Clinical trials: Degenerative Osteoarthritis
Knee Osteoarthritis
Periosteal Electrical Dry Needling for Knee Osteoarthritis
The purpose of this research is to treat patients with knee osteoarthritis (OA) with periosteal electric dry needling (PEDN). It is also to determine the optimal "maintenance" regiment (i.e.
- Trial name
- NCT05365061
- Testing
- periosteal electrical dry needling with no maintenance treatments, periosteal electrical dry needling with maintenance treatments every other month, periosteal electrical dry needling with monthly maintenance treatments
- Where
- United States
- Volunteers
- 586 people
- Sponsor
- Alabama Physical Therapy & Acupuncture
Knee Osteoarthritis
Evaluation of the Evolution of Biological and Imaging Markers of Bone and Cartilage Degradation in Patients With Knee Osteoarthritis Receiving Intra-articular Injections of a Hyaluronan Derivative HYMOVIS®
This pilot study MOKHA is aimed to evaluate the beneficial effect of HYMOVIS® on cartilage of patients suffering of knee osteoarthritis as revealed by using scientifically sound, objective measurements of biological and MRI-based…
- Trial name
- MOKHA (NCT04293861)
- Testing
- HYMOVIS
- Where
- 8 sites in Belgium, France
- Volunteers
- 50 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Osteoarthritis, Traumatic Arthritis
The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy
A clinical trial to evaluate the long-term efficacy and safety of Chondron (Autologous cultured Chondrocyte) administered through arthroscopy from the drug's 48 weeks efficacy and safety evaluation with 96 weeks follow-up in…
- Trial name
- NCT02539069
- Testing
- Chondron Implantation
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Knee Arthritis Osteoarthritis, Chronic Knee Pain
The Predictive Value of Ultrasonographic Quadriceps Muscle Parameters for Genicular Nerve Block Outcomes in Knee Osteoarthritis
The goal of this observational study is to learn whether thigh muscle structure can help predict pain relief after a genicular nerve block in people with knee osteoarthritis.
- Trial name
- NCT07781059
- Testing
- genicular nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Marmara University
Osteoarthritis of the Shoulder
Unravelling the Etiology of Shoulder Osteoarthritis
Osteoarthritis (OA) is a progressive disease resulting from the degradation of synovial joint articular cartilage over time. The hallmark symptom is diffuse aching and progressive pain made worse with activity.
- Trial name
- UESOA (NCT04634773)
- Testing
- Low-dose CT, T1Rho MRI, Motion Analysis
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Rheumatoid Arthritis, Osteoarthritis
Compare the Effect of Eupatilin and Rebamipide on the Prevention of Gastroenteropathy
The purpose of this study is to evaluate the efficacy of eupatilin on the prevention of gastroenteropathy in patients with NSAIDs and low dose steroid by comparing with rebamipide.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis, Other Musculoskeletal Disorder
- Trial name
- CEERS (NCT04885751)
- Testing
- Eupatilin, Rebamipide
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Seoul National University Boramae Hospital
Osteoarthritis
Blocking Extracellular Galectin-3 in Patients With Osteoarthritis
The proposed study is a pilot, double-blind, randomized clinical trial comparing galectin-3 inhibition with MCP to placebo for the treatment of knee osteoarthritis.
- Trial name
- NCT02800629
- Testing
- Modified Citrus Pectin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Hip Osteoarthritis, Knee Osteoarthritis
Fit-Joints: Getting Fit for Hip or Knee Replacement
Osteoarthritis leads to reduced independence and quality of life. Total hip replacement is a successful and cost-effective surgical intervention to relieve pain and improve functioning in patients with osteoarthritis.
- Trial name
- Fit-Joints (NCT02885337)
- Testing
- Multi-Modal Frailty Intervention, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Dry Needling Treatment for Knee Osteoarthritis
The population affected by degenerative knee arthritis is very large. The investigator performed dry needle (DN) treatments with acupuncture needles.
- Trial name
- NCT03639441
- Testing
- dry needling, Transcutaneous electrical nerve stimulation
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- China Medical University Hospital
Knee Osteoarthritis, Total Knee Replacement
The Effect of Laser Acupuncture Intervention to the Prognosis After TKR Surgery
This study protocol is mainly focus on the patients, who suffer pain, swelling, or range of motion limitation after total knee replacement (TKR) surgery procedure,would be relieved by use non-invasive laser acupuncture to stimuli…
- Trial name
- NCT05263856
- Testing
- laser acupuncture
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Knee Osteoarthritis, Pain
Magnetotherapy Versus Microwave Combined With Exercise for Knee Osteoarthritis.
The high prevalence of knee osteoarthritis and the absence of well-defined protocols for the application of Magnetotherapy (MT), makes it necessary to investigate the effect of this therapy on patients with knee osteoarthritis.
- Trial name
- MT-MW-EX (NCT04866745)
- Testing
- Magnetotherapy plus exercise, Microwave plus exercise
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Castilla-La Mancha
Knee Osteoarthritis
Efficacy Study of Pre-emptive Etoricoxib for Postoperative Pain and Functional Outcome in Total Knee Arthroplasty
The purpose of this study is to study the efficacy of pre-emptive etoricoxib in reducing post-operative pain and improving function outcome after a total knee arthroplasty.
- Trial name
- NCT01246362
- Testing
- Control, Etoricoxib
- Where
- Singapore
- Volunteers
- 65 people
- Sponsor
- Singapore General Hospital
Osteoarthritis
Prospective Multicenter Non-interventional Study in Patients With Knee or Hip Osteoarthritis Having a Theraflex Treatment
The main purpose of this study is to evaluate how a long-term treatment with Theraflex during 64 weeks affects pain intensity in the affected knee or hip joint, the activity in daily living, the quality of life and patient…
- Trial name
- NCT03330288
- Testing
- Theraflex, BAY 874017
- Where
- 2 sites in Russia
- Volunteers
- 1,102 people
- Sponsor
- Bayer
Osteoarthritis, Knee
A Study of LY2828360 in Patients With Osteoarthritic Knee Pain
To investigate the safety, efficacy and pharmacokinetics of single daily oral dose of LY2828360 in male and female subjects with osteoarthritic knee pain
- Trial name
- NCT01319929
- Testing
- LY2828360
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis
Visual Feedback Non-weight Bearing Exercise on the Elderly With Knee Osteoarthritis.
Degenerative knee arthritis is the most common chronic arthritis disease. Once the elderly suffer from this disease, it will accelerate the loss of body function and autonomy.
- Trial name
- NCT04919486
- Testing
- visual feedback with non-weight bearing exercise, elastic band exercise
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Osteoarthritis, Knee
Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study In Subjects With Osteoarthritic Pain Of The Knee
To evaluate the efficacy, safety, tolerability, pharmacodynamics, and pharmacokinetics in patients with osteoarthritic pain of the knee.
- Trial name
- NCT00689273
- Testing
- PF-04136309
- Where
- 22 sites in United States, South Korea
- Volunteers
- 159 people
- Sponsor
- Pfizer
Osteoarthritis, Knee, Dementia
Effect of Tai Chi on Osteoarthritic Knee Pain in Elders With Mild Dementia
This is the first study to test the effect of Tai Chi on pain from knee osteoarthritis in community-dwelling elders with mild cognitive impairment.
- Trial name
- NCT01528566
- Testing
- Tai Chi, Attention control
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Arkansas
Osteoarthritis
Home Telerehabilitation for Deconditioned Older Adults
The purpose of this study is to develop a home exercise program for patients 60 years of age and over who are deconditioned following their discharge from the hospital, or recruited from GLA outpatient clinics.
- Trial name
- NCT00386256
- Testing
- Health Buddy, Home telehealth technology, Telephone counseling
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- US Department of Veterans Affairs
Osteoarthritis, Knee, Osteoarthritis, Hip
Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip
The objective of this exploratory study is to evaluate the cellular and connective tissue composition of joints from patients with Osteoarthritis (OA) who have been treated with fasinumab, compared with those treated with placebo…
- Trial name
- NCT03949673
- Testing
- Fasinumab, Naproxen, Diclofenac
- Where
- 15 sites in United States, Poland and 1 more
- Volunteers
- 23 people
- Sponsor
- Regeneron Pharmaceuticals
Knee Osteoarthritis, Hip Osteoarthritis
Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties
Barbed sutures offer several potential advantages in layered wound closure of hip and knee replacement surgeries. It use is gaining increased acceptance across many of the other surgical disciplines at this time.
- Trial name
- NCT00834483
- Testing
- Knotless suture for wound closure, Layered traditional wound closure (monocryl)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
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