Clinical trials: Degenerative Spine Diseases
Degenerative Disease of the Lumbosacral Spine
Transforaminal Lumbar Interbody Fusion (TLIF)
This is a global, multi-center, prospective, randomized, blinded, controlled pivotal study. Clinical and radiological evaluation will be performed preoperatively and postoperatively up to 24 months; and endpoint success will be…
- Trial name
- TLIF (NCT04073563)
- Testing
- Infuse™ Bone Graft (Infuse™), Intervertebral body fusion device and Medtronic posterior Fixation Systems
- Where
- 46 sites in United States, China
- Volunteers
- 600 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Disc Disease, Cervical Spine Degenerative Disease
Retrospective Analysis of Patients Implanted With 2 Levels of Prodisc® C Vivo Devices
The objective of the study is to evaluate the safety and post-operative performance profile of the prodisc® C Vivo after implantation in comparison to the relevant clinical literature.
- Conditions
- Degenerative Disc Disease, Cervical Spine Degenerative Disease, Symptomatic Cervical Disc Disease, Cervical Spine Degenerative Disc Disease
- Trial name
- NCT07370493
- Testing
- Prodisc C Vivo
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Centinel Spine
Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease
ISOVUE Comparative Trial
This study aimed to investigate a novel technique for intraoperative quantitative and qualitative feedback during discectomy and endplate preparation in TLIF.
- Conditions
- Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease, Degenerative Spine
- Trial name
- ISOVUE (NCT07363759)
- Testing
- ISOVUE 300 Observation, ISOVUE 300 Feedback
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Degenerative Disc Disease in Cervical Spine
Osteocel® Plus in Anterior Cervical Discectomy and Fusion (ACDF)
This is a prospective, non-randomized multi-center study to compare the use of Osteocel Plus in subjects who receive ACDF surgery at one or two levels.
- Trial name
- NCT00942045
- Testing
- Biologic - Osteocel Plus
- Where
- 17 sites in United States
- Volunteers
- 182 people
- Sponsor
- NuVasive
Degenerative Disc Disease, Craniocervical Injuries
Posterior Cervical Fixation Study
The objective of this study is to evaluate the safety and performance of occipito-cervico-thoracic spine surgery using posterior fixation as measured by reported complications, radiographic outcomes, and patients reported…
- Conditions
- Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
- Trial name
- NCT04770571
- Testing
- observational study
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- NuVasive
Spinal Disorders, Degenerative Spine Disease
Dose-Dependent Effects of Intraoperative Tranexamic Acid on Surgical Bleeding and Transfusion Requirements in Multilevel Thoracolumbar Spinal Surgery
Multilevel spinal stabilization surgery is frequently associated with substantial blood loss and increased transfusion requirements.
- Conditions
- Spinal Disorders, Degenerative Spine Disease, Blood Loss, Surgical
- Trial name
- NCT07288697
- Testing
- low-dose TXA, high-dose TXA
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Spine Fusion, Spinal Stenosis
Single Position Spine Surgery Registry
The purpose of this study is to systematically, prospectively compare surgical fusion techniques for thoracolumbar spinal fusion patients and assess long-term patient outcomes and revision rates following surgery.
- Conditions
- Spine Fusion, Spinal Stenosis, Degenerative Disc Disease
- Trial name
- SPSG Registry (NCT04839783)
- Where
- 6 sites in United States, Australia
- Volunteers
- 234 people
- Sponsor
- Spine and Scoliosis Research Associates
Disc Degenerative Disease, Spine Fusion for Degenerative Spine Disease
Comparison of Posterior Cellular Bonegraft Options for Single Level Lumbar Spinal Fusion
This study involves the assessment of alternatives to iliac bone graft during spinal fusion surgery. Four types of bone graft alternatives are being compared to iliac bone graft during the posterior portion of an…
- Trial name
- NCT07187362
- Testing
- Use iliac bone graft, use bone morphogenetic protein, use bone derived allograft MSCs
- Volunteers
- 119 people
- Sponsor
- Midwest Spine & Brain Institute
Spine Degeneration, Spine Disorder
Rate of Bone Union After Surgery With Stand-alone Fibergraft
Some people have back problems caused by degenerative conditions or instability of the spine (eg. Spondylolisthesis). These problems can lead to pain, nerve issues, or difficulties in walking.
- Conditions
- Spine Degeneration, Spine Disorder, Spine Pain, Spine Fusion
- Trial name
- Fibergraft (NCT07199075)
- Testing
- Questionnaires, Computer Tomography
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- AO Innovation Translation Center
Degenerative Lumbar Spine Diseases
Digital Health for Lumbar Degeneration
This study will integrate wireless wearable sensors, smartphone imaging, and multimodal artificial intelligence (AI) to address the rehabilitation needs of patients with lumbar degeneration.
- Trial name
- NCT07133724
- Testing
- AI-Based Smart Assessment and Rehabilitation Training
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Degenerative Lumbar Spine Diseases
Remote Intelligent Interactive Virtual Reality Assessment in Patients With Degenerative Lumbar Spine Diseases
This study will combine virtual reality (VR) technology with machine learning to focus on functional movement. Patients' symptoms will be evaluated, and exercise instruction with real-time feedback will be provided.
- Trial name
- NCT05425680
- Testing
- Core muscle training
- Where
- 2 sites in Taiwan
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Degenerative Disc Disease, Spondylolisthesis
PMCF Neo Pedicle Screw and Cage Systems
The objectives of this clinical observational study is to evaluate the safety and efficacy (performance) of the Neo Pedicle Screw System™ and the Neo Cage System™ interbody fusion device.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis, Spinal Tumor
- Trial name
- NCT03956537
- Testing
- NEO Pedicle Screw System™, Neo Cage System™
- Where
- 2 sites in Germany, Spain
- Volunteers
- 150 people
- Sponsor
- Neo Medical SA
Degenerative Spine, Degeneration of Lumbar Intervertebral Disc
Percutaneous Trans-facet Spine Fixation
Percutaneous Trans-facet Fixation Massoud-Goel Technique and Theory for Treatment of Degenerative Spine
- Conditions
- Degenerative Spine, Degeneration of Lumbar Intervertebral Disc, Degenerative Cervical Disc Disease, Ligamentum Flavum Hypertrophy
- Trial name
- Massoud-Goel (NCT07001969)
- Testing
- Massoud-Goel Technique and Theory, Percutaneous Trans-facet Fixation for Treatment of Degenerative Spine
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- Mahmoud Massoud
Cervical Spine Degenerative Disease
AO CSH Mainstream Study on Cervical Spine Degeneration
Adult patients with cervical degenerative diseases undergoing primary anterior and/or posterior cervical fusion will be prospectively enrolled from participating sites.
- Trial name
- CASDEM (NCT06845293)
- Volunteers
- 300 people
- Sponsor
- AO Innovation Translation Center
Osteoporosis, Degenerative Lumbar Disease
Osteo Match Cages Versus PEEK Cages in Osteoporotic Patients
This is a multicenter, prospective cohort study. The osteoporotic patients requiring posterior lumbar interbody fusion(LIF) with cages are prospectively enrolled and followed up.
- Conditions
- Osteoporosis, Degenerative Lumbar Disease, Degeneration Spine
- Trial name
- OMC (NCT05981222)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Peking University Third Hospital
Scoliosis; Adolescence, Degenerative Disc Disease
Personalized Spine Study Group (PSSG) Registry
The primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with patient specific rods.
- Conditions
- Scoliosis; Adolescence, Degenerative Disc Disease, Spinal Fusion, Kyphoscoliosis
- Trial name
- PSSG (NCT04601363)
- Testing
- Patient Specific Rod
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Colorado, Denver
Degenerative Spine Disease, Sagittal Balance
Evaluation of Deterioration in Body Posture of Older Patients During Gait Compared to Stance
The goal of this observational study is to analyze how spinal alignment changes when walking compared to standing still in adults aged 50 to 80 years who have sagittal imbalance. The main questions we aim to answer are: 1.
- Trial name
- NCT06557837
- Testing
- Questionnaires and pain assessment, Standing sagittal whole spine X-ray, Dynamic test
- Where
- 2 sites in Slovenia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Degenerative Lumbar Spine Diseases
Outcomes of Surgery for Degenerative Lumbar Spine Diseases
The purpose of this study is to determine the effectiveness of surgery on the elderly patients with DSD.
- Trial name
- NCT06540274
- Testing
- lumbar surgery
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Assiut University
Degenerative Spine Diseases, Surgical Wound
Effect of Topical Tranexamic Acid on Postoperative Drainage in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF)
The randomized controlled study which compare the efficacy outcomes (reducing blood loss and drainage output in patients) in patients undergoing single-level minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) and…
- Trial name
- NCT06427850
- Testing
- Tranexamic acid, Normal saline
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Thanawan Longsuwan
Degenerative Disc Disease, Spondylolisthesis
Quintex® Follow-up After One Year Minimum
Prospective study, not randomised, non-interventional, monocentric, investigating an intended patient cohort of 60 patients already operated on the cervical spine due to degenerative disc disease of the cervical spine down to the…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Trauma, Spinal Stenosis
- Trial name
- Quintex (NCT04489394)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Aesculap AG