Clinical trials: Degenerative Neurologic Disease
Dementia, Caregivers
VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers
The purpose of this study is to study the effects of an education and skill-building intervention on family caregivers of Veterans with dementia.
- Conditions
- Dementia, Caregivers, Neurodegenerative Diseases, Brain Diseases
- Trial name
- VACARES (NCT02106065)
- Testing
- Education and Skill-Building Rehabilitation (ESBR), Supplemental Education Materials
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson's Disease
A Study With an Increased Dose Step in Patients That Have Previously Received Placebo or sNN0031.
The purpose of this study is to assess the safety and tolerability of a dose of 95μg sNN0031 after intracerebroventricular administration to patients with Parkinson's disease
- Trial name
- NCT01829867
- Testing
- sNN0031
- Where
- 2 sites in Sweden
- Volunteers
- 5 people
- Sponsor
- Newron Sweden AB
Parkinson's Disease
A Study Comparing the Safety and Tolerability of Two Doses of Fipamezole in Adult Patients With Parkinson's Disease
The purpose of this clinical trial is to compare the safety and tolerability of two dose regimens of fipamezole in adult patients with Parkinson's Disease who are receiving levodopa.
- Trial name
- Fipamezole (NCT01149811)
- Testing
- Fipamezole ODT, Fipamezole ODT Cohort 2
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Bausch Health Americas, Inc.
Vascular Cognitive Impairment, Alzheimer's Disease, Fronto-temporal Dementia
The Influence of Vascular Burden, Amyloid Plaque and Tau Protein in Patients With Vascular Cognitive Impairment and Dementia With Tauopathy
Background and objects Amyloid plaques and tau protein are the landmarks of neurodegeneration in Alzheimer's disease (AD). On the other hand, it is reported that cerebral ischemia may induce amyloid plaques and tau protein…
- Trial name
- NCT04309253
- Testing
- PMPBB3, AV45
- Where
- Taiwan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Parkinson's Disease
Comparison of Constant Current to Constant Voltage Stimulation in Subthalamic Deep Brain Stimulation for Parkinson's Disease
HYPOTHESIS: Constant current stimulation for STN DBS will allow better and more stable control of Parkinson's disease symptoms than constant voltage stimulation.
- Trial name
- NCT01423565
- Testing
- Deep Brain Stimulation (Medtronic, Activa PC)
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Hadassah Medical Organization
Chronic Low-back Pain, Disc Degeneration
Evaluation of Safety, Tolerability, and Efficacy of CordSTEM-DD in Patients With Chronic Low Back Pain
The purpose of this clinical study is to evaluate the safety, tolerability, and efficacy of CordSTEM-DD, an allogeneic umbilical cord-derived mesenchymal stem cell, as a cell-therapeutic drug in patients with chronic low back…
- Trial name
- NCT04530071
- Testing
- CordSTEM-DD (0.7 x 10^7 cells), CordSTEM-DD (2.1 x 10^7 cells)
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- CHABiotech CO., Ltd
Idiopathic Parkinson Disease, Primary Parkinsonism
Evaluation of Safety and Tolerability of Fetal Mesencephalic Dopamine Neuronal Precursor Cells for Parkinson's Disease
The purpose of clinical trials is to evaluate safety and tolerability of Fetal Mesencephalic Dopamine Neuronal Precursor Cells as a treatment for Patients with Parkinson's disease.
- Trial name
- NCT01860794
- Testing
- Mesencephalic Neuronal Precursor Cells
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bundang CHA Hospital
Myasthenia Gravis
Perioperative Efgartigimod for Thymoma and Myasthenia Gravis
It is evidenced that efgartigimod can rapidly and significantly improve the symptoms of myasthenia gravis. The global multicenter clinical trials hace confirmed that efgartigimod is safe and well tolerated.
- Trial name
- NCT06221501
- Testing
- Efgartigimod Alfa
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Essential Tremor, Parkinson's Disease
Neurotransmitter Measurements Using (WINCS) During Deep Brain Stimulation Neurosurgery
In this study, the investigators will monitor extracellular neurotransmitter levels using a probe that is able to perform real time electrochemical detection during deep brain stimulation surgery.
- Conditions
- Essential Tremor, Parkinson's Disease, Dystonia
- Trial name
- NCT01705301
- Testing
- WINCS
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
ALS (Amyotrophic Lateral Sclerosis)
A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
The purpose of this study is to evaluate how well LY4256984 is tolerated and what side effects may occur in participants with sporadic amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT07100119
- Testing
- LY4256984
- Where
- 12 sites in Belgium, Canada and 3 more
- Volunteers
- 32 people
- Sponsor
- Eli Lilly and Company
Tourette Syndrome, Chronic Tic Disorder
Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Tic Disorders/Tourette's Syndrome in Children and Adolescents
The objective of this trial is to evaluate the effect of transcutaneous auricular vagus nerve stimulation compared to sham stimulation in improving chronic tic disorder or Tourette's syndrome in children and adolescents.
- Trial name
- NCT07854665
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 124 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Parkinson's Disease
Efficiency of Physiotherapeutic Care in Parkinson's Disease
In the course of their disease, most patients with Parkinson's Disease (PD) face mounting mobility deficits, including difficulties with walking, balance, posture and transfers.
- Trial name
- NCT00330694
- Testing
- ParkNet, Usual Care
- Where
- 18 sites in Netherlands
- Volunteers
- 708 people
- Sponsor
- Radboud University Medical Center
Alzheimer's Disease
Effect of Memantine on Functional Communication in Patients With Alzheimer's Disease
The objective of this study is to evaluate the effect of memantine versus placebo on functional communication in patients with Alzheimer's Disease
- Trial name
- NCT00469456
- Testing
- Memantine
- Where
- 25 sites in Australia, New Zealand and 1 more
- Volunteers
- 265 people
- Sponsor
- Forest Laboratories
Parkinson Disease
Treatment of Parkinson's Disease With a Transdermal Skin Patch
Patients with Parkinson's disease are missing the chemical neurotransmitter dopamine. This occurs as a result of destructive changes in an area of the brain responsible for making dopamine, the basal ganglia.
- Trial name
- NCT00001931
- Testing
- N-0923
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neurofibromatosis 1
Everolimus for Treatment of Disfiguring Cutaneous Lesions in Neurofibromatosis1 CRAD001CUS232T
This trial is evaluating the use of oral Everolimus to determine if there is a reduction in the size of the disfiguring cutaneous lesions in patients with Neurofibromatosis 1 over a 6 month period.
- Trial name
- DCLNF1 (NCT02332902)
- Testing
- Everolimus
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center, Houston
Muscular Atrophy, Spinal
Two Different Treatment Modalities in Patients With Spinal Muscular Atrophy
Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of alpha motor neurons in the spinal cord, resulting in progressive muscle atrophy and weakness, particularly in proximal and…
- Trial name
- NCT06178653
- Testing
- Pulmonary Rehabilitation, Trunk Control Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Medipol University Hospital
Alzheimer Disease, Preclinical Alzheimer
β-AARC: Cohort Study for the Identification of Blood-based Biomarkers in a Population With Subjective Cognitive Decline
The overall (cross-sectional) objective of this study is to detect and describe the profile of AD-related blood biomarkers in a population with SCD (including individuals with MCI) with the ultimate goal of investigating their…
- Conditions
- Alzheimer Disease, Preclinical Alzheimer, Mild Cognitive Impairment
- Trial name
- β-AARC (NCT04935372)
- Testing
- Observational
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Osteoarthritis, Rheumatoid Nodule
Cellular & Biocellular Regenerative Therapy in Musculoskeletal Pain, Dysfunction,Degenerative or Inflammatory Disease
Musculoskeletal disorders and degeneration represent injuries or pain in the body's joint ligaments, tendons, muscles, nerves, and skeletal elements that support extremities, spine and related tissues.
- Conditions
- Osteoarthritis, Rheumatoid Nodule, Degenerative Joint Disease, Tendinopathy
- Trial name
- BRT (NCT03090672)
- Testing
- Normal Saline, Tissue Stromal Vascular Fraction, Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Robert W Alexander, MD
Neurological Disease
Development, Reliability and Validity of the Telerehabilitation Usability Questionnaire- TrUQ
Neurological diseases are central nervous system diseases that cause an increase in the level of disability and limitations in daily life.
- Trial name
- NCT05970939
- Testing
- Development of the Telerehabilitation Usability Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Gazi University
Myasthenia Gravis Generalized
PANORAMA: Neuromuscular Organoids for Refractory AChR+ Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies attack the neuromuscular junction, the site at which nerve cells communicate with muscle fibres, impairing signal transmission and causing fluctuating muscle…
- Trial name
- PANORAMA (NCT07717281)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
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