Clinical trials: Degenerative Neurologic Disease
Parkinson Disease, Apathy
Non Motors Aspects in De Novo Parkinson's Disease
Clinical description and pathophysiological study of recently diagnosed untreated patients with Parkinson's Disease. Effect of a dopamine agonist (rotigotine) on apathy in de novo patients with Parkinson disease: A controlled…
- Trial name
- Honeymoon (NCT02786667)
- Testing
- Rotigotine
- Where
- France
- Volunteers
- 199 people
- Sponsor
- University Hospital, Grenoble
Parkinson Disease
Effects of AMPS on Cardiovascular and Functional Variables in Patients With Parkinson's Disease
This study evaluates the addition of automated mechanical peripheral stimulation (AMPS) to physical exercise in the treatment of cardiovascular and motor disabilities in Parkinson's patients.
- Trial name
- NCT04251728
- Testing
- Automated mechanical peripheral stimulation, Physical Exercise
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Universidad Católica del Maule
Parkinson's Disease
Clinical Trial on the Effectiveness of Herbal Medicinal Mixture in Parkinson Disease
This study was designed to evaluate the symptomatic effects or potential disease progression slowing down effect of a kind of Herbal Medicinal Mixture in Parkinson's disease (PD) patients.
- Trial name
- NCT00656253
- Testing
- Herbal Medicinal Mixture (Roucongrong, Heshouwu etc.)
- Where
- 10 sites in China
- Volunteers
- 158 people
- Sponsor
- Fudan University
Mild Cognitive Impairment, Alzheimer's Disease
Home-Based Assessment for Alzheimer Disease Prevention
The purpose of this study is to evaluate three methods of performing home-based assessments in Alzheimer's Disease (AD) prevention trials. The initial in-person assessment will be done in the clinic or at home.
- Trial name
- HBA (NCT00546767)
- Testing
- Mail and Live Phone, Interactive Voice Response (IVR), Home-based Computer Kiosk
- Where
- 28 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Traumatic Brain Injury, Alzheimer Disease
The Aging Brain ANSWERS Program
This study will test the effectiveness of an intervention for Veterans diagnosed with Alzheimer's Disease (AD) or Traumatic Brain Injury (TBI) and the burden on their informal (family/friend) caregiver.
- Conditions
- Traumatic Brain Injury, Alzheimer Disease, Veterans, Family Caregivers
- Trial name
- ABC ANSWERS (NCT03397667)
- Testing
- ABC ANSWERS, Control
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Indiana University
Parkinson Disease
Pharmacokinetic Interaction Between BIA 9-1067 and Standard-release Levodopa/Carbidopa
To investigate the pharmacokinetics of levodopa when administered concomitantly with BIA 9-1067 or 1 hour after.
- Trial name
- NCT01533077
- Testing
- BIA 9-1067, Sinemet® 100/25 mg
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Cardiac Amyloidosis
Cardiac Amyloidosis in Spinal Stenosis: the CASS-study
Background: A significant portion of cardiac amyloidosis patients have a 5 to 10 years prior history of spinal canal stenosis, reflecting a diagnostic red flag that should raise suspicion for amyloidosis presence.
- Trial name
- CASS (NCT04653675)
- Where
- Belgium
- Volunteers
- 105 people
- Sponsor
- AZ Sint-Jan AV
Dementia, Cognitive Impairment
Implementation and Evaluation of Improved Access to Medical Imaging for Geriatric Patients of The Royal Ottawa Hospital
In this study, the investigators implement FDG-PET imaging for clients in the Geriatric Psychiatry department at The Royal Ottawa Hospital (ROH) and evaluate the impact of this advanced imaging technique on client care.
- Conditions
- Dementia, Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT05428475
- Testing
- [18F]FDG-PET Scan
- Volunteers
- 15 people
- Sponsor
- Tim Lau
Myasthenia Gravis (MG)
The Effectiveness of an ETP Programme in Myasthenia Gravis: a Proof-of-concept Study.
CONTEXTE. Myasthenia gravis is a rare neuromuscular junction disorder affecting one in five thousand people (ORPHA 589). It is a chronic condition that progresses in episodes.
- Trial name
- MY-EDUC (NCT07512375)
- Testing
- CBSM
- Volunteers
- 62 people
- Sponsor
- University Hospital, Grenoble
PARKINSON DISEASE (Disorder)
Singing Therapy for Rehabilitating Facial Mimicry in Parkinson's Disease: A Randomised Controlled Trial
Parkinson's disease can reduce facial expression and change the voice, making it harder to communicate emotions. This study examined whether practising facial and vocal imitation through speech and singing could improve facial…
- Trial name
- NCT07905612
- Testing
- Singing Imitation Therapy, Singing Observation Therapy
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Parkinson's Disease
Single Dose Study to Assess the Pharmacokinetics of SCH 900800 in Subjects With Parkinson's Disease Being Treated With Levodopa (L-DOPA) (P08235)
This study is being done to assess the pharmacokinetics of SCH 900800 in participants with moderate to severe Parkinson's Disease (PD) being treated with L-DOPA.
- Trial name
- NCT01500707
- Testing
- SCH 900800
- Sponsor
- Merck Sharp & Dohme LLC
Parkinson Disease
A Study to Assess the Safety and Effectiveness of Pridopidine Compared to Placebo in the Treatment of Levodopa-Induced Dyskinesia in Patients With Parkinson's Disease
This is a multicenter, randomized, three-arm, parallel-group, double-blind, placebo-controlled, study to evaluate the efficacy, safety and pharmacokinetics (PK) of pridopidine vs.
- Trial name
- NCT03922711
- Testing
- Pridopidine
- Where
- 33 sites in United States
- Volunteers
- 23 people
- Sponsor
- Prilenia
Alzheimer's Disease, Mild Cognitive Impairment
Evolution of Memory Related Activity
The purpose of this study is to begin the process of validating fMRI (functional magnetic resonance imaging) as a biomarker for use in clinical trials and longitudinal studies of clinical progression in mild cognitive impairment…
- Trial name
- NCT00902499
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Amyotrophic Lateral Sclerosis
Investigation on Home Care Needs of ALS Patients and Their Caregivers
The research target 1. To investigate the home nursing knowledge needs of ALS patients; 2. Investigate the needs of ALS caregivers for home nursing knowledge; 3.
- Trial name
- NCT04950231
- Testing
- The questionnaire survey
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Parkinson Disease
Effects of Resistant Starch on Bowel Habits, Fecal Short Chain Fatty Acids and Gut Microbiota in Parkinson Disease
The investigators will investigate the effects of an 8-week resistant starch (RS) supplementation (5 g twice a day) in patients with Parkinson Disease and matched controls on: 1.
- Trial name
- RESISTA-PD (NCT02784145)
- Testing
- Resistant starch, Recommendation with regard to nutrition
- Where
- Germany
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Universität des Saarlandes
Incomplete Spinal Cord Injury, Transverse Myelitis
Ultrasound Imaging Based Sensing of Human Ankle Motion Intent and Control Strategies for Ankle Assistance
Robotic therapies aim to improve limb function in individuals with neurological injury. Modulation of robotic assistance in many of these therapies is achieved by measuring the extant volitional strength of limb muscles.
- Trial name
- NCT05249595
- Testing
- Surface electromypgraphy-based interface to predict human ankle joint motion intent and use in ankle assistive devices, Ultrasound imaging-based interface to predict human ankle joint motion intent and use in ankle assistive devices, Surface electromypgraphy and ultrasound imaging-based interface to predict human ankle joint motion intent and use in ankle assistive devices
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Auto-immune Encephalitis, Epilepsy
Antibodies Causing Epilepsy Syndromes: The ACES Study.
The Antibodies Causing Epilepsy Syndromes (ACES) Study is a observational cohort study focusing on detection of auto-immune epilepsy in patients with epilepsy of unknown origin.
- Trial name
- ACES (NCT02802475)
- Testing
- vena punction
- Where
- 8 sites in Netherlands
- Volunteers
- 582 people
- Sponsor
- Erasmus Medical Center
Myasthenia Gravis
Tacrolimus Combined With Low-dose Prednisone for Treatment of Myasthenia Gravis
This study is designed to evaluate the effectiveness and safety of tacrolimus combined with low-dose prednisone in the management of myasthenia gravis patients, compared to tacrolimus as initial immune monotherapy.
- Trial name
- NCT04768465
- Testing
- Pyridostigmine, Prednisone, Tacrolimus, Pyridostigmine, Tacrolimus
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Da, Yuwei, M.D.
Alzheimer Disease
Healthy Aging and Memory Study
This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in Alzheimer's Disease (AD) primary prevention trials.
- Trial name
- NCT00034567
- Where
- 39 sites in United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Dementia Associated With Parkinson's Disease, Dementia With Lewy Bodies
Efficacy and Safety of Memantine for Parkinson's Disease Dementia (PDD) and Dementia With Lewy Bodies (DLB)
A 24-week placebo-controlled parallel group multicentre trial to study the safety and efficacy of memantine in patients with dementia associated with Parkinson's disease and dementia with Lewy bodies.
- Trial name
- MEMPDD (NCT00630500)
- Testing
- Memantine
- Where
- 4 sites in Norway, Sweden and 1 more
- Volunteers
- 75 people
- Sponsor
- Helse Stavanger HF
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