Clinical trials: Degenerative Neurologic Disease
Neurofibromatosis Type 1
Gait in Young Children With NF1
The objective of this study is to develop office-based tools to quantify gait in young children with NF1 that reflect overall gross motor impairment and predict future gross motor difficulties.
- Trial name
- NCT07564622
- Volunteers
- 56 people
- Sponsor
- NYU Langone Health
Multiple Sclerosis
BrainAgeMS - a Comparative Study of Brain Aging in Healthy and Patients With Multiple Sclerosis
The purpose of this study is to investigate new quantitative MRI-sequences for assessment of age-specific data for the prediction of brain aging.
- Trial name
- BrainAgeMS (NCT06221631)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson s Disease, Dystonic Disorders
Genetics of Motor Learning
Background: New studies in human genetics have revealed information about genetic connections to memory and motor behavior. Researchers are interested in investigating the role of genetics in motor learning, in conjunction with…
- Conditions
- Parkinson s Disease, Dystonic Disorders, Focal Dystonia, Movement Disorders
- Trial name
- NCT01105845
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease
Temporal Relationship Between Motor Fluctuations and Nonmotor Fluctuations
The purpose of this study is to determine the temporal relationship between motor fluctuations and non-motor fluctuations in persons with Parkinson's disease. Observational study case-only
- Trial name
- NCT02060695
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Seoul National University Hospital
Parkinson's Disease
Safety and Efficacy Study of Parkinson's Disease Gene Therapy Drug (BBM-P002)
Safety and Efficacy Study of BBM-P002 in participants with primary advanced Parkinson's disease
- Trial name
- NCT05822739
- Testing
- BBM-P002
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Xiangya Hospital of Central South University
Parkinson Disease, Weight-Lifting Exercise Program
Daily Undulating Periodization Methods With Parkinson's Disease
Compare periodized (cyclic) resistance training with and without motor training specific to activities of daily living.
- Trial name
- NCT03867877
- Testing
- Periodized training with motor practice, Simple Periodized Training
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Alzheimer's Disease
Study Investigating the Effects of JNJ-54861911 on Amyloid-beta Processing in Cerebrospinal Fluid (CSF) and Plasma in Japanese Participants Asymptomatic at Risk for Alzheimer Dementia
The purpose of this study is to determine the safety, tolerability and effect of JNJ-54861911 on level of amyloid-beta in Cerebrospinal Fluid (CSF) and plasma following 4 weeks of treatment in Japanese participants asymptomatic…
- Trial name
- NCT02360657
- Testing
- JNJ-54861911, 10 mg, JNJ-54861911, 50 mg
- Where
- 2 sites in Japan
- Volunteers
- 18 people
- Sponsor
- Janssen Pharmaceutical K.K.
Alzheimer's Disease
Control and Intervention Programme on Alzheimer's Disease Risk Factors
Recent epidemiologic studies are identifying a number of modifiable risk and protective factors that may influence in the incidence of Alzheimer's disease (AD).
- Trial name
- ALFAlife (NCT02772523)
- Testing
- Lifestyle recommendations
- Where
- Spain
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Dementia Alzheimers
Ageing Gut Brain Interactions
This research project will address a desperate need for evidence on how diet could be used to treat and improve symptoms of Alzheimer's disease (AD).
- Trial name
- NCT03593941
- Testing
- Standard Diet
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Parkinson Disease, Motor Disorders
Motor-cognitive Dual-task in Healthy Older Adults and Early Parkinson's Disease Patients
Neuromuscular dysfunction is common in older adults and even more pronounced in neurodegenerative diseases. In Parkinson's disease (PD), a complex set of factors often prevents effective performance of activities of daily living…
- Conditions
- Parkinson Disease, Motor Disorders, Cognitive Impairment
- Trial name
- TwinBrainPD (NCT05477654)
- Testing
- Extensive motor-cognitive testing protocol
- Where
- Slovenia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Parkinson Disease
Validation of a Diagnostic Self-assessment Scale Non-motor Fluctuations at the Parkinson's Patient
The objective of this study is to validate a diagnostic tool severity of these common non-motor manifestations, disturbing and little recognized as a self-questionnaire.
- Trial name
- NCT02859805
- Testing
- validation of a diagnostic tool severity of non-motor symptoms in Parkinson patients
- Volunteers
- 255 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Parkinson's Disease (PD)
Pharmacokinetic-pharmacodynamic Interaction Between BIA 3-202 and Levodopa/Benserazide
The purpose of this study is to determine the effect of three single oral doses of nebicapone (50 mg, 100 mg and 200 mg) on the levodopa pharmacokinetics when administered in combination with a single-dose of controlled release…
- Trial name
- NCT02778594
- Testing
- BIA 3-202, levodopa 100 mg / benserazide 25 mg
- Where
- Portugal
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
ALS (Amyotrophic Lateral Sclerosis)
Safety and Feasibility of the EyeControl Device
The EyeControl device is an eye movement-based communication device in the form of wearable glasses with connected infrared cam-era that tracks the pupil and translates blinks and movements into commands.This study is aimed to…
- Trial name
- NCT02891629
- Testing
- EyeControl device
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eyefree Assisting Communication Ltd
Tourette Syndrome, Chronic Tic Disorder
Neurofeedback for Tourette Syndrome
The aim of this study is to train patients with tic disorders to control activity in a region of their brain that has been associated with the urge to tic.
- Trial name
- NCT01702077
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Visual Impairment, Macular Edema
A Clinical Study in Current Medical Practice of the Efficacy and Safety of Ranibizumab 0.5mg in Diabetic Patients Presenting a Visual Impairment Due to Macular Edema
The purpose of this study is to evaluate the proportion of patients with a 10 letters gain on Best Corrected Visual Acuity (BCVA) at 6 months in current medical practice.
- Trial name
- LUDIC (NCT01315275)
- Testing
- Ranibizumab
- Where
- 43 sites in France
- Volunteers
- 394 people
- Sponsor
- Novartis Pharmaceuticals
Amyloid Cardiomyopathy, Transthyretin Cardiac Amyloidosis
Exercise Training in Transthyretin Cardiac Amyloidosis
Transthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training program to improve functional capacity in patients on optimal treatment for…
- Trial name
- NCT05797857
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Neurofibromatosis Type 1
Ophthalmological Screening and Follow-up of Optic Pathway Gliomas in Children With Neurofibromatosis Type 1.
The goal of this project is to get more insight into the (neuro)ophthalmological characteristics of children with neurofibromatosis type 1.
- Trial name
- NCT02078401
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Huntington's Disease
Safety Study of the Novel Drug Dimebon to Treat Patients With Huntington's Disease
This study is being conducted to determine the safety and tolerability of Dimebon in people with Huntington's disease after short-term exposure (one week) and after longer exposure (three months).
- Trial name
- NCT00387270
- Testing
- Dimebon
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Medivation, Inc.
Idiopathic Parkinson Disease
Phase 2a Study of VTX3232 in Parkinson's Disease
This is a study to understand if taking VTX3232 is safe in participants diagnosed with early stage idiopathic Parkinson's Disease (PD). Approximately 10 patients will take VTX3232 Dose A.
- Trial name
- NCT06556173
- Testing
- VTX3232
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Zomagen Biosciences Ltd.
Amyotrophic Lateral Sclerosis
Personalized Antisense Oligonucleotide Therapy for A Single Patient With CHCHD10 ALS (nL18576)
This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for a single participant with amyotrophic lateral sclerosis (ALS) due to a pathogenic variant in CHCHD10
- Trial name
- NCT07423494
- Testing
- nL-CHCHD-001
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- n-Lorem Foundation
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