Clinical trials: Degenerative Spine Diseases
Degeneration of Lumbar Intervertebral Disc
Pilot Study of rhBMP-2/ACS/LT-CAGE® for Anterior Lumbar Interbody Fusion in Patients With Degenerative Disc Disease
This study is designed to evaluate the feasibility of recombinant human bone morphogenetic protein-2 and absorbable collagen sponge with the tapered interbody fusion device (LT-CAGE® ) for anterior lumbar interbody fusion in…
- Trial name
- NCT01491373
- Testing
- rhBMP-2/ACS/LT-CAGE® Device, Autograft/LT-CAGE® Device
- Volunteers
- 14 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis
The LimiFlex™ Clinical Trial is a prospective, concurrently controlled, multi-center study to evaluate the safety and effectiveness of decompression and stabilization with the Empirical Spine LimiFlex™ Paraspinous Tension Band…
- Trial name
- NCT03115983
- Testing
- LimiFlex, Fusion Instrumentation, Decompression
- Where
- 28 sites in United States
- Volunteers
- 299 people
- Sponsor
- Empirical Spine, Inc.
Lower Back Pain, Degenerative Disc Disease (DDD)
Luna Interbody System for Fusion Trial
The purpose of this trial is to evaluate the performance, safety and effectiveness of the Luna system for the treatment of degenerative disc disease.
- Trial name
- LIFT (NCT01551901)
- Testing
- Spinal fusion
- Where
- 5 sites in Belgium, Germany
- Volunteers
- 100 people
- Sponsor
- Benvenue Medical, Inc.
Degenerative Lumbar Disease, Scoliosis
Priority-Matching Correction Technique in Degenerative Lumbar Scoliosis
Surgical outcomes, including radiographic outcomes, patient-reported outcomes, postoperative complications, and revision surgery rates, were compared in patients with degenerative lumbar scoliosis (DLS) who underwent correction…
- Conditions
- Degenerative Lumbar Disease, Scoliosis, Degenerative Scoliosis
- Trial name
- PMCTDLS (NCT06470165)
- Testing
- Priority-matching correction technique in DLS, Traditional correction technique in DLS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Degenerative Spondylolisthesis, Spinal Stenosis
"Is Instrumentation Necessary for "Static" Degenerative Spondylolisthesis"
The purpose of this study is to determine whether instrumented lumbar fusion provides superior clinical outcomes in comparison to non-instrumented fusion in patients with "static" degenerative spondylolisthesis.
- Trial name
- NCT02530775
- Testing
- instrumented spinal fusion with laminectomy, non-instrumented spinal fusion with laminectomy
- Sponsor
- University of Pittsburgh
Cervical Spine Degenerative Disease Nos, Cervical Spondylosis With Myelopathy
Baxter: Actifuse SHAPE vs DBX in ACC
The purpose of this single-center, prospective, randomized study is to determine the fusion rates along with the clinical outcomes of commercially available bone graft substitutes Actifuse mixed with bone marrow aspirate (BMA)…
- Trial name
- NCT02005081
- Testing
- Actifuse SHAPE, Autograft with Demineralized Bone Matrix
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wayne State University
Stenosis, Herniated Nucleus Pulposus
Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion
Neural injury is a well-known complication following extreme lateral lumbar interbody fusion (XLIF). It has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit.
- Conditions
- Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis
- Trial name
- NCT03327272
- Testing
- Methylprednisolone, Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Recurrent Low Back Pain, Degenerative Disc Disease (DDD)
Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive
This will be a multicenter, prospective, double blind, randomized phase 2/3 trial comparing culture-expanded allogeneic adult BM-MSCs with sham-treated controls.
- Trial name
- RESPINE (NCT03737461)
- Testing
- Allogenic BM-MSCs Injection
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 113 people
- Sponsor
- University Hospital, Montpellier
Lumbar Degenerative Disease
The Study of INTRA Spine Non Fusion Technique in the Treatment of Lumbar Degenerative Disease
Lumbar degenerative diseases such as lumbar disc herniation (LDH) and lumbar spinal stenosis (LSSS) are common and frequently encountered in orthopaedics.
- Trial name
- NCT06075966
- Testing
- Non-fusion group, Fusion group
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Qianfoshan Hospital
Degenerative Disc Disease, Spine Degeneration
A Prospective Study of Clinical Outcomes Following a Single Intradiscal Injection of Bone Marrow Aspirate Concentrate (BMAC) for Single Level Discogenic Low Back Pain
This single-institution prospective case series (single arm) study will assess the clinical outcomes of patients diagnosed with 1 or 2 level level discogenic low back pain following an intradiscal injection of bone marrow…
- Trial name
- NCT03912454
- Testing
- Autologous Bone Marrow Aspirate Concentrate (BMAC) Injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bone and Joint Clinic of Baton Rouge
Degenerative Disc Disease, Chronic Low-back Pain
Post Market Observational Trial for the PerQdisc Nucleus Replacement Device
PerQdisc PMCF1 is a post-market clinical follow-up observational trial to follow subjects receiving a PerQdisc spinal implant for a duration of 5 years.
- Trial name
- PMCF1 (NCT05105490)
- Testing
- PerQdisc
- Where
- Germany
- Sponsor
- Spinal Stabilization Technologies
Spondylolisthesis
XLIF® vs. MAS®TLIF for the Treatment of Symptomatic Lumbar Degenerative Spondylolisthesis With or Without Central Stenosis.
The purpose of this study is to determine differences in the XLIF and TLIF procedures with respect to perioperative variables in adult patients with low-grade symptomatic spondylolisthesis.
- Trial name
- NCT01024699
- Where
- 9 sites in United States
- Volunteers
- 55 people
- Sponsor
- NuVasive
Intervertebral Disk Degeneration, Intervertebral Disk Displacement
Evaluation of Bone Union Following Anterior Cervical Fusion Using a NovoMax™
The purpose of this study is to evaluate the efficacy and safety of NovoMax™ in Anterior Cervical Interbody Fusion - Comparison of NovoMax™ versus ChronOs®.
- Trial name
- NCT02425514
- Testing
- Cervios ChronOs, NovoMax™
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- BioAlpha Inc.
Cervical Degenerative Disease
Improving Cervical Spine Alignment and Intervertebral Foramen Expansion Using a Novel Distally Expanding Cervical Facet Implant for Cervical Degenerative Disease
Cervical degenerative disease (CDD) resulting in myelopathy represents the commonest disease affecting the spinal cord in adults. Cervical radiculopathy can be associated with myelopathy or occurs alone.
- Trial name
- CeLFI (NCT07142174)
- Testing
- cervical facet implant will be introduced into the cervical levels that were mobile on flexion-extension x-ray and exhibited foramen stenosis or spondylolisthesis
- Where
- Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- King Saud University
Intervertebral Disc Degeneration
Adjacent Segment Mechanics in Cervical Arthrodesis Patients
This study aims to determine to what extent patient-specific factors, iatrogenic factors, and biomechanical factors influence cervical spine mechanics after single-level and two-level arthrodesis.
- Trial name
- NCT03028402
- Testing
- C5-C6 arthrodesis
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Spondylosis, Cervical, Spinal Cord Compression
Validity of the Turkish Translation of the Modified JOA
Degenerative cervical myelopathy (DCM) is the most common cause of non-traumatic spinal cord dysfunction in adults and may lead to progressive motor, sensory, and autonomic impairment.
- Trial name
- NCT07448883
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Izmir Democracy University
Cervical Degenerative Disc Disease
Multi-Centre Post-Market Data Collection
This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts.
- Trial name
- NCT06413225
- Testing
- Synergy cervical disc system
- Where
- 2 sites in United Kingdom
- Sponsor
- Synergy Spine Solutions
Diskectomy, Intervertebral Disk Displacement
Cervical Spine; Movement Before and After Anterior Cervical Discectomy, With or Without a Cervical Disc Prosthesis
The purpose of this study is to find out if use of a cervical disc prosthesis in the treatment of a cervical disc herniation preserves or restores normal mobility and movement in the cervical spine.
- Trial name
- NCT00868335
- Testing
- Activ C disc prosthesis, Anterior cervical discectomy
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Spinal Disease
ROMEO®2 PAD. 2 YEARS PROSPECTIVE FOLLOW-UP
This study is designed as a post-marketing observational, controlled, prospective, non-inferiority study where the efficacy and safety of the Degenerative Disc Disease treatment by arthrodesis using…
- Trial name
- ROMEO 2 PAD FR (NCT04174534)
- Where
- 3 sites in France
- Volunteers
- 3 people
- Sponsor
- Spineart SA
Scoliosis
Body Structure and Capacity Evaluation of Adults With Scoliosis
Adults with scoliosis have not been the focus of much research in physical therapy despite their prevalence being very important. Adults with idiopathic scoliosis have a reported prevalence of about 2-11%.
- Trial name
- NCT05538871
- Testing
- Survey + Physical exam
- Where
- Canada
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Alberta