Clinical trials: Degenerative Osteoarthritis
Osteoarthritis, Rheumatoid Arthritis
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
The purpose of this study is to evaluate performance of the Vanguard 360 revision knee system utilizing offset on either the tibial component, femoral component, or both in terms of the restoration of mechanical alignment…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Post Traumatic Deformity
- Trial name
- NCT01542580
- Testing
- Vanguard SSK 360 with PS Bearing, Vanguard SSK 360 with PSC bearing, Vanguard DA 360
- Where
- 12 sites in United States, Belgium and 6 more
- Volunteers
- 255 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Reinforcement of Placebo Response in Knee Osteoarthritis: A Randomised Trial
Saline intra-articular injections used as placebo treatments have been shown to provide pain relief in knee osteoarthritis (OA) It has further been shown that beneficial effects can be induced merely by having a conversation with…
- Trial name
- NCT05225480
- Testing
- Illness perception conversation, research motivation conversation
- Where
- Denmark
- Volunteers
- 103 people
- Sponsor
- Frederiksberg University Hospital
Osteoarthritis (OA)
Effect of Chair Yoga on Elders With Osteoarthritis
The current study is a two-arm randomized controlled clinical trial to test the feasibility of recruiting, randomizing, and having older adults with osteoarthritis (OA) adhere to and safely complete the 8-week Sit 'N' Fit Chair…
- Trial name
- NCT02113410
- Testing
- Sit 'N' Fit Chair Yoga (SNFCY), Health Education Program (HEP)
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Florida Atlantic University
Osteoarthritis of Knees
The Effectiveness of Arthroscopic Cartilage Regeneration Facilitating Procedure for Patients With Knee Osteoarthritis
The aim of this study is to discuss the effect of gait pattern in patients receiving arthroscopic cartilage regeneration facilitating procedure (ACRFP) for treatment of osteoarthritis of knees.
- Trial name
- NCT03452423
- Testing
- ACRFP
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Knee Osteoarthritis
Knee Osteoarthritis and Thermal Spa Treatment
The goal of this interventional study is to evaluate the effectiveness at 6 months of the Enghien-les-Bains thermal spa treatment on functional disability and pain, assessed by the Minimal Clinically Important Improvement (MCII)…
- Trial name
- ENERGIE (NCT07370480)
- Testing
- Thermal spa sessions, Thermal water, Standard of Care for Knee Osteoarthritis
- Where
- 2 sites in France
- Volunteers
- 76 people
- Sponsor
- CEN Biotech
Knee Osteoarthritis
Inflammatory Targeted Laser Treatment of Knee Osteoarthritis
This study is conducted to evaluate the effectiveness of low-level laser therapy (LLLT) as an adjunct to exercise therapy in knee osteoarthritis (KOA).
- Trial name
- NCT03750279
- Testing
- Exercise therapy, LLLT
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University of Bergen
Osteoarthritis, Knee
Radiofrequency Ablation on Pain Relief of Knee Osteoarthritis
Introduction Osteoarthritis (OA) is a chronic, progressive disease with high disability and teratogenicity in the joints. Deterioration of the articular cartilage is the main problem associated with osteoarthritis, which…
- Trial name
- NCT05050396
- Testing
- Cooled versus thermocoagulant Radiofrequency Ablation in pain relief of knee osteoarthritis
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Assiut University
Knee Osteoarthritis
Hydrolyzed Collagen Formulation vs Placebo in Knee Osteoarthritis
The aim of the study is to compare the 6 months clinical outcome of the treatment with a single intra-articular collagen injection versus a single placebo (saline solution) infiltration in the infiltrative treatment of knee…
- Trial name
- NCT04998188
- Testing
- Collagen
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Istituto Ortopedico Rizzoli
Short Bowel Syndrome
Comparison of Different Oral Rehydration Solutions
Compliance is the biggest challenge in patients with Short Bowel Syndrome (SBS) on Home Parenteral Nutrition. These patients need to hydrate themselves to meet the excess fluid loss due to their anatomy.
- Trial name
- ORS (NCT02142582)
- Testing
- WHO ORS, Commercial ORS
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Chronic Knee Pain
Genicular Nerve Radiofrequency Ablation Versus Hyaluronic Acid Injection for Knee Osteoarthritis Pain
The goal of this clinical trial is to learn if thermal radiofrequency ablation of the genicular nerves (the nerves that carry pain signals from the knee) works better than a single injection of hyaluronic acid into the knee to…
- Trial name
- RF-PROSPECTIU (NCT07901374)
- Testing
- Thermal Radiofrequency Ablation of the Genicular Nerves, Intra-articular Hyaluronic Acid
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.
Primary Arthrosis
Post-Approval Study to Investigate the Long Term (8 Year) Survivorship of STAR Ankle Among Continued Access Study Patients
The purpose of this study is to examine the long term survivorship of the Scandinavian Total Ankle Replacement (STAR). Specifically, this study focuses on the revision and/or removal rate of any component of the STAR ankle.
- Trial name
- STAR 8 (NCT01288586)
- Testing
- Scandinavian Total Ankle Replacement System (STAR Ankle)
- Where
- 5 sites in United States
- Volunteers
- 87 people
- Sponsor
- Stryker Trauma and Extremities
Analgesia
Intra-Articular Morphine Versus Bupivacaine on Knee Motion in Patients With Osteoarthritis
CONTEXT AND OBJECTIVE: Osteoarthritis causes pain and disability in a high percentage of elderly people. The aim of the present study was to compare the analgesic effect of intra-articular bupivacaine and morphine in patients…
- Trial name
- NCT00636415
- Testing
- morphine
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Unilateral Primary Osteoarthritis of Knee, Osteoarthritis Knee
Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid
This study seeks to evaluate a treatment for multiple full thickness chondral lesions in the knee. Eligible subjects will undergo a microdrilling surgery and up to 12 post operative intra-articular injections of bone marrow…
- Conditions
- Unilateral Primary Osteoarthritis of Knee, Osteoarthritis Knee, Degeneration; Articular Cartilage, Knee, Degenerative Lesion of Articular Cartilage of Knee
- Trial name
- NCT02285725
- Testing
- Microdrilling Surgery, Injections of BMAC + PRP + HA
- Volunteers
- 21 people
- Sponsor
- Joseph E. Broyles
Osteoarthritis, Knee
Fenugreek Wraps in Osteoarthritis of the Knee
This randomised controlled trial aims to investigate the efficacy of fenugreek wraps in the treatment of primary symptomatic osteoarthritis of the knee.
- Trial name
- BoGon (NCT03528824)
- Testing
- Fenugreek wrap, Diclofenac Gel
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Universität Duisburg-Essen
Knee Osteoarthritis
Bracing to Treat Knee Osteoarthritis in Elderly
Background: Osteoarthritis (OA) is highly prevalent in the elderly, with the knee being the most commonly affected joint in this population. Knee braces are often used to prevent common problems in knees during daily activities.
- Trial name
- NCT02443974
- Testing
- Brace (Fisiotensor®), Sleeve (Fisiotensor®)
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of São Paulo
Osteoarthritis, Knee, Orthopedic Disorder
Gait, Pain and Physical Activity After HTO
This study aims to investigate the relationship between pain, gait and activity intensity in HTO patients that are healed and have had their fixation plate removed.
- Trial name
- NCT04619550
- Testing
- High tibial osteotomy
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Winchester
Knee Osteoarthritis, Total Knee Arthroplastry
The Effect of Proprioceptive Neuromuscular Facilitation and Tendon Vibration After Total Knee Arthroplasty
Knee osteoarthritis is a degenerative joint disease characterized by the destruction and progressive loss of articular cartilage.
- Trial name
- NCT05920590
- Testing
- PNF, PNF plus Tendon Vibration, Control
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- International Hellenic University
Osteoarthritis, Quality of Life
Osteoarthritis in Terms of ICF Components
Osteoarthritis (OA) is a common degenerative disease associated with functional impairments, activity limitations, participation restrictions, as well as poor quality life.
- Conditions
- Osteoarthritis, Quality of Life, OUTCOME MEASURES
- Trial name
- NCT04956510
- Testing
- Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Pamukkale University
Osteoarthritis, Knee
Comparative Effectiveness and Safety of Two Hyaluronic Acid Products in Knee Osteoarthritis
Knee osteoarthritis is a condition that causes pain, stiffness, and difficulty moving the knee. Some people continue to have symptoms despite receiving usual treatments, such as pain medications, exercise, and physical therapy.
- Trial name
- NCT07911696
- Testing
- Hylan G-F 20, Cross-Linked Sodium Hyaluronate
- Where
- Mexico
- Volunteers
- 160 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Knee Osteoarthritis
The Effect of Intra-articular Bilateral Knee Injections of Zilretta on Performance Measures in Adults With Knee OA
This study will be an open-label trial to determine the functional effects of bilateral IA injections of Zilretta into knee joints of 70 subjects with bilateral KL grade 2-4 symptomatic knee osteoarthritis (OA).
- Trial name
- NCT03895840
- Testing
- Zilretta
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Kansas Medical Center
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