Clinical trials: Degenerative Osteoarthritis
Osteo Arthritis Knee
Metformin Safety and Efficacy in Osteoarthritis.
Knee osteoarthritis (OA) is a chronic, painful disease associated with considerable morbidity, costs and disability. It is estimated that over a third of people aged over 60 have radiographic knee OA2 and over 50% of these with…
- Trial name
- NCT06231758
- Testing
- Celecoxib 200mg, Metformin
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mostafa Bahaa
Knee Osteoarthritis, Virtual Reality
The Effects of Non-Immersive Virtual Reality Exercises on Muscle Excitability in Knee Osteoarthritis
The main goal of this sham-controlled clinical trial is to learn the excitability levels of the muscles around the knee and balance using objective measurement methods in patients with knee osteoarthritis of non-immersive virtual…
- Trial name
- NCT05595317
- Testing
- Non-immersive Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Mehmet Sönmez
Primary Gonarthrosis, Bilateral, Knee Osteoarthritis
Association Between Sagittal Patellar Offset and Anterior Knee Pain in Total Knee Arthroplasty
The aim of this study to evaluate whether the position of the sagittal patellar offset is a predictive factor for anterior knee pain in subjects having undergone bilateral multiradius total knee replacement.
- Conditions
- Primary Gonarthrosis, Bilateral, Knee Osteoarthritis, Knee Arthritis
- Trial name
- NCT04353440
- Volunteers
- 80 people
- Sponsor
- Bezmialem Vakif University
Osteoarthrosis of the Carpometacarpal Joint of the Thumb
Study on Basal Joint Arthritis Prospective
The data in this prospective registry will be used 1) to define which surgical and nonoperative techniques are most effective at providing pain relief, restoring function, are cost effective, and patients are satisfied with their…
- Trial name
- NCT01376024
- Where
- 3 sites in United States
- Volunteers
- 800 people
- Sponsor
- Columbia University
Osteoarthritis, Knee
Medial Unicondylar Knee Arthroplasty vs Total Knee Arthroplasty
In treatment of isolated medial unicondylar osteoarthritis of the knee (MU-OA), it is possible to choose between surgery with a unicondylar knee arthroplasty (UKA), or a total knee arthroplasty (TKA).
- Trial name
- UKAvsTKA (NCT03396640)
- Testing
- Unicondylar Knee Arthroplasty, Total Knee Arthroplasty
- Where
- 11 sites in Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Glenohumeral Osteoarthritis
Prosthesis Versus Active Exercise Program in Patients With Glenohumeral Osteoarthritis
Anatomical total shoulder arthroplasty (TSA) is a well-established treatment for pronounced glenohumeral osteoarthritis. However, the effectiveness of TSA has not been compared to non-surgical treatment in a randomised controlled…
- Trial name
- PROACT (NCT04845074)
- Testing
- TSA-group, Exercise-group
- Where
- 7 sites in Denmark, Finland and 1 more
- Volunteers
- 102 people
- Sponsor
- University of Aarhus
Knee Osteoarthritis
Self Transcranial Direct Current Stimulation and Mindfulness-based Meditation for Pain in Older Adults With Knee Osteoarthritis
The purpose of this study is to determine the feasibility and preliminary efficacy of a two-week self tDCS and mindfulness-based meditation for pain in older adults with knee osteoarthritis (OA).
- Trial name
- NCT03747640
- Testing
- Self Transcranial Direct Current Stimulation (tDCS), mindfulness-based meditation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Osteoarthritis, Sarcopenia
Prevalence of Sarcopenia and Its Associated Factors in Patients With Knee Osteoarthritis in a Tertiary Care Hospital in Upper Egypt
Osteoarthritis (OA) and sarcopenia are two highly prevalent, interconnected geriatric syndromes that often coexist, leading to a condition termed "osteosarcopenia".
- Trial name
- NCT07566520
- Where
- Egypt
- Volunteers
- 224 people
- Sponsor
- Assiut University
Femoro Acetabular Impingement
HAFAI Cohort 5 Year Follow up of Patients With Femoroacetabular Impingement Undergoing Hip Arthroscopy
Patients included in the HAFAI cohort will be invited for 5 year follow up.
- Trial name
- NCT04590924
- Testing
- Hip arthroscopy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Horsens Hospital
Knee Osteoarthritis, Musculoskeletal Disease
Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving…
- Conditions
- Knee Osteoarthritis, Musculoskeletal Disease, Surgery
- Trial name
- TKACSI (NCT07151417)
- Testing
- PAI, PAI + steroid, PAI + zilretta
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Walter Reed National Military Medical Center
Osteoarthritis, Hip
Celecoxib Versus Diclofenac In The Treatment Of Osteoarthritis Of The Hip
To determine if celecoxib 200 mg once daily is as effective as diclofenac 50 mg three times daily in the treatment of pain symptoms associated with osteoarthritis of the hip
- Trial name
- NCT00174317
- Testing
- Celecoxib, Diclofenac
- Where
- 44 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- Pfizer
Knee Osteoarthritis, Energy Transfer Capacitative and Resistive Therapy
Efficacy of TECAR Therapy in Patients With Knee Osteoarthritis
Objective: The aim of the present study was to investigate the treatment efficacy of TECAR therapy, a modern application that has been increasingly used in recent years, compared to conventional physical therapy applications in…
- Trial name
- NCT06418360
- Testing
- TECAR, conventional physical therapy; Transcutaneous Electrical Nerve Stimulation, hotpack
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Arthritis, Osteoarthritis
Role of ASICs in Human Inflammatory Pain
In recent years, ion channels have emerged as new therapeutic targets for pain. Among these channels, ASICs (Acid Sensing Ion Channels) are of particular interest because they are directly activated by extracellular acidity…
- Conditions
- Arthritis, Osteoarthritis, Chondrocalcinosis, Gouty Arthritis
- Trial name
- NCT01867840
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Meniscus; Degeneration, Osteoarthritis, Knee
Treatment of the Medial Meniscus With the NUsurface(R) Meniscus Implant
This is a prospective, multi-center, open label, non-randomized study, evaluating the treating of medial meniscus deficiency with the NUsurface Meniscus Implant.
- Trial name
- NCT01712191
- Testing
- NUsurface Meniscus Implant
- Where
- 10 sites in Belgium, Germany and 4 more
- Volunteers
- 128 people
- Sponsor
- Phoenix Kinetics
Anterior Cruciate Ligament Injury, Osteoarthritis
Safety and Efficacy Study of MSB-CAR001 in Subjects 6 Weeks Post an Anterior Cruciate Ligament Reconstruction
The purpose of this study is to evaluate safety and preliminary efficacy of MSB-CAR001 in subjects who have recently undergone an Anterior Cruciate Ligament Reconstruction
- Trial name
- NCT01088191
- Testing
- MSB-CAR001 Combined With Hyaluronan, Hyaluronan
- Where
- Australia
- Volunteers
- 17 people
- Sponsor
- Mesoblast, Ltd.
Osteoarthritis, Knee
Ultrasound-Guided Pulsed Radiofrequency In The Treatment Of Patients With Osteoarthritis Knee (USPRFGENOAK)
The purpose of this study is to determine if patients with chronic painful knee osteoarthritis experience meaningful and long-term improvement in pain, function, and analgesic use after ultrasound-guided pulsed radiofrequency of…
- Trial name
- USPRFGENOAK (NCT02915120)
- Testing
- Real Pulsed Radiofrequency
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Hospital Son Llatzer
Pain, Inflammation
Efficacy of Tart Cherry Juice to Reduce Pain and Inflammation Among Patients With Inflammatory Osteoarthritis
The purpose of this study is to assess the effects of tart cherry juice to reduce pain and inflammation among individuals with arthritis.
- Trial name
- NCT01073982
- Testing
- tart cultivar Montmorency cherry juice
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Osteoarthritis, Knee
Quantitative Assessment of BB-02 Therapy Effect on Cartilage Status in Patients Affected by Early Knee Osteoarthritis
Knee osteoarthritis is a condition that affects young or middle-aged patients with high functional demands. Knee replacement surgery in patients under 65 years of age is associated with a high risk of failure and the need for…
- Trial name
- JOCARE-OA (NCT06459817)
- Testing
- BB-02 therapy
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Stefano Zaffagnini
Osteoarthritis, Knee
Oxytocin Pharmacokinetics After Intramuscular Injection
In this study people with knee arthritis so severe that a joint replacement is needed are recruited for a one day study. Study participants will have an intravenous catheter (IV) inserted in the forearm.
- Trial name
- NCT04427540
- Testing
- Oxytocin
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis, Knee, Endocrine System Diseases
Influence of Adipocytokines in Osteoarthritis
Adipocytokines play an important role in joint inflammation in patients with knee osteoarthritis as measured by ultrasound and high sensitivity protein-C reactive.
- Conditions
- Osteoarthritis, Knee, Endocrine System Diseases, Cardiovascular Risk Factors
- Trial name
- NCT01906281
- Testing
- Blood analyse, arthrocentesis, ultrasound examination
- Where
- 2 sites in Spain
- Volunteers
- 105 people
- Sponsor
- Parc Taulí Hospital Universitari
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