Clinical trials: Degenerative Osteoarthritis
Knee Osteoarthritis
Digital Motivation to Decrease Inactive Behaviour in Patients With Knee Osteoarthritis
Physical inactivity is a major risk behaviour with a potential for causing premature death, particularly among people with mobility limitations, such as knee osteoarthritis.
- Trial name
- NCT03339011
- Testing
- Motivational SMS text message
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Marius Henriksen
Knee Osteoarthritis
Efficacy of Different Doses of Pregabalin as a Multimodal Analgesic Agent in Postoperative Pain Control After Total Knee Arthroplasty
The purpose of this study is to compare the efficacy of 75 mg of Pregabalin and 150 mg of Pregabalin in postoperative pain control after TKA.
- Trial name
- NCT05447364
- Testing
- Pregabalin 75mg, Pregabalin 150mg
- Where
- Thailand
- Volunteers
- 82 people
- Sponsor
- Thammasat University
Knee Osteoarthristis
Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis.
A double-blind, randomized controlled trial designed to evaluate the symptomatic modulating efficacy of amniotic suspension allograft (ASA) in comparison to platelet-rich plasma (PRP), hyaluronic acid (HA) and normal saline (NS)…
- Trial name
- NCT04698265
- Testing
- Human amniotic suspension allograft (ASA)
- Volunteers
- 150 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Osteoarthritis of Knee Joint
Allogeneic Mesenchymal Stem Cells for Osteoarthritis
This study is designed to know the safety and efficacy of 2 different doses of mesenchymal stem cells in patients suffering from osteoarthritis of knee joint.
- Trial name
- NCT01448434
- Testing
- Ex- vivo cultured adult allogeneic MSCs, Plasmalyte-A
- Where
- 4 sites in Malaysia
- Volunteers
- 72 people
- Sponsor
- Stempeutics Research Pvt Ltd
Hip Osteoarthritis
Gait Analysis and Clinical Outcomes of Anterior and Lateral Approach Total Hip Arthroplasty.
The goal of this Prospective Randomized Study is to confirm presence or absence of differences in gait mechanics in direct anterior and lateral approaches for total hip arthroplasty.
- Trial name
- NCT06538519
- Testing
- total hip replacement using lateral approach, total hip replacement using anterior approach, gait analysis at 6wks, 3 months and 18 months
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Ain Shams University
Trapeziometacarpal Osteoarthritis
Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of Trapeziometacarpal Osteoarthritis
The objective of this clinical trial is to evaluate whether a human umbilical cord amniotic membrane allograft can serve as an interposition implant in the surgical treatment of trapeziometacarpal osteoarthritis.
- Trial name
- NCT07435571
- Testing
- with SclerFIX
- Where
- 4 sites in France
- Volunteers
- 22 people
- Sponsor
- TBF Genie Tissulaire
Osteoarthritis, Knee
A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee
This was a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase 2 trial of Sprifermin administered intra-articularly in participants with primary osteoarthritis of the knee and Kellgren-Lawrence Grade 2…
- Trial name
- FORWARD (NCT01919164)
- Testing
- Sprifermin
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 549 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Osteoarthritis
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the hip.
- Trial name
- NCT02844764
- Testing
- [StroMed + platelet rich plasma (PRP)]
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- VivaTech International, Inc.
Osteoarthritis
Medico-economic Interest of the Patient Matched Cutting Blocks (Ancillary) MyKnee ® LBS During the Poses of Complete Prosthesis of Knee GMK ®. Multicentric, Prospective, Controlled, Opened, Randomised Study About a Medical Device. (My Knee)
Over 70.000 total knee arthroplasty (TKA) are performed in France every year, with a 10% yearly increase since the early 1990s. The clinical experience shows a strong rate of success on pain relief and on function.
- Trial name
- MY Knee (NCT01818401)
- Testing
- the prosthesis GMK ® without the ancillary MyKnee ® LBS, Matched patient cutting blocks MyKnee ® LBS
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Nantes University Hospital
Knee Osteoarthritis
Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis
Introduction: Osteoarthritis of the knee is a very common disease. However there are few treatment options for these patients. Botulinum toxin type A is an option for chronic pain.
- Trial name
- NCT02829281
- Testing
- Botulinum Toxin Type A, Triamcinolone hexacetonide, Saline
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Federal University of São Paulo
Unilateral Knee Osteoarthritis
Durolane Compared to Saline in Patients With Unilateral Knee Osteoarthritis
This was a study that compared Durolane injections to saline injections in the treatment of unilateral osteoarthritis of the knee.
- Trial name
- NCT01806207
- Testing
- Durolane injection, Saline injection
- Where
- United Kingdom
- Volunteers
- 218 people
- Sponsor
- Galderma R&D
ERAS, Knee Osteoarthritis
Enhanced Recovery After Surgery Protocols in Total Knee Arthroplasty Via Midvastus Approach
The study aimed to investigate the impact of enhanced recovery after surgery (ERAS) protocols on the clinical effect of total knee arthroplasty (TKA) via the midvastus approach
- Trial name
- NCT04873544
- Testing
- ERAS protocols for TKA
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Ocular Surface Disease, Osteoarthritis
Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients
Dry eyes is multi-factorial disease which inflammation play etiological role. Diacerein is drug which has anti-inflammatory effect by antagonist Interleukin-1, decrease Interleukin-1 receptor, increase Interleukin-1 Receptor…
- Conditions
- Ocular Surface Disease, Osteoarthritis, Diacerein
- Trial name
- NCT04351100
- Testing
- Diacerein
- Where
- Thailand
- Volunteers
- 34 people
- Sponsor
- Chulalongkorn University
Osteoarthritis
AMS Study: Inflammatory and Biomechanical Contributors to Arthritis Development Following Arthroscopic Meniscectomy
The purpose of this study is to examine the relationship between muscle activation and heart rate on joint generalized inflammation and arthritis development.
- Trial name
- NCT00752271
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Osteoarthritis
Rosehip Powder for Knee Osteoarthritis
The aim of this study is to compare three combinations of preparations in a comparative trial program on rosehip powder for knee OA.
- Trial name
- NCT01430481
- Testing
- Rosehip powder
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Frederiksberg University Hospital
Glenohumeral Osteoarthritis, Rotator Cuff Disease
Objective Evaluation of Shoulder Pathology and Surgery
The goal of this study was to clinically validate a new device for the objective outcome evaluation of adult patients undergoing shoulder surgery for glenohumeral osteoarthritis and rotator cuff disease, using the activities of…
- Trial name
- NCT00500630
- Testing
- Body fixed 3D sensors
- Where
- Switzerland
- Sponsor
- University of Lausanne Hospitals
Arthritis, Rheumatoid, Osteoarthritis
12-Week No-Rofecoxib Plus Aspirin Endoscopy Study (0782-003)
This study will look at the incidence of gastric and/or duodenal ulcers in patients with osteoarthritis or rheumatoid arthritis in four different treatment groups (a) MK0782 21 mg plus enteric-coated aspirin, (b) MK0782 42 mg…
- Trial name
- NCT00543465
- Testing
- MK0782
- Volunteers
- 49 people
- Sponsor
- Merck Sharp & Dohme LLC
Osteo Arthritis Knee, Central Sensitisation
Central Sensitization in Knee Osteoarthritis
The stimuli that activate nociceptors cause the dorsal horn of the spinal cord neurons to be sensitive to low-intensive afferent stimuli by decreasing the excitation threshold in patients with osteoarthritis.
- Trial name
- NCT04308967
- Testing
- balance exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cukurova University
Ankle Osteoarthritis
Effects of Intraarticular Botulinum Toxin A in Ankle Osteoarthritis
The purpose of this study is to compare the effects of intraarticular Botulinum Toxin A versus intraarticular hyaluronate plus rehabilitation exercise in patients with ankle osteoarthritis.
- Trial name
- NCT01760577
- Testing
- Botulinum Toxin A (Allergan, Inc, Irvine CA), Hyalgan (Hyalgan, Fidia , Italy)
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Arthroplasty, Bone Morphing
Is It Possible to Obtain Reliable MPTA and LDFA Values Using Imageless Navigation in Total Knee Arthroplasty? Comparison Between Preoperative CT Scan Measurements and Intraoperative Bone Morphing Before and After Articular Cartilage Removal
Title: Evaluation of Image-less Navigation Accuracy in Total Knee Arthroplasty (CARNAVAL) Summary: The purpose of this study is to evaluate the accuracy of an imageless navigation system in measuring key anatomical angles (MPTA…
- Conditions
- Arthroplasty, Bone Morphing, Knee Osteoarthritis
- Trial name
- CAR-NAV-AL (NCT07574775)
- Testing
- Non-image-based Computer-Assisted Navigation with Bone Morphing
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
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