Clinical trials: Deglutition Disorder
Barrett Esophagus, Proton Pump Inhibitor
On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus.
On-demand PPI therapy is feasible for the long-term treatment of patients with Barrett's esophagus.
- Conditions
- Barrett Esophagus, Proton Pump Inhibitor, Symptom, Reflux
- Trial name
- NCT04329000
- Testing
- Esomeprazole 40mg, Esomeprazole
- Volunteers
- 218 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Brief Resolved Unexplained Event, Apparent Life Threatening Event
Effect of Thickened Feeds on Clinical Outcomes in Children With Brief Resolved Unexplained Event
This observational study will examine the effects of thickened feeds on clinical outcomes and healthcare utilization in infants with brief resolved unexplained event (BRUE).
- Conditions
- Brief Resolved Unexplained Event, Apparent Life Threatening Event, Oropharyngeal Dysphagia
- Trial name
- BRUE (NCT04477460)
- Testing
- Thickened feeds, Non-thickened feeds
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Children's Hospital
Acute Stroke
Effect of Sour Liquid On Swallowing Function of the Patients With Stroke
The aim of this study was to evaluate the effect of early administration of sour liquid on swallowing function of patients with post-stroke dysphagia.
- Trial name
- NCT06013254
- Testing
- sour liquid
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Trakya University
Pulmonary Aspiration of Gastric Contents
SMART Study (Sellick's Maneuver Assisted Real Time) to Deliver Target Cricoid Pressure in Simulated Environment
Cricoid force is applied during airway management to prevent pulmonary aspiration of regurgitated gastric contents. This force is usually applied by a nurse or anaesthesia assistant.
- Trial name
- NCT02749175
- Testing
- Cricoid force sensor monitor system
- Where
- Singapore
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Non-erosive Reflux Disease
Phase 2 Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH1885L in Patients With Non-erosive Reflux Disease(NERD)
Randomized, double-blind, active-controlled, multi-center phase 2 clinical trial to investigate the safety, tolerability and efficacy of YH1885L in patients with non-erosive reflux disease(NERD)
- Trial name
- NCT01750437
- Testing
- YH1885L(Revaprazan), Esomeprazole 20mg
- Where
- 10 sites in South Korea
- Volunteers
- 149 people
- Sponsor
- Yuhan Corporation
GERD
Prospective Evaluation of PH-impedance Tracings According to the Wingate Consensus, and Influence on GERD Classification According to the Lyon Consensus
Commonly, in clinical practice an automated analysis of pH-MII tracings is obtained.
- Trial name
- WinPro (NCT06084572)
- Testing
- Questionnaires
- Where
- 3 sites in Belgium, Germany
- Volunteers
- 120 people
- Sponsor
- Universitair Ziekenhuis Brussel
GERD, Cardiac Event
Cardiac Safety of Lansoprazole and Domperidon Combination
The aim of current study is to compare safety and efficacy of lansoprazole/domperidone 30/30 mg sustained release capsules (brand name: Duolans) and lansoprazole 30 mg micropellet capsules (brand name: Lasotab) in GERD patients…
- Conditions
- GERD, Cardiac Event, Safety Issues
- Trial name
- NCT03355170
- Testing
- Lansoprazole/Domperidone, Lansoprazole
- Where
- 16 sites in Turkey (Türkiye)
- Sponsor
- Neutec Ar-Ge San ve Tic A.Ş
Esophageal Motility Disorders
U-POEM vs CO2-POEM
Multicenter randomized trial comparing post-procedural pain intensity after Per-Oral endoscopic myotomy (POEM) between two types of standard of care insufflation methods (CO2 vs Underwater).
- Trial name
- U-POEM (NCT06918730)
- Testing
- U-POEM, CO2-POEM
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- AdventHealth
Gastroesophageal Reflux Disease
Efficacy of Imipramine for Treatment of Patients With Esophageal Hypersensitivity/ Functional Heartburn
Esophageal hypersensitivity/Functional heartburn are common among non-erosive reflux disease (NERD) patients who do not response to proton pump inhibitors.
- Trial name
- NCT01753128
- Testing
- imipramine
- Where
- Thailand
- Volunteers
- 83 people
- Sponsor
- Mahidol University
Dysphagia With Normal Endoscopy
The Role Of Empiric Dilation In Patients With Dysphagia With Normal Endoscopy
The goal of our study is to determine if stretching the esophagus with a rubber dilator helps patients with swallowing difficulties who have a normal appearing esophagus on upper endoscopy.
- Trial name
- NCT01444066
- Testing
- Dilation of the esophagus
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Stroke, Acute
Neuro Anatomical Correlation of Oropharyngeal Swallowing Revisited in Cerebrovascular Stroke Patients
Stroke, main cause of disability in adults, is thought to be the primary cause of swallowing difficulty (dysphagia). Dysphagia is one of the common physical condition among patients with stroke, affecting the large number of…
- Trial name
- NCT05603377
- Testing
- functional endoscopic evaluation of swallow
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Gastroesophageal Reflux Disease
A Study to Estimate Effect of 4 Different Doses of AZD3355 on Reflux Episodes, Which Patients With Gastroesophageal Reflux Disease (GERD) May Experience
The purpose of the study is to estimate what effect 4 different doses of AZD3355 will have on the number of reflux episodes, in patients who have GERD and still experience symptoms despite proton pump inhibitor (PPI) treatment.
- Trial name
- NCT01043185
- Testing
- AZD3355
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Full-Thickness-Gastroplication For The Treatment Of Gastroesophageal Reflux Disease GERD
This is a prospective study to extensively evaluate subjective patient parameters on quality of life, reflux-symptoms, side effects, medication-use and measurements of esophageal manometry and Impedance-pH-Monitoring after…
- Trial name
- NCT01453985
- Testing
- Full-Thickness-Gastroplication
- Where
- Austria
- Sponsor
- General Public Hospital Zell am See
Bronchial Asthma, Gastroesophageal Reflux
Improvement in Bronchial Asthma in Patients With Extraesophageal Reflux After Acid Suppression
The purpose of this study is to determine if 20mg BID of Rabeprazole is effective in controlling GERD in patients with concomitant bronchial asthma and to assess improvement in asthma after reflux control.
- Trial name
- NCT00234117
- Testing
- Rabeprazole
- Where
- Puerto Rico
- Volunteers
- 40 people
- Sponsor
- Ponce Gastroenterology Research
Gastro-intestinal Tolerance
GI Tolerance and Acceptability of a New Thickener
The current study is designed to evaluate the gastrointestinal tolerance and acceptability of a new thickener for dysphagia patients.
- Trial name
- NCT04104815
- Testing
- Experimental Thickener
- Sponsor
- Abbott Nutrition
GERD
Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
This study is a randomised, double-blind, parallel-group and placebo controlled study comparing the efficacy of esomeprazole 40 mg orally qd vs. placebo and esomeprazole 20 mg orally qd vs.
- Trial name
- NCT00241540
- Testing
- Esomeprazole
- Where
- 119 sites in United States, Belgium and 4 more
- Volunteers
- 808 people
- Sponsor
- AstraZeneca
Parkinson Disease, Dysphagia
Prevalence of Subclinical and Clinical Dysphagia in Parkinson's Disease
Background: In idiopathic Parkinson's disease, 50% of patients develop in the course of the disease a dysphagia and aspiration pneumonia is the leading cause of death in all parkinsonian syndromes .
- Trial name
- NCT04889170
- Testing
- Intervention
- Where
- Austria
- Volunteers
- 180 people
- Sponsor
- Neurological Rehabilitation Hospital Rosenhügel
Stroke, Spinocerebellar Ataxia
Laryngeal Adaptation for Speech and Swallowing
This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6.
- Conditions
- Stroke, Spinocerebellar Ataxia, Cerebral Stroke, Dysphagia
- Trial name
- NCT03770377
- Testing
- Intermittent Perturbation to Continuous Perturbation, Continuous Perturbation to Intermittent Perturbation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Gastroesophageal Reflux, Gastroparesis
Domperidone Expanded Access Protocol for Patients With Gastrointestinal Disorders
FDA currently allows patients 12 years of age and older with various gastrointestinal (GI) conditions to be treated with Domperidone through the Expanded Access to Investigational Drugs program.
- Conditions
- Gastroesophageal Reflux, Gastroparesis, Chronic Constipation With Overflow, Pseudo Obstruction
- Trial name
- NCT02567175
- Testing
- Domperidone
- Where
- United States
- Sponsor
- Prasanna K Kapavarapu
Stroke, Complication, Parkinson's Disease
Innovative Treatments for Neurogenic Dysphagia
This study aims to evaluate different non-invasive and neuromuscular stimulation treatments for neurogenic dysphagia in post-stroke and Parkinson's disease patients. The study is divided into three sub-studies: 1.
- Trial name
- NCT07152899
- Testing
- Unilateral anodal tDCS, Bihemispheric anodal tDCS, NMES + swallowing therapy
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation