Clinical trials: Deglutition Disorder
Barrett's Esophagus, Gastroesophageal Reflux Disease
Quality of Life in Barrett's Esophagus and Gastro-Esophageal Reflux Disease
To Compare the overall quality of life of patients with no Barrett's esophagus , non-dysplastic Barrett's Esophagus (NDBE), Barrett's esophagus with low grade dysplasia (LGD), and Barrett's esophagus with high grade dysplasia…
- Trial name
- NCT01572974
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Midwest Biomedical Research
Bronchopulmonary Dysplasia, Gastroesophageal Reflux
Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia
The goal of this clinical trial is to learn if transpyloric tube feeding (feeding directly into the small intestine) versus gastric tube feeding tolerably and effectively reduces gastroesophageal reflux in infants born premature…
- Trial name
- NCT06534359
- Testing
- Transpyloric tube feeding, Gastric tube feeding
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Philadelphia
Clostridium Difficile Infection
Effect of Acid Suppression Medication on Pediatric Microbiome
The colonic microbiome is essential in health and disease, and is highly dynamic during the first several years of life. Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) are widely used in children, but…
- Trial name
- NCT02016820
- Testing
- Omeprazole (suspension), Lifestyle Modification
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Gastroesophageal Reflux Disease
A Study of Nexium (Esomeprazole) 40 mg Once Daily in Subjects With Symptoms of Gastroesophageal Reflux Disease (GORD) After Treatment With a Full Dose of Proton Pump Inhibitor (PPI)
The purpose of this study is to assess how patients with gastro-oesophageal reflux disease (heartburn) who are currently receiving treatment with a proton pump inhibitor but are still experiencing symptoms will benefit from a…
- Trial name
- NEON (NCT00734097)
- Testing
- Esomeprazole 40 mg, Physical Exam, Quality of Life Questionnaires
- Where
- 10 sites in Argentina, Chile and 2 more
- Volunteers
- 314 people
- Sponsor
- AstraZeneca
Oculopharyngeal Muscular Dystrophy
Treatment of Oculopharyngeal Muscular Dystrophy With Trehalose
BB-OPMD-202 is a randomized, double-blind, placebo-controlled study of IV trehalose for treatment of OPMD. The study includes a 4-week screening period, a 24-week blinded treatment period during which patients will receive weekly…
- Trial name
- NCT04226924
- Testing
- Trehalose
- Where
- 3 sites in Canada
- Sponsor
- Bioblast Pharma Ltd.
Achalasia
Sensorimotor Dysfunction in Achalasia
This study is being done to assess the esophageal muscle (swallowing tube) in patients with and without achalasia to further understand and help direct the treatment for patients with achalasia.
- Trial name
- NCT02434991
- Testing
- Barostat
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Stroke, Dysphagia
Ultrasonographic Parameters in Stroke Patients With Dysphagia
ultrasonographic parameters in stroke patients with dysphagia
- Trial name
- NCT06615310
- Testing
- ultrasonograpic evaluotion
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Deglutition Disorders
Dysphagia on the Intensive Care Unit
Recording of routine practice patterns to detect and/or treat Dysphagia on the ICU via interview of local colleagues. This will not allow to record generalizable data, but will reflect the actual routine standard of care.
- Trial name
- DICE-SWISS (NCT03487510)
- Testing
- NO interventions apply
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Gastroesophageal Reflux, Heartburn
Esomeprazole and Gastric Emptying of Beer
To investigate the effect of 20 mg esomeprazole daily for one week on gastric emptying of 500 ml beer, the consecutive blood alcohol levels, the gastroesophageal reflux and plasma levels of gastrin and CCK in a randomized…
- Trial name
- NCT00472550
- Testing
- esomeprazole 20 mg
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Abdominal Pain, Deglutition Disorders
Development and Validation of the Automated Evaluation of Gastrointestinal Symptoms (AEGIS) Platform
Through a four-year grant awarded to the University of California at Los Angeles in 2009, Dr. Brennan Spiegel served as a principal investigator (PI) for a project to develop and initially validate a bank of items to assess…
- Conditions
- Abdominal Pain, Deglutition Disorders, Fecal Incontinence, Nausea
- Trial name
- NCT02436057
- Testing
- AEGIS (Automated Evaluation of Gastrointestinal Symptoms)
- Where
- 3 sites in United States
- Volunteers
- 255 people
- Sponsor
- Cedars-Sinai Medical Center
Dysphagia, Esophageal, Dysphagia, Oral Phase
Post-thyroidectomy Dysphagia: An International Multicentric CONSORT - Compatible RCT
The most common and feared complications of total thyroidectomy are vocal cord paralyses and hypocalcemia. However, post-thyroidectomy dysphagia is not uncommon and has important consequences on the quality of life (QoL).
- Conditions
- Dysphagia, Esophageal, Dysphagia, Oral Phase, Dysphagia Comes and Goes, Thyroiditis
- Trial name
- Dysphagia-TT (NCT04410601)
- Testing
- Total thyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Umraniye Education and Research Hospital
Gastroesophageal Reflux Disease, Depression
Zuojin Wan Combined With Woonosan Fumarate for the Treatment of GRD Combined With Depression
To evaluate the improvement of symptoms in patients with gastroesophageal reflux disease combined with depression (hepatic and gastric depression-heat type) by Zuojin Wan combined with vornodine fumarate regimen as a control, and…
- Trial name
- NCT06481787
- Testing
- Vonorasan Fumarate, Zuojin Pills
- Volunteers
- 300 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Stroke, Acute, Swallowing Disorder
Functionality, Cognition And Swallowing Skills In Patients With AcuteSTROKE
Aim: Studies in which the results of the screening test evaluating swallowing skills in acute stroke patients are evaluated together with other components that may affect swallowing function are limited.
- Conditions
- Stroke, Acute, Swallowing Disorder, Cognitive Impairment, Stroke
- Trial name
- NCT06288243
- Testing
- Clinician-observed assessment tests
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Medipol University
Benign Esophageal Lesions
SX ELLA Esophageal Degradable BD Stent System
The SX-ELLA Stent Esophageal Degradable BD (BD Stent) is designed for dilation of benign esophageal lesions, namely: (1) stenosis (peptic, anastomotic or caustic) refractory to standard therapy, (2) achalasia refractory to…
- Trial name
- DESTINY (NCT01337206)
- Testing
- Stenting with ELLA Biodegradable stent, Standard Dilations
- Where
- 8 sites in Belgium, Italy and 3 more
- Volunteers
- 66 people
- Sponsor
- Cook Group Incorporated
Dysphagia, Parkinson Disease (PD)
Exploring the Efficacy of the Effortful Swallow Maneuver for Improving Swallowing in People With PD
The goal of this clinical trial is to learn whether a 4-week effortful swallow exercise program helps adults with Parkinson disease who have swallowing problems.
- Trial name
- EFFORT-PD (NCT07773025)
- Testing
- Effortful swallow
- Volunteers
- 74 people
- Sponsor
- University of Alberta
Esophagus Disorder, Esophageal Achalasia
Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders
No recommendation regarding antibiotic prophylaxis and preparation modalities are available for patients with esophageal motor disorders who benefit from Per-Oral Endoscopic Myotomy (POEM).
- Trial name
- NCT03944863
- Testing
- Antibiotics
- Volunteers
- 252 people
- Sponsor
- Société Française d'Endoscopie Digestive
Mitral Valve Regurgitation
Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System
The purpose of this study is to evaluate the safety and initial performance of the Neovasc Tiara Mitral Transcatheter Heart Valve with the Tiara Transapical Delivery System.
- Trial name
- TIARA-I (NCT02276547)
- Testing
- Mitral valve replacement
- Where
- 10 sites in United States, Belgium and 1 more
- Volunteers
- 27 people
- Sponsor
- Shockwave Medical, Inc.
Dysphagia, Dysphonia
Voice and Swallowing Outcomes Following Revision Anterior Cervical Spine Surgery
Evaluate voice and swallowing outcomes post operatively.
- Trial name
- NCT01017055
- Testing
- Voice and Swallowing evaluations
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Obesity
Study of Stomatognathic System of the Obese Subjects
The aim is to identify differences in the stomatognathic system, mastication and deglutition functions between obese and normal weight subjects.
- Trial name
- SSSCDFO (NCT00868049)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Gastroesophageal Reflux Disease
Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease
BACKGROUND: Gastroesophageal reflux disease is a very frequent clinical condition and nocturnal symptoms are a cause of quality of life impairment, poor sleep quality and absenteeism.
- Trial name
- IBELGA (NCT02706938)
- Testing
- Head of bed elevation, Standard treatment
- Where
- Colombia
- Volunteers
- 65 people
- Sponsor
- Universidad Nacional de Colombia
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