Clinical trials: Degenerative Osteoarthritis
Osteoarthritis, Knee
Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement
Tranexamic acid (TXA) is a drug that is being used more frequently at the Hospital for Special Surgery to lessen the amount of blood loss after total knee replacement (TKR).
- Trial name
- TXA Knee (NCT02540226)
- Testing
- Intravenous tranexamic acid, Topical tranexamic acid, Intravenous saline
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Knee, Total Knee Arthroplasty
Oral Fluid vs IV Fluid After Primary TKA
The goal of this study is to compared efficacy of oral fluid and intravenous fluid after primary unilateral total knee arthroplasty.
- Conditions
- Osteoarthritis, Knee, Total Knee Arthroplasty, Oral Fluid Replacement
- Trial name
- NCT06288815
- Testing
- Oral fluid, IV fluid
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Thammasat University Hospital
Osteoarthritis, Knee
Does Rehabilitation After Total Knee Arthroplasty Work? - Feasibility Trial
The aim of this feasibility trial is to investigate the feasibility of a trial intervention for a population of patients after total knee replacement for osteoarthritis.
- Trial name
- DRAW-TKA-Fea (NCT05935020)
- Testing
- Usual care - Municipal exercise-based rehabilitation, Return to Everyday life, Symptom guide and encouragement to follow DHA/WHO recommendations for physical activity
- Where
- 2 sites in Denmark
- Volunteers
- 25 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Knee Osteoarthritis
Pharmacokinetics of Imrecoxib in Subjects With Hepatic Insufficiency
This clinical research study will assess pharmacokinetics and the safety of Imrecoxib in patients with impaired hepatic function as compared to healthy volunteers.
- Trial name
- NCT02456688
- Testing
- Imrecoxib
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Osteoarthritis of Knee
Accuracy of MRI-based Patients Matched Instruments vs Jig-based Instruments in Total Knee Arthroplasty (TKA)
Total knee arthroplasty (TKA) is the common and effective procedure for treatment of end-staged knee osteoarthritis. Postoperative alignment of TKA is one of the important factors which effects on survival of prosthesis.
- Trial name
- NCT01449474
- Testing
- Patient matched instruments, Jig based instruments
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Osteoarthritis, Osteoarthritis, Knee
A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis
The purpose of this study is to evaluate pain relief, safety, and tolerability of a new treatment (JNJ-42160443) for moderate to severe pain of osteoarthritis of the knee in comparison to a standard pain treatment and placebo.
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Pain, Arthralgia
- Trial name
- NCT01094262
- Testing
- Oxycodone CR (standard pain medication), JNJ-42160443
- Where
- 44 sites in United States, Canada
- Volunteers
- 196 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteoarthritis (OA) of the Knee, Osteoarthitis
Effect of High-Intensity Laser Therapy on Femoral Cartilage in Knee Osteoarthritis
This clinical trial will evaluate the effects of High-Intensity Laser Therapy (HILT) on femoral cartilage thickness and other clinical outcomes in people with knee osteoarthritis.
- Trial name
- HILT-KOA (NCT07584603)
- Testing
- High-Intensity Laser Therapy (HILT) + Conventional Physiotherapy, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- University of Lahore
Osteoarthritis, Knee, Osteoarthritis, Hip
Role of Topical Vancomycin in Reducing Infections in Hip and Knee Arthroplasty
The study is designed to assess the efficacy of vancomycin powder and dilute povidone-iodine lavage (VIP protocol) in reducing the PJI after primary Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA).
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis of Hip
- Trial name
- NCT05972603
- Testing
- 1.0 g Vancomycin powder into the wound, 0,35% povidone-iodine solution lavage
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Independent Public Healthcare Center in Rypin
Osteoarthritis (OA) of the Knee, Physiotherapy
Pharmacist-physiotherapist Collaborative Management for Early Knee Osteoarthritis
Osteoarthritis (OA) is a slowly progressive chronic condition that is associated with aging and is characterized as joint pain. Individuals with early-stage OA usually do not seek medical attention.
- Conditions
- Osteoarthritis (OA) of the Knee, Physiotherapy, Pharmacy
- Trial name
- PACE-OA (NCT06681142)
- Testing
- Pharmacy-Physiotherapy Intervention
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- University of Alberta
Degenerative Joint Disease
Platelet-Rich Plasma vs Corticosteroid Injection as Treatment for Degenerative Pathology of the Temporomandibular Joint
1.0 BACKGROUND AND HYPOTHESES 1.1 Osteoarthritis is a continuous and entirely physiologic adaptive process that occurs in every joint.
- Trial name
- NCT01920373
- Testing
- Group A (corticosteroid injection group), Group B (platelet rich plasma injection group)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Osteoarthritis, Knee
Efficacy and Safety Study of Transdermal Therapeutic System (TTS) Fentanyl in Participants With Osteoarthritis Knee Pain
The purpose of this study is to evaluate the efficacy and safety of Transdermal therapeutic system (TTS) fentanyl patches (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01742897
- Testing
- TTS-fentanyl
- Where
- Thailand
- Volunteers
- 35 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Osteoarthritis, Knee
TKA Operating Room Efficiency for TKA Using Customized Implant Techniques
This is a multi-centered prospective, consecutively enrolled study that will be conducted in the United States. Surgeons that are new users of the iTotal Knee system (defined by no experience using the customized Total Knee…
- Trial name
- NCT04180423
- Testing
- Off-the-Shelf Implant Total Knee Replacement, Customized Implant Total Knee Replacement
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Restor3D
Osteoarthritis, Knee
The Study of the Efficacy of Laser Acupuncture on Osteoarthritis Knees by Using Magnetic Resonance Imaging, Clinical Evaluation, and Movement Analysis
To study the efficacy of laser acupuncture on osteoarthritis (OA) knee patients by magnetic resonance imaging (MRI), clinical evaluation and movement analysis.
- Trial name
- NCT04275427
- Testing
- LA-400 laser acupuncture
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Osteoarthritis of the Shoulder, Avascular Necrosis
Database Retrieval for the Comprehensive Shoulder
This study is a retrieval of database information regarding survivorship of the Comprehensive Shoulder System family of products.
- Conditions
- Osteoarthritis of the Shoulder, Avascular Necrosis, Rheumatoid Arthritis, Prior Failed Revision
- Trial name
- NCT03409718
- Testing
- Biomet Comprehensive Shoulder System
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical
The purpose of this study is to determine whether topical or intravenous administration of tranexamic acid during unilateral total knee replacement is more effective at reducing bleeding in the first 24 hours following surgery.
- Trial name
- NCT01940523
- Testing
- Topical Tranexamic Acid, Intravenous Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 640 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Knee, Depressive Symptoms
Study on Brain Structure and Function of Pain-related Emotion Disorder
By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.
- Conditions
- Osteoarthritis, Knee, Depressive Symptoms, Anxiety State
- Trial name
- NCT03912610
- Testing
- Functional magnetic resonance examination
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zhoujie
Hip Arthropathy, Hip Osteoarthritis
Post Market Clinical Follow-up of EUROSCUP Fixe Acetabular Cup
EUROSCUP Fixe is intended for use in primary and revision total hip replacement surgery. Hip replacement is intended to provide increased patient mobility and reduce pain by replacing the damages hip joint articulation in…
- Conditions
- Hip Arthropathy, Hip Osteoarthritis, Hip Necrosis, Hip Fractures
- Trial name
- NCT05142462
- Testing
- Hip arthroplasty
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- EUROS
Knee Osteoarthritis
Optimization of Synvisc-One for Knee OA
The study hypothesis is that the use of Synvisc-One will improve physical therapy compliance and performance, resulting in improved knee function and pain when compared to a group that receives a sham injection (an injection that…
- Trial name
- NCT02029703
- Testing
- Synvisc-One Injection
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Elaine Husni
Osteoarthritis, Knee
Cycling Intervention on Symptoms of Patients With Knee Osteoarthritis
This study is designed to determine the effect of a cycling training program which modulates frontal and sagittal plane knee joint loading with graded increases of Q-Factor and cycling workrate in persons with symptomatic knee…
- Trial name
- NCT04139161
- Testing
- Q-Factor Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Tennessee, Knoxville
Femoral Neck Fracture, Osteoarthritis
Dual Mobility Cup in Total Hip Arthroplasty Preventing Dislocation in Patients at Risk
Retrospectively study reviewing 34 patients operated with dual mobility cups in total hip arthroplasty between January 2009 and June 2012 at Sundsvall Hospital.
- Trial name
- NCT01644227
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Sundsvall Hospital
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