Clinical trials: Deglutition Disorder
Cervical Spine
Effect of Local Steroid Application on a Cervical Plate Versus Intravenous Steroids on Dysphagia Following Anterior Cervical Discectomy and Fusion (ACDF)
Local application of steroids in ACDF surgery will lead to decreased incidence of dysphagia compared to intravenous steroids or a control group
- Trial name
- NCT02577991
- Testing
- Decadron, Triamcinolone
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
GERD
Canadian, Multi-Centre Study of Symptom Burden and Clinical Management in Subjects With GERD
This is a cross-sectional study of symptom burden and clinical management. A subset of patients who have attended the Primary Care (PC) office with reflux symptoms during a retrospective period of 4 months (Index Visit) are…
- Trial name
- RANGE (NCT00634023)
- Where
- 15 sites in Canada
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Barrett's Esophagus, Radiofrequency Ablation
Radiofrequency Ablation in Patients With Barrett's Esophagus
The aim of this study is to establish a nationwide registry to collect data regarding the treatment of Barrett's Esophagus (BE) with radiofrequency ablation.
- Conditions
- Barrett's Esophagus, Radiofrequency Ablation, Gastroesophageal Reflux Disease
- Trial name
- RABE (NCT02793479)
- Where
- Austria
- Volunteers
- 500 people
- Sponsor
- Matthias Paireder
Deglutition
Remote Orthophonic Follow-up on Patients With Chronic Swallowing Disorders
The study will assess the feasibility of monthly post rehabilitation remote monitoring, using the "MAX Educ" webvision app, in patients with sequelae of aerodigestive cancer treatments.
- Trial name
- E-CRIL_MAX (NCT04969874)
- Testing
- Remote follow-up
- Where
- France
- Sponsor
- University Hospital, Toulouse
Cardiovascular Disease
Prevention and Treatment of Cardiovascular Disease
In view of the close interrelationship between the various organs and systems of the body, which cannot be examined in a parceled fashion but rather as an integrated system, this study aims to consider the potential risks…
- Trial name
- VPC (NCT06413823)
- Where
- Italy
- Volunteers
- 218 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Gastroesophageal Reflux Disease, Excessive Weight Loss
Sleeve Gastrectomy With Reestablishment of the Acute Angle of His (SG-REACH) in Obese Patients
Gastroesophageal reflux disease (GERD) is one of the most common chronic conditions that can affect one's quality of life. Laparoscopic sleeve gastrectomy (LSG) has become a popular technique and currently is the most frequently…
- Conditions
- Gastroesophageal Reflux Disease, Excessive Weight Loss, Total Weight Loss, Sleeve Gastrectomy
- Trial name
- SG-REACH (NCT05452980)
- Testing
- reestablishment of the acute angle of His, sleeve gastrectomy
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhen Jun Wang
Non-erosive Reflux Disease, Gastroesophageal Reflux
Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection
Primary Objective: Evaluate response to NERD treatment between patients with normal endomicroscopy findings compared with patients with abnormal endomicroscopy findings.
- Trial name
- CENERDD (NCT02788591)
- Testing
- Proton Pump Inhibitor (PPI) Therapy, Sucralfate
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- LCMC Health
GERD
Endoscopic Band Ligation for Treating Reflux Disease
GERD is a chronic disease the require different treatment modalities; non have proven long term efficacy with concerns about their safety. The use of band ligation in endoscopy appears safe, repeatable with short learning curve.
- Trial name
- NCT06126055
- Testing
- Band Ligation
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- El Katib Hospital
Anesthesia, Intensive Care
Pressure Course in the Tube Cuff During Swallowing
Leakage of fluid from the subglottic space to the lungs occurs along the longitudinal folds within the wall of endotracheal tube (ETT) cuffs.
- Trial name
- NCT00862797
- Testing
- pressure measurement during swallowing
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Freiburg
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Covid19
Swallowing Impairment After COVID-19 Infection
This is an observational study, in which people recovering from COVID-19 infection will attend an outpatient clinic for a comprehensive swallowing assessment.
- Trial name
- NCT04537650
- Testing
- Videofluoroscopic Swallowing Study (VFSS)
- Where
- 2 sites in United States, Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
Esophageal Motility Disorders
Observational Field Study of Acute Esophageal Food Bolus Impaction by Mean Esophageal Manometry and 24h-pH-monitoring
The aim of this study is to evaluate standard investigations performed in patients with bolus impaction in a prospective observational field study. In bolus impaction, ingested food boluses have to be endoscopically removed.
- Trial name
- NCT01447823
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Gastroesophageal Reflux Disease
Scintigraphy Study to Compare the Antireflux Activity of the Z0063 Versus Gaviscon Double Action Tablets, in Healthy Adult Subjects
Primary Objective: Pharmacodynamics: assessment and comparison by gamma scintigraphy of the gastric retention of alginate rafts (raft performance) of Z0063 to the effect of Gaviscon Double Action Tablets, in healthy adult…
- Trial name
- NCT03065816
- Testing
- Z0063, Gaviscon
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sanofi
GERD
Response Surface Pathway Design With Two Interventional- and One Response Variable in Estimating Minimum Efficacy Dose
Response Surface Pathway (RSP) design was previously developed for dose-finding studies with one interventional and one response variable, but RSP to higher dimensions is requested.
- Trial name
- NCT03568825
- Testing
- Osteopatic Manual Therapy (OMT)
- Volunteers
- 15 people
- Sponsor
- Meddoc
Asthma, GERD
Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma
The purpose of this study is to determine whether treatment with esomeprazole for 6 months will improve asthma in adult patients with moderate to severe asthma and symptoms of gastroesophageal reflux disease.
- Trial name
- RELAX (NCT00317044)
- Testing
- Esomeprazole
- Where
- 130 sites in United States, Argentina and 12 more
- Volunteers
- 961 people
- Sponsor
- AstraZeneca
Deglutition Disorders
Design and Development of a Functional Plant-based Beverage Formulated According to the Main Nutritional Guides for Early Elderly Requirements to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
Populations around the world are aging and this demographic transition will impact almost every aspect of society. Furthermore, the COVID-19 pandemic has highlighted the seriousness of gaps in policies, systems and services.
- Trial name
- IMMUGOLD (NCT06445309)
- Testing
- Sensory test of functional plant-based drink
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Obesity, GERD
One Anastomosis Gastric Bypass With Excluded Stomach Fundoplication: FundoRing vs Nissen vs OAGB Without Fundoplication
Background and study aims: Currently, one anastomosis Gastric Bypass (OAGB) is a common bariatric procedure. Obesity and gastroesophageal reflux disease (GERD) are steadily increasing world weight and antireflux surgery must be…
- Trial name
- FundoRing (NCT04828733)
- Testing
- laparoscopic one anastomosis gastric bypass with excluded stomach fundoplication: FundoRingOAGB and suture cruroplasty, laparoscopic one anastomosis gastric bypass with excluded stomach Nissen fundoplication and suture cruroplasty, Standard laparoscopic one anastomosis gastric bypass with cruroplasty. Not used fundoplication.
- Where
- Kazakhstan
- Volunteers
- 150 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Gastroesophageal Reflux
The Use of Proton Pump Inhibitor for the Treatment of Non-erosive Gastro-oesophageal Reflux Disease in Chinese Population
The purpose of this study is to evaluate the efficacy of proton pump inhibitor for the treatment of non-erosive reflux disease (NERD) in Chinese population.
- Trial name
- NCT00516971
- Testing
- Esomeprazole 20mg once daily
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hospital Authority, Hong Kong
Achalasia, Esophageal
Comparative Study of Per-oral Endoscopic Myotomy (POEM) in Treatment - naïve Achalasia Patients Versus Patients With Previous Pneumatic Dilation
The aim of this study is to compare the clinical efficacy, safety, and technical outcomes of per-oral endoscopid myotomy( POEM )in treatment-naïve achalasia patients versus patients with previous pneumatic dilation.
- Trial name
- NCT07287787
- Testing
- per-oral endoscopic myotomy (POEM)
- Volunteers
- 32 people
- Sponsor
- Assiut University
Dysphagia, Laryngeal Edema
Corticosteroids for Post-Extubation Dysphagia
This is a placebo-controlled, double-blind randomized trial of a short course of intravenous corticosteroids for Acute Respiratory Failure Survivors with Fiberoptic Endoscopic Evaluation of Swallowing (FEES) documented laryngeal…
- Trial name
- COPED (NCT06670521)
- Testing
- Methylprednisolone, Normal Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
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