Clinical trials: Deglutition
Dysphagia
Efficacy of Electrical Stimulation for Dysphagia in Head & Neck Cancer Patients
The purpose of the investigation is to learn whether intense swallowing exercise or intense swallowing exercise coupled with electrical stimulation (E-Stim) helps patients who had head/neck cancer and currently have dysphagia…
- Trial name
- NCT00629265
- Testing
- Neurotech NT2000 Neuromuscular Electrical Stimulation (NMES)
- Where
- 14 sites in United States
- Volunteers
- 170 people
- Sponsor
- Boston Medical Center
Deglutition Disorders, Tracheostomy Complication
Deflating the Tracheostomy Tube Cuff and Time for Decannulation
Introduction: Inpatients in an intensive care unit can need tracheostomy. To start the tracheostomy decannulation process, one of the procedures is to deflate the cuff.
- Trial name
- NCT05395728
- Testing
- Deflate the tracheostomy cuff early, Deflate the tracheostomy cuff after complete weaning mechanical ventilation
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hospital Moinhos de Vento
Gastroesophageal Reflux Disease
Symptom Control and Impact on Daily Life in Patients With Gastroesophageal Reflux Disease
The purpose of this study is to evaluate the impact of gastroesophageal reflux disease (GERD) treatment in primary care setting on symptom control and daily life in symptomatic GERD patients, using both GERD questionnaire and…
- Trial name
- NCT01432392
- Where
- 2 sites in Bulgaria
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
GERD
An Open, Randomized, Two Way Crossover Study Comparing the Effect of 20mg Esomeprazole Administered Orally and Intravenously as a 15 Minute Infusion on Basal and Pentagastrin-Stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD)
This study looks at the effect on basal and pentagastrin-stimulated acid output of 40 mg Esomeprazole (Nexium) administered orally and intravenously as a 15-minute infusion to people with symptoms of Gastroesophageal Reflux…
- Trial name
- NCT00629564
- Testing
- Esomeprazole
- Volunteers
- 60 people
- Sponsor
- AstraZeneca
Cerebral Palsy, Dysphagia
Functional Endoscopic Evaluation of Swallowing
The investigators objective is to describe functional endoscopic evaluation of swallowing findings in children with cerebral palsy.
- Trial name
- NCT00717028
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- Fortaleza University
Gastro Esophageal Reflux
Effect of Fermented Soybean (FSB) Supplementation on Gas-troesophageal Reflux Disease (GERD)
Gastroesophageal reflux disease (GERD) is a prevalent chronic condition affecting the well-being of both adults and children in general medical practice.
- Trial name
- NCT06524271
- Testing
- Fermented Soybean, Supplement without fermented soybean
- Where
- Malaysia
- Volunteers
- 110 people
- Sponsor
- NATTOME SDN BHD
Asthma, GERD
Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma
The purpose of this study is to determine whether treatment with esomeprazole for 6 months will improve asthma in adult patients with moderate to severe asthma and symptoms of gastroesophageal reflux disease.
- Trial name
- RELAX (NCT00317044)
- Testing
- Esomeprazole
- Where
- 130 sites in United States, Argentina and 12 more
- Volunteers
- 961 people
- Sponsor
- AstraZeneca
Postoperative Sore Throat, Endotracheal Intubation
Scheduled Endotracheal Tube Cuff Pressure Management and Postoperative Sore Throat
This randomized controlled trial evaluated whether scheduled measurement and adjustment of endotracheal tube cuff pressure using a handheld manometer could reduce postoperative sore throat in adults undergoing elective surgery…
- Trial name
- NCT07842081
- Testing
- Handheld Endotracheal Tube Cuff Manometer, Pilot-Balloon Palpation
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Hitit University
Stroke, Dysphagia
Liu-Zi-Jue Exercise Combined With Conventional Rehabilitation Treat Dysphagia in Post-stroke
In this study, a prospective, randomized controlled method was adopted, with patients with post-stroke dysphagia as the main research objects, applying "Liu-Zi-Jue" to the patients for rehabilitation intervention, and to explore…
- Trial name
- NCT05602922
- Testing
- Liu-Zi-Jue Exercise, Basic treatment +Swallowing rehabilitation training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding
Comparison of Sedated and Unsedated PEG in Elderly ASA IV Patients
This prospective observational cohort study aims to compare the safety and clinical outcomes of sedated and unsedated percutaneous endoscopic gastrostomy procedures in elderly patients classified as ASA IV.
- Conditions
- Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding, Dysphagia, Elderly Patients (>65 Years)
- Trial name
- NCT07758153
- Volunteers
- 70 people
- Sponsor
- Mersin University
Speech and Language Disorder, Speech Therapy
Providing Speech Therapy Awareness in Private Schools
There has been limited research in the area of speech and language therapy awareness in Pakistan. The study aims to assess the efficacy of providing speech therapy awareness in private schools through a pre-post model.
- Conditions
- Speech and Language Disorder, Speech Therapy, Speech Delay, Swallowing Disorder
- Trial name
- NCT04505696
- Testing
- Speech-Language Pathology Presentation
- Where
- Pakistan
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Hospitalisation in Geriatrics, Swallowing Disorder
Design of a Food Preference Assessment Tool for Older Patients in Geriatrics units_DYSPHAGING-PREFERENCES
Swallowing disorders - or oral dysphagia (OD) - are identified as a cause of malnutrition. They gradually lead patients to withdraw certain foods from their diet, leading to progressive dietary imbalances, or increased…
- Conditions
- Hospitalisation in Geriatrics, Swallowing Disorder, Eating Habits
- Trial name
- DYSPHAGING-PRE (NCT07205354)
- Testing
- ADAPTATION, test-retest reliability, Cross-sectional study
- Where
- 3 sites in France
- Volunteers
- 209 people
- Sponsor
- Hospices Civils de Lyon
Gastroparesis, GERD
Domperidone for Relief of Gastrointestinal Disorders
The purpose of this study is to make Domperidone available to patients with gastrointestinal disorders who have failed standard therapy and who might benefit from it.
- Conditions
- Gastroparesis, GERD, Esophagitis, Dyspepsia
- Trial name
- NCT00761254
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Carle Physician Group
Dysphagia, Swallowing Disorder
tACS and tRNS Studies on Brain Control of Swallowing
Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) are two (CE marked medical devices) new, non-invasive (over the scalp) brain stimulation (NIBS) techniques.
- Trial name
- NCT04040803
- Testing
- Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS)
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Patients With Typical Symptoms of GERD (GERD Q >= 8)
Proton Pump Inhibitor Empirical Treatment in Management of Outpatients With Gastroesophageal Reflux Disease.
China Survey of Proton Pump Inhibitor Empirical Treatment in Management of Outpatients with Gastroesophageal Reflux Disease
- Trial name
- NCT02606851
- Where
- 10 sites in China
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Pharmacokinetics, Cardiodynamic ECG
A Study to Investigate the Pharmacokinetics and ECG Effects of Linaprazan Glurate
This is a Phase I, single-center, double blind, placebo-controlled, parallel-group, randomized trial designed to evaluate the PK, cardiodynamic ECG effects, safety, and tolerability of single oral doses of linaprazan glurate.
- Conditions
- Pharmacokinetics, Cardiodynamic ECG, Safety, and Tolerability, GERD
- Trial name
- NCT05469854
- Testing
- Linaprazan glurate
- Where
- Sweden
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
GERD (Gastroesophageal Reflux Disease)
A Study to Evaluate Tegoprazan as a Diagnostic Tool for GERD
The purpose of this study is to evaluate the diagnostic value of tegoprazan for GERD. Patients experiencing typical GERD symptoms, such as heartburn and acid regurgitation, will take either tegoprazan or a placebo once daily for…
- Trial name
- NCT07826455
- Testing
- Tegoprazan 50 mg
- Volunteers
- 100 people
- Sponsor
- HK inno.N Corporation
Oral Hypofunction
Program of Community Oral Function Enhancement
The purpose of this study examined the effects of oral exercise on oral function among older adults in Taiwan, focusing on gender-related outcome differences.
- Trial name
- NCT06794814
- Testing
- oral exercise
- Where
- Taiwan
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Stroke, Cerebrovascular Accident
Outcomes of Swallowing Rehabilitation After Stroke
This project proposes to evaluate the relative effectiveness of four therapy protocols for pharyngeal phase swallowing impairment in the stroke population.
- Conditions
- Stroke, Cerebrovascular Accident, Dysphagia
- Trial name
- NCT00288834
- Testing
- dysphagia rehabilitation
- Where
- 9 sites in Australia, Canada and 2 more
- Sponsor
- University of Canterbury
Dysphagia, Oropharyngeal, Parkinson Disease
Benefit From the Chin Down Maneuver in the Swallowing Performance and Self-perception of Parkinson's Disease Patients
Objective: To verify the effectiveness of chin-down posture maneuver in swallowing therapy for Parkinson's disease (PD).
- Conditions
- Dysphagia, Oropharyngeal, Parkinson Disease, Speech Therapy, Orientation
- Trial name
- NCT02973698
- Testing
- chin-down posture maneuver, Orientations about swallowing, Control
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre