Clinical trials: Degenerative Neurologic Disease
Parkinson Disease
Compensation Mechanisms in Parkinson's Disease
Parkinson's disease onset is clinically defined as the appearance of motor symptoms including akinesia, tremor and hypertonia. Several studies have shown that motor symptoms occur when at least 50 % of dopaminergic neurons are…
- Trial name
- DATACOMT (NCT02869945)
- Testing
- Identification of COMT HH, COMT HL or COMT LL genes, Brain MRI with resting state scan, Brain MPET
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Precision Sensorimotor Neurorehabilitation Through Personalized Stimulation Loops
Parkinson's disease (PD) is a neurodegenerative disease that affects about 1% of the elderly population and accounts for substantial disability and health care costs.
- Trial name
- StimuLOOP-PD (NCT06608875)
- Testing
- Hyper-personalized feedback (HPF intervention), Targeted auditory stimulation during sleep (TASS verum intervention)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Neurofibromatosis 2, Meningioma
AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas
The goal of this clinical research study is to learn if the study drug AZD2014 can shrink growing or symptomatic meningiomas.
- Trial name
- NCT02831257
- Testing
- AZD2014
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer's Disease, Dementia With Lewy Bodies
Imaging of Brain Amyloid Plaques in the Aging Population
This is a prospective, open label, non-therapeutic, diagnostic imaging study. The purpose of this study is to utilize Pittsburgh Compound B positron emission imaging (PiB PET) to ascertain the relationship between change in…
- Conditions
- Alzheimer's Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Vascular Dementia
- Trial name
- NCT00950430
- Testing
- Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451)
- Where
- United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Optic, Atrophy, Hereditary, Leber
Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation
The goal of this clinical trial is to assess the effectiveness of GS010, a gene therapy, in improving the visual outcome in participants with Leber Hereditary Optic Neuropathy (LHON) due to the G11778A ND4 mitochondrial mutation…
- Trial name
- RESCUE (NCT02652767)
- Testing
- GS010
- Where
- 7 sites in United States, France and 3 more
- Volunteers
- 39 people
- Sponsor
- GenSight Biologics
Parkinson Disease
Evaluation of Functional and Biochemical Effectiveness of a Strength Training Protocol in Parkinson's Disease
Parkinson's Disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, which results in a range of motor symptoms such as tremor, rigidity, and bradykinesia, as well as…
- Trial name
- POWER-PD (NCT07095400)
- Testing
- strength training
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Universidad Villanueva
Dementia, Movement Disorders
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.
The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner.
- Conditions
- Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy
- Trial name
- NCT07595666
- Testing
- Standard-of-care PET/CT, NeuroEXPLORER
- Where
- Belgium
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Parkinson Disease, Idiopathic Parkinson Disease
Physiological Effects of Nutritional Support in Patients With Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder of unknown cause that affects more than a million Americans. It's most prominent pathology is the degeneration of dopaminergic neurons in the brain.
- Trial name
- NCT02445651
- Testing
- Intravenous and Oral n-acetyl cysteine, Control group, Oral Supplements: Baicalin, Ganoderma, Omega 3 and Curcumin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Thomas Jefferson University
Alzheimer Disease
Illiteracy and Vulnerability to Alzheimer's Disease: Evaluation of Amyloid Pathology by PET Imaging
The goal of this study is to improve the diagnosis of Alzheimer's disease (AD) at two different stages (MCI and dementia) in illiterate subjects, using FDG- fluorodeoxyglucose - and florbetapir F 18 -PET imaging.
- Trial name
- AVILL (NCT02494531)
- Testing
- Fluorodeoxyglucose-PET, florbetapir F 18-PET
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson's Disease (PD), Parkinson Disease 6, Early-Onset
Phase Ⅲ Clinical Trial to Evaluate the Efficacy and Safety of TJ0113 Capsules in Patients With Early-Onset Parkinson's Disease
This study is a randomized, double-blind, multicenter, placebo-controlled Phase III clinical trial designed to evaluate the efficacy, safety, and Pop PK characteristics of TJ0113 Capsules in treating EOPD patients.
- Trial name
- NCT07741045
- Testing
- TJ0113 200mg, TJ0113 400mg
- Where
- 21 sites in China
- Volunteers
- 300 people
- Sponsor
- Hangzhou PhecdaMed Co., Ltd.
Parkinson Disease
Primary Parkinsonian Pain Diagnostic Questionnaire: Development and Validation of This Questionnaire
Development and validation of a diagnosis questionnaire of parkinsonian primary pain: the "Primary Parkinsonian Pain Diagnostic Questionnaire" (3PDQ)
- Trial name
- 3PDQ (NCT03940872)
- Testing
- Self-questionnaire 3PDQ
- Where
- 10 sites in France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Toulouse
Atherosclerosis, Cardiovascular Diseases
Multi-Ethnic Study of Atherosclerosis (MESA) - Ancillary Eye Study
To evaluate the relation of retinal microvascular characteristics to subclinical cardiovascular disease, clinical disease, and their risk factors in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease
- Trial name
- MESA-Eye (NCT00041444)
- Volunteers
- 6,176 people
- Sponsor
- University of Wisconsin, Madison
Alzheimer's Disease
Preliminary Efficacy and Safety Study of ST101 in Alzheimer's Disease
This study will investigate the ability of ST101 to improve memory in people with Alzheimer's disease. This study also will examine the safety and tolerability of the drug.
- Trial name
- NCT00842673
- Testing
- ST101
- Where
- 18 sites in United States, Canada
- Volunteers
- 168 people
- Sponsor
- Sonexa Therapeutics, Inc.
Parkinson Disease
Strategy for Daily Activity Improvement in Patients With Parkinson's Disease
The symptoms and signs of patients with Parkinson's disease (PD) include bradykinesia, rigidity, tremor and poor sensory integration, which result in mobility disability.
- Trial name
- Parkinson (NCT03972241)
- Testing
- foot insole
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kwan-Hwa Lin
Parkinson's Disease, Physical Activity
Effect of High Intensity Interval Training on Mechanisms of Neuroplasticity in Parkinson's Disease Patients
There are experimental evidences of the important role of high intensity physical exercise in Parkinson's disease (PD) treatment, that induces similar effects to pharmacotherapy.
- Conditions
- Parkinson's Disease, Physical Activity, Neurorehabilitation, Neuroplasticity
- Trial name
- NCT04204551
- Testing
- high-intensity interval training (HIIT), conventional physical therapy
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Lewy Body Dementia
Non-invasive Transcranial Focused Low-intensity Ultrasound Stimulation in Patients With Mild Lewy Body Dementia
A randomized controlled clinical study was conducted in the xuanwu hospital Single Center of Capital Medical University to preliminarily explore the efficacy and safety of transcranial focused low-intensity ultrasound stimulation…
- Trial name
- tFUS in DLB (NCT05499429)
- Testing
- Transcranial low intensity focused ultrasound stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Voice Quality and Voice Loudness Associated With Parkinson's Disease
Singing in Groups for Parkinson's Disease; A Pilot Study of Group Singing Therapy for PD-related Voice/Speech Impairment
This study will compare group singing to group speech therapy without singing. You may be eligible for this study if you have been diagnosed with PD for one year or more and you have a quiet voice or difficulty being understood.
- Trial name
- SING-PD (NCT01163331)
- Testing
- Singing Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Amyotrophic Lateral Sclerosis
The Use of Airway Clearance Devices in ALS
The investigator is examining the use of one airway clearance medical device compared to the use of two airway clearance medical devices together in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT02682030
- Testing
- High Frequency Chest Compression Device (HFCC), Cough Assist
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Cedars-Sinai Medical Center
ALS
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
This study is a placebo-controlled Phase I study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide (ASO) AMX0114 in adult participants with amyotrophic lateral sclerosis…
- Trial name
- LUMINA (NCT06665165)
- Testing
- AMX0114
- Where
- 14 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- Amylyx Pharmaceuticals Inc.
Alzheimer Disease
DORA and LP in Alzheimer's Disease Biomarkers
The purpose of this study is to see if the sleep aid, lemborexant, can decrease the amount of amyloid-beta and tau in the blood. Amyloid-beta and tau are proteins involved in the disease process leading to Alzheimer's disease.
- Trial name
- NCT06274528
- Testing
- Lemborexant 10 mg, Lemborexant 20mg
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
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