Clinical trials: Deglutition Disorder
Hiatal Hernia, GERD
Laparoscopic Total Left-sided Surgical Approach Versus Traditional Bilateral Surgical Approach for Hiatal Hernia
Background: In China, guidelines for the treatment of hiatal hernia (HH) are lacking. Furthermore, efficacy and safety assessments of surgical approaches for HH and for the protection of the vagus nerve and organ function are…
- Trial name
- NCT06828627
- Testing
- TLSA, TBSA
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Beijing Friendship Hospital
Voice Disorders, Gastroesophageal Reflux
Quantifying Effects of Treatment of Pediatric Dysphonia
The diagnosis and management of childhood dysphonia is a significant clinical problem; however, there have been few studies aimed at defining standard assessment methods for pediatric dysphonia.
- Trial name
- NCT00237679
- Testing
- Neuromuscular Electrical Stimulation, Unstimulated
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Wisconsin, Madison
Swallowing Disorder, Chewing Problem
Chewing and Swallowing Training Program in Coffin-Lowry Syndrome
This study will report the chewing and swallowing disorders of a Coffin-Lowry Syndrome (CLS) patient, and effects of chewing and swallowing training on chewing and swallowing function.
- Trial name
- NCT04199546
- Testing
- Chewing and swallowing rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Hacettepe University
Cough, Gastroesophageal Reflux
Exhaled Breath Condensate pH in Patients With Cough Caused by Gastroesophageal Reflux
Cough is the most common complaint for which patients seek medical attention in the United States, accounting for approximately 1 billion dollars in health care expenses annually.
- Trial name
- NCT00451841
- Testing
- RTube Exhaled Breath Condensate Collection System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Massachusetts, Worcester
Esophagitis
Prospective Analysis of Eosinophilic Esophagitis in Patients Presenting With Dysphagia
This is a prospective descriptive cross sectional study to determine the percentage of patients presenting with dysphagia who are found to have eosinophilic esophagitis (EoE) and to establish which presenting factors warrant…
- Trial name
- NCT00256529
- Testing
- EGD with biopsies
- Where
- United States
- Volunteers
- 483 people
- Sponsor
- University of Utah
Dysphagia
Chewing and Oral Processing of Solid Food
Food texture modification is commonly used as an intervention for people with dysphagia (swallowing impairment). However, the field currently lacks a proper understanding of how this intervention works.
- Trial name
- NIH_HVX6 (NCT05594173)
- Testing
- Food texture modification
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Gastroesophageal Reflux
Diagnostic Tests in Supra-Esophageal Gastroesophageal Reflux Disease (SE-GERD)
After defining the manometric characteristics of UES incompetence associated with documented pharyngeal reflux, we will determine the reproducibility of manometric criteria for UES incompetence in prevention of pharyngeal reflux.
- Trial name
- SE-GERD (NCT05695846)
- Testing
- externally applied cricoid cartilage pressure
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Obesity, Morbid, Gastroesophageal Reflux (GERD)
AJYR+GV vs RYGB for GERD
This study focuses on gastroesophageal reflux disease (GERD), a condition in which stomach acid flows back into the esophagus (the tube that carries food from the mouth to the stomach), causing heartburn and other symptoms.
- Trial name
- NCT07768202
- Testing
- sleeve gastrectomy with Roux-en-Y antrojejunal anastomosis, AJYR+SG, Roux-en-Y gastric bypass, RYGB
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Victor Dib Institute
Gastroesophageal Reflux
Validation of RDQ Questionnaire
The primary objective of this study is to determine the accuracy of the Reflux Disease Questionnaire (RDQ) as a diagnostic test for gastroesophageal reflux disease.
- Trial name
- NCT00291746
- Testing
- Esomeprazole, Bravo technique
- Where
- 30 sites in Canada, Denmark and 4 more
- Volunteers
- 350 people
- Sponsor
- AstraZeneca
Cancer Survivor, Dysphagia
Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors
This trial studies how well manual therapy works in treating fibrosis-related late effect dysphagia in head and neck cancer survivors.
- Conditions
- Cancer Survivor, Dysphagia, Fibrosis, Head and Neck Carcinoma
- Trial name
- MANTLE (NCT03612531)
- Testing
- Manual Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
Achalasia
Peroral Endoscopic Myotomy for the Treatment of Achalasia
There will be a retrospective chart review for patients who underwent endoscopic procedures and POEM from 06/2016 - 01/2019 \& a prospective chart review will be performed for patients who will undergo endoscopic procedures and…
- Trial name
- NCT04640753
- Testing
- Endoscopic procedure for achalasia
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Methodist Health System
Opioid Induced Pharyngeal and Esophageal Dysfunction
Opioid Effects on Swallowing and Esophageal Sphincter Pressure
The purpose of this study is to determine whether a dopamine receptor antagonist metoclopramide can counteract opioid induced effects on esophageal motility and lower esophageal sphincter.
- Trial name
- NCT01191645
- Testing
- naloxone, remifentanil, Sodium Chloride
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Dysphagia, Dysphagia, Swallowing Function, Diet Modification, Dysphagia Diet, Diet Standardization
GUSS-ICU Safe Nutrition Program After Extubation in ICU Patients
The aim of this study is to evaluate the effects of using the GUSS-ICU Safe Nutrition Program after extubation in Intensive Care Unit patients.
- Trial name
- NCT07195383
- Testing
- Nutrion plan based on GUSS-ICU scale
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Istanbul University - Cerrahpasa
Gastroparesis, Gastroesophageal Reflux
Domperidone for Gastroparesis in Solid Organ Transplantation
The purpose of this study is to examine the clinical response to domperidone in solid organ transplant recipients with gastroparesis.
- Trial name
- NCT00552422
- Testing
- domperidone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- David J. Lederer, M.D.
Gastroesophageal Reflux Disease
Drug Interaction Study Between AZD3355 and Nexium
The purpose of the study is to evaluate if AZD3355 and Nexium interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.
- Trial name
- NCT00684190
- Testing
- AZD3355, Esomeprazole
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Dysphagia, Oropharyngeal
AspiRATE: Novel Intervention to Acoustically Detect Silent Aspiration in Acquired Dysphagia.
This study will investigate whether silent aspiration during swallowing can reliably be detected using acoustic signal processing plus pulse oximetry.
- Trial name
- AspiRATE (NCT03676582)
- Testing
- Acoustic analysis plus pulse oximetry
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Esophageal Spasm, Diffuse
Botulinum Toxin Injection to Treat Diffuse Esophageal Spasm
This study evaluates the effect of botulinum toxin 100 U or saline, injected endoscopically in the distal esophagus, on symptoms and manometry pattern in patients with diffuse esophageal spasm.
- Trial name
- Botox (NCT01432782)
- Testing
- Botulinum Toxin Type A
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dysphagia After Stroke
Effect of Applying Oral Hygiene Care on Swallowing in Stroke Patients With Oropharyngeal Dysphagia
Post-stroke dysphagia (PSD) is a common condition, affecting over 40% of patients within hours to days following a stroke. It is associated with negative outcomes, including higher rates of mortality and dependency, incidence of…
- Trial name
- NCT06847217
- Testing
- Mouth moisturization, Mechanical oral hygiene care, Combined care
- Where
- Belgium
- Volunteers
- 260 people
- Sponsor
- University Hospital, Ghent
Refractory GERD, NERD
Vonoprazan Test for PPI Refractory GERD
Among patients suffering from gastroesophageal reflux disease (GERD) symptoms, esophageal pH monitoring and the assessment of symptom-reflux correlation can identify two distinct subgroups characterized by normal acid exposure…
- Conditions
- Refractory GERD, NERD, PCAB
- Trial name
- NCT07437768
- Testing
- Patients received a 4-week treatment of vonoprazan 20 mg once daily (VOCINTI®)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fu Jen Catholic University Hospital
Fundoplication, GERD
Transoral Incisional Fundoplication (TIF) for Patients Suffering From Gastroesophageal Reflux Disease in an Asian Population
Transoral incisionless fundoplication (TIF) has become a widely used intervention to restore the valve at the gastroesophageal junction in selected patients suffering from gastroesophageal reflux disease (GERD).
- Trial name
- NCT07556289
- Testing
- Transoral incisional fundoplication
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
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