Clinical trials: Degenerative Osteoarthritis
Osteoarthritis Knee, Corticosteroid
Intra-articular Platelet Rich Plasma vs Corticosteroid in Treatment of Knee Osteoarthritis Patients
Knee osteoarthritis is the most common type of osteoarthritis in the lower extremity and constitutes 23% of all arthritis cases, about 13% of females and 10% of males aged above 60 years have symptomatic knee OA.
- Conditions
- Osteoarthritis Knee, Corticosteroid, Platelet Rich Plasma
- Trial name
- NCT05742061
- Testing
- Corticosteroid, Platelet Rich Plasma
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Benha University
Osteoarthritis of the Knee
A Pragmatic Trial To Determine the Benefit of Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee
Knee osteoarthritis (KOA) is one of the most common and disabling conditions among Veterans. Management of KOA is challenging as there are few effective treatments other than joint replacement.
- Trial name
- MOVE-OK (NCT03835910)
- Testing
- Social Incentives and Gamification to Promote Exercise, Corticosteroid Injection given in A-B order, No Social Incentive applied
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis, Hypertension
A Study to Assess the Effects of Naproxcinod and Naproxen on Blood Pressure Measurements in Osteoarthritis Patients With Controlled High Blood Pressure
To assess the effect of naproxcinod vs. naproxen on arterial blood pressure patients with osteoarthritis and controlled essential hypertension
- Trial name
- HCT3012-X-111 (NCT00662610)
- Testing
- naproxcinod 375 mg -750 mg -1125 mg bid, naproxen 250 mg - 500mg -750 mg bid
- Where
- 29 sites in United States
- Volunteers
- 120 people
- Sponsor
- NicOx
Osteoarthritis, Knee
Radiofrequency Ablation on Pain Relief of Knee Osteoarthritis
Introduction Osteoarthritis (OA) is a chronic, progressive disease with high disability and teratogenicity in the joints. Deterioration of the articular cartilage is the main problem associated with osteoarthritis, which…
- Trial name
- NCT05050396
- Testing
- Cooled versus thermocoagulant Radiofrequency Ablation in pain relief of knee osteoarthritis
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteoarthritis
Massachusetts General Hospital Evaluation of DePuy ASR Hip System
DePuy Orthopaedics has issued a voluntary recall of the ASR hip replacement system due to a higher than expected revision rate reported in the England/Wales and Australian national joint registries.
- Trial name
- NCT01611233
- Where
- 13 sites in United States, Australia and 3 more
- Volunteers
- 1,950 people
- Sponsor
- Massachusetts General Hospital
Arthritis
Allograft Meniscal Arthroplasty for the Treatment of Basal Joint Arthritis of the Thumb
Hypothesis: The use of knee meniscal allograft as a joint spacer and stabilizer is a viable option for the surgical treatment of basal joint arthritis of the thumb.
- Trial name
- NCT01542515
- Testing
- Meniscal allograft arthroplasty of the carpometacarpal joint of the thumb
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Corewell Health East
Knee Osteoarthritis, Pain, Postoperative
Investigation of the Effect of Preoperative Education on Postoperative Outcomes in Total Knee Arthroplasty Patients
Total knee arthroplasty surgery is a common surgical procedure used in the treatment of patients in the end stages of osteoarthritis.
- Conditions
- Knee Osteoarthritis, Pain, Postoperative, Kinesiophobia
- Trial name
- NCT05178615
- Testing
- preoperative education
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Knee Osteoarthritis
Effects of Bandaging and Kinesiotaping® in Patients With Total Knee Arthroplasty
The study aimed to compare the effectiveness of elastic bandaging, Kinesio taping, and short stretch bandaging techniques on postoperative pain, edema, and functional level in the early stage after total knee arthroplasty.
- Trial name
- NCT05847725
- Testing
- Elastic bandaging, Short stretch bandaging, Kinesio taping
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Knee Osteoarthritis
Comparison of Mini Squat and Endurance Training in Improving Quality of Life in Knee Osteoarthritis
Interventional type of study in which one group of participants will be given mini squats training and other endurance training to improve the quality of life of knee osteoarthritis patients.
- Trial name
- NCT06056076
- Testing
- Mini Squats Training, Endurance Training
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neuro Counsel Hospital, Pakistan
Osteoarthritis, Total Knee Replacement
Time-dependent Improvement of Functional Outcome Following LCS Rotating Platform TKR
The objective of this prospective study is to determine (1) the time course of patient-relevant functional outcome evaluated by the Knee injury and Osteoarthritis Outcome Score (KOOS) and (2) the time course of range of motion…
- Trial name
- NCT01030848
- Testing
- Total Knee Replacement (LCS rotating platform)
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Vestre Viken Hospital Trust
Osteoarthritis, Knee
Stryker Triathlon® Cruciate Substituting vs. Posterior Stabilized Outcomes Study
This study compares the clinical and radiographic outcomes obtained with the use of the Stryker Triathalon® Cruciate Substituting (CS) and Posterior Stabilized (PS) tibial inserts.
- Trial name
- NCT01367925
- Testing
- Stryker Triathlon® CS Tibial Insert, Stryker Triathlon® PS Tibial Insert
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Knee Osteoarthritis
Effect of Foot Massage on Pain and Analgesic Consumption in Total Knee Prosthesis
This randomized controlled trial aims to examine the effects of foot massage combined with cold application on postoperative pain, patient satisfaction, and analgesic consumption in individuals undergoing Total Knee Arthroplasty…
- Trial name
- NCT07126340
- Testing
- Foot Massage and Cold Application, Cold Application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alev Keskin
Osteoarthritis, Knee
Study to Evaluate the Efficacy and Safety of Intra-articular DA-5202 in Patients With Osteoarthritis of the Knee
This Phase II clinical study is to evaluate the efficacy and safety of DA-5202 in patients with osteoarthritis of the knee.
- Trial name
- NCT02554240
- Testing
- DA-5202 20mg, DA-5202 10mg, Na Hyaluronate 20mg
- Where
- South Korea
- Volunteers
- 115 people
- Sponsor
- Dong-A ST Co., Ltd.
Osteoarthritis, Knee
Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain
This is a multi-center, randomized, double-blind, parallel group, placebo controlled trial to compare the safety and effectiveness of a single injection of Cingal® to a single injection of Triamcinolone Hexacetonide (TH) to…
- Trial name
- NCT04231318
- Testing
- Cingal, Triamcinolone Hexacetonide (TH)
- Where
- 26 sites in United States
- Volunteers
- 231 people
- Sponsor
- Anika Therapeutics, Inc.
Osteoarthritis, Rheumatoid Arthritis
A Randomised Trial Comparing Anterior Versus Posterior Approach in Total Hip Replacement
This is a single-centre, randomised, prospective clinical follow-up study to evaluate clinical outcome and gait analysis after total hip arthroplasty using the standard postero-lateral approach or the minimally invasive anterior…
- Trial name
- NCT01106560
- Testing
- Minimally Invasive Anterior Approach, Standard postero-lateral approach
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Medacta International SA
Postsurgical Pain
Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty
Total knee arthroplasty is a surgical treatment which involves replacing the damaged articular cartilage of the knee joint with an artificial prosthetic in end-stage knee osteoarthritis.
- Trial name
- MP-TKA (NCT06202989)
- Testing
- Multiprofen-CC™ plus standard treatment
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- KAZM Pharmaceuticals Inc.
Older Adults (60 - 85 Years Old), OA Knee
Home-Based Quadriceps Isometric Exercise for Knee Osteoarthritis Pain
Knee osteoarthritis is a common cause of pain and reduced mobility in older adults. Many people have limited access to supervised rehabilitation programs, highlighting the need for simple and safe home-based treatment options.
- Trial name
- KOA-ISO01 (NCT07445568)
- Testing
- Cannabidiol (CBD) Topical Gel, Arnica montana Topical Gel, Home-based Quadriceps Isometric Exercise
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Universidad del Valle de México, Campus Cuernavaca
Osteoarthritis, Genu Varum
Clinical Outcomes of Open Wedge High Tibial Osteotomy With Autologous Bone Marrow or Adipose-derived Stem Cell Therapy
The purpose of this research is to confirm the efficacy of cartilage regeneration (or stem cell transplant) simultaneously performed with high tibial osteotomy.
- Trial name
- HTOSC (NCT02642848)
- Testing
- HTO with microfracture, Transplantation of bone marrow stem cell, Transplantation of adipose derived stem cell
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Dongsik Chae
Osteoarthritis of the Knee, Female
A Gender-Specific Posterior Cruciate-Substituting High-Flexion Knee Prosthesis Does Not Improve Fit and Function
The purpose of this study was to compare functional and radiographic results, range of motion of the knee, patient satisfaction, femoral component, revision and complication rates in patients receiving either a standard posterior…
- Trial name
- NCT00917774
- Testing
- Standard LPS flex TKA, Gender specific LPS -Flex TKA
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Ewha Womans University
Osteoarthritis, Rheumatoid Arthritis
Ankle Joint Replacement Outcomes Study
This post market outcome study will look at the therapeutic results of the Salto Talaris Anatomic ankle prosthesis. The study population will consist of patients who will undergo an ankle arthroplasty procedure with a Salto…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Septic Arthritis
- Trial name
- NCT00503438
- Testing
- Salto Talaris Ankle
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Smith & Nephew, Inc.
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