Clinical trials: Degenerative Osteoarthritis
Osteo Arthritis of the Knees
Effect of Interventions on the Progression of Knee Osteoarthritis
There has been intensive search for a substance that can have disease-modifying activity for osteoarthritis. A number of medications have been reported to be of benefit on slowing progression of knee OA.
- Trial name
- KAPS (NCT02178137)
- Testing
- Diacerien, Glucosamine/Chondroitin
- Where
- Pakistan
- Volunteers
- 322 people
- Sponsor
- Indus Hospital and Health Network
Knee Osteoarthritis (Mild to Moderate, Medial Compartment)
Enhancing Medial Knee Pain Rehabilitation : A Clinical Trial On The Effectiveness Of Blood Flow Restriction In Combination With Targeted Exercises For Adult With Varus Deformity
Medial knee pain is common in active adults with varus knee alignment and can limit daily and sports activities. Standard physiotherapy can reduce pain and improve function, but strength gains may be suboptimal when patients…
- Trial name
- NCT07283237
- Testing
- Targeted Exercise Program, Blood Flow Restriction (BFR) Training with Targeted Exercise Program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Osteoarthritis, Knee
The Inclination of the Proximal Tibiofibular Joint Surface and Medial Compartment Knee Osteoarthritis
This study aims to research on the association between the inclination of the proximal tibiofibular joint surface and medial compartment knee osteoarthritis.
- Trial name
- NCT03147495
- Testing
- Standing anteroposterior knee radiographs and special proximal tibiofibular joint radiograph.
- Where
- China
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- 113th Hospital of Chinese People's Liberation Army
Inflammation, Osteoarthritis
Photobiomodulation Therapy in Patients Receiving Total Knee Arthroplasty
Photobiomdoulation is the use of near-infrared light to relieve pain, stimulate healing and reduce inflammation. Swelling and inflammation is a common condition after orthopedics surgeries over extremity and spine.
- Conditions
- Inflammation, Osteoarthritis, Post Operative Pain
- Trial name
- NCT06426251
- Testing
- Photobiomodulation
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Osteoarthritis (OA) of the Knee
Impact of Blood-Flow-Restriction Prehabilitation on Pre- and Postoperative Rehabilitation After Total Knee Arthroplasty
Degenerative and traumatic diseases of the musculoskeletal system lead to increased immobility of a patient, which in turn results in muscle atrophy.
- Trial name
- NCT06964022
- Testing
- BFR
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital, Bonn
Osteoarthritis of the Knees
Determining the Optimal Dose of AD-211 in Patients With Osteoarthritis of the Knee
The purpose of this study is to determine the optimal dose of AD-211 in patients with osteoarthritis of the knee.
- Trial name
- NCT07550231
- Testing
- AD-211-L, AD-211-M, AD-211-H
- Volunteers
- 200 people
- Sponsor
- Addpharma Inc.
Osteoarthritis, Knee
JOURNEY™ II CR Total Knee System
The purpose of this study is to evaluate the safety and effectiveness of the JOURNEY™ II CR Total Knee System in subjects with degenerative joint disease (DJD) requiring primary total knee replacement.
- Trial name
- NCT02440672
- Testing
- JOURNEY™ II CR Total Knee System (J II CR TKS)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis
Importance of Restoring Biomechanical Correct Hip Anatomy During Total Hip Arthroplasty
The purpose of this prospective, randomized study is to evaluate the importance of restoring the exact individual hip biomechanics during total hip arthroplasty.
- Trial name
- NCT01512550
- Testing
- GF hip guide, Stryker Navigation System, ABG II modular femoral component
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Region Skane
Osteoarthritis of the Hip, Postoperative Pain
FRONT Block for Quality of Recovery After Total Hip Arthroplasty
This prospective randomized controlled trial evaluates the effect of ultrasound-guided unilateral Femoral Rami and Obturator Nerve Trunk (FRONT) block on postoperative quality of recovery in patients undergoing elective total hip…
- Conditions
- Osteoarthritis of the Hip, Postoperative Pain, Quality of Recovery
- Trial name
- NCT07458360
- Testing
- FRONT Block (Femoral Rami and Obturator Nerve Trunk Block), Standard Multimodal Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya Meram State Hospital
Mild to Moderate Acne, Stiffness of Joint, Nec, Involving Ankle and Foot in MDR24_1
A Proof of Science, Dose-Response Study to Evaluate the Safety, Efficacy of Different Dosages of Test Treatments
A proof of science clinical study with randomized, four-arm, comparative, single-blind, within the arm - Dose-Response Study to evaluate the safety and efficacy of different collagen peptide-containing test treatments in adult…
- Conditions
- Mild to Moderate Acne, Stiffness of Joint, Nec, Involving Ankle and Foot in MDR24_1, Other Specified Diseases of Hair and Hair Follicles, Brittle Nails
- Trial name
- NCT05613660
- Testing
- Veg Collagen Peptide, Bovine Collagen Peptide, Fish | Marine Collagen Peptide
- Where
- India
- Volunteers
- 264 people
- Sponsor
- NovoBliss Research Pvt Ltd
Knee Osteoarthritis, Knee Arthritis
Maximal Rate of Force Development of Ankle Muscles and Functional Ability in Patients With Knee Osteoarthritis
This study is a detailed assessment of the maximal rate of force development of ankle muscles and its association with functional ability in patients with knee osteoarthritis (OA).
- Trial name
- NCT06063889
- Testing
- Maximal Rate of Force Development Test for Ankle Muscles
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Ahram Canadian University
Osteoarthritis,Knee
Celebrex Short Versus Long Therapy In Osteoarthritis Of The Knee
This is a phase III, multicentre, randomized, double blind, parallel-group, pilot study designed to compare a long term (12 weeks) versus a short term (2 weeks) treatment with celecoxib 200 mg/die in treatment and prevention of…
- Trial name
- NCT00137410
- Testing
- Celebrex
- Where
- 16 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Pfizer
Knee Osteoarthritis
Cartilage Recovery in Adults With Knee Osteorthritis by Mesenchymal Cell Therapy: Randomized Trial of Radiologic and Clinical Outcomes
The treatment of osteoarthritis (OA) of the knee remains still controversial. Despite that fact advanced stages with symptomatic and functional improvement are obtained with total knee replacement, however, there is no treatment…
- Trial name
- INMUNOCEM-OA (NCT05936060)
- Testing
- INMUNOCEM
- Volunteers
- 32 people
- Sponsor
- GUSTAVO SALGUERO
Knee Arthritis Osteoarthritis
An Open-Label, Double-Treatment Group Study to Evaluate the Efficacy and Safety of Human Allogeneic Bone-Marrow- Derived Mesenchymal Stromal Cell Product StromaForte Compared With Hyaluronic Acid for the Treatment of Knee Osteoarthritis
StromaForte injection for knee OA
- Trial name
- NCT07542808
- Testing
- Mesenchymal Stem Cells (MSC), Hyaluronic Acid (HA)
- Where
- United Arab Emirates
- Volunteers
- 140 people
- Sponsor
- Cellcolabs Clinical SPV Limited
Rheumatoid Arthritis
Transplantation of Bone Marrow Derived Mesenchymal Stem Cells in Affected Knee Osteoarthritis by Rheumatoid Arthritis
Osteoarthritis of the knee is one of the most common causes of disability among elderly. Arthritis rheumatoid is an autoimmune disease which causes multi articular arthritis, such as knee osteoarthritis.
- Trial name
- NCT01873625
- Testing
- mesenchymal cell transplantation
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Royan Institute
Osteoarthritis, Degenerative Arthritis
Pinnacle RSA Study
The primary objective is to establish the mean superior cup migration of the Pinnacle Acetabular Shell using model-based RSA over the first two years post-implantation.
- Trial name
- NCT04070989
- Testing
- THA
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis, Knee
Effects of Central Sensitization on Response to Conventional Physical Therapy in Patients With Knee Osteoarthritis
The aim of this study was to investigate the relationship between central sensitization (CS) and poor response to conventional physical therapy in patients with knee osteoarthritis (OA) by evaluating clinical parameters of pain…
- Trial name
- NCT05518097
- Testing
- Conventional physical therapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara University
Osteoarthritis, Knee
Evaluation of Platelet Rich Plasma (PRP) for Knee Osteoarthritis
Study was designed to evaluate efficacy of autologous platelet rich plasma (PRP) injections guided by ultrasound for treatment of knee osteoarthritis.
- Trial name
- NCT03138317
- Testing
- PRP, Plasma
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Pain, Chronic Postsurgical, Knee Osteoarthritis
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain.
- Conditions
- Pain, Chronic Postsurgical, Knee Osteoarthritis, Sensitization, Central
- Trial name
- NCT05575310
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Barcelona
Osteoporosis, Osteoarthritis, Hip
Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)
Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations.
- Conditions
- Osteoporosis, Osteoarthritis, Hip, Hip Fractures, Clonal Hematopoiesis of Indeterminate Potential
- Trial name
- NCT05246813
- Testing
- Blood and bone marrow cell collection
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Imelda Hospital, Bonheiden
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.