Clinical trials: Degenerative Neurologic Disease
Parkinson Disease
Investigating Inhibitory Control Networks in Parkinson's Disease
The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor.
- Trial name
- NCT04735458
- Testing
- Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Alabama at Birmingham
Alzheimer Disease
Neuro Imaging and Multimodal Alzheimer's Disease
The present study aimed at measuring cerebral changes in Alzheimer Disease (AD) patients, who responded to strict physiological criteria typical of AD pathology.
- Trial name
- NIMAD (NCT02839187)
- Testing
- Neuroimaging
- Where
- France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Toulouse
Dementia
Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD)
The purpose of this clinical trial is to test whether or not the medication amantadine is effective in reducing behavioral disturbances in patients with frontotemporal dementia.
- Trial name
- NCT00127114
- Testing
- Amantadine
- Where
- United States
- Sponsor
- Johns Hopkins University
Huntington Disease
Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their…
- Trial name
- NCT06667414
- Where
- 45 sites in United States, Argentina and 10 more
- Volunteers
- 574 people
- Sponsor
- Hoffmann-La Roche
Caregiver Burden, Cognitive Impairment
Evaluating the Efficacy of the Pain Identification and Communication Toolkit
This study will evaluate the Pain Identification and Communication Toolkit (PICT), a multicomponent intervention for caregivers of people with Alzheimer's disease and related dementias (ADRD).
- Conditions
- Caregiver Burden, Cognitive Impairment, Dementia, Alzheimer Disease
- Trial name
- PICT (NCT06168604)
- Testing
- Pain Identification and Communication Toolkit, Health Promotion Program
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Weill Medical College of Cornell University
Spinocerebellar Ataxias, Cerebellar Ataxia
Investigating the Genetic and Phenotypic Presentation of Ataxia and Nucleotide Repeat Diseases
The purpose of this study is to create a repository for cerebellar ataxia and nucleotide repeat diseases in order to fully investigate the genetic and phenotypic presentations of both.
- Conditions
- Spinocerebellar Ataxias, Cerebellar Ataxia, Nucleotide Repeat Disease
- Trial name
- NCT04529252
- Testing
- Specimen collection
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tourette's Disorder
Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder (TD)
The goal of the current trial is to determine efficacy and safety of once-weekly aripiprazole in reducing Total Tic Severity (TTS) score in children and adolescents with Tourette's Disorder.
- Trial name
- NCT01418352
- Testing
- Aripiprazole
- Where
- 35 sites in United States, Bulgaria and 3 more
- Volunteers
- 83 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Parkinson Disease
the Effect of Speed Dependent Treadmill Training on Dual Task Performance in Patient With Parkinson's Disease.
The aim of this randomized clinical trail is to identify the impact of treadmill training on walking while doing dual task in patients with Parkinson's disease.
- Trial name
- NCT05903755
- Testing
- speed dependent treadmill training on moderate speed, speed dependent treadmill training on slow speed
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Primary Progressive Aphasia, Semantic Dementia
Primary Progressive Aphasia Multicomponent Language Treatment Study
The goal of this clinical trial is to learn if a speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language.
- Conditions
- Primary Progressive Aphasia, Semantic Dementia, Semantic Memory Disorder, Logopenic Progressive Aphasia
- Trial name
- NCT06649084
- Testing
- Multicomponent Lexical Retrieval Training (Multi-LRT), Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA), Multicomponent Communication Partner Training (Multi-CPT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Texas at Austin
Parkinson's Disease, Sleep Disorder; Excessive Somnolence
Light Therapy Treatment in Parkinson's Disease Patients With Daytime Somnolence
Study objectives are to determine the efficacy, safety and tolerability of bright light treatment in Parkinson's Disease (PD) patients with daytime sleepiness.
- Trial name
- NCT01338649
- Testing
- Bright Light Treatment (Sun Ray Sunbox SB-558), Dim red light (Sun Ray Sunbox SB-558)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Northwestern University
Huntington Disease
Resveratrol and Huntington Disease
The purpose of this study is to evaluate the therapeutic potential of Resveratrol on the caudate volume in HD patients, using volumetric MRI.
- Trial name
- REVHD (NCT02336633)
- Testing
- Resveratrol
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer' Disease
Optimizing Rural Community Health Through Dementia Detection and Care
The overall goal of this one-year study is to test a comprehensive protocol for Alzheimer's Disease and Related Dementias (ADRD) diagnosis and care management that can be used as a model for rural communities, which experience…
- Trial name
- ORCHID (NCT05760521)
- Testing
- Provider Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Alzheimer Disease
Valproate in Dementia (VALID)
The purpose of this trial is to demonstrate whether valproate therapy delays the emergence of agitation and/or psychosis in outpatients with probable Alzheimer's disease (AD) who have not experienced agitation and psychosis in…
- Trial name
- NCT00071721
- Testing
- Valproate
- Where
- 46 sites in United States
- Volunteers
- 313 people
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Batten Disease, Late Infantile Neuronal Ceroid Lipofuscinosis
Safety Study of a Gene Transfer Vector for Children With Late Infantile Neuronal Ceroid Lipofuscinosis
The aim of this study is to treat the signs and symptoms of late infantile neuronal ceroid lipofuscinosis (LINCL), a fatal inherited disease in the brain.
- Trial name
- NCT00151216
- Testing
- AAV2CUhCLN2 (3x10^12 particle units)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Weill Medical College of Cornell University
Parkinson Disease
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease.
There is no consensus on the treatment of Impulse Control Disorder (ICD) in Parkinson Disease (PD) though it is recommended to reduce the dosage of dopamine agonists (DA).
- Trial name
- PIMPARK (NCT03947216)
- Testing
- Active drug: pimavanserin 17mg (2 strength tablets), Assessment of severity of ICD (impulse control disorders), Assessment of motor and non-motors symptoms of PD Evaluation of hyper- and hypodopaminergic behaviors
- Where
- 16 sites in France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Strasbourg, France
Parkinson Disease
Combining rTMS and Video Game-based Dexterity Training to Improve Dexterity in Parkinson's Disease
We investigate the effectiveness of a combined repetitive transcranial magnetic stimulation (rTMS) - video game-based training (VBT) dexterity intervention in Parkinson's diseases.
- Trial name
- rTMSVR (NCT04699149)
- Testing
- Transcranial magnetic stimulation
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Luzerner Kantonsspital
Alzheimer Disease, Gut Microbiota
Design of Personalised SupplemenTs Based on the Gut MicRobiota Through Artificial Intelligence for Alzheimer's Patients
Studies indicate that the intestinal microbiota could have an implication in Alzheimer's disease; recently, a positive relationship has been established between levels of bacterial lipopolysaccharide (LPS) and cerebral…
- Trial name
- TREAT (NCT06199193)
- Testing
- Personalized diet, Dietary counseling
- Where
- 2 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Alzheimer Disease
Near-Infrared Light Therapy Combined With Lecanemab for Mild Alzheimer's Disease
The goal of this study is to explore the efficacy and safety of near-infrared light combined with lecanemab in patients with mild Alzheimer's disease (AD).
- Trial name
- NCT06992804
- Testing
- NirsCure with Lecanemab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson Disease
Controlled Trial With Deep Brain Stimulation in Patients With Early Parkinson's Disease
Earlystim Study: Patients are randomized either to medical treatment or subthalamic stimulation. The observation period was 2 years. The primary outcome criterium: PDQ-39.
- Trial name
- EARLYSTIM (NCT00354133)
- Testing
- Kinetra and Soletra (neurostimulator, Medtronic), Best Medical Treatment
- Where
- 16 sites in France, Germany
- Volunteers
- 251 people
- Sponsor
- German Parkinson Study Group (GPS)
Amyotrophic Lateral Sclerosis, Kennedy Disease
Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS), is a rapidly progressive neurodegenerative disorder, usually leading to death from respiratory failure in 3-5 years.
- Trial name
- CERMALS (NCT05107349)
- Testing
- Muscle biopsy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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