Clinical trials: Deglutition Disorder
Achalasia
Per-Oral Endoscopic Esophagomyotomy (POEM)
Achalasia is an esophageal motility disease that usually requires surgical intervention (esophagomyotomy). Laparoscopic techniques have reduced the morbidity associated with myotomy, but post-op GERD, wound infection, hernia and…
- Trial name
- POEM (NCT01635374)
- Testing
- Per-Oral Endoscopic Esophagomyotomy
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Northwestern University
Thymidine Kinase 2 (TK2)
A RETROspective Study of Patients With TK2d
This is a medical chart review study to collect information for patients who have been taking pyrimidine nucleosides for treatment of TK2 deficiency.
- Trial name
- RETRO (NCT03701568)
- Testing
- dC/dT
- Where
- 8 sites in United States, Israel and 1 more
- Volunteers
- 38 people
- Sponsor
- Zogenix MDS, Inc.
Gastroesophageal Reflux, Sleep Apnea
Evaluation of Gastroesophageal Reflux in Patients on Continuous Positive Airway Pressure Ventilation for Obstructive Sleep Apnea
Patients with a clinically indicated sleep study will be enrolled in this study. They will have a diagnostic and a therapeutic sleep study with continuous positive airway pressure ventilation.
- Trial name
- NCT00194376
- Testing
- Continuous positive airway pressure ventilation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Gastroesophageal Reflux Disease
Compound Sodium Alginate Double Action Chewable Tablets 4-hour Esophageal pH Study in GERD Patients
This study is being conducted to assess the effectiveness of the Compound Sodium Alginate Double Action Chewable Tablets compared to placebo on acidic reflux events into the esophagus in patients diagnosed with Gastroesophageal…
- Trial name
- NCT01872897
- Testing
- Sodium Alginate Double Action Chewable Tablets
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive
Randomized Controlled Study of Optical 3D Navigated Repetitive Transcranial Magnetic Stimulation for Achalasia.
The goal of this clinical trial is to investigate the clinical efficacy of repetitive transcranial magnetic stimulation in the treatment of achalasia in patients diagnosed with achalasia by comprehensive evaluation of clinical…
- Conditions
- Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive, Vagus Nerve Motor Disorder, Functional Magnetic Resonance Imaging
- Trial name
- NCT06027190
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Zhang Nina
Dysphagia, Swallowing Disorder
tACS and tRNS Studies on Brain Control of Swallowing
Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) are two (CE marked medical devices) new, non-invasive (over the scalp) brain stimulation (NIBS) techniques.
- Trial name
- NCT04040803
- Testing
- Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS)
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Dysphagia
Clinical Trial for Clinical Excellence and Safety Evaluation of 4-channel Functional Electric Stimulator
This study is a pilot study to prepare clinical trials to evaluate the safety and effectiveness of 4-channel electric stimulation therapy devices as a newly developed function for the treatment of dysphagia disorders.
- Trial name
- NCT05483582
- Testing
- 4-channel Electrical Stimulation Device, 2-channel Electrical Stimulation Device
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Swallowing Disorders
Follow-up After a Stay in Intensive Rehabilitation for Patients With Swallowing Disorders
Prospective, open-label, randomized, single-center study evaluating the benefit of a months long monthly telephone follow-up for patients with chronic disorders following the after-effects of anti-cancer treatments after an…
- Trial name
- E-CRIL (NCT04859595)
- Testing
- Telephone follow-up
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Toulouse
Gastroesophageal Reflux Disease (GERD), Non-erosive Reflux Disease (NERD)
Assessment of Esophageal Epithelium Integrity With Mucosal Impedance
Gastroesophageal reflux disease (GERD) is a common condition affecting more than 100 million adults in the U.S., and it significantly impacts patients' quality of life while imposing billions of dollars of direct and indirect…
- Trial name
- NCT02318862
- Testing
- Standard of Care esophagogastroduodenoscopy (EGD) with mucosal impedance testing
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia, Pain
Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer
This randomized pilot clinical trial studies dexamethasone in reducing oral pain and dry mouth after surgery in patients with oropharyngeal cancer. Dexamethasone may help lower pain and dry mouth caused by surgery.
- Conditions
- Dysphagia, Pain, Stage I Oropharyngeal Squamous Cell Carcinoma, Stage II Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT01748942
- Testing
- Dexamethasone, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- OHSU Knight Cancer Institute
Paraesophageal Hernia, GERD
Mesh Vs Pledgets for Repair of Paraesophageal Hernia
The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at…
- Trial name
- NCT05974722
- Testing
- OviTex Mesh, Pledgeted sutures
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- David Krpata
Perforation Esophagus, Esophageal Cancer
Feasibility and Efficacy of a Combination of a SEMS and Vacuum Wound Treatment (VACStent)
Open, prospective, one-arm feasibility and efficacy study of a European conformity (CE) certified Combination product of two CE certified medical devices in the intended indication.
- Conditions
- Perforation Esophagus, Esophageal Cancer, Esophageal Achalasia, Esophageal Diseases
- Trial name
- VACStent (NCT03962179)
- Testing
- VACStent
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital of Cologne
Reflux, Renal Excretion
Renal Impairment Study
The purpose of this study is to see how quickly AZD3355 is taken up in to the blood and leaves the blood in people with normal kidney function or with different degrees of reduced kidney function.
- Trial name
- NCT00863161
- Testing
- AZD3355
- Where
- 3 sites in Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cancer Survivor, Dysphagia
Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors
This trial studies how well manual therapy works in treating fibrosis-related late effect dysphagia in head and neck cancer survivors.
- Conditions
- Cancer Survivor, Dysphagia, Fibrosis, Head and Neck Carcinoma
- Trial name
- MANTLE (NCT03612531)
- Testing
- Manual Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Stroke, Dysphagia
Prediction of Functional Health Status and Aspiration Using Multiple Dysphagia Scales Over 6 Months After Acute Stroke
In order to discover dysphagia scales, which shows meaningful predictability of aspiration and functional health status in patients with acute stroke, authors plan to find out more predictable indicators than existing…
- Trial name
- NCT03787524
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Ulsan University Hospital
Swallowing Disorder
The Effect of Active Breathing Exercises for Elderly People in the Community
The goal of this clinical trial is to explore the impact of Active Breathing Exercises on swallowing function and quality of life in community-dwelling elderly individuals (≥60 year old) with swallowing disorders.
- Trial name
- ABE (NCT06232031)
- Testing
- Active Breathing Exercises
- Sponsor
- Zeng Changhao
Swallowing Disorder
The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals
The purpose of this study is to test the reliability and validity of the The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals among adult patients with swallowing disorders.
- Trial name
- NCT03907566
- Testing
- The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Hacettepe University
Laryngeal Cancer, Dysphagia
Using the Subglottic Pressure to Predict the Dysphagia After Partial Laryngectomy
Recruited patients are divided into two arms depending on laryngeal carcinoma's T1 and T2 stages. Two interventions were undergone, including transoral endoscopic laser cordectomy and open partial horizontal laryngectomy (OPHL).
- Trial name
- SPPDPL (NCT06024980)
- Testing
- Open partial horizontal laryngectomy(OPHL), Type I-III, Transoral endoscopic laser cordectomy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial People's Hospital
GERD
Alginate vs Sucralfate for GERD Symptomatic Relief
Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal disorder characterized by the regurgitation of gastric contents into the esophagus.It can also present in an atypical manner such as chest pain, dental…
- Trial name
- NCT07310927
- Testing
- Alginate, Sucralfate
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
Heartburn
Esomeprazole And Symptomatic Response In Patients With Or Without An Elevated Risk For Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated GI Damage
The purpose of this study is to compare the treatment effect in patients with upper gastro-intestinal complaints with an elevated risk for NSAID-associated GI-damage to those without an elevated risk for NSAID-associated damage…
- Trial name
- Synchronise (NCT00524329)
- Volunteers
- 1,220 people
- Sponsor
- AstraZeneca
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