Clinical trials: Degenerative Neurologic Disease
Depression
Accelerated Transcranial Magnetic Stimulation (TMS) for Depression
The purpose of this study is to determinate if accelerated rTMS treatment over 1.5 days is effective for ameliorating depression in Parkinson's disease.
- Trial name
- ATMS (NCT00248768)
- Testing
- Transcranial magnetic Stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- US Department of Veterans Affairs
Parkinson's Disease
Cognitive Rehabilitation in Parkinson's Disease
We are testing a computer game-style rehabilitation program for people with Parkinson's disease (PD). People with PD often have difficulty with motor planning, such as initiating or starting movements.
- Trial name
- NCT01085968
- Testing
- PC based training
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Virtual Reality Effects on Functional Capacity and Quality of Life of People With Parkinson's Disease
Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder of dopaminergic neurons that can cause some mobility limitations and it has association with quality of life (QOL) in patients with PD.
- Trial name
- NCT02786433
- Testing
- conventional physiotherapy, Virtual Reality with X- Box Kinect®
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Parkinson Disease (PD), Cognition Disorders
Dual-Task Improvement in Parkinson's Via rTMS
This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex on cognitive function and dual-task performance in individuals with Parkinson's…
- Conditions
- Parkinson Disease (PD), Cognition Disorders, Gait Disorders, Neurologic, Dual Task
- Trial name
- rTMS (NCT07310238)
- Testing
- Active Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- University of Gaziantep
Spinal Cord Injuries, Transverse Myelitis
The Impact of Expressive Emotional Writing on Facilitating Grief Resolution in Adults With Spinal Cord Injury
The aim of this study is to evaluate the therapeutic benefits of a 10-week online coach-guided EEWP on psychosocial health among adults with SCI.
- Trial name
- NCT06147258
- Testing
- expressive writing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cartilage Diseases
Molecular Biomarkers Associated With Degenerative Joint Disease in the Knee
This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy.
- Trial name
- NCT01006278
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scuderi, Gaetano J., M.D.
Alzheimer Disease
A Study of Healthy Subjects to Assess the Effect of LY450139 on Amyloid Beta Peptide Production Rate and or Dose Response.
To test that LY450139, a gamma-secretase inhibitor, will reduce the rate of newly synthesize Amyloid Beta by determining the amount of newly synthesized 13C6 leucine-labeled Amyloid Beta in lumbar cerebrospinal fluid from…
- Trial name
- NCT00765115
- Testing
- LY450139
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Parkinson Disease
Towards the Validation of a New Blood Biomarker for the Early Diagnosis of Parkinson's Disease
The investigators have recently discovered a metabolic biomarker which predicts Parkinson's disease (PD) at the early stages in patients and in animal models.
- Trial name
- BIOPARK (NCT05385315)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Grenoble
Frontotemporal Lobar Degeneration, Amyotrophic Lateral Sclerosis
Predict to Prevent Frontotemporal Lobar Degeneration (FDT) and Amyotrophic Lateral Sclerosis (ALS)
The project focuses on C9orf72, the most frequent genetic form of frontotemporal dementias (FTD, or frontotemporal lobar degeneration, FTLD) and amyotrophic lateral sclerosis (ALS).
- Trial name
- PREV-DEMALS (NCT02590276)
- Testing
- characterization
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer's Disease
Encapsulated Cell Biodelivery of Nerve Growth Factor to Alzheimer´s Disease Patients
Cholinergic neurons in the basal forebrain project widely to the cerebral cortex and hippocampus. These neurons depend on nerve growth factor (NGF) from their target areas for survival.
- Trial name
- NsG0202 (NCT01163825)
- Testing
- Nerve Growth Factor
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- NsGene A/S
Parkinson, Parkinson Disease
Mediterranean Diet Effects on Parkinson's Disease
Currently, there are no disease-modifying treatments for Parkinson's disease (PD), the second most common neurodegenerative disorder worldwide, making it crucial to find interventions that can change the disease's trajectory.
- Conditions
- Parkinson, Parkinson Disease, Parkinson Disease, Idiopathic, PARKINSON DISEASE (Disorder)
- Trial name
- MED-PARK (NCT06705517)
- Testing
- Mediterranean Diet
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Università degli Studi dell'Insubria
Alzheimer Disease, Dementia
Old School Hip Hop: Parent Follow-Up & Spanish Speakers Inclusion
These are the exploratory aims of the original trial cohort study "Old School Hip Hop RCT (AAAR5473)," which recruited 783 parents. 1.
- Trial name
- NCT06699589
- Testing
- Old SCHOOL Hip-Hop (Dementia Education), My Plate (Nutrition Education)
- Where
- United States
- Volunteers
- 278 people
- Sponsor
- Columbia University
Parkinson's Disease
A Study of LY3154207 in Healthy Participants and Participants With Parkinson's Disease
This two-part study will evaluate how safe LY3154207 is and the effects it has on the body. Part A will include healthy participants. Each participant will receive daily doses of LY3154207 or placebo for 14 days.
- Trial name
- NCT02562768
- Testing
- LY3154207
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Parkinson Disease
Chest PNF on Pulmonary Function in Parkinson Disease
Background: Parkinson disease (PD) is a progressive neurodegenerative disorder and characterized by tremor, rigidity and bradykinesia.
- Trial name
- NCT03977740
- Testing
- chest PNF, Conventional
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Subhasish Chatterjee
Alzheimer's Disease
Clinical- and Immunological Activity, Safety and Tolerability of Different Doses / Formulations of AFFITOPE AD02 in Early Alzheimer's Disease
This is a multiple vaccination study to find out if it is a safe treatment and what effects it has on the symptoms of early Alzheimer's disease in male and female patients aged 50 to 80 years.
- Trial name
- NCT01117818
- Testing
- active: AFFITOPE AD02
- Where
- 31 sites in Austria, Croatia and 4 more
- Volunteers
- 335 people
- Sponsor
- Affiris AG
Amyotrophic Lateral Sclerosis
ALS Testing Through Home-based Outcome Measures
ALS AT HOME is a single-center study of up to 150 participants being done to determine the extent to which frequent sampling can improve the qualities of outcome measures collected at home by study participants.
- Trial name
- ALS AT HOME (NCT03016897)
- Testing
- Respirometer, Handgrip Meter, Skulpt Chisel, ActigraphyMeter
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Jeremy Shefner
Parkinson Disease
Clinical Evaluation of the Infinity Deep Brain Stimulation System
The purpose of this post-market study is to characterize the clinical performance of the Infinity Deep Brain Stimulation (DBS) system, including the Implantable Pulse Generator (IPG), directional DBS leads, extensions, iPad…
- Trial name
- PROGRESS (NCT02989610)
- Testing
- Omnidirectional stimulation, Directional stimulation
- Where
- 41 sites in United States, Australia and 6 more
- Volunteers
- 234 people
- Sponsor
- Abbott Medical Devices
Mild Cognitive Impairment
Impact of Grape Consumption on Brain Metabolism and Neuropsychological Performance Over 1 Year
Constituents of grapes have been studied for their antioxidant, anti-inflammatory, and anticarcinogenic properties. In the past decade, there has been emerging evidence regarding a potential role for grapes in slowing cognitive…
- Trial name
- NCT03361410
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Los Angeles
Amyotrophic Lateral Sclerosis (ALS)
Testing Pulse Stimulation to Improve Motor Function in People With ALS: A Pilot Study
The goal of this clinical trial is to assess the efficacy of TPS of the motor cortex on biomarkers and clinical endpoints in patients with ALS.
- Trial name
- TPS4ALS (NCT06681610)
- Testing
- Transcranial Pulse Stimulation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Parc de Salut Mar
Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders
Lemborexant on Perioperative Sleep Quality in Patients With Parkinson's Disease Undergoing Deep Brain Stimulation
This study tests whether lemborexant, an approved sleep medicine, can improve sleep and recovery in people with Parkinson's disease undergoing deep brain stimulation (DBS) surgery.
- Conditions
- Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders, Deep Brain Stimulation
- Trial name
- NCT07903038
- Testing
- Lemborexant 5 mg, Placabo
- Volunteers
- 128 people
- Sponsor
- Beijing Tiantan Hospital
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