Clinical trials: Degenerative Osteoarthritis
Knee Osteoarthritis
Effects of Bracing on Knee Osteoarthritis (OA)
Knee osteoarthritis (OA) is characterized by complaints of knee pain, aching and stiffness that commonly alter the way one will climb stairs and walk reducing an individual's function and the activities they may perform on a…
- Trial name
- NCT01886144
- Testing
- Knee OA Brace
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Osteoarthritis
Flavocoxid, A Plant-Derived Therapy, for the Treatment of Knee Osteoarthritis
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to treat arthritis. The purpose of this study is to test the effectiveness of flavocoxid, a plant-derived compound, for the treatment of knee osteoarthritis…
- Trial name
- NCT00294125
- Testing
- Flavocoxid
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Alabama at Birmingham
Kinesiophobia, Osteo Arthritis Knee
Impact of Breathing and Yoga Poses on Kinesiophobia in Knee Osteoarthritis Patients
The study aimed to determine if deep breathing and conventional physiotherapy were more effective than yoga poses and conventional physiotherapy in reducing kinesiophobia among knee osteoarthritis patients.
- Trial name
- NCT07325032
- Testing
- Deep Breathing exercise, Three typical yoga poses
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Saveetha University
Knee Osteoarthritis
The Efficacy of Exercise and Alternative Applications of NMES on Pain and Function in Patients With Knee OA
The aim of the study was to investigate the efficacy of exercise and different size electrodes of neuromuscular electrical stimulation (NMES) applications on pain, range of motion (ROM), muscle strength, function status and…
- Trial name
- NCT03571698
- Testing
- Neuromuscular Electrical Stimulator
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Osteoarthritis
Synovial Tissue as a Biomarker in the Early Management of Osteoarthritis
Osteoarthritis is a common disease whose prevalence continues to increase. To date, there is no medical treatment that has proven effective, and only symptomatic treatments exist, mainly to reduce pain.
- Trial name
- SYNPA (NCT07473414)
- Testing
- synovial biopsies
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Arthritis, Rheumatoid, Post-traumatic Osteoarthritis
UK Infinity, Post-Market Clinical Follow-up Study
Study Title UK Post-Market Clinical Follow-Up Of The INFINITY® Total Ankle System Study Design Prospective, multi-site, multi-year post-market clinical follow-up study Study Group Primary/Unilateral and/or bilateral Total Ankle…
- Conditions
- Arthritis, Rheumatoid, Post-traumatic Osteoarthritis, Degenerative Arthritis
- Trial name
- NCT03063593
- Where
- 12 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Stryker Trauma and Extremities
Osteoarthritis of the Knee
A Study of the Efficacy and Safety of CF101 to Patients With Osteoarthritis of the Knee
This study will test the effectiveness of CF101 in treating the symptoms of osteoarthritis (OA) of the knee. Eligible patients will be given either CF101 or matching placebo tablets and their symptoms will be evaluated over the…
- Trial name
- NCT00837291
- Testing
- CF101
- Where
- Israel
- Sponsor
- Can-Fite BioPharma
Osteoarthritis, Arthroplasty Complications
Varus Stem Positioning of a Cementless Anatomical THA. (VARABG)
Varus positioning is the most common femoral malposition in total hip arthroplasty (THA). The aim of this study was to compare the long-term results of an anatomical cementless femoral stem positioned in varus with those in…
- Trial name
- VARABG (NCT04653090)
- Testing
- Xray
- Where
- France
- Volunteers
- 283 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Idiopathic Osteoarthritis, Posttraumatic Osteoarthritis
Humeral Head Implants: Radiological and Clinical Evaluation
In the past years several shoulder reconstruction systems with different types of prostheses and fixation methods have been developed to improve shoulder arthroplasty, trying to cover a wide range of pathologies and revision…
- Conditions
- Idiopathic Osteoarthritis, Posttraumatic Osteoarthritis, Humeral Head Necrosis, Instability Arthritis
- Trial name
- NCT02754024
- Testing
- Total shoulder arthroplasty (TSA), Hemi shoulder arthroplasty (HSA), Eclipse™ (Arthrex Inc., Naples, FL, USA)
- Volunteers
- 100 people
- Sponsor
- Werner Anderl
Osteoarthritis, Knee, Knee Osteoarthritis
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
Patients with degenerative joint disease can effectively be treated with a primary total knee replacement to reduce pain and improve function in their daily lives.
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Osteoarthritis Knees Both, Osteoarthritis Knee Left
- Trial name
- NCT04814082
- Testing
- MicroPort Evolution Medial-Pivot Knee System (Cruciate-substituting), Stryker Triathlon Tritanium Knee System (Condylar Stabilizing)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- LifeBridge Health
Osteoarthritis, Knee
Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty
This study is designed to compare the surgical efficiency of TruMatch® Personalized Solutions surgical technique compared to conventional surgical technique.
- Trial name
- NCT01301950
- Testing
- Custom Patient Instrumentation, Conventional Instruments
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- DePuy Orthopaedics
Metalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek Population
Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.
Does the presence of gene polymorphisms -1575G / A in the MMP-2 gene, 836A / G in the MMP-9 gene and -77A / G in the MMP-13 gene, affect the risk of developing idiopathic knee osteoarthritis in the Greek population?
- Trial name
- NCT04463290
- Testing
- No intervention, Patients selection based on clinical symptoms and radiological imaging
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Osteoarthritis, Knee, Obesity
Effect Of The Use Of Navigation In The Alignment Obtained When Performing A Total Knee Arthroplasty In Obese Patients
NAOBE is a randomized, open and prospective clinical trial that evaluates the accuracy to achieve an adequate mechanical axis of the lower extremity in obese patients after total knee replacement.
- Conditions
- Osteoarthritis, Knee, Obesity, Arthropathy of Knee
- Trial name
- NCT03865524
- Testing
- Total knee arthroplasty implanted with GPS navigation system, Total knee arthroplasty implanted with standard guides.
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- Pedro-José Torrijos-Garrido
Osteoarthritis
Osteopuncture for Osteoarthritis-Associated Knee Pain & Disability
The purpose of this study is to investigate the feasibility, effectiveness, and duration of treatment response of periosteal electro-acupuncture (osteopuncture) for osteoarthritis (OA)-associated chronic knee pain.
- Trial name
- NCT00417313
- Testing
- periosteal electro-acupuncture (osteopuncture).
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute on Aging (NIA)
Hip Osteoarthritis
Estimating VO2 Max and Recovery
The study aims to estimate VO2 max levels at pre- and post-operative timepoints before and after hip arthroplasty surgery, using non-exercise-based measurement methods.
- Trial name
- NCT06744582
- Testing
- VO2 max
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Bournemouth University
Osteo Arthritis Knee, Joint Diseases
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
An open label, prospective, two-arm, multicenter, randomized controlled trial comparing SakuraBead genicular artery embolization (GAE) with a control (corticosteroid injection).
- Conditions
- Osteo Arthritis Knee, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases
- Trial name
- SURE (NCT06550024)
- Testing
- SakuraBead Resorbable Microspheres, Corticosteroid Injection
- Where
- 8 sites in United States, Georgia and 2 more
- Volunteers
- 89 people
- Sponsor
- CrannMed
Osteoarthritis, Knee
Effect of Hydrotherapy After Unilateral UKA
Osteoarthritis (OA) is a progressive disease of the synovial joints that causes joint pain and limitation of function resulting in considerable morbidity and impairment of quality of life.
- Trial name
- NCT06459960
- Testing
- Hydrotherapy, Convention
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis, Osteo Arthritis Knee
Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis
The goal of this clinical trial is to examine the effect of a single autologous, intra-articular injection of MFat versus saline injection for the treatment of pain and function associated with K/L grade 2/3 knee Osteoarthritis.
- Trial name
- ARISE2 (NCT06121882)
- Testing
- Microfragmented Adipose Tissue derived using the Lipogems® System, Saline Injection
- Where
- 16 sites in United States
- Volunteers
- 173 people
- Sponsor
- Lipogems International spa
Osteoarthritis, Knee
Reaching Exercise Goals: Comparison of Exercise Means in Patients With Knee Osteoarthritis
The primary objective is to evaluate water based treadmill exercise, land based treadmill exercise, and upright cycling in meeting American College of Sports Medicine exercise goals for moderate exercise.
- Trial name
- NCT01359124
- Testing
- Exercise Cycle, Land-based Treadmill, Water-based Treadmill
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Milton S. Hershey Medical Center
Osteoarthritis, Pain
Pharmacist Provided Intervention (Education and Medication Review) in Osteoarthritis
The purpose of this study is to initiate pharmacist intervention (educational and medication review) among osteoarthritis patients visiting community pharmacies.
- Trial name
- NCT05337709
- Testing
- Education intervention and medication review
- Where
- Nepal
- Volunteers
- 154 people
- Sponsor
- Monash University Malaysia
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