Clinical trials: Deglutition Disorder
Achalasia Cardia
Serum Anti-enteric Neuronal Antibodies in Patients With Achalasia and Their Association With Clinical Profiles
Achalasia is a rare esophageal motility disorder characterized by impaired relaxation of the lower esophageal sphincter and progressive esophageal dilation.
- Trial name
- NCT07451301
- Testing
- peroral endoscopic myotomy (POEM)
- Where
- China
- Volunteers
- 195 people
- Sponsor
- Peking Union Medical College Hospital
GERD, Gastroesophageal Reflux Disease
LINX Reflux Management System in Subjects With GERD Who Have Previously Undergone a Laparoscopic Sleeve Gastrectomy
The purpose of this study is to evaluate the LINX device in patients who have previously undergone laparoscopic sleeve gastrectomy (LSG) for obesity and have chronic gastroesophageal reflux disease (GERD).
- Trial name
- RELIEF (NCT02429830)
- Testing
- LINX device
- Where
- 12 sites in United States
- Volunteers
- 30 people
- Sponsor
- Torax Medical Incorporated
Gastroesophageal Reflux Disease
Stretta In Reflux Uncontrolled by IPP
The aim of the study is to compare the Stretta procedure and the Sham procedure efficiency 6months post-procedure in reflux uncontrolled by intake of Inhibitors of Protons Pump (IPP) patients.
- Trial name
- SIRUP (NCT01682265)
- Testing
- Stretta procedure
- Where
- 6 sites in France
- Volunteers
- 62 people
- Sponsor
- Nantes University Hospital
Feeding; Difficult, Newborn, Premature Infant Disease
Psychometric Properties of the SMART Feeding Tool
This observational study aims to evaluate the psychometric properties of a new infant feeding tool called "SMART Tool" in the neonatal intensive care unit. The main questions it aims to answer are: 1.
- Conditions
- Feeding; Difficult, Newborn, Premature Infant Disease, Dysphagia of Newborn, Nurse's Role
- Trial name
- NCT05729828
- Where
- 4 sites in United States
- Volunteers
- 76 people
- Sponsor
- Wake Forest University Health Sciences
Gastroesophageal Reflux, Chronic Obstructive Pulmonary Disease
COPD Patients Diagnosed With GERD,COPD Exacerbations After Treatment With High Dose PPI
The purpose of this study is to determine which COPD patients have GERD and if COPD patients with GERD treated with high dose lansoprazole for 1 year decreases the frequency of COPD exacerbations compared to the previous year…
- Trial name
- GERD/COPD (NCT00523367)
- Testing
- 24 hour pH testing
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Achalasia
Endoscopic Myotomy for the Treatment of Achalasia (Motility Disorder) of the Esophagus - POEM Procedure
Endoscopic Esophageal Myotomy (POEM), the research procedure, splits the lower esophageal sphincter muscle fibers from the inside of the esophagus, avoiding several abdominal incisions (belly area cuts), by using an endoscope to…
- Trial name
- POEM (NCT01873300)
- Testing
- Endoscopic Esophageal Myotomy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Stroke, Dysphagia
Role of Genetic Polymorphism in Neuroplasticity Involved in Dysphagia Recovery
The purpose of this study is to assess the association of genetic polymorphism such as the Brain-derived Neurotrophic factor (BDNF), in neurogenic dysphagia in those with brain lesion.
- Trial name
- NCT03577444
- Where
- 2 sites in South Korea
- Volunteers
- 220 people
- Sponsor
- The Catholic University of Korea
Laryngopharyngeal Reflux
Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux
The purpose of this study is to determine whether Lansoprazole 30mg taken twice daily is effective in the treatment of laryngitis due to gastroesophageal reflux.
- Trial name
- NCT00369265
- Testing
- Lansoprazole, Sugar pill
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- American Institute for Voice and Ear Research
Gastroesophageal Reflux Disease
Narrow-band Imaging, Autofluorescence Imaging and Gastroesophageal Reflux Disease
Aim of this study is to compare the efficacy of narrow band imaging (NBI) and autofluorescence imaging (AFI) to distinguish subtle mucosal change related to acid reflux that is not visible in standard white light imaging (WLI)…
- Trial name
- NCT01504971
- Testing
- symptom questionaire, pH monitoring, Tri-modal imaging endoscopy
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Gastroesophageal Disease
To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure
The purpose of this study is to determine if sleep deprivation results in increased esophageal acid exposure in healthy controls and gastroesophageal reflux disease (GERD) patients.
- Trial name
- IRUSESOM0428 (NCT01093339)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Southern Arizona VA Health Care System
Gastroesophageal Reflux
Gastro-intestinal Physiology After Anti-Reflux Procedures
Gastro-oesophageal reflux disease (GORD) affects 1 in 4 adults and is a condition where stomach acid leaks back up into the oesophagus (gullet).
- Trial name
- GASP (NCT05238636)
- Testing
- Anti-reflux surgery - Stretta procedure or LINX device or laparoscopic fundoplication
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- St George's, University of London
Gastroesophageal Reflux, Obesity
Laparoscopic Roux-en-Y Gastric Bypass and Gastro-esophageal Reflux
Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is considered the weight loss procedure of choice for patients suffering of gastro-esophageal reflux (GER).
- Trial name
- NCT02618044
- Volunteers
- 86 people
- Sponsor
- University of Turin, Italy
Stroke, Dysphagia
The Effect of Repetitive Transcranial Magnetic Stimulation for Poststroke Dysphagia Recovery
Dysphagia is one of severe complications among stroke survivors. Dysphagia is usually associated with high levels of morbidity, mortality, and financial cost.
- Trial name
- NCT02090231
- Testing
- rTMS, Magstim Rapid2
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gastroesophageal Reflux Disease (GERD)
Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to determine the safety and efficacy of Rabeprazole extended release (ER) 50 mg versus Esomeprazole 40 mg for healing and symptomatic relief among subjects with erosive gastroesophageal reflux disease…
- Trial name
- NCT00658528
- Testing
- Rabeprazole sodium, Esomeprazole
- Where
- 88 sites in United States, Argentina and 11 more
- Volunteers
- 1,061 people
- Sponsor
- Eisai Inc.
Dysphagia, Healthy Aging
Swallowing Impairments in ICU Survivors and Community-Dwelling Adults
Post-intensive care syndrome (PICS), which consists of physical, cognitive, and psychosocial problems, is a pervasive complication for older intensive care unit (ICU) survivors and contributes to detrimental health outcomes and…
- Conditions
- Dysphagia, Healthy Aging, Post Intensive Care Syndrome, Caregiver Burden
- Trial name
- NCT07005037
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Post Operative Sore Throat, Dysphagia
Post-operative Sore Throat as Determined by Endotracheal Tube Inflation Technique
The purpose of this study is to test whether the incidence of sore throat and other tracheal co-morbidities such as dysphagia and hoarseness can be lessened by use of a cuff manometer at the beginning of surgery to inflate to the…
- Conditions
- Post Operative Sore Throat, Dysphagia, Hoarseness
- Trial name
- NCT01305265
- Testing
- cuff manometer
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Swallowing
Longitudinal Ultrasound Kinematic Evaluation of Digastric Muscles
Ultrasound applied to the upper aerodigestive tract for the assessment of swallowing disorders has been the subject of numerous publications in recent years.
- Trial name
- LUKE (NCT07670429)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hopital Forcilles
Gastro-esophageal Reflux Disease
Diagnostic Yield of Post PRandial Esophageal High Resolution Impedance Manometry in Patients With Gastro-Esophageal Reflux Disease Symptoms Resistant to Proton Pump Inhibitor Therapy
Gastro-esophageal reflux disease (GERD) is defined as the reflux of gastric content into the esophagus that causes troublesome symptoms or complications.
- Trial name
- PRIMER (NCT03596476)
- Testing
- Upper gastrointestinal (GI) endoscopy, Wireless pH monitoring, Post prandial esophageal High Resolution Impedance Manometry
- Where
- 7 sites in France
- Volunteers
- 330 people
- Sponsor
- Hospices Civils de Lyon
Gastroesophageal Reflux
Jejunal Feeding Via Gastrojejunal Tube in Refractory Gastroesophageal Reflux
Gastroesophageal reflux disease (GERD) in children can be severe and lead to multiple complications, dizziness, esophagitis, respiratory failure or ENT infections.
- Trial name
- ReJej (NCT05278689)
- Testing
- No intervention
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Esophageal Squamous Cell Carcinoma, Patient-reported Outcomes
Patient-reported Outcomes in Preoperative Immunochemotherapy/Radiotherapy-treated Esophageal Cancer Patients
Preoperative Immune checkpoint inhibitors combined with chemotherapy have revolutionized the treatment landscape of locally advanced esophageal squamous cell carcinoma.
- Conditions
- Esophageal Squamous Cell Carcinoma, Patient-reported Outcomes, Immunotherapy
- Trial name
- PICCRT (NCT05596890)
- Testing
- Paclitaxel-albumin, Cisplatin, Carboplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial People's Hospital
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