Clinical trials: Deglutition Disorder
Dyspepsia, GERD
Famotidine and Antacids for Treatment of Dyspepsia
The aim of this study is to compare intravenous famotidine, an H2 receptor antagonist, and Maalox/ Mylanta, an oral antacid, in treatment of dyspepsia in the emergency department.
- Conditions
- Dyspepsia, GERD, Acid Reflux
- Trial name
- NCT06241183
- Testing
- Intravenous Famotidine, Oral Maalox/ Mylanta
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Dysphagia
The Impact of Practicing Active Breathing Exercises on Elderly Individuals Living in the Community
The goal of this clinical trial is to explore the impact of Active Breathing Exercises on swallowing function and quality of life in community-dwelling elderly individuals (≥60 year old) with swallowing disorders.
- Trial name
- NCT06328192
- Testing
- Active Breathing Exercises
- Volunteers
- 300 people
- Sponsor
- Copka Sonpashan
Peripheral Facial Paralysis
Lengthening Temporalis Myoplasty and Improvement of Primary Swallowing Disorders in Facial Paralysis
The facial paralysis is a frequent disease causing important functionals swallowing dysfunctions. The purpose of our study was to evaluate the improvement of the swallowing disorders after surgery by lengthening temporalis…
- Trial name
- MATPF (NCT03284125)
- Testing
- Swallowing disorders evaluation
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Tours
Sleep Apnea
Evolution of Swallowing in Patients Undergoing Lateral Pharyngoplasty With Preservation Stylopharyngeal Muscle
Evolution of swallowing in patients undergoing lateral pharyngoplasty with preservation stylopharyngeal muscle.
- Trial name
- NCT01576926
- Where
- Brazil
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hospital do Servidor Publico Estadual
Gastro Esophageal Reflux, Gastro Esophageal Reflux Disease
The Effect of Postural Correction On Gastroesophageal Reflux Disease
The main aim of this randomized controlled trial is to investigate the effects of postural correctional exercises and interventions on the severity of symptoms of gastroesophageal reflux disease (GERD) as well as the quality of…
- Trial name
- NCT06564558
- Testing
- Spinal Strengthening Exercises, Thoracic Spine Stretching, Thoracic Spine Mobilization
- Where
- Lebanon
- Volunteers
- 30 people
- Sponsor
- Cairo University
Esophageal Diseases, Esophagitis
Twenty Four Hour Ambulatory pH & Impedance Testing: Normative Data for Indian Population
GERD is common in Indian population and the normative data which is used to diagnose \& manage GERD and its complications are based on western data which is not validated in the Indian population.
- Conditions
- Esophageal Diseases, Esophagitis, Reflux Disease
- Trial name
- NCT05004155
- Testing
- 24 hour pH & impedance monitoring
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Reflux
Study to Investigate the Pharmacodynamic Effect of a Single Dose of AZD2516 in Healthy Male Subjects
The purpose of this study is to investigate the pharmacodynamic effect of AZD2516 in healthy male subjects.
- Trial name
- NCT01154634
- Testing
- AZD2516, 5 mg, AZD2516, 16 mg, AZD2516, 40 mg
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Oropharyngeal Dysphagia
Autologous Muscle Derived Cells for Gastro-Intestinal Repair (AMDC-GIR) for Tongue Dysphagia
The primary objective of this study is to evaluate the safety of Autologous Muscle Derived Cells for Gastro-Intestinal Repair (AMDC-GIR) during the 12 months following treatment of tongue dysphagia in male and female patients who…
- Trial name
- NCT02838316
- Testing
- Autologous Muscle Derived Cells for Gastro-Intestinal Repair (AMDC-GIR)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Peter Belafsky, MD
Chronic Dysphagia, Multiple Sclerosis
A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia
This study will compare an implant with the technique of sensory training to determine which method may improve the ability to swallow and reduce the risk of choking.
- Conditions
- Chronic Dysphagia, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT00376506
- Testing
- Neurostimulation device for dysphagia, External vibrotactile device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Dysphagia
Pilot Study of Efficacy of Mechanical Insufflation Exsufflation in Stroke
Stroke patients with dysphagia have restrictive lung dysfunction and impaired cough response. This pilot study was performed to determine if Mechanical Insufflation Exsufflation (MIE) therapy can help recover impaired cough…
- Trial name
- NCT02080806
- Testing
- Mechanical Insufflation Exsufflation
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- The Catholic University of Korea
Dysphagia
Comprehensive Oral Care Long-term Care Facilities
Oral care is a common way of caring for long-term care facility residents, particularly for those with swallowing difficulties, as oral health is closely related to eating function.
- Trial name
- NCT06606548
- Testing
- comprehensive oral care
- Where
- Taiwan
- Volunteers
- 91 people
- Sponsor
- National Taiwan University Hospital
Gastroesophageal Reflux Disease
Symptoms and Management Strategies in Gastroesophageal Reflux Disease (GERD)
This a non-interventional multi-centre study to evaluate the symptom load and management strategies in PPI-treated GERD patients with persistent GERD symptoms..
- Trial name
- PHENIX (NCT00768443)
- Where
- 32 sites in Croatia
- Volunteers
- 2,674 people
- Sponsor
- AstraZeneca
Achalasia, Epidermoid Carcinoma
Epidermoid Cancer Development in Esophageal Achalasia
Esophageal achalasia is a precancerous condition for epidermoid carcinoma; incidence and risk factors for cancer development are not defined.
- Trial name
- NCT03546998
- Testing
- Clinical instrumental examinations
- Where
- Italy
- Volunteers
- 681 people
- Sponsor
- Sandro Mattioli
Dysphagia, Cerebral Small Vessel Diseases
Stellate Ganglion Block in Patients With Cerebral Small Vessel Disease
A prospective study was conducted on 84 CSVD patients with dysphagia and cognitive impairment. They were divided into the comparison group and observation group evenly.
- Conditions
- Dysphagia, Cerebral Small Vessel Diseases, Cognitive Impairment
- Trial name
- NCT06176404
- Testing
- Stellate ganglion block, Rehabilitation therapy
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Zeng Changhao
Elderly (People Aged 65 or More), Swallowing Training on Muscle Strength
Efficacy of Oral Exercise Training in Oral Frailty
As the elderly grow older, the quality and function of skeletal muscle are affected. Sarcopenia is commonly seen in the elderly, due to the loss of skeletal muscle mass and function, often resulting in loss of activity and…
- Conditions
- Elderly (People Aged 65 or More), Swallowing Training on Muscle Strength, Dysphagia
- Trial name
- NCT06926426
- Testing
- oral function training
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- China Medical University Hospital
Esophageal Achalasia
Quality of Life After POEM for Achalasia
Achalasia is an esophageal motility disorder, characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis.
- Trial name
- NCT05010889
- Testing
- Peroral endoscopic myotomy (POEM)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Stroke Associated Pneumonia, Non Severe Ischemic Stroke
Study on the Treatment of Post-stroke Dysphagia and Stroke-associated Pneumonia With Bronchoscopy
Select 50 non-severe ischemic SAP patients with swallowing difficulties in our intensive care unit and randomly divide them into two group.The control group was given conventional anti-infective drugs, expectorants, and…
- Conditions
- Stroke Associated Pneumonia, Non Severe Ischemic Stroke, Dysphagia
- Trial name
- Sottopdaspwb (NCT07345078)
- Testing
- Tracheoscopy suction and bronchoalveolar lavage
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First People's Hospital of Zunyi
GERD, Dysbiosis
How Reflux Medications Affect the Microbiome of Infants
The changes in the organisms making up the gut microbiota in infants who are taking anti-acid reflux medications (histamine 2 receptor antagonists) as compared to infants who are not taking these medications is not well-studied…
- Trial name
- NCT03747991
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Pulmonary Valve Insufficiency, Pulmonary Regurgitation
COMPASSION - COngenital Multicenter Trial of Pulmonic VAlve Regurgitation Studying the SAPIEN InterventIONal THV
To assess the safety and effectiveness of pulmonic THV implantation in subjects with dysfunctional RVOT conduit requiring treatment for moderate or severe pulmonary regurgitation (≥3+ pulmonary regurgitation) and/or RVOT conduit…
- Conditions
- Pulmonary Valve Insufficiency, Pulmonary Regurgitation, Dysfunctional RVOT Conduit, Pulmonary Obstruction
- Trial name
- NCT00676689
- Testing
- SAPIEN Transcatheter Valve Implantation
- Where
- 7 sites in United States
- Volunteers
- 81 people
- Sponsor
- Edwards Lifesciences
GERD (Gastroesophageal Reflux Disease)
Normal Values of Ambulatory 24-hour Oesophageal pH-impedance Monitoring in an Indian Cohort of Participants
This study aims to determine normal 24-hour pH-impedance monitoring values, including acid exposure time (AET), in healthy Indian adults. It will help improve GERD diagnosis in India by providing population-specific data.
- Trial name
- NCT06928350
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India