01283347)
- Testing
- 18F-DTBZ
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Amyotrophic Lateral Sclerosis (ALS)
A Study for Patients Who Completed VITALITY-ALS (CY 4031)
The purpose of this study is to assess the long-term safety and tolerability of tirasemtiv in patients with ALS who had completed the double-blind placebo-controlled study of tirasemtiv in ALS (CY 4031).
- Trial name
- VIGOR-ALS (NCT02936635)
- Testing
- tirasemtiv
- Where
- 67 sites in United States, Belgium and 9 more
- Volunteers
- 280 people
- Sponsor
- Cytokinetics
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Alzheimer Disease, Major Depressive Disorder
Aβ Dynamics in LLMD
This study will examine the biological factors that may modulate the relationship between depression and the development of Alzheimer's disease (AD).
- Trial name
- NCT05004987
- Testing
- Escitalopram Oxalate
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
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