Clinical trials: Degenerative Osteoarthritis
Osteoarthritis
Physical Activity Pathway for Patients With Osteoarthritis in Primary Care (OA-PCP)
This is a multi-phase study that will develop and test an osteoarthritis (OA) primary care Physical activity Care Pathway (OA-PCP), a scalable intervention that includes: 1) a practical process for physical inactivity screening…
- Trial name
- NCT03780400
- Testing
- Osteoarthritis Physical Activity Care Pathway
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis, Rheumatoid Arthritis
Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA
The study will evaluate the clinical performance of the rotating platform and fixed bearing implants through patient questionnaires, outcomes scoring and radiographic assessment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Other Inflammatory Arthritis, Post-Traumatic Arthritis
- Trial name
- NCT00289107
- Testing
- Total Knee Arthroplasty, Total knee replacement
- Where
- 3 sites in United States
- Volunteers
- 149 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee
The objective of this 2-year study is to evaluate the safety, tolerability and disease modifying efficacy of SD 6010, an inhibitor of inducible nitric oxide synthase (iNOS), in overweight and obese subjects with knee…
- Trial name
- ITIC (NCT00565812)
- Testing
- SD-6010
- Where
- 183 sites in United States, Argentina and 12 more
- Volunteers
- 1,457 people
- Sponsor
- Pfizer
Osteoarthritis, Rheumatoid Arthritis
Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement
This study is a clinical evaluation of survivorship of an acetabular cup system after total hip replacement using patient examinations and questionnaires.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Arthritis, Avascular Necrosis
- Trial name
- NCT00306930
- Testing
- Acetabular cup
- Where
- United States
- Volunteers
- 1,593 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
Standard Total Knee Arthroplasty Using Platelet Rich Plasma (PRP)
Clinical study to determine if there is a difference in hemoglobin level between patients undergoing total knee arthroplasty with and without platelet-rich plasma.
- Trial name
- NCT01075230
- Testing
- Total knee arthroplasty
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Exactech
Osteoarthritis
Efficacy of Acupuncture With Physical Therapy for Knee Osteo-Arthritis
This study will examine the efficacy of acupuncture in combination with exercise physical therapy for moderate osteoarthritis (OA) of the knee.
- Trial name
- NCT00035399
- Testing
- Acupuncture
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Osteo Arthritis Knee, Ultrasound Therapy; Complications
Effect of Pulsed Electromagnetic Field and Pulsed Ultrasound in Treating Knee Osteoarthritis
This study will be carried out to combine the effect of PEMF and PUT on pain, function, and ROM in patients with knee OA.
- Trial name
- NCT05151432
- Testing
- Pulsed Ultrasound, Pulsed Electromagnetic field, Traditional exercise program
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Horus University
Knee Osteoarthritis, Older Women
Adding Group-Based Pain Neuroscience Education to a Community Exercise Program for Older Women With Knee Osteoarthritis
This pilot trial aimed to estimate preliminary clinical effects and to assess the feasibility of adding group-based pain neuroscience education (PNE) to exercise in women aged ≥60 years with medically diagnosed knee…
- Conditions
- Knee Osteoarthritis, Older Women, Pain, Disability
- Trial name
- NCT07565298
- Testing
- Pain neuroscience education (PNE), Exercise program
- Where
- Chile
- Volunteers
- 19 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Osteoarthritis
A Trial Between the Intra-articular Local Anesthetic Infiltration With Catheter and Interscalene Block With Catheter in Postoperative Analgesia After Shoulder Prosthesis
The control of perioperative pain is necessary to avoid worst surgical suites after shoulder arthroplasty. Interscalene block (ISB) with or without catheter is the gold standard in postoperative analgesia after shoulder…
- Trial name
- LIA (NCT02365181)
- Testing
- intra-articular local anesthetic infiltration, inter-scalene block, Ropivacaine 2 %
- Where
- 5 sites in France
- Volunteers
- 98 people
- Sponsor
- Hospital Ambroise Paré Paris
Osteoarthritis (OA) of the Knee
Comparison of Effectiveness Between PL and PRP on Knee Osteoarthritis: a Prospective,Randomized,Placebo-controlled Trial
This study will focus on grade I to III knee osteoarthritis by randomized controlled trials which comparing the effectiveness between placebo, autologous platelet rich plasma and autologous platelet lysate injections.
- Trial name
- NCT03734900
- Testing
- Saline injection, PRP injection, PL injection
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Osteoarthritis
Multi-Center Study to Evaluate the ConforMIS iUni Knee Implant
Study is prospective and multi-center. Study will include 100 to 200 patients across up to 20 sites.The study sites will be located in the United States.The study objective is to evaluate the safety and performance of the…
- Trial name
- iUni (NCT01117571)
- Testing
- iUni® Unicompartmental Knee Resurfacing Device
- Where
- 8 sites in United States
- Volunteers
- 120 people
- Sponsor
- Restor3D
Knee Osteoarthritis, Total Knee Arthroplasty
Intraoperative Direct vs Postoperative Ultrasound Guided Adductor Canal Nerve Block After Total Knee Arthroplasty
This study compares analgesic effect between two techniques of adductor canal nerve block after total knee arthroplasty. The first group of the patients will receive intraoperative adductor canal nerve block; and the other group…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Nerve Block
- Trial name
- NCT03733509
- Testing
- Intraoperative Block, Ultrasound Block
- Where
- Chile
- Volunteers
- 121 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Obesity, Overweight
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo.
- Conditions
- Obesity, Overweight, Osteoarthritis, Knee
- Trial name
- AMAZE 6 (NCT07509307)
- Testing
- NNC0487-0111
- Where
- 81 sites in United States, Australia and 9 more
- Volunteers
- 400 people
- Sponsor
- Novo Nordisk A/S
Osteoarthritis
Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee
A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of single injection of RTX-GRT7039 versus placebo in patients who have pain associated with…
- Trial name
- NCT05449132
- Testing
- RTX-GRT7039
- Where
- 81 sites in United States, Denmark and 3 more
- Volunteers
- 466 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis, Knee
Autologous Stem Cells in Osteoarthritis
Patients with osteoarthritis, a degenerative joint disease, that meet inclusion criteria will be allocated into two groups: The control group will receive Acetaminophen 750mg orally every 8 hours The experimental group will…
- Trial name
- NCT01485198
- Testing
- Bone Marrow Autologous Stem Cells Infusion, Acetaminophen
- Where
- 2 sites in Mexico
- Volunteers
- 61 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Knee Osteoarthritis
Effects of Hyaluronic Acid Injection and Exercise Treatments in Knee Osteoarthritis
Background: Osteoarthritis (OA) is one of the most common joint diseases that most often causes physical disability. Physical therapy modalities, exercise programs and intra-articular injections are widely used in the treatment…
- Trial name
- NCT06196021
- Testing
- Intra-articular hyaluronic acid injection
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Balikesir University
Osteoarthritis, Obesity
Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Loss
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- IM-LOSEIT-I (NCT02928471)
- Testing
- Intensive dietary intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Henrik Gudbergsen
Knee Injuries, Knee Osteoarthritis
Walking Gait Biomechanics Following Knee Joint Effusion
The purpose of this study is to determine the sensitivity of a wearable sensor to detect changes in knee joint loading using an experimental knee joint effusion as a model for a common clinical physiological alteration in joint…
- Trial name
- NCT03805464
- Testing
- Knee Joint Effusion
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Osteoarthritis, Knee
MRI Markers of Cartilage Damage in Knee With Osteoarthritis
The objectives of this study are: to identify and develop techniques to minimize precision errors in magnetic resonance imaging (MRI) evaluation of knee cartilage, and to determine if results from newly-identified MRI techniques…
- Trial name
- NCT00820430
- Testing
- Magnetic Resonance Imaging
- Where
- 5 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- American College of Radiology
Osteoarthritis, Avascular Necrosis
Cormet Post-PMA Study: New Enrollment
The primary objective of this study is to evaluate the performance of the Cormet Hip Resurfacing implant system in the post-approval environment.
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis
- Trial name
- PASNew (NCT00722007)
- Testing
- Cormet Hip Resurfacing
- Where
- 6 sites in United States
- Volunteers
- 147 people
- Sponsor
- Corin
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