Clinical trials: Degenerative Neurologic Disease
Wilson Disease
Study of Zinc for Wilson Disease
OBJECTIVES: I. Establish the safety and efficacy of extended maintenance zinc therapy in 200 patients with Wilson disease. II. Establish further the role of zinc in the prophylactic treatment of presymptomatic patients by…
- Trial name
- NCT00004338
- Testing
- zinc acetate
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Center for Research Resources (NCRR)
Alzheimer Disease, Dementia
BarcelonaBeta Dementia Prevention Research Clinic: a Study on Risk Factors Disclosure
Alzheimer's disease (AD) is the leading cause of dementia and its prevalence is estimated to exceed 100 million affects by 2050, becoming the main public health problem worldwide.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT03847038
- Testing
- Preventive strategies advice and dementia risk estimate disclosure
- Where
- Spain
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Amyotrophic Lateral Sclerosis
Inspiratory Muscle Training With Powerbreath Device in Patients With ALS
Abstract: Context/background: people affected by Amyotrophic Lateral Sclerosis (ALS) see their own life totally disturbed after the diagnosis.
- Trial name
- NCT04889248
- Testing
- Inspiratory Muscle Training with Powerbreath IMT device.
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universidad Francisco de Vitoria
Alzheimer Disease
Study Evaluating Safety, Tolerability and Pharmacokinetics of Single and Multiple Dose of SAM-531
The main objectives of this study is to assess the safety and tolerability of ascending single and multiple oral doses of SAM-531 in healthy subjects
- Trial name
- NCT00726115
- Testing
- SAM-531
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Parkinson's Disease
Absorption, Distribution, Metabolism and Excretion of [14C]-Labelled BIA 3-202 and Metabolites
The purpose of this study is: To determine the rate and routes of excretion of BIA 3-202 and the mass balance in urine and faeces To determine the kinetics of total radioactivity in blood To determine the kinetics of total…
- Trial name
- NCT02772614
- Testing
- BIA 3-202 (200 mg)
- Where
- Switzerland
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Duchenne Muscular Dystrophy, Amyotrophic Lateral Sclerosis
Evaluation of a Mechanical Device During Acute Respiratory Failure in Patients With Neuromuscular Disorders
The hypothesis is that a mechanical insufflation-exsufflation (MI-E) is associated with a decrease in the number of intubations and more rapid clinical improvement in children and adults with neuromuscular disease who are…
- Conditions
- Duchenne Muscular Dystrophy, Amyotrophic Lateral Sclerosis, Neuromuscular Diseases
- Trial name
- Nemucough (NCT00839033)
- Testing
- mechanical insufflation - exsufflation, Standard respiratory physiotherapy
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myotonic Dystrophy 1
Myotonic Dystrophy Type 1 and Resistance Exercise
The purpose of this study is to investigate the response after one bout of moderate-heavy resistance exercise in patients suffering from Myotonic Dystrophy type 1.
- Trial name
- STYRK DM1 (NCT05036447)
- Testing
- Moderate-Heavy Resistance Exercise
- Where
- Norway
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Parkinson's Disease
Hub and Spoke, Comparative Outcomes for Parkinson's Disease Treated With Deep Brain Stimulation
Outcomes study to test the hypothesis that patients first identified by community-based neurologists, implanted by a networked movement disorders center, and then managed by the same community-based neurologist will have clinical…
- Trial name
- Hub&Spoke (NCT02541617)
- Testing
- Programming by community Neurologist, Standard of care
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Psychosis, Dementia
A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression
A ten-week study to assess MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression
- Conditions
- Psychosis, Dementia, Aggression, Agitation
- Trial name
- NCT03044249
- Testing
- MP-101
- Where
- 20 sites in United States, Canada
- Volunteers
- 81 people
- Sponsor
- Mediti Pharma Inc.
Lateral Sclerosis
Validation of the French Version of the Primary Lateral Sclerosis Functioning Rating Scale (PLSFRS)
This is a national, multicentric, prospective, descriptive study evaluating the psychometric properties of the French version PLSFRS scale
- Trial name
- FRENPRILS (NCT06878235)
- Testing
- Assessment of the functional status
- Where
- 7 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Tours
Cardiac Amyloidosis, Chest Pain
CHEST-CA: Study of Chest Pain and Hidden Cardiac Amyloidosis
The objective of this observational, prospective study is to determine the prevalence of Cardiac Amyloidosis (CA) in males over the age of 65 who experience chest pain but show no signs of coronary artery disease (CAD).
- Trial name
- CHEST-CA (NCT07435168)
- Testing
- Screening thourgh examinations including bonescintigraphy
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Alzheimer Disease
Therapeutic Role of Transcranial DCS in Alzheimer
The aim of this study is to evaluate the oxidative stress and brain damage biomarkers induced by tDCS in patients with AD and to assess the long term neurophysiological and behavioral effects after repeated daily tDCS sessions…
- Trial name
- NCT03313518
- Testing
- tDCS
- Volunteers
- 30 people
- Sponsor
- Assiut University
Presbycusis, Bilateral, Alzheimer Disease 2 Due to Apoe4 Isoform
Hearing Aid and Individuals With Cognitive Disorders
This is a pilot study with the aim of evaluating the feasibility of the procedures of a future clinical trial that will help determine the impacts of hearing aid interventions on older patients with Alzheimer's Disease and…
- Conditions
- Presbycusis, Bilateral, Alzheimer Disease 2 Due to Apoe4 Isoform, Mild Cognitive Impairment
- Trial name
- NCT04049643
- Testing
- Audiologist-based fitting, Service-only Fitting, Device-only fitting
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Yu-Hsiang Wu
Alzheimer Disease, Subjective Cognitive Decline
Early Diagnosis of SCD Based on Radiogenomics
The incidence of AD dementia is increasing due to the aging population, putting a heavy burden on our society and economics. Exploring the mechanisms underlying SCD due to preclinical AD has scientific and clinical significance.
- Conditions
- Alzheimer Disease, Subjective Cognitive Decline, Neuroimaging, Gene
- Trial name
- NCT04696315
- Testing
- Multiple features extraction
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Ying Han
Parkinson's Disease
Parkinson's Disease Evaluated by PET and the Effect of Memantine
Purpose of study: To investigate whether the NMDA antagonist Memantine has a substantial effect of brain metabolism in patients with Parkinson's disease (PD), using Positron Emission Tomography (PET).
- Trial name
- NCT00375778
- Testing
- memantine (drug)
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Alzheimer Dementia (AD), Caregiver Burden of People With Dementia
VICA: A Virtual Care Assistant for Dementia Caregivers
This pilot randomized controlled trial evaluates the feasibility and preliminary efficacy of VICA, an AI-powered virtual care assistant that delivers evidence-based education, symptom monitoring, and coaching to informal…
- Trial name
- VICA (NCT07779785)
- Testing
- VICA - Virtual Informal Care Assistant, Education only BPSD mobile app
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
Alzheimer Disease, Healthy
A Study of LY3372993 in Participants With Alzheimer's Disease (AD) and Healthy Participants
The main purpose of this study is to evaluate the safety and tolerability of LY3372993 in participants with AD, non-Japanese, and Japanese healthy participants who are of first-generation Japanese origin.
- Trial name
- NCT04451408
- Testing
- LY3372993
- Where
- 13 sites in United States, Japan
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Parkinson Disease (PD)
Bayesian Optimization of DBS for Gait
This project aims to establish the feasibility of Bayesian optimization for tuning deep brain stimulation (DBS) to treat gait symptoms in Parkinson's disease (PD) patients.
- Trial name
- BOG DBS (NCT07835308)
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Huntington Disease
Mitochondrial Biomarkers in Huntington's Disease
The objective of this study is to discover a panel of mitochondrial metabolomics biomarkers for Huntington's disease.
- Trial name
- NCT04515550
- Testing
- lumbar puncture
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Neurogenic Dysphonia, Neurogenic Dysphagia
Neurogenic Dysphonia/Dysphagia Registry
The Neurogenic Dysphonia/Dysphagia Registry is designed to be purely observational (i.e. non-interventional, exploratory). Patient data collected from the registry is expected to be consistent with any information which can be…
- Trial name
- StrongVoice (NCT02493491)
- Where
- 12 sites in United States
- Volunteers
- 146 people
- Sponsor
- Merz North America, Inc.
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